Abstract:
BACKGROUND:Data on the relationship between behavioral disturbances in Alzheimer's disease (AD) and global clinical deterioration is still controversial. The purpose of this study was to explore potential correlations of neuropsychiatric syndromes with global clinical deterioration in patients with AD, with particular consideration on severity levels of dementia. METHODS:AD patients (n = 156) aged 76.7 years from Brazilian clinical centers were assessed to diagnose the five neuropsychiatric syndromes measured by the Neuropsychiatric Inventory-Clinician rating scale (NPI-C): psychosis, agitation, affective, apathy, and sleep. These syndromes were then analyzed for their correlation with the Global Deterioration Scale (GDS). To analyze the association of neuropsychiatric syndromes with the GDS, considering the total sample and patients grouped by dementia severity levels, we applied the coefficient of multiple correlation (Ryy), adjusted multiple linear regression, and the coefficient of determination (R2yx). We tested the significance of correlation coefficients using the Student t-test for simple correlations (a single independent variable) and analysis of variance (ANOVA) for multiple correlations. ANOVA was also used to compare means of demographic and some clinical variables at different levels of dementia. RESULTS:For the total sample, apathy and agitation syndromes were most strongly correlated (0.74; 0.72, respectively) with clinical deterioration according to the GDS, followed by psychosis (0.59), affective (0.45), and sleep syndromes (0.34). Agitation significantly correlated with mild and moderate dementia (CDR 1: 0.45; and CDR 2: 0.69, respectively). At CDR 2, agitation and affective syndromes were most strongly correlated (0.69; 0.59, respectively) with clinical deterioration while at CDR 3, the apathy syndrome was most strongly correlated with clinical deterioration (0.52). CONCLUSIONS:Agitation, apathy, and affective disorders were the syndromes most strongly correlated with global deterioration in AD patients, becoming more evident at severe stages of dementia.
journal_name
Int Psychogeriatrjournal_title
International psychogeriatricsauthors
Stella F,Laks J,Govone JS,de Medeiros K,Forlenza OVdoi
10.1017/S1041610215002069subject
Has Abstractpub_date
2016-05-01 00:00:00pages
779-86issue
5eissn
1041-6102issn
1741-203Xpii
S1041610215002069journal_volume
28pub_type
杂志文章,多中心研究abstract:OBJECTIVE:Despite delirium being common in older hospitalized people, little is known about its management. The aims of this study are (1) to describe the pharmacological management of delirium in an acute care setting as a baseline measure prior to the implementation of newly developed Australian guidelines; and (2) t...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610208008028
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:Young-onset dementia (YOD) is defined as dementia that develops before the age of 65 years. The prevalence and type of neuropsychiatric symptoms (NPS) in YOD differ from patients with late onset dementia. NPS in dementia patients are often treated with psychotropic drugs. The aim of this study was to investi...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610213002330
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abstract:BACKGROUND:The Addenbrooke's Cognitive Examination (ACE) and its Revised version (ACE-R) are relatively new screening tools for cognitive impairment that may improve upon the well-known Mini-Mental State Examination (MMSE) and other brief batteries. We systematically reviewed diagnostic accuracy studies of ACE and ACE-...
journal_title:International psychogeriatrics
pub_type: 杂志文章,meta分析,评审
doi:10.1017/S1041610213002329
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:Sleep disturbance is common in caregivers of older adults with memory disorders. Little is known, however, about the implications of caregivers' poor sleep with regard to their physical functioning. METHODS:In this cross-sectional study, we investigated the association between objectively measured sleep and...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610209991153
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:This review presents an overview of the published literature on the effectiveness of continuing professional education (CPE), which includes continuing medical education (CME) of different health care professionals in healthcare settings, for improving patient management and patient outcomes. This review sum...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/S1041610209008746
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:Clinical syndromes such as amnestic mild cognitive impairment (MCI) are highly predictive of future development of Alzheimer's disease (AD), but it is not known how many of the individuals that develop the disease can be identified with these syndromes. This study aims to determine how many individuals with A...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610207006564
更新日期:2008-04-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610206004339
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:A careful characterization of behavioral abnormalities in corticobasal degeneration syndrome (CBDS) and progressive supranuclear palsy (PSP) by reliable tools is still lacking. Literature data provided evidence of the usefulness of the Frontal Behavioral Inventory (FBI) to operationalize such disturbances, p...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610209008862
更新日期:2009-06-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
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journal_title:International psychogeriatrics
pub_type: 杂志文章
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更新日期:2018-10-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章,多中心研究
doi:10.1017/S1041610218000832
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Few current studies explore psychological well-being among older Chinese immigrants in Australia. The study addressed this gap and provided preliminary data on psychological well-being among this group. Four indicators, namely depression, anxiety, loneliness, and quality of life, were used to present a compr...
journal_title:International psychogeriatrics
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doi:10.1017/S1041610216001010
更新日期:2016-10-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章,多中心研究
doi:10.1017/s1041610202008074
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to examine the impact of residential respite care on disruptive behavior displayed by older people, particularly those with dementia. METHODS:A quasi-experimental, repeated-measures, single-group design was used. The participants were a consecutive series of 100 older people with a...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610205002553
更新日期:2006-03-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/s1041610289000141
更新日期:1989-10-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610201007852
更新日期:2001-12-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/S1041610209009065
更新日期:2009-06-01 00:00:00
abstract::Major depression in the elderly is often a relapsing, chronic illness with high risk for chronic invalidism, poor treatment compliance, and suicide. In most cases, maintenance treatment to prevent recurrence and to enhance the quality of life is thought to be indicated. We review recent data from our ongoing studies t...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/s104161029500233x
更新日期:1995-01-01 00:00:00
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journal_title:International psychogeriatrics
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更新日期:2020-06-02 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
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更新日期:2012-03-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
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更新日期:1999-06-01 00:00:00
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更新日期:2020-05-07 00:00:00
abstract:BACKGROUND:Emotional distress associated with Parkinson's disease (PD) increases disease burden and decreases functioning. The literature supports the benefits of psychological interventions for amelioration of emotional distress in persons with PD. The objective of this study is to apply the Contextual Adult Lifespan ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
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更新日期:2016-10-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/s1041610204000092
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND:Delirium is frequently observed in clinical practice, particularly in medical and surgical wards and more so among patients at risk, especially elderly with preexisting central nervous system impairments. OBJECTIVE:Despite the severe consequences of delirium, epidemiological data relating to incidence of de...
journal_title:International psychogeriatrics
pub_type: 杂志文章
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更新日期:2002-09-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610214000581
更新日期:2014-04-09 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
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更新日期:2016-06-01 00:00:00
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journal_title:International psychogeriatrics
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更新日期:2007-10-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
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journal_title:International psychogeriatrics
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更新日期:2009-04-01 00:00:00