Sleep/wake cycle disturbance in Alzheimer's disease: how much is due to an inherent trait?

Abstract:

:Major advances in understanding the physiology and genetics of circadian rhythm in the past decade challenge the researcher of sleep/wake disorders in Alzheimer's disease (AD) to distinguish patient characteristics stable across the course of illness ("traits") from characteristics that vary with stage of illness ("states"). A components-of-variance approach with a repeated measures model was used to examine the between-subjects variance over time ("trait") vs. within-subjects ("state") variance in 42 patients with probable AD followed, on average, over 2 years on actigraphic sleep/wake measures. Mental status scores indexed stage of illness. Actigraphic measures of sleep efficiency and circadian rhythmicity appeared predominantly "trait," with between-individual differences accounting for over 55% of variance compared to the less than 5% of variance related to stage of cognitive impairment. We discuss how "state-trait" analyses can be helpful in identifying areas of assessment most likely to be fruitful objectives of physiologic and genetic research on sleep/wake disturbance in AD.

journal_name

Int Psychogeriatr

authors

Yesavage JA,Taylor JL,Kraemer H,Noda A,Friedman L,Tinklenberg JR

doi

10.1017/s1041610202008293

keywords:

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

73-81

issue

1

eissn

1041-6102

issn

1741-203X

journal_volume

14

pub_type

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