Abstract:
OBJECTIVES:Older people commonly present with memory loss although on assessment are not found to have a full dementia complex. Previous studies have suggested however that people with subjective and objective cognitive loss are at higher risk of dementia. We aimed to determine from the literature the rate of conversion from mild cognitive impairment to dementia. METHODS:Systematic review of MedLine, PsychLit and EmBase. RESULTS:We identified 19 longitudinal studies published between 1991 and 2001 that addressed conversion of mild cognitive impairment to dementia. Overall the rate of conversion was 10% but with large differences between studies. The single biggest variable accounting for between study heterogeneity was source of subjects, with self-selected clinic attenders having the highest conversion rate. The most important factor accounting for heterogeneity within studies was cognitive testing, with poor performance predicting conversion with a high degree of accuracy. CONCLUSIONS:These data strongly support the notion that subjective and objective evidence of cognitive decline is not normal and predicts conversion to dementia. The more stringent the measures of both variables the better the prediction of conversion. Mild cognitive impairment, appropriately diagnosed, is a good measure with which to select subjects for disease modification studies.
journal_name
Int Psychogeriatrjournal_title
International psychogeriatricsauthors
Bruscoli M,Lovestone Sdoi
10.1017/s1041610204000092keywords:
subject
Has Abstractpub_date
2004-06-01 00:00:00pages
129-40issue
2eissn
1041-6102issn
1741-203Xjournal_volume
16pub_type
杂志文章,评审abstract:BACKGROUND:Few studies have estimated care burden in large, representative, multi-ethnic Asian population-based informal caregivers of older adults with care needs. This study describes informal caregivers' care participation for a population-based sample of older adults with care needs in Singapore, investigates diffe...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S104161021500160X
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Patients with dementia often receive poor end-of-life care, with inadequate pain control and without access to the palliative care services that patients with cancer are offered. This has been identified as an area of need in recent UK. Government reports and by the Alzheimer's Society (UK). Our objective wa...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/s1041610205001018
更新日期:2005-03-01 00:00:00
abstract::ABSTRACTIntroduction:The relationship between Alzheimer's Disease (AD) and alcohol addiction is poorly characterized. Arrests for driving under the influence (DUI) can serve as a proxy for alcohol addiction. Therefore, the potential association between DUI and AD could be helpful in understanding the relationship betw...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610218001151
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:The aim of this survey is to investigate professional attitudes to the presence and value of spiritual care from Old Age Psychiatrists. METHOD:All registered members of the Faculty of the Psychiatry of Old Age in the United Kingdom were asked to complete a 21-question semi-structured questionnaire. The firs...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610206004339
更新日期:2007-10-01 00:00:00
abstract::This article reviews longitudinal data collected from patients with Alzheimer's disease (AD) that are relevant to the design and interpretation of clinical treatment trials. Longitudinal data from patients tested with the Alzheimer's Disease Assessment Scale demonstrate that cognitive symptoms, including memory loss, ...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/s1041610296002578
更新日期:1996-07-01 00:00:00
abstract:BACKGROUND:It is of considerable public health importance to prevent or delay the progression of mild cognitive impairment (MCI) to more severely impaired cognitive states. This study examines the risk of progression from mild to severe cognitive impairment in relation to engagement in social activities while mildly im...
journal_title:International psychogeriatrics
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doi:10.1017/S1041610212002086
更新日期:2013-04-01 00:00:00
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journal_title:International psychogeriatrics
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doi:10.1017/S1041610208007709
更新日期:2008-12-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
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更新日期:2018-03-01 00:00:00
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journal_title:International psychogeriatrics
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更新日期:2006-03-01 00:00:00
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更新日期:2009-08-01 00:00:00
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journal_title:International psychogeriatrics
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更新日期:2017-08-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610205002309
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:Cognitive impairment and depression are common and disabling non-motor symptoms of Parkinson's disease (PD). Previous studies have shown associations between them but the nature of the relationship remains unclear. In chronic illness, problem- or task-oriented coping strategies are associated with better out...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212000749
更新日期:2012-10-01 00:00:00
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journal_title:International psychogeriatrics
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更新日期:2016-09-01 00:00:00
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journal_title:International psychogeriatrics
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更新日期:2012-07-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章,随机对照试验
doi:10.1017/S1041610205003017
更新日期:2006-09-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
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更新日期:2010-05-01 00:00:00
abstract::The authors would like to apologise for a typographical error in the discussion of the above mentioned article. In the discussion on page 830 of the article, paragraph 'In the present sample, when we tested the accuracy of the MoCA to discriminate between MCI and healthy participants using ROC curves, the best cut-off...
journal_title:International psychogeriatrics
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更新日期:2017-04-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2009-04-01 00:00:00
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journal_title:International psychogeriatrics
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更新日期:2017-12-01 00:00:00
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更新日期:2014-05-09 00:00:00
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更新日期:1995-04-01 00:00:00
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journal_title:International psychogeriatrics
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更新日期:2007-06-01 00:00:00
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journal_title:International psychogeriatrics
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更新日期:2013-04-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
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更新日期:2013-02-01 00:00:00
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journal_title:International psychogeriatrics
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更新日期:1997-03-01 00:00:00
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journal_title:International psychogeriatrics
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更新日期:2018-10-01 00:00:00
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journal_title:International psychogeriatrics
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更新日期:2017-01-01 00:00:00