Neuropathology of vascular cognitive impairment and vascular dementia.

Abstract:

:Understanding of vascular substrates of cognitive decline in the elderly is evolving to include a major emphasis on the impact of small vessel disease (SVD). While existing concepts of multi-infarct dementia and strategic infarct dementia remain valid, they present difficulty in generalizing clinicopathological correlations from patient to patient. The range and significance of lesions that should be included as manifestations of SVD are unresolved, as is their impact on, and association with, neurodegenerative changes. This mini-review summarizes the authors' views on SVD substrates leading to cognitive decline and proposes priorities for pathological investigations of human cerebrovascular mechanisms leading to cognitive decline.

journal_name

Int Psychogeriatr

authors

Ince PG,Fernando MS

doi

10.1017/S1041610203008998

keywords:

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

71-5

eissn

1041-6102

issn

1741-203X

pii

S1041610203008998

journal_volume

15 Suppl 1

pub_type

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