A randomized, placebo-controlled trial of the discontinuation of long-term antipsychotics in dementia.

abstract：:ABSTRACT Background: Mild cognitive impairment (MCI) is a diagnostic classification used to describe patients experiencing cognitive decline but without a corresponding impairment in daily functioning. Over the years, MCI diagnostic criteria have undergone major changes that correspond to advancements in research. Des...

journal_title：International psychogeriatrics

authors： Gerstenecker A,Mast B

更新日期：2014-11-05 00:00:00

abstract：:Alzheimer´s disease (AD) is a severe neurodegenerative brain disorder characterized by beta-amyloid plaques, Tau pathology, inflammation, neurodegeneration, and cerebrovascular dysfunction. Besides that, alterations in monocytes and platelets have been reported in the blood of Alzheimer patients. In the present study,...

journal_title：International psychogeriatrics

authors： Defrancesco M,Marksteiner J,Humpel C

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:We assessed eight-year mortality rates and predictors in a rural cohort of elderly individuals with cognitive impairment. METHODS:A total of 1,035 individuals, including 155 (15.0%) individuals with cognitive impairment, no dementia (CIND), and 69 (6.7%) individuals with clinically diagnosed dementia were f...

journal_title：International psychogeriatrics

authors： Park JE,Lee JY,Suh GH,Kim BS,Cho MJ

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Individualized guidelines have the potential to offer clinicians assistance in decision-making at the point of consultation to improve health outcomes for patients. This project aims to develop individualized guidelines for the management of aggression in dementia. At an earlier stage, we developed a map of ...

journal_title：International psychogeriatrics

authors： Vickland V,Chilko N,Draper B,Low LF,O'Connor D,Brodaty H

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Differentiating Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), two of the commonest forms of dementia in older age, remains a diagnostic challenge. To assist with better understanding of the differences between the conditions during life, we assessed limbic and subcortical brain volumes in AD,...

journal_title：International psychogeriatrics

authors： Watson R,Colloby SJ,Blamire AM,O'Brien JT

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Identification of factors associated with quality of life (QoL) in people having dementia will help develop strategies for maintenance and improvement of patient QoL. This study examined the predictors of QoL in a community-dwelling population aged 75 years and over, with or without dementia. METHODS:This w...

journal_title：International psychogeriatrics

authors： Mate KE,Pond CD,Magin PJ,Goode SM,McElduff P,Stocks NP

更新日期：2012-12-01 00:00:00

abstract：:Health-related quality of life (HRQL) was investigated in 211 inhabitants of five residential homes in The Netherlands and was assessed again 1 year later. It was examined (a) if HRQL was related to the presence of specific general medical illnesses, (b) if comorbidity resulted in poorer HRQL, independent of the type ...

journal_title：International psychogeriatrics

authors： Cuijpers P,van Lammeren P,Duzijn B

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:The Geriatric Anxiety Inventory (GAI) was developed for assessing anxiety in older adults. The objectives of this work were: (a) to analyze the psychometric properties of the Spanish version of the GAI, and (b) to explore the associations between anxiety and other variables related to emotional distress (dep...

journal_title：International psychogeriatrics

authors： Márquez-González M,Losada A,Fernández-Fernández V,Pachana NA

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:While dementia is more common in older people and suicide rates in many countries are higher among the elderly, there is some doubt about the association between these two phenomena. METHODS:A search of the major relevant databases was carried out to examine the evidence for this possible association. RESU...

journal_title：International psychogeriatrics

authors： Haw C,Harwood D,Hawton K

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Previous studies have shown that the presence of depressive symptoms among older persons was evidently associated with subsequent physical and functional decline. However, few studies have directly examined the impact of changes in depressive symptoms or depressed mood on changes in functional ability. The p...

journal_title：International psychogeriatrics

authors： Nyunt MS,Lim ML,Yap KB,Ng TP

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Alterations in iron metabolism have been suggested as potential pathological markers in patients with manifest depression. No data on the association between iron and depression exist from population-based studies, in which milder forms of depressive symptoms are much more common. The aim of this study was t...

journal_title：International psychogeriatrics

authors： Baune BT,Eckardstein Av,Berger K

更新日期：2006-09-01 00:00:00

abstract：UNLABELLED:The aim of the current study was to test the properties of a scale especially developed for use in epidemiological surveys in low sociocultural populations, and to determine whether this scale can be used in a clinical population. MATERIAL AND METHODS:Two hundred fifty subjects took part; 150 were controls ...

journal_title：International psychogeriatrics

authors： Fountoulakis KN,Tsolaki M,Paulopoulos H,Kazis A

更新日期：2000-06-01 00:00:00

abstract：:Cholinergic deficits are a hallmark of Alzheimer's disease (AD) and Lewy body dementia (LBD). The nucleus basalis of Meynert (NBM) provides the major source of cortical cholinergic input; studying its functional connectivity might, therefore, provide a tool for probing the cholinergic system and its degeneration in ne...

journal_title：International psychogeriatrics

authors： Schumacher J,Thomas AJ,Peraza LR,Firbank M,O'Brien JT,Taylor JP

更新日期：2021-01-08 00:00:00

abstract：BACKGROUND:It is unclear how brain reserve interacts with gender and apolipoprotein E4 (APOE4) genotype, and how this influences the progression of Alzheimer's disease (AD). The association between intracranial volume (ICV) and progression to AD in subjects with mild cognitive impairment (MCI), and differences accordin...

journal_title：International psychogeriatrics

authors： An H,Son SJ,Cho S,Cho EY,Choi B,Kim SY,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:The IPA Taskforce on Mental Health Issues in Long-Term Care Homes seeks to improve mental health care in long-term care (LTC) homes. The aim of this paper is to provide recommendations on comprehensive assessment of depression and behavioral problems in order to further stimulate countries and professionals ...

journal_title：International psychogeriatrics

authors： Koopmans RT,Zuidema SU,Leontjevas R,Gerritsen DL

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Despite the magnitude of dementia, little research on survival duration and prognosis of dementia has been reported in developing countries. This study was conducted to investigate survival times, identify related prognostic factors and construct a prognostic index (PI) for community-based dementia patients ...

journal_title：International psychogeriatrics

authors： Wang Y,Huang Y,Liu Z,Zhuo C,Li S,Prince M

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVE:Despite delirium being common in older hospitalized people, little is known about its management. The aims of this study are (1) to describe the pharmacological management of delirium in an acute care setting as a baseline measure prior to the implementation of newly developed Australian guidelines; and (2) t...

journal_title：International psychogeriatrics

authors： Tropea J,Slee J,Holmes AC,Gorelik A,Brand CA

更新日期：2009-02-01 00:00:00

abstract：:Positive psychiatry is the science and practice of psychiatry that focuses on psycho-bio-social study and promotion of well-being and health through enhancement of positive psychosocial factors (such as resilience, optimism, wisdom, and social support) in people with illnesses or disabilities as well as the in communi...

journal_title：International psychogeriatrics

authors： Jeste DV

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Few current studies explore psychological well-being among older Chinese immigrants in Australia. The study addressed this gap and provided preliminary data on psychological well-being among this group. Four indicators, namely depression, anxiety, loneliness, and quality of life, were used to present a compr...

journal_title：International psychogeriatrics

authors： Lin X,Bryant C,Boldero J,Dow B

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Behavioral and psychological symptoms of dementia (BPSD) cause caregiver distress and earlier institutionalization. We compared the prevalence and characteristics of BPSD between institution residents and memory clinic outpatients with Alzheimer's disease (AD) to test the hypothesis that there is more BPSD a...

journal_title：International psychogeriatrics

authors： Cheng TW,Chen TF,Yip PK,Hua MS,Yang CC,Chiu MJ

更新日期：2009-12-01 00:00:00

abstract：:ABSTRACTBackground:Dementia is a neurodegenerative syndrome that interferes with multiple aspects of life, including cognition, daily functioning, and behavior. Despite the large heterogeneity in symptom development, these three domains are seldom studied simultaneously. This study investigates how trajectories of the...

journal_title：International psychogeriatrics

authors： Haaksma ML,Leoutsakos JS,Bremer JAE,Aalten P,Ramakers IHGB,Verhey FRJ,Olde Rikkert MGM,Melis RJF

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Data on the relationship between behavioral disturbances in Alzheimer's disease (AD) and global clinical deterioration is still controversial. The purpose of this study was to explore potential correlations of neuropsychiatric syndromes with global clinical deterioration in patients with AD, with particular ...

journal_title：International psychogeriatrics

authors： Stella F,Laks J,Govone JS,de Medeiros K,Forlenza OV

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Family involvement in long-term care (LTC) is important but it can prove challenging and result in conflict with staff if families do not feel connected to the LTC facility or if they believe that their contributions are undervalued. According to McMillan & Chavis (1986), sense of community (SOC) refers to a...

journal_title：International psychogeriatrics

authors： Petrovic-Poljak A,Konnert C

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Vocally disruptive behavior (VDB) in the elderly is a common condition, especially in people with dementia, but difficult to treat. It may occur in as many as 40% of nursing home residents. This study is a review of the existing literature on this condition. METHOD:The literature review was conducted using ...

journal_title：International psychogeriatrics

authors： von Gunten A,Alnawaqil AM,Abderhalden C,Needham I,Schupbach B

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Subjective memory complaints (SMCs) are a common occurrence for adults, which increase with age, and cause considerable distress. Traditionally SMCs have been assessed by either questionnaires, which ask whether a person has experienced given examples of SMCs, or open-ended questions which elicit spontaneous...

journal_title：International psychogeriatrics

authors： Burmester B,Leathem J,Merrick P

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Understanding the prevalence, incidence and cofactors of depression among long-term elderly nursing home (LTNH) residents domiciled for eight months or more may help optimize depression treatment in this vulnerable group. We quantified first year depression in American LTNH residents and the associations bet...

journal_title：International psychogeriatrics

authors： Hoover DR,Siegel M,Lucas J,Kalay E,Gaboda D,Devanand DP,Crystal S

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Whereas the State-Trait Anxiety Inventory (STAI-Y) is probably the most widely used self-reported measure of anxiety, the lack of current norms among elderly people appears to be problematic in both a clinical and research context. The objective of the present study was to provide normative data for the STAI...

journal_title：International psychogeriatrics

authors： Bergua V,Meillon C,Potvin O,Bouisson J,Le Goff M,Rouaud O,Ritchie K,Dartigues JF,Amieva H

更新日期：2012-07-01 00:00:00

abstract：:The Clinician Interview-Based Impression of Change, plus carer interview (CIBIC-Plus), is widely used in antidementia drug trials. It comprises Likert scales for disease severity and changes, and written accounts summarizing semistructured interviews evaluating behavior, cognition, and function. Studies using the CIBI...

journal_title：International psychogeriatrics

authors： Joffres C,Graham J,Rockwood K

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:The elderly are at high risk of developing tuberculosis. The prevalence and incidence of depression and anxiety are higher in those with tuberculosis than in the general population. A positive correlation between national suicide rates and rates of mortality due to tuberculosis has been reported. METHODS:Th...

journal_title：International psychogeriatrics

authors： Shah A

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:A carer-held record (CHR) was developed to enable carers to contribute to care plans for their relatives with dementia, alongside other professionals. The aim of this study was to establish whether CHRs provide any measurable benefits for carers, in the areas of health, stress, knowledge of dementia and locu...

journal_title：International psychogeriatrics

authors： Simpson R,Wakefield P,Spiers N,Jagger C,Lindesay J

更新日期：2006-06-01 00:00:00