Association of neuropsychiatric syndromes with global clinical deterioration in Alzheimer's disease patients.

Abstract:

BACKGROUND:Data on the relationship between behavioral disturbances in Alzheimer's disease (AD) and global clinical deterioration is still controversial. The purpose of this study was to explore potential correlations of neuropsychiatric syndromes with global clinical deterioration in patients with AD, with particular consideration on severity levels of dementia. METHODS:AD patients (n = 156) aged 76.7 years from Brazilian clinical centers were assessed to diagnose the five neuropsychiatric syndromes measured by the Neuropsychiatric Inventory-Clinician rating scale (NPI-C): psychosis, agitation, affective, apathy, and sleep. These syndromes were then analyzed for their correlation with the Global Deterioration Scale (GDS). To analyze the association of neuropsychiatric syndromes with the GDS, considering the total sample and patients grouped by dementia severity levels, we applied the coefficient of multiple correlation (Ryy), adjusted multiple linear regression, and the coefficient of determination (R2yx). We tested the significance of correlation coefficients using the Student t-test for simple correlations (a single independent variable) and analysis of variance (ANOVA) for multiple correlations. ANOVA was also used to compare means of demographic and some clinical variables at different levels of dementia. RESULTS:For the total sample, apathy and agitation syndromes were most strongly correlated (0.74; 0.72, respectively) with clinical deterioration according to the GDS, followed by psychosis (0.59), affective (0.45), and sleep syndromes (0.34). Agitation significantly correlated with mild and moderate dementia (CDR 1: 0.45; and CDR 2: 0.69, respectively). At CDR 2, agitation and affective syndromes were most strongly correlated (0.69; 0.59, respectively) with clinical deterioration while at CDR 3, the apathy syndrome was most strongly correlated with clinical deterioration (0.52). CONCLUSIONS:Agitation, apathy, and affective disorders were the syndromes most strongly correlated with global deterioration in AD patients, becoming more evident at severe stages of dementia.

journal_name

Int Psychogeriatr

authors

Stella F,Laks J,Govone JS,de Medeiros K,Forlenza OV

doi

10.1017/S1041610215002069

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

779-86

issue

5

eissn

1041-6102

issn

1741-203X

pii

S1041610215002069

journal_volume

28

pub_type

杂志文章,多中心研究
  • Use of antipsychotic medications for the management of delirium: an audit of current practice in the acute care setting.

    abstract:OBJECTIVE:Despite delirium being common in older hospitalized people, little is known about its management. The aims of this study are (1) to describe the pharmacological management of delirium in an acute care setting as a baseline measure prior to the implementation of newly developed Australian guidelines; and (2) t...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610208008028

    authors: Tropea J,Slee J,Holmes AC,Gorelik A,Brand CA

    更新日期:2009-02-01 00:00:00

  • Prevalence and correlates of psychotropic drug use in community-dwelling people with young-onset dementia: the NeedYD-study.

    abstract:BACKGROUND:Young-onset dementia (YOD) is defined as dementia that develops before the age of 65 years. The prevalence and type of neuropsychiatric symptoms (NPS) in YOD differ from patients with late onset dementia. NPS in dementia patients are often treated with psychotropic drugs. The aim of this study was to investi...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610213002330

    authors: Koopmans RT,Reinders R,van Vliet D,Verhey FR,de Vugt ME,Bor H,Bakker C

    更新日期:2014-12-01 00:00:00

  • A meta-analysis of the accuracy of the Addenbrooke's Cognitive Examination (ACE) and the Addenbrooke's Cognitive Examination-Revised (ACE-R) in the detection of dementia.

    abstract:BACKGROUND:The Addenbrooke's Cognitive Examination (ACE) and its Revised version (ACE-R) are relatively new screening tools for cognitive impairment that may improve upon the well-known Mini-Mental State Examination (MMSE) and other brief batteries. We systematically reviewed diagnostic accuracy studies of ACE and ACE-...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章,meta分析,评审

    doi:10.1017/S1041610213002329

    authors: Larner AJ,Mitchell AJ

    更新日期:2014-04-01 00:00:00

  • Sleep and physical functioning in family caregivers of older adults with memory impairment.

    abstract:BACKGROUND:Sleep disturbance is common in caregivers of older adults with memory disorders. Little is known, however, about the implications of caregivers' poor sleep with regard to their physical functioning. METHODS:In this cross-sectional study, we investigated the association between objectively measured sleep and...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610209991153

    authors: Spira AP,Friedman L,Beaudreau SA,Ancoli-Israel S,Hernandez B,Sheikh J,Yesavage J

    更新日期:2010-03-01 00:00:00

  • The effect of continuing professional education on health care outcomes: lessons for dementia care.

    abstract:BACKGROUND:This review presents an overview of the published literature on the effectiveness of continuing professional education (CPE), which includes continuing medical education (CME) of different health care professionals in healthcare settings, for improving patient management and patient outcomes. This review sum...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章,评审

    doi:10.1017/S1041610209008746

    authors: Rampatige R,Dunt D,Doyle C,Day S,van Dort P

    更新日期:2009-04-01 00:00:00

  • Early symptoms and signs of cognitive deficits might not always be detectable in persons who develop Alzheimer's disease.

    abstract:OBJECTIVE:Clinical syndromes such as amnestic mild cognitive impairment (MCI) are highly predictive of future development of Alzheimer's disease (AD), but it is not known how many of the individuals that develop the disease can be identified with these syndromes. This study aims to determine how many individuals with A...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610207006564

    authors: Palmer K,Bäckman L,Winblad B,Fratiglioni L

    更新日期:2008-04-01 00:00:00

  • Clinicians' attitudes to spirituality in old age psychiatry.

    abstract:BACKGROUND:The aim of this survey is to investigate professional attitudes to the presence and value of spiritual care from Old Age Psychiatrists. METHOD:All registered members of the Faculty of the Psychiatry of Old Age in the United Kingdom were asked to complete a 21-question semi-structured questionnaire. The firs...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610206004339

    authors: Lawrence RM,Head J,Christodoulou G,Andonovska B,Karamat S,Duggal A,Hillam J,Eagger S

    更新日期:2007-10-01 00:00:00

  • Pattern of behavioral disturbances in corticobasal degeneration syndrome and progressive supranuclear palsy.

    abstract:BACKGROUND:A careful characterization of behavioral abnormalities in corticobasal degeneration syndrome (CBDS) and progressive supranuclear palsy (PSP) by reliable tools is still lacking. Literature data provided evidence of the usefulness of the Frontal Behavioral Inventory (FBI) to operationalize such disturbances, p...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610209008862

    authors: Borroni B,Alberici A,Agosti C,Cosseddu M,Padovani A

    更新日期:2009-06-01 00:00:00

  • Psychotherapy of an older adult with an avoidant personality disorder.

    abstract::This case describes the differential diagnosis and treatment of a 70-year-old man with an avoidant personality disorder. It illustrates that diagnostic assessment and treatment of personality problems in the elderly are possible in mental health care. It demonstrates that multiple stand-alone treatment modules can for...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610210001948

    authors: van Alphen SP

    更新日期:2011-05-01 00:00:00

  • Does a cognitive stress test predict progression from mild cognitive impairment to dementia equally well in clinical versus population-based settings?

    abstract::ABSTRACTBackground:Evidence suggests that semantic interference may be a sensitive indicator of early dementia. We examined the utility of the Semantic Interference Test (SIT), a cognitive stress memory paradigm which taps proactive and retroactive semantic interference, for predicting progression from mild cognitive ...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610217002666

    authors: Beer JC,Snitz BE,Chang CH,Loewenstein DA,Ganguli M

    更新日期:2018-10-01 00:00:00

  • Validation of the Rowland Universal Dementia Assessment Scale (RUDAS) in a multicultural sample across five Western European countries: diagnostic accuracy and normative data.

    abstract::ABSTRACTBackground:With increasing cultural diversity and growing elderly immigrant populations in Western European countries, the availability of brief cognitive screening instruments adequate for assessment of dementia in people from diverse backgrounds becomes increasingly important. The aim of the present study wa...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1017/S1041610218000832

    authors: Nielsen TR,Segers K,Vanderaspoilden V,Bekkhus-Wetterberg P,Bjørkløf GH,Beinhoff U,Minthon L,Pissiota A,Tsolaki M,Gkioka M,Waldemar G

    更新日期:2019-02-01 00:00:00

  • Psychological well-being of older Chinese immigrants living in Australia: a comparison with older Caucasians.

    abstract:BACKGROUND:Few current studies explore psychological well-being among older Chinese immigrants in Australia. The study addressed this gap and provided preliminary data on psychological well-being among this group. Four indicators, namely depression, anxiety, loneliness, and quality of life, were used to present a compr...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610216001010

    authors: Lin X,Bryant C,Boldero J,Dow B

    更新日期:2016-10-01 00:00:00

  • Use of the chronic disease score to measure comorbidity in the Canadian Study of Health and Aging.

    abstract::Most older adults have multiple chronic diseases. Consideration of these conditions can improve the performance of statistical models in epidemiological analyses. The Chronic Disease Score (CDS) is a measure of comorbidity derived from medication usage, which may have some advantages over measures derived from other s...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1017/s1041610202008074

    authors: MacKnight C,Rockwood K

    更新日期:2001-01-01 00:00:00

  • The impact of residential respite care on the behavior of older people.

    abstract:BACKGROUND:The aim of this study was to examine the impact of residential respite care on disruptive behavior displayed by older people, particularly those with dementia. METHODS:A quasi-experimental, repeated-measures, single-group design was used. The participants were a consecutive series of 100 older people with a...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610205002553

    authors: Neville CC,Byrne GJ

    更新日期:2006-03-01 00:00:00

  • The effects of mood changes and antidepressants on the cognitive capacity of elderly depressed patients.

    abstract::Seventy-eight nondemented elderly depressed patients underwent an extensive battery of cognitive tests both before and after seven weeks of treatment with nortriptyline, phenelzine, or placebo. Clinical and cognitive evaluations of the patients were under double-blind conditions. Response to treatment did not appear t...

    journal_title:International psychogeriatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1017/s1041610289000141

    authors: Georgotas A,McCue RE,Reisberg B,Ferris SH,Nagachandran N,Chang I,Mir P

    更新日期:1989-10-01 00:00:00

  • Prevalence of dementia in an urban Indian population.

    abstract:UNLABELLED:This article reports the findings of a 3-year epidemiological survey for dementia in an urban community-resident population in Mumbai (Bombay), India, wherein the prevalence of all types of dementia was determined. METHOD:The study was conducted in three stages. Stage 1: From a potential pool of 30,000 subj...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/s1041610201007852

    authors: Vas CJ,Pinto C,Panikker D,Noronha S,Deshpande N,Kulkarni L,Sachdeva S

    更新日期:2001-12-01 00:00:00

  • Dementia and suicidal behavior: a review of the literature.

    abstract:BACKGROUND:While dementia is more common in older people and suicide rates in many countries are higher among the elderly, there is some doubt about the association between these two phenomena. METHODS:A search of the major relevant databases was carried out to examine the evidence for this possible association. RESU...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章,评审

    doi:10.1017/S1041610209009065

    authors: Haw C,Harwood D,Hawton K

    更新日期:2009-06-01 00:00:00

  • Maintenance therapies for late-life recurrent major depression: research and review circa 1995.

    abstract::Major depression in the elderly is often a relapsing, chronic illness with high risk for chronic invalidism, poor treatment compliance, and suicide. In most cases, maintenance treatment to prevent recurrence and to enhance the quality of life is thought to be indicated. We review recent data from our ongoing studies t...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章,评审

    doi:10.1017/s104161029500233x

    authors: Reynolds CF 3rd,Frank E,Perel JM,Mazumdar S,Kupfer DJ

    更新日期:1995-01-01 00:00:00

  • Ethnic disparities in the uptake of anti-dementia medication in young and late-onset dementia.

    abstract:OBJECTIVES:People with dementia can face barriers when trying to access care after a diagnosis, particularly in young-onset dementia (YOD). Little is known about the effects of ethnicity on the use of anti-dementia medication and variations between age groups. The aim of this study was to analyze national data on varia...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610220000794

    authors: Giebel C,Cations M,Draper B,Komuravelli A

    更新日期:2020-06-02 00:00:00

  • Individual variability and environmental characteristics influence older adults' abilities to manage everyday technology.

    abstract:BACKGROUND:The ability to manage everyday technology (ET), such as computers and microwave ovens, is increasingly required in the performance of everyday activities and participation in society. This study aimed to identify aspects that influence the ability to manage ET among older adults with and without cognitive im...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610211002092

    authors: Malinowsky C,Almkvist O,Nygård L,Kottorp A

    更新日期:2012-03-01 00:00:00

  • Reliability and validity of the subjective burden scale in family caregivers of elderly relatives with dementia.

    abstract::The reliability and validity of the Subjective Burden Scale (SBS) were investigated in 255 Japanese family caregivers of elderly relatives with dementia. Values of the Cronbach's alpha reliability, split-half reliability (r), and test-retest reliability (r) were .87, .80, and .72, respectively. The SBS score was signi...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/s1041610299005712

    authors: Matsuda O

    更新日期:1999-06-01 00:00:00

  • Attachment anxiety, depression, and perceived social support: a moderated mediation model of suicide ideation among the elderly.

    abstract:OBJECTIVES:Issues concerning the association among attachment anxiety, depression and suicidal ideation among the elderly have rarely been explored. The present study investigated the relationship among attachment anxiety, depression and perceived support concerning suicidal ideation among older people. DESIGN:Cross-s...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S104161022000054X

    authors: Oonarom A,Wongpakaran T,Kuntawong P,Wongpakaran N

    更新日期:2020-05-07 00:00:00

  • Adapting psychotherapy for older patients with Parkinson's disease.

    abstract:BACKGROUND:Emotional distress associated with Parkinson's disease (PD) increases disease burden and decreases functioning. The literature supports the benefits of psychological interventions for amelioration of emotional distress in persons with PD. The objective of this study is to apply the Contextual Adult Lifespan ...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610216000569

    authors: Knight B,Dissanayaka NN,Pachana NA

    更新日期:2016-10-01 00:00:00

  • Is MCI really just early dementia? A systematic review of conversion studies.

    abstract:OBJECTIVES:Older people commonly present with memory loss although on assessment are not found to have a full dementia complex. Previous studies have suggested however that people with subjective and objective cognitive loss are at higher risk of dementia. We aimed to determine from the literature the rate of conversio...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章,评审

    doi:10.1017/s1041610204000092

    authors: Bruscoli M,Lovestone S

    更新日期:2004-06-01 00:00:00

  • Confusion/delirium following cataract surgery: an incidence study of 1-year duration.

    abstract:BACKGROUND:Delirium is frequently observed in clinical practice, particularly in medical and surgical wards and more so among patients at risk, especially elderly with preexisting central nervous system impairments. OBJECTIVE:Despite the severe consequences of delirium, epidemiological data relating to incidence of de...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/s1041610202008499

    authors: Milstein A,Pollack A,Kleinman G,Barak Y

    更新日期:2002-09-01 00:00:00

  • "Being all alone makes me sad": loneliness in older adults with depressive symptoms.

    abstract::ABSTRACT Background: The consequences of co-occurring persistent loneliness and late life depression are yet unknown. The aim of this study was to get a deeper insight into the mental health consequences of loneliness in older persons with depressive symptoms and their perspectives of emotional distress by using a mix...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610214000581

    authors: van Beljouw IM,van Exel E,de Jong Gierveld J,Comijs HC,Heerings M,Stek ML,van Marwijk HW

    更新日期:2014-04-09 00:00:00

  • Social interactions between people with dementia: pilot evaluation of an observational instrument in a nursing home.

    abstract:BACKGROUND:In dementia, cognitive and psychological disorders might interfere with maintaining social interactions. We have little information about the nature of these interactions of people with dementia in nursing homes. The aim of this study is to investigate social interactions between people with dementia and to ...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610215002483

    authors: Mabire JB,Gay MC,Vrignaud P,Garitte C,Vernooij-Dassen M

    更新日期:2016-06-01 00:00:00

  • An assessment of the attitudes of potential caregivers toward the abuse of elderly persons with and without dementia.

    abstract:BACKGROUND:Dementia in the elderly is associated with a greater risk of being subjected to abuse. More than half of those in Japan who abuse elderly relatives with dementia do not realize that their behavior corresponds to abuse. OBJECTIVE:This study sought to examine the effect of the presence of dementia in the elde...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610206004789

    authors: Matsuda O

    更新日期:2007-10-01 00:00:00

  • Assessing subjective memory complaints: a comparison of spontaneous reports and structured questionnaire methods.

    abstract:BACKGROUND:Subjective memory complaints (SMCs) are a common occurrence for adults, which increase with age, and cause considerable distress. Traditionally SMCs have been assessed by either questionnaires, which ask whether a person has experienced given examples of SMCs, or open-ended questions which elicit spontaneous...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610214001161

    authors: Burmester B,Leathem J,Merrick P

    更新日期:2015-01-01 00:00:00

  • The relationship between population growth and elderly suicide rates: a cross-national study.

    abstract:BACKGROUND:Elderly suicide rates are associated with the elderly population size, the proportion of elderly in the general population and the elderly dependency ratio. METHODS:A cross-national study examining the "a priori" hypothesis that the relationship between elderly suicide rates and average annual population gr...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610208007953

    authors: Shah A

    更新日期:2009-04-01 00:00:00