Smell identification function as a severity and progression marker in Alzheimer's disease.

abstract：:Psychotic symptoms in Alzheimer's disease (AD) have been associated with increased rates of cognitive impairment and functional decline. Prior studies have been conflicting with regard to whether AD patients with psychosis (AD+P) have evidence of more severe neuropathologic findings at postmortem exam. We examined the...

journal_title：International psychogeriatrics

authors： Sweet RA,Hamilton RL,Lopez OL,Klunk WE,Wisniewski SR,Kaufer DI,Healy MT,DeKosky ST

更新日期：2000-12-01 00:00:00

abstract：:The role of the physician is critical in the evaluation of cognitively impaired patients for two reasons: (a) The longitudinal relationship between the patient and physician provides a unique opportunity to observe changes over time, generating confidence that may encourage the patient and family to report any concern...

journal_title：International psychogeriatrics

authors： Finkel SI,Woodson C

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Despite the high prevalence and morbidity of minor and subsyndromal depression in primary care elderly people, there are few data to identify those at highest risk of poor outcomes. The goal of this observational cohort study was to characterize the one-year outcomes of minor and subsyndromal depression, exa...

journal_title：International psychogeriatrics

authors： Lyness JM,Chapman BP,McGriff J,Drayer R,Duberstein PR

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:The clinical presentations in dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD) overlap considerably with that of Alzheimer's disease (AD) despite different pathological processes. Autopsy studies have also shown that multiple brain pathology occurs frequently, even in cases with a single cli...

journal_title：International psychogeriatrics

authors： Piguet O,Halliday GM,Creasey H,Broe GA,Kril JJ

更新日期：2009-08-01 00:00:00

abstract：:ABSTRACTIntroduction:The relationship between Alzheimer's Disease (AD) and alcohol addiction is poorly characterized. Arrests for driving under the influence (DUI) can serve as a proxy for alcohol addiction. Therefore, the potential association between DUI and AD could be helpful in understanding the relationship betw...

journal_title：International psychogeriatrics

authors： Miller M,Orwat D,Rahimi G,Mintzer J

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Identification of factors associated with quality of life (QoL) in people having dementia will help develop strategies for maintenance and improvement of patient QoL. This study examined the predictors of QoL in a community-dwelling population aged 75 years and over, with or without dementia. METHODS:This w...

journal_title：International psychogeriatrics

authors： Mate KE,Pond CD,Magin PJ,Goode SM,McElduff P,Stocks NP

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:This study sought to conduct a comprehensive search for genetic risk of cognitive decline in the context of geriatric depression. DESIGN:A genome-wide association study (GWAS) analysis in the Neurocognitive Outcomes of Depression in the Elderly (NCODE) study. SETTING:Longitudinal, naturalistic follow-up stu...

journal_title：International psychogeriatrics

authors： Steffens DC,Garrett ME,Soldano KL,McQuoid DR,Ashley-Koch AE,Potter GG

更新日期：2020-07-09 00:00:00

abstract：:ABSTRACT Background: Mild cognitive impairment (MCI) is a diagnostic classification used to describe patients experiencing cognitive decline but without a corresponding impairment in daily functioning. Over the years, MCI diagnostic criteria have undergone major changes that correspond to advancements in research. Des...

journal_title：International psychogeriatrics

authors： Gerstenecker A,Mast B

更新日期：2014-11-05 00:00:00

abstract：BACKGROUND:Frailty is a complex health state of increased vulnerability associated with adverse outcomes such as disability, falls, hospitalization, and death. Along with physical impairments, cognition and quality of life may be affected in frail older adults. Yet, evidence is still lacking. The aim of this study was ...

journal_title：International psychogeriatrics

authors： Langlois F,Vu TT,Kergoat MJ,Chassé K,Dupuis G,Bherer L

更新日期：2012-09-01 00:00:00

abstract：:The objectives of this randomized clinical trial were to investigate the impact of the discontinuation of long-term antipsychotics in residents with dementia in chronic care institutions and to identify clinical predictors of safe discontinuation. Subjects included 34 residents with dementia who were on antipsychotics...

journal_title：International psychogeriatrics

authors： van Reekum R,Clarke D,Conn D,Herrmann N,Eryavec G,Cohen T,Ostrander L

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:There has been an increasing interest in the relationship between severity of disease and costs in the care of people with dementia. Much of the current evidence is based on cross-sectional data, suggesting the need to examine trends over time for this important and growing cohort of the population. METHODS...

journal_title：International psychogeriatrics

authors： Gillespie P,O'Shea E,Cullinan J,Buchanan J,Bobula J,Lacey L,Gallagher D,Mhaolain AN,Lawlor B,Enhancing Care in Alzheimer’s Disease (ECAD) Study Team.

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:We assessed eight-year mortality rates and predictors in a rural cohort of elderly individuals with cognitive impairment. METHODS:A total of 1,035 individuals, including 155 (15.0%) individuals with cognitive impairment, no dementia (CIND), and 69 (6.7%) individuals with clinically diagnosed dementia were f...

journal_title：International psychogeriatrics

authors： Park JE,Lee JY,Suh GH,Kim BS,Cho MJ

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Despite the increasing prevalence of Alzheimer's disease (AD), very few studies have examined advanced preparation for the possibility of becoming sick with AD, and these few studies indicate a general lack of preparation. This study aimed to expand knowledge regarding preparedness for AD among younger and o...

journal_title：International psychogeriatrics

authors： Werner P

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Recognizing and diagnosing early onset dementia (EOD) can be complex and often takes longer than for late onset dementia. The objectives of this study are to investigate the barriers to diagnosis and to develop a typology of the diagnosis pathway for EOD caregivers. METHODS:Semi-structured interviews with 9...

journal_title：International psychogeriatrics

authors： van Vliet D,de Vugt ME,Bakker C,Koopmans RT,Pijnenburg YA,Vernooij-Dassen MJ,Verhey FR

更新日期：2011-11-01 00:00:00

abstract：:Loss of brain tissue becomes notable to cerebral magnetic resonance imaging (MRI) at age 30 years, and progresses more rapidly from mid 60s. The incidence of dementia increases exponentially with age, and is all too frequent in the oldest old (≥ 90 years of age), the fastest growing age group in many countries. Howeve...

journal_title：International psychogeriatrics

authors： Apostolova I,Lange C,Spies L,Ritter K,Mäurer A,Seybold J,Fiebach JB,Steinhagen-Thiessen E,Buchert R

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:It remains unclear so far whether the role of cognitive reserve may differ between physically frail compared to less frail individuals. Therefore, the present study set out to investigate the relation of key markers of cognitive reserve to cognitive status in old age and its interplay with physical frailty i...

journal_title：International psychogeriatrics

authors： Ihle A,Gouveia ÉR,Gouveia BR,Freitas DL,Jurema J,Odim AP,Kliegel M

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:The IPA Taskforce on Mental Health Issues in Long-Term Care Homes seeks to improve mental health care in long-term care (LTC) homes. The aim of this paper is to provide recommendations on comprehensive assessment of depression and behavioral problems in order to further stimulate countries and professionals ...

journal_title：International psychogeriatrics

authors： Koopmans RT,Zuidema SU,Leontjevas R,Gerritsen DL

更新日期：2010-11-01 00:00:00

abstract：:ABSTRACTThe aim of the present study is to investigate the impact of benzodiazepine use on cognitive performance in primary care patients with first cognitive complaints. The association between the exposition to benzodiazepines (short and long half-life) and cognitive performance, evaluated through the Mini Mental St...

journal_title：International psychogeriatrics

authors： Grande G,Tramacere I,Vetrano DL,Pomati S,Mariani C,Filippini G

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Clinical guidelines have the potential to assist in the management of aggression in dementia. This study aims to develop a conceptual framework for the construction of individualized guidelines for this group. METHODS:A concept map of the topic "How to manage aggression in dementia" was developed by reviewi...

journal_title：International psychogeriatrics

authors： Vickland V,Chilko N,Draper B,Low LF,O'Connor D,Brodaty H

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Emotional distress associated with Parkinson's disease (PD) increases disease burden and decreases functioning. The literature supports the benefits of psychological interventions for amelioration of emotional distress in persons with PD. The objective of this study is to apply the Contextual Adult Lifespan ...

journal_title：International psychogeriatrics

authors： Knight B,Dissanayaka NN,Pachana NA

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Children of patients with young onset dementia (YOD) who are confronted with a parent who has a progressive disease, often assist in caregiving tasks, which may have a great impact on their lives. The objective of the present study is to explore the experiences of children living with a young parent with dem...

journal_title：International psychogeriatrics

authors： Millenaar JK,van Vliet D,Bakker C,Vernooij-Dassen MJ,Koopmans RT,Verhey FR,de Vugt ME

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Global suicide rates among older adults are very high. Public attitudes towards older adults' suicide may affect older adults upon their contemplating such an act. Previous research has demonstrated that message framing affects persons' judgments and decision making. Thus, message framing may have particular...

journal_title：International psychogeriatrics

authors： Gamliel E,Levi-Belz Y

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Patients with dementia often receive poor end-of-life care, with inadequate pain control and without access to the palliative care services that patients with cancer are offered. This has been identified as an area of need in recent UK. Government reports and by the Alzheimer's Society (UK). Our objective wa...

journal_title：International psychogeriatrics

authors： Sampson EL,Ritchie CW,Lai R,Raven PW,Blanchard MR

更新日期：2005-03-01 00:00:00

abstract：:Nimodipine is a calcium antagonist which improves learning and memory in brain-lesioned or aged animals (LeVere & Sandin, 1989; Schuurman & Traber, 1989). It also accelerates the recovery of experimentally damaged sciatic nerves (van der Zee et al., 1987) and reduces age-associated gait abnormalities in aging rats (Sc...

journal_title：International psychogeriatrics

authors： Schmage N,Bergener M

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Mild cognitive impairment (MCI) is proposed to describe the transitional stage between normal cognitive aging and dementia. It has had significant impact in the field of dementia research, but it remains controversial whether or not it should be used as a diagnostic category in clinical practice. METHODS:Se...

journal_title：International psychogeriatrics

authors： Moreira T,Hughes JC,Kirkwood T,May C,McKeith I,Bond J

更新日期：2008-08-01 00:00:00

abstract：:Seventy-eight nondemented elderly depressed patients underwent an extensive battery of cognitive tests both before and after seven weeks of treatment with nortriptyline, phenelzine, or placebo. Clinical and cognitive evaluations of the patients were under double-blind conditions. Response to treatment did not appear t...

journal_title：International psychogeriatrics

authors： Georgotas A,McCue RE,Reisberg B,Ferris SH,Nagachandran N,Chang I,Mir P

更新日期：1989-10-01 00:00:00

abstract：:Thirty-seven subjects, 15 with a clinical diagnosis of Alzheimer's disease and 22 normal controls, participated in a study of the accuracy of telephone screening in identifying potential dementia cases. The telephone protocol and scoring algorithm resulted in 100% sensitivity and 91% specificity. The findings suggest ...

journal_title：International psychogeriatrics

authors： Gatz M,Reynolds C,Nikolic J,Lowe B,Karel M,Pedersen N

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:Vocally disruptive behavior (VDB) in the elderly is a common condition, especially in people with dementia, but difficult to treat. It may occur in as many as 40% of nursing home residents. This study is a review of the existing literature on this condition. METHOD:The literature review was conducted using ...

journal_title：International psychogeriatrics

authors： von Gunten A,Alnawaqil AM,Abderhalden C,Needham I,Schupbach B

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:The study aimed to evaluate the Cognitive Assessment Battery (CAB) in a specialist clinic setting in order to find out if it if it could be a supplement to the Mini-mental State Examination (MMSE) and distinguish between normal aging, mild cognitive impairment (MCI) and dementia, as well as MCI of different ...

journal_title：International psychogeriatrics

authors： Nordlund A,Påhlsson L,Holmberg C,Lind K,Wallin A

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Elderly people living in residential homes are at high risk for developing major depressive and anxiety disorders, and therefore deserve attention in terms of preventive interventions. We evaluated the feasibility and effectiveness of a guided self-help intervention for the prevention of depression and anxie...

journal_title：International psychogeriatrics

authors： Dozeman E,van Schaik DJ,van Marwijk HW,Stek ML,Beekman AT,van der Horst HE

更新日期：2011-08-01 00:00:00