Abstract:
BACKGROUND:The aim of this study is to investigate the diagnostic value of perfusion 99mTc-exametazime single photon emission computed tomography (SPECT) in the diagnosis of dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) in comparison with dopaminergic 123I-2beta-carbomethoxy-3beta-(4-iodophenyl)-n-(3-fluoropropyl) nortropane (FP-CIT) SPECT imaging. METHODS:Subjects underwent 99mTc-exametazime scanning (39 controls, 36 AD, 30 DLB) and 123I-FP-CIT scanning (33 controls, 33 AD, 28 DLB). For each scan, five raters performed visual assessments blind to clinical diagnosis on selected transverse 99mTc-exametazime images in standard stereotactic space. Diagnostic accuracy of 99mTc-exametazime was compared to 123I-FP-CIT results for the clinically relevant subgroups AD and DLB using receiver operating characteristic (ROC) curve analysis. RESULTS:Inter-rater agreement for categorizing uptake was "moderate" (mean kappa = 0.53) for 99mTc-exametazime and "excellent" (mean kappa = 0.88) for 123I-FP-CIT. For AD and DLB, consensus rating matched clinical diagnosis in 56% of cases using 99mTc-exametazime and 84% using 123I-FP-CIT. In distinguishing AD from DLB, ROC analysis revealed superior diagnostic accuracy with 123I-FP-CIT (ROC curve area 0.83, sensitivity 78.6%, specificity 87.9%) compared to occipital 99mTc-exametazime (ROC curve area 0.64, sensitivity 64.3%, specificity 63.6%) p = 0.03. CONCLUSION:Diagnostic accuracy was superior with 123I-FP-CIT compared to 99mTc-exametazime in the differentiation of DLB from AD.
journal_name
Int Psychogeriatrjournal_title
International psychogeriatricsauthors
Colloby SJ,Firbank MJ,Pakrasi S,Lloyd JJ,Driver I,McKeith IG,Williams ED,O'Brien JTdoi
10.1017/S1041610208007709subject
Has Abstractpub_date
2008-12-01 00:00:00pages
1124-40issue
6eissn
1041-6102issn
1741-203Xpii
S1041610208007709journal_volume
20pub_type
杂志文章abstract:OBJECTIVE:To validate a shorter version of the Geriatric Depression Scale (GDS) for older, visually impaired patients. PARTICIPANTS:Subjects were 70 visually impaired adults over age 65 who were presenting for services at a low vision clinic. METHOD:Subjects were interviewed by a geriatric nurse practitioner. A struc...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610200006554
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND:Older Puerto Rican adults have particularly high risk of diabetes compared to the general US population. Diabetes is associated with both higher depressive symptoms and cognitive decline, but less is known about the longitudinal relationship between cognitive decline and incident depressive symptoms in those...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217000746
更新日期:2017-08-01 00:00:00
abstract::This article reviews longitudinal data collected from patients with Alzheimer's disease (AD) that are relevant to the design and interpretation of clinical treatment trials. Longitudinal data from patients tested with the Alzheimer's Disease Assessment Scale demonstrate that cognitive symptoms, including memory loss, ...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/s1041610296002578
更新日期:1996-07-01 00:00:00
abstract:BACKGROUND:Global suicide rates among older adults are very high. Public attitudes towards older adults' suicide may affect older adults upon their contemplating such an act. Previous research has demonstrated that message framing affects persons' judgments and decision making. Thus, message framing may have particular...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610216000636
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:This study was conducted to estimate prevalence rates and risk factors for late-life depression in a large nationwide representative sample from Taiwan. METHODS:A total of 5,664, randomly sampled individuals aged ≥55 years were enrolled. Clinically, relevant depressive symptoms were classified using the Cen...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217000199
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:The objectives of this study were to examine the factors modifying the relationship between cortisol level and prevalent/incident cognitive impairment in older adults and to verify whether these relationships were non-linear. METHODS:Data were collected from 1,226 individuals aged 65 and older by two in-hom...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212001706
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Most research on family members' experience of dementia has focused on the time after diagnosis. Yet, once people reach clinical attention, families have already been living with the changes for some time. These pre-diagnosis experiences can influence later caregiving. We aimed to synthesize qualitative rese...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/S1041610217000862
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:Clinical syndromes such as amnestic mild cognitive impairment (MCI) are highly predictive of future development of Alzheimer's disease (AD), but it is not known how many of the individuals that develop the disease can be identified with these syndromes. This study aims to determine how many individuals with A...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610207006564
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND:Effectiveness of educational interventions targeted at improving delirium care is limited by implementation barriers. Studying factors which shape learning needs can overcome these knowledge transfer barriers. This in-depth qualitative study explores learning needs of hospital staff relating to care needs of...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212002074
更新日期:2013-04-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610200006323
更新日期:2000-06-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:
更新日期:1992-01-01 00:00:00
abstract::Neuroimaging has become part of the required investigations when assessing a patient with dementia. In this brief paper, we summarize the role of computed tomography (CT) in the routine work-up in dementia and provide some information about the role of the CT scan in the field of dementia research. Although CT is far ...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/S1041610211000950
更新日期:2011-09-01 00:00:00
abstract::This article reviews the evidence available from natural history studies and randomized clinical trials (RCT) concerning what is now coined as amnestic MCI and vascular MCI and will answer the question about the similarity and difference of their progression toward dementia. The issues to be resolved prior to the use ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610203009293
更新日期:2003-01-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212001743
更新日期:2013-02-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610298005444
更新日期:1998-12-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/s1041610205001018
更新日期:2005-03-01 00:00:00
abstract::ABSTRACTBackground:The number of elderly individuals living in China is increasing rapidly. The aim of this study was to examine the potential risk factors of geriatric depression in rural areas. METHODS:A repeated cross-sectional study was conducted between January 2015 and October 2016 in rural China. Nine hundred ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610218000030
更新日期:2018-10-01 00:00:00
abstract::The objectives of this randomized clinical trial were to investigate the impact of the discontinuation of long-term antipsychotics in residents with dementia in chronic care institutions and to identify clinical predictors of safe discontinuation. Subjects included 34 residents with dementia who were on antipsychotics...
journal_title:International psychogeriatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/s1041610202008396
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:Raising understanding of dementia has become a key focus of international health and social care. An up-to-date, psychometrically sound measure of dementia knowledge that embraces a biopsychosocial perspective is lacking. The aim of this study is to develop and evaluate the psychometric properties of the DK-...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610213001142
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:People with behavioral and psychological symptoms of dementia (BPSD) are often prescribed psychotropic medications. There is little evidence that one class of medication is more effective and safer than another and so expert opinion plays an important role in shaping local practice. In an earlier U.S. survey...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610205001481
更新日期:2005-06-01 00:00:00
abstract::ABSTRACTBackground:Getting lost is a recognized complication in patients with dementia. Preventive measures are lacking. This study aims to investigate the effectiveness of a home-based missing incident prevention program (HMIPP) in reducing missing incidents, time of searching, and caregivers' stress. METHODS:The de...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610218000546
更新日期:2019-01-01 00:00:00
abstract::ABSTRACTBackground:Cognition is multidimensional, and each domain plays a unique and crucial part in successful daily life engagement. However, less attention has been paid to multi-domain cognitive health for the elderly, and the role of lifestyle factors in each domain remains unclear. METHODS:We conducted a cross-...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217003076
更新日期:2018-10-01 00:00:00
abstract::ABSTRACTObjectives:The objectives of the study were to examine the trajectory of spirituality among older adults, to investigate the roles of gender and religion on the developmental trajectory of spirituality, and to explore whether the linear growth of spirituality accelerated or decelerated at time points at which ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610218000029
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVES:To explore the extent to which staff members in long-term care facilities (LTCF) have experienced situations of sexual harassment, how they commonly and ideally manage the situation, and how their work position influences their responses. DESIGN:Cross-sectional quantitative study, using the vignette techniq...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610219001431
更新日期:2020-03-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610210000797
更新日期:2011-02-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 社论
doi:10.1017/S104161021800087X
更新日期:2018-07-01 00:00:00
abstract::Understanding of vascular substrates of cognitive decline in the elderly is evolving to include a major emphasis on the impact of small vessel disease (SVD). While existing concepts of multi-infarct dementia and strategic infarct dementia remain valid, they present difficulty in generalizing clinicopathological correl...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610203008998
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate survival time and life-expectancy in people with young-onset dementia (YOD) and to examine the relationship with age, sex, dementia subtype and comorbidity. DESIGN, SETTING AND PARTICIPANTS:Survival was examined in 198 participants in the Needs in Young-onset Dementi...
journal_title:International psychogeriatrics
pub_type: 杂志文章,多中心研究
doi:10.1017/S1041610219000152
更新日期:2019-12-01 00:00:00
abstract::ABSTRACTBackground:Psychosocial models suggest that the lived experience of dementia is affected by interpersonal factors such as the ways in which others view, talk about, and behave toward the person with dementia. This review aimed to illuminate how informal, everyday interpersonal relationships are experienced by ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
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更新日期:2018-06-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610220000344
更新日期:2020-09-01 00:00:00