Functional connectivity of the nucleus basalis of Meynert in Lewy body dementia and Alzheimer's disease.

Abstract:

:Cholinergic deficits are a hallmark of Alzheimer's disease (AD) and Lewy body dementia (LBD). The nucleus basalis of Meynert (NBM) provides the major source of cortical cholinergic input; studying its functional connectivity might, therefore, provide a tool for probing the cholinergic system and its degeneration in neurodegenerative diseases. Forty-six LBD patients, 29 AD patients, and 31 healthy age-matched controls underwent resting-state functional magnetic resonance imaging (fMRI). A seed-based analysis was applied with seeds in the left and right NBM to assess functional connectivity between the NBM and the rest of the brain. We found a shift from anticorrelation in controls to positive correlations in LBD between the right/left NBM and clusters in right/left occipital cortex. Our results indicate that there is an imbalance in functional connectivity between the NBM and primary visual areas in LBD, which provides new insights into alterations within a part of the corticopetal cholinergic system that go beyond structural changes.

journal_name

Int Psychogeriatr

authors

Schumacher J,Thomas AJ,Peraza LR,Firbank M,O'Brien JT,Taylor JP

doi

10.1017/S1041610220003944

subject

Has Abstract

pub_date

2021-01-08 00:00:00

pages

1-6

eissn

1041-6102

issn

1741-203X

pii

S1041610220003944

pub_type

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