Global rating, symptoms, behavior, and cognitive performance as indicators of efficacy in clinical studies with nimodipine in elderly patients with cognitive impairment syndromes.

Abstract:

:Nimodipine is a calcium antagonist which improves learning and memory in brain-lesioned or aged animals (LeVere & Sandin, 1989; Schuurman & Traber, 1989). It also accelerates the recovery of experimentally damaged sciatic nerves (van der Zee et al., 1987) and reduces age-associated gait abnormalities in aging rats (Schuurman et al., 1987). Selective action on cerebral vessels has also been proven. Vasoconstriction was prevented or reduced with nimodipine under experimental conditions (Toward, 1981) and cerebral blood flow could be increased (Kazda et al., 1982). The drug has been tested in subarachnoid hemorrhage, stroke, severe head injury, cerebral resuscitation after cardiac arrest, impaired brain function in old age, and dementia. Methodological aspects of clinical studies with this agent are examined in this paper.

journal_name

Int Psychogeriatr

authors

Schmage N,Bergener M

keywords:

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

89-99

eissn

1041-6102

issn

1741-203X

journal_volume

4 Suppl 1

pub_type

杂志文章,评审
  • Impact of anesthesia on the cognitive functioning of the elderly.

    abstract::Exposure to general anesthesia has been suggested as a possible cause of long-term cognitive impairment in elderly subjects. The present study reviews the literature in this field in order to describe postoperative cognitive impairment in elderly populations, to determine to what extent this may be attributed to anest...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章,评审

    doi:10.1017/s1041610297004468

    authors: Ritchie K,Polge C,de Roquefeuil G,Djakovic M,Ledesert B

    更新日期:1997-09-01 00:00:00

  • Food group intake and brain lesions in late-life vascular depression.

    abstract:BACKGROUND:Studies indicate that diet may be related to the occurrence of brain lesions. The cross-sectional association between food intake and brain lesion volumes in late-life depression was examined in a cohort of elderly individuals with current or prior depression. METHODS:Food intake was assessed in 54 elderly ...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610206004431

    authors: Payne ME,Haines PS,Chambless LE,Anderson JJ,Steffens DC

    更新日期:2007-04-01 00:00:00

  • Disability but not social support predicts cognitive deterioration in late-life depression.

    abstract:BACKGROUND:Depression in late life is a risk factor for cognitive decline. Depression is also associated with increased disability and social support deficits; these may precede conversion to dementia and inform risk. In this study, we examined if baseline or one-year change in disability and social support predicted l...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610214002543

    authors: Riddle M,McQuoid DR,Potter GG,Steffens DC,Taylor WD

    更新日期:2015-05-01 00:00:00

  • Structural validity and internal consistency of the Qualidem in people with severe dementia.

    abstract:BACKGROUND:Since its development, the Qualidem has had items that were considered unsuited for people with very severe dementia. This study attempted to investigate the applicability of all Qualidem items in people with all stages of dementia severity. METHODS:Four data sets that contained Qualidem observations on peo...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610217001405

    authors: Arons AMM,Wetzels RB,Zwijsen S,Verbeek H,van de Ven G,Ettema TP,Koopmans RTCM,Gerritsen DL

    更新日期:2017-09-04 00:00:00

  • Attachment anxiety, depression, and perceived social support: a moderated mediation model of suicide ideation among the elderly.

    abstract:OBJECTIVES:Issues concerning the association among attachment anxiety, depression and suicidal ideation among the elderly have rarely been explored. The present study investigated the relationship among attachment anxiety, depression and perceived support concerning suicidal ideation among older people. DESIGN:Cross-s...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S104161022000054X

    authors: Oonarom A,Wongpakaran T,Kuntawong P,Wongpakaran N

    更新日期:2020-05-07 00:00:00

  • Eating disorders in the elderly.

    abstract:BACKGROUND:Eating disorders in the elderly are often overlooked. When they occur, significant morbidity and mortality result. In this study we review all existing literature on eating disorders in the elderly and provide practical guidelines for clinicians in recognizing and managing eating disorders in the elderly. M...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610210000104

    authors: Lapid MI,Prom MC,Burton MC,McAlpine DE,Sutor B,Rummans TA

    更新日期:2010-06-01 00:00:00

  • A social robot intervention on depression, loneliness, and quality of life for Taiwanese older adults in long-term care.

    abstract:OBJECTIVES:To investigate the effect of a social robot intervention on depression, loneliness, and quality of life of older adults in long-term care (LTC) and to explore participants' experiences and perceptions after the intervention. DESIGN:A mixed-methods approach consisting of a single group, before and after quas...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610220000459

    authors: Chen SC,Moyle W,Jones C,Petsky H

    更新日期:2020-08-01 00:00:00

  • Late-onset obsessive-compulsive disorder: the role of stressful life events.

    abstract::The onset of obsessive-compulsive disorder (OCD) for the first time in old age is uncommon and has been mostly related to cerebral abnormalities. We report a case of late-onset OCD in a 77-year-old woman following stressful life events but with a normal cerebral structure. The contribution of life events and vulnerabi...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610205002735

    authors: Velayudhan L,Katz AW

    更新日期:2006-06-01 00:00:00

  • Relationships between social and health factors and depression in old age in a multivariate analysis.

    abstract::This community-based epidemiological survey concerns relationships between social and health factors and depression in a Finnish population aged 60 years or over. A multivariate analysis based on log-linear models is used in this study. The log-linear model showed five interactions for the depressed men and eight for ...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/s104161029300136x

    authors: Pahkala K,Kivelä SL,Laippala P

    更新日期:1993-04-01 00:00:00

  • Clinico-tomographical aspects in the pathogenesis of vascular dementia.

    abstract::This article discusses the role of some pathogenetical factors in the main morphological variants of vascular dementia and their correlation with certain clinical parameters. On the basis of computer-tomographical (CT) studies of 62 patients with dementia, it was possible to distinguish three groups of patients, accor...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/s1041610292001054

    authors: Kontsevoy VA,Medvedev AV,Vavilov SB,Shchirina MG

    更新日期:1992-10-01 00:00:00

  • The process of family-centered counseling for caregivers of persons with dementia: barriers, facilitators and benefits.

    abstract:BACKGROUND:Despite the high consistency of evidence in favor of person-centered care, little information is available on how person-centered and family-centered interventions are actually provided. The aim of this study is to gain insight into the provision of the effective New York University Caregiver Intervention (N...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610210000050

    authors: Vernooij-Dassen M,Joling K,van Hout H,Mittelman MS

    更新日期:2010-08-01 00:00:00

  • Psychotic symptoms in Alzheimer's disease are not associated with more severe neuropathologic features.

    abstract::Psychotic symptoms in Alzheimer's disease (AD) have been associated with increased rates of cognitive impairment and functional decline. Prior studies have been conflicting with regard to whether AD patients with psychosis (AD+P) have evidence of more severe neuropathologic findings at postmortem exam. We examined the...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/s1041610200006657

    authors: Sweet RA,Hamilton RL,Lopez OL,Klunk WE,Wisniewski SR,Kaufer DI,Healy MT,DeKosky ST

    更新日期:2000-12-01 00:00:00

  • Ethnic disparities in the uptake of anti-dementia medication in young and late-onset dementia.

    abstract:OBJECTIVES:People with dementia can face barriers when trying to access care after a diagnosis, particularly in young-onset dementia (YOD). Little is known about the effects of ethnicity on the use of anti-dementia medication and variations between age groups. The aim of this study was to analyze national data on varia...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610220000794

    authors: Giebel C,Cations M,Draper B,Komuravelli A

    更新日期:2020-06-02 00:00:00

  • Design and evaluation protocol for 'DEALTS 2': a simulation-based dementia education intervention for acute care settings.

    abstract:BACKGROUND:There is a paucity of simulation-based dementia education programmes for acute care settings that support the development of interpersonal skills pertinent to good care. Moreover, few studies measure the effectiveness of such programmes by evaluating the persistence of practice change beyond the immediate ti...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610218002193

    authors: Heward M,Board M,Spriggs A,Murphy J

    更新日期:2020-12-01 00:00:00

  • A novel approach to assessing memory at the population level: vulnerability to semantic interference.

    abstract:BACKGROUND:There is increasing interest in identifying novel cognitive paradigms to help detect preclinical dementia. Promising results have been found in clinical settings using the Semantic Interference Test (SIT), a modification of an existing episodic memory test (Fuld Object Memory Evaluation) that exploits vulner...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610209991657

    authors: Snitz BE,Loewenstein DA,Chang CC,Lee CW,Vander Bilt J,Saxton J,Ganguli M

    更新日期:2010-08-01 00:00:00

  • Development and initial testing of the Person-Centred Health Care for Older Adults Survey.

    abstract:BACKGROUND:Health services are encouraged to adopt a strong person-centered approach to the provision of care and services for older people. The aim of this project was to establish a user-friendly, psychometrically valid, and reliable measure of healthcare staff's practice, attitudes, and beliefs regarding person-cent...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610213000471

    authors: Dow B,Fearn M,Haralambous B,Tinney J,Hill K,Gibson S

    更新日期:2013-07-01 00:00:00

  • Effect of SSRI and calcium channel blockers on depression symptoms and cognitive function in elderly persons treated for hypertension: three city cohort study.

    abstract::ABSTRACTBackground:Emerging genetic, ex-vivo, and clinical trial evidence indicates that calcium channel blockers (CCB) can improve mood and cognitive function. The objective of this study was to examine the effect of selective serotonin reuptake inhibitor (SSRI) therapy augmented with CCB on depression and cognitive ...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1017/S1041610217002903

    authors: Tully PJ,Peters R,Pérès K,Anstey KJ,Tzourio C

    更新日期:2018-09-01 00:00:00

  • The association between cognitive decline and incident depressive symptoms in a sample of older Puerto Rican adults with diabetes.

    abstract:BACKGROUND:Older Puerto Rican adults have particularly high risk of diabetes compared to the general US population. Diabetes is associated with both higher depressive symptoms and cognitive decline, but less is known about the longitudinal relationship between cognitive decline and incident depressive symptoms in those...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610217000746

    authors: Bell T,Dávila AL,Clay O,Markides KS,Andel R,Crowe M

    更新日期:2017-08-01 00:00:00

  • A test of the measurement invariance of a brief version of the Penn State Worry Questionnaire between American and Spanish older adults.

    abstract:BACKGROUND:Both anxiety disorders and subclinical anxiety symptoms are related to poorer health and functioning in later life. Because worry is an important component of anxiety, the accurate measurement of worry is crucial to studying the etiology, prevention and treatment of anxiety disorders. Assessment of the trait...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610206003450

    authors: Nuevo R,Mackintosh MA,Gatz M,Montorio I,Wetherell JL

    更新日期:2007-02-01 00:00:00

  • Relation between quality of life and chronic illnesses in elderly living in residential homes: a prospective study.

    abstract::Health-related quality of life (HRQL) was investigated in 211 inhabitants of five residential homes in The Netherlands and was assessed again 1 year later. It was examined (a) if HRQL was related to the presence of specific general medical illnesses, (b) if comorbidity resulted in poorer HRQL, independent of the type ...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/s1041610299006067

    authors: Cuijpers P,van Lammeren P,Duzijn B

    更新日期:1999-12-01 00:00:00

  • Social interactions between people with dementia: pilot evaluation of an observational instrument in a nursing home.

    abstract:BACKGROUND:In dementia, cognitive and psychological disorders might interfere with maintaining social interactions. We have little information about the nature of these interactions of people with dementia in nursing homes. The aim of this study is to investigate social interactions between people with dementia and to ...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610215002483

    authors: Mabire JB,Gay MC,Vrignaud P,Garitte C,Vernooij-Dassen M

    更新日期:2016-06-01 00:00:00

  • The Cognitive Assessment Battery (CAB): a rapid test of cognitive domains.

    abstract:BACKGROUND:The study aimed to evaluate the Cognitive Assessment Battery (CAB) in a specialist clinic setting in order to find out if it if it could be a supplement to the Mini-mental State Examination (MMSE) and distinguish between normal aging, mild cognitive impairment (MCI) and dementia, as well as MCI of different ...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610210002334

    authors: Nordlund A,Påhlsson L,Holmberg C,Lind K,Wallin A

    更新日期:2011-09-01 00:00:00

  • Dementia clinical trial implications of mild behavioral impairment.

    abstract::The World Alzheimer Report 2016 estimated that 47 million people are living with dementia worldwide (Alzheimer's Disease International, 2016). In the inaugural World Health Organization Ministerial Conference on Global Action against Dementia, six of the top ten research priorities were focused on prevention, identifi...

    journal_title:International psychogeriatrics

    pub_type: 评论,杂志文章

    doi:10.1017/S1041610218000042

    authors: Mortby ME,Black SE,Gauthier S,Miller D,Porsteinsson A,Smith EE,Ismail Z

    更新日期:2018-02-01 00:00:00

  • Behavioral and psychological symptoms of dementia in developing countries.

    abstract:BACKGROUND:Little is known about the prevalence of, or associations with behavioral and psychological symptoms of dementia (BPSD) in developing countries. METHODS:Individuals diagnosed as having dementia according to DSM-IV criteria (mild and moderate cases as defined by the Clinical Dementia Rating scale only), toget...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1017/s1041610204000833

    authors: Ferri CP,Ames D,Prince M,10\/66 Dementia Research Group.

    更新日期:2004-12-01 00:00:00

  • Only death and taxes.

    abstract::Most people who work in aged care have a fair idea of what is meant by cognitive impairment or decline, and we have some moderately robust instruments for detecting it and measuring change over time. Frailty is much more difficult to define, but like hard core pornography (Stewart, 1964), many of us "know it when we s...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610217000060

    authors: Ames D

    更新日期:2017-04-01 00:00:00

  • Lack of association between iron metabolism and depressive mood in an elderly general population.

    abstract:BACKGROUND:Alterations in iron metabolism have been suggested as potential pathological markers in patients with manifest depression. No data on the association between iron and depression exist from population-based studies, in which milder forms of depressive symptoms are much more common. The aim of this study was t...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610205002759

    authors: Baune BT,Eckardstein Av,Berger K

    更新日期:2006-09-01 00:00:00

  • The measuring, meaning and importance of activities of daily living (ADLs) as an outcome.

    abstract::Dementia is defined as global cognitive impairment that interferes with function; however, function has been less well measured than cognition in anti-dementia drug trials. In the modern era of anti-dementia clinical trials, measurement of function has improved by differentiating between the aspects of function that h...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610207004966

    authors: Rockwood K

    更新日期:2007-06-01 00:00:00

  • Stability of the factor structure of the Neuropsychiatric Inventory in a 31-month follow-up study of a large sample of nursing-home patients with dementia.

    abstract:BACKGROUND:Neuropsychiatric symptoms (NPS) are highly prevalent among nursing home patients with dementia. Several studies have investigated subsyndromes of NPS but the stability of these subsyndromes over time has rarely been examined. We have examined the stability over time of the factor structure of the Neuropsychi...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S104161021100086X

    authors: Selbæk G,Engedal K

    更新日期:2012-01-01 00:00:00

  • The use of CT in dementia.

    abstract::Neuroimaging has become part of the required investigations when assessing a patient with dementia. In this brief paper, we summarize the role of computed tomography (CT) in the routine work-up in dementia and provide some information about the role of the CT scan in the field of dementia research. Although CT is far ...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章,评审

    doi:10.1017/S1041610211000950

    authors: Pasi M,Poggesi A,Pantoni L

    更新日期:2011-09-01 00:00:00

  • The impact of diagnostic disclosure in dementia: a qualitative case analysis.

    abstract:OBJECTIVE:The aim of this study was to give an in-depth description of the impact of disclosure of the diagnosis of dementia on a patient and the patient's partner. METHODS:Grounded theory interview study. RESULTS:Analysis of the interviews revealed that disclosure had an impact on three key domains: awareness of dem...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/s1041610205001316

    authors: Derksen E,Vernooij-Dassen M,Gillissen F,Olde-Rikkert M,Scheltens P

    更新日期:2005-06-01 00:00:00