Abstract:
:ABSTRACTBackground:Dementia is a neurodegenerative syndrome that interferes with multiple aspects of life, including cognition, daily functioning, and behavior. Despite the large heterogeneity in symptom development, these three domains are seldom studied simultaneously. This study investigates how trajectories of these domains are interrelated within individuals over time, and how they in turn are related to dementia severity and quality of life (QoL). METHODS:We used data from a longitudinal clinical cohort study, including 331 dementia patients. Cognitive status was measured using the Mini-Mental State Examination, daily functioning was measured with the disability assessment for dementia and neuropsychiatric symptoms (NPS) were scored using the neuropsychiatric inventory. We investigated the relationships in the time course of the various dementia domains using random effects multilevel models and parallel-process growth models. RESULTS:Changes in cognition and daily functioning were highly correlated over time (r = 0.85, p < 0.01), as were changes in NPS and functioning (r = -0.60, p < 0.01), while changes in cognition and NPS were not (r = -0.20, p = 0.06). All three domains were strongly associated with dementia severity over time (p < 0.01). Decreased functioning and increased NPS were both associated with decreased QoL (β = 2.97, p < 0.01 and β = -2.41, p < 0.01, respectively), while cognition was not (β = 0.01, p = 0.93). CONCLUSION:This study demonstrates the heterogeneity of dementia progression between individuals and between different dementia domains within individuals. To improve our understanding of dementia progression, future research should embrace a broader perspective encompassing multiple outcome measures along with the patient's profile, including neurological factors as well as physical, social, and psychiatric health.
journal_name
Int Psychogeriatrjournal_title
International psychogeriatricsauthors
Haaksma ML,Leoutsakos JS,Bremer JAE,Aalten P,Ramakers IHGB,Verhey FRJ,Olde Rikkert MGM,Melis RJFdoi
10.1017/S1041610217000321subject
Has Abstractpub_date
2018-06-01 00:00:00pages
859-866issue
6eissn
1041-6102issn
1741-203Xpii
S1041610217000321journal_volume
30pub_type
杂志文章,多中心研究abstract:BACKGROUND:Earlier research showed that multi-component dyadic interventions - including a combination of intervention strategies and addressing both the person with dementia and caregiver - have a beneficial impact on the mental and physical health of people with dementia and their family caregivers. A randomized cont...
journal_title:International psychogeriatrics
pub_type: 杂志文章,随机对照试验
doi:10.1017/S104161021500071X
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Dementia in the elderly is associated with a greater risk of being subjected to abuse. More than half of those in Japan who abuse elderly relatives with dementia do not realize that their behavior corresponds to abuse. OBJECTIVE:This study sought to examine the effect of the presence of dementia in the elde...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610206004789
更新日期:2007-10-01 00:00:00
abstract::Few would argue that achieving the age of 100 years is extraordinary, but what about the quality of life at this extreme age? Is it worth it to live to 100 and beyond? The study by Araújo, Ribero, Teixeira, and Paúl (2015) in three ways provided an answer to this question substantiating and complementing recent findin...
journal_title:International psychogeriatrics
pub_type: 评论,杂志文章
doi:10.1017/S1041610215002021
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Whereas the State-Trait Anxiety Inventory (STAI-Y) is probably the most widely used self-reported measure of anxiety, the lack of current norms among elderly people appears to be problematic in both a clinical and research context. The objective of the present study was to provide normative data for the STAI...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212000300
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:It remains unclear so far whether the role of cognitive reserve may differ between physically frail compared to less frail individuals. Therefore, the present study set out to investigate the relation of key markers of cognitive reserve to cognitive status in old age and its interplay with physical frailty i...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217000795
更新日期:2017-09-01 00:00:00
abstract::Psychotic symptoms in Alzheimer's disease (AD) have been associated with increased rates of cognitive impairment and functional decline. Prior studies have been conflicting with regard to whether AD patients with psychosis (AD+P) have evidence of more severe neuropathologic findings at postmortem exam. We examined the...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610200006657
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND:Apathy, characterized by diminished motivation, is a highly prevalent neuropsychiatric symptom in dementia. However, there is a substantial knowledge gap with regard to prevalence rates, neurobiological underpinnings, and effective treatments for apathy in pre-dementia states, including mild cognitive impair...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/S1041610217000527
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:The aim of the present study was to investigate the psychometric characteristics of the Perceived Stress Scale (PSS) in a sample of dementia patients and their spousal caregivers. METHODS:We investigated the reliability and validity of the 14-item PSS in a sample of 80 couples, each including one spouse who...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217001387
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Depression in late life is a risk factor for cognitive decline. Depression is also associated with increased disability and social support deficits; these may precede conversion to dementia and inform risk. In this study, we examined if baseline or one-year change in disability and social support predicted l...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610214002543
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:The Charles Bonnet syndrome (CBS) is characterized by distinct visual hallucinations and ocularpathology causing visual impairment in patients with insight and the absence of psychiatric comorbidity. The number of reported cases of CBS is expanding as the population ages and the prevalence of vision disorder...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610213000719
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVES:To investigate the presence of neuropsychiatric symptoms (NPS) and sub-syndromes in elderly community-dwelling Asians with varying severity of cognitive impairment. METHODS:Chinese and Malay participants (n = 613) from the Epidemiology of Dementia in Singapore (EDIS) Study aged ≥ 60 years underwent clinical...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610215000976
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Mental capacity has been little studied among older general hospital inpatients. METHODS:A retrospective analysis was undertaken of routinely collected data (age, gender, ethnicity, admission diagnosis, psychiatric diagnosis, Mini-mental State Examination score, whether capacity was assessed, the outcome of...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S104161020900917X
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:There are difficulties in accurately defining patients with vascular dementia (VaD) and, therefore, little is known about the characteristics of this population. OBJECTIVE:To examine the population characteristics in patients with VaD enrolled in two randomized, double-blind, placebo-controlled, 24-week cli...
journal_title:International psychogeriatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/S1041610203009190
更新日期:2003-01-01 00:00:00
abstract::Delirium significantly increases morbidity and mortality in older people, especially those affected by other organic disorders, notably dementia (Siddiqi et al., 2006; Davis et al., 2012; Martins and Fernandes, 2012). Both delirium and dementia are characterized by cognitive decline through disintegration of brain fun...
journal_title:International psychogeriatrics
pub_type: 评论,杂志文章
doi:10.1017/S1041610216001988
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:The objectives of this study were to examine the factors modifying the relationship between cortisol level and prevalent/incident cognitive impairment in older adults and to verify whether these relationships were non-linear. METHODS:Data were collected from 1,226 individuals aged 65 and older by two in-hom...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212001706
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:This subanalysis of a large, double-blind, placebo-controlled trial examined the prevalence of behavioral symptoms in moderate to severe Alzheimer's disease (AD), and the effect of treatment with donepezil. METHODS:Two hundred ninety patients with moderate to severe AD (standardized Mini-Mental State Examina...
journal_title:International psychogeriatrics
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1017/s104161020200858x
更新日期:2002-12-01 00:00:00
abstract::Epidemiologic survey data were used to examine relationships between alcohol use and abuse and the physical and mental health status of elderly public housing residents (weighted n = 865) and to determine the influence that drinking behavior had on mortality. Residents with a current alcohol disorder (4%) were more li...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610298005407
更新日期:1998-09-01 00:00:00
abstract::Major advances in understanding the physiology and genetics of circadian rhythm in the past decade challenge the researcher of sleep/wake disorders in Alzheimer's disease (AD) to distinguish patient characteristics stable across the course of illness ("traits") from characteristics that vary with stage of illness ("st...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610202008293
更新日期:2002-03-01 00:00:00
abstract::ABSTRACTBackground:Little is known about the combined use of benzodiazepines and antidepressants in older psychiatric patients. This study examined the prescription pattern of concurrent benzodiazepines in older adults treated with antidepressants in Asia, and explored its demographic and clinical correlates. METHODS...
journal_title:International psychogeriatrics
pub_type: 杂志文章,多中心研究
doi:10.1017/S1041610217002563
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Due to previously reported mixed findings, there is a need for further empirical research on the factorial structure of the commonly used Geriatric Anxiety Inventory (GAI). Therefore, the psychometric properties of the GAI and its short form version (GAI-SF) were evaluated in a psychogeriatric mixed in-and-o...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217001004
更新日期:2017-10-01 00:00:00
abstract::Over 20 years ago, the Australian Liberal/National Party Federal Opposition had a set of policies with which it hoped to persuade the Australian people to return it to government in the election due in 1996. This particular collection of proposed initiatives was called "The things that matter". When the then leader of...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610216000387
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Hospital-treated deliberate self harm and suicide among older adults have rarely been examined at a national level. METHODS:The Irish Central Statistics Office provided suicide and undetermined death data for 1980-2006. The National Registry of Deliberate Self Harm collected data relating to deliberate self...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610210001377
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Foreign home care services provided to frail older adults by individuals from the developing world are a global phenomenon. This study evaluated the challenges associated with live-in foreign home care from the perspective of older care recipients and their family members. METHODS:Qualitative interviews wer...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610209990421
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:A third of family members caring for people with dementia report acting abusively towards them, but there are currently no evidence-based interventions to reduce or prevent such behavior. Family carers who act abusively have not previously been consulted about what may help to reduce abuse. METHOD:We prospe...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S104161020800834X
更新日期:2009-04-01 00:00:00
abstract::ABSTRACTBackground:With increasing cultural diversity and growing elderly immigrant populations in Western European countries, the availability of brief cognitive screening instruments adequate for assessment of dementia in people from diverse backgrounds becomes increasingly important. The aim of the present study wa...
journal_title:International psychogeriatrics
pub_type: 杂志文章,多中心研究
doi:10.1017/S1041610218000832
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:The aim of this study was to test the association between anxiety at the time of hospitalization and falls occurring within one month of discharge, and to offer potential mechanisms for this association. METHODS:One-month, prospective cohort study of 556 older adults in two medical centers in Israel. Anxiet...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610215002306
更新日期:2016-06-01 00:00:00
abstract::With now over 50 million people worldwide with dementia (Prince et al., 2013), there are almost certainly well over 100 million people with cognitive concerns and many of these will attend their health professional keen to know what is going on. We need those without intensive training in this field to be more confide...
journal_title:International psychogeriatrics
pub_type: 评论,杂志文章
doi:10.1017/S1041610217001818
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:A past history of self-harm is a significant risk factor for suicide in older people. The aims of this study are to (i) characterize older people who present with self-harm to emergency departments (EDs); and (ii) determine the predictors for repeat self-harm and suicide. METHODS:Demographic and clinical da...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217000308
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:Nearly half of care home residents with advanced dementia have clinically significant agitation. Little is known about costs associated with these symptoms toward the end of life. We calculated monetary costs associated with agitation from UK National Health Service, personal social services, and societal per...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610219002059
更新日期:2020-03-01 00:00:00
abstract::The role of the physician is critical in the evaluation of cognitively impaired patients for two reasons: (a) The longitudinal relationship between the patient and physician provides a unique opportunity to observe changes over time, generating confidence that may encourage the patient and family to report any concern...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610297004729
更新日期:1997-01-01 00:00:00