Abstract:
:Nimodipine is a calcium antagonist which improves learning and memory in brain-lesioned or aged animals (LeVere & Sandin, 1989; Schuurman & Traber, 1989). It also accelerates the recovery of experimentally damaged sciatic nerves (van der Zee et al., 1987) and reduces age-associated gait abnormalities in aging rats (Schuurman et al., 1987). Selective action on cerebral vessels has also been proven. Vasoconstriction was prevented or reduced with nimodipine under experimental conditions (Toward, 1981) and cerebral blood flow could be increased (Kazda et al., 1982). The drug has been tested in subarachnoid hemorrhage, stroke, severe head injury, cerebral resuscitation after cardiac arrest, impaired brain function in old age, and dementia. Methodological aspects of clinical studies with this agent are examined in this paper.
journal_name
Int Psychogeriatrjournal_title
International psychogeriatricsauthors
Schmage N,Bergener Mkeywords:
subject
Has Abstractpub_date
1992-01-01 00:00:00pages
89-99eissn
1041-6102issn
1741-203Xjournal_volume
4 Suppl 1pub_type
杂志文章,评审abstract::Exposure to general anesthesia has been suggested as a possible cause of long-term cognitive impairment in elderly subjects. The present study reviews the literature in this field in order to describe postoperative cognitive impairment in elderly populations, to determine to what extent this may be attributed to anest...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/s1041610297004468
更新日期:1997-09-01 00:00:00
abstract:BACKGROUND:Studies indicate that diet may be related to the occurrence of brain lesions. The cross-sectional association between food intake and brain lesion volumes in late-life depression was examined in a cohort of elderly individuals with current or prior depression. METHODS:Food intake was assessed in 54 elderly ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610206004431
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:Depression in late life is a risk factor for cognitive decline. Depression is also associated with increased disability and social support deficits; these may precede conversion to dementia and inform risk. In this study, we examined if baseline or one-year change in disability and social support predicted l...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610214002543
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Since its development, the Qualidem has had items that were considered unsuited for people with very severe dementia. This study attempted to investigate the applicability of all Qualidem items in people with all stages of dementia severity. METHODS:Four data sets that contained Qualidem observations on peo...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217001405
更新日期:2017-09-04 00:00:00
abstract:OBJECTIVES:Issues concerning the association among attachment anxiety, depression and suicidal ideation among the elderly have rarely been explored. The present study investigated the relationship among attachment anxiety, depression and perceived support concerning suicidal ideation among older people. DESIGN:Cross-s...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S104161022000054X
更新日期:2020-05-07 00:00:00
abstract:BACKGROUND:Eating disorders in the elderly are often overlooked. When they occur, significant morbidity and mortality result. In this study we review all existing literature on eating disorders in the elderly and provide practical guidelines for clinicians in recognizing and managing eating disorders in the elderly. M...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610210000104
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVES:To investigate the effect of a social robot intervention on depression, loneliness, and quality of life of older adults in long-term care (LTC) and to explore participants' experiences and perceptions after the intervention. DESIGN:A mixed-methods approach consisting of a single group, before and after quas...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610220000459
更新日期:2020-08-01 00:00:00
abstract::The onset of obsessive-compulsive disorder (OCD) for the first time in old age is uncommon and has been mostly related to cerebral abnormalities. We report a case of late-onset OCD in a 77-year-old woman following stressful life events but with a normal cerebral structure. The contribution of life events and vulnerabi...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610205002735
更新日期:2006-06-01 00:00:00
abstract::This community-based epidemiological survey concerns relationships between social and health factors and depression in a Finnish population aged 60 years or over. A multivariate analysis based on log-linear models is used in this study. The log-linear model showed five interactions for the depressed men and eight for ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s104161029300136x
更新日期:1993-04-01 00:00:00
abstract::This article discusses the role of some pathogenetical factors in the main morphological variants of vascular dementia and their correlation with certain clinical parameters. On the basis of computer-tomographical (CT) studies of 62 patients with dementia, it was possible to distinguish three groups of patients, accor...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610292001054
更新日期:1992-10-01 00:00:00
abstract:BACKGROUND:Despite the high consistency of evidence in favor of person-centered care, little information is available on how person-centered and family-centered interventions are actually provided. The aim of this study is to gain insight into the provision of the effective New York University Caregiver Intervention (N...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610210000050
更新日期:2010-08-01 00:00:00
abstract::Psychotic symptoms in Alzheimer's disease (AD) have been associated with increased rates of cognitive impairment and functional decline. Prior studies have been conflicting with regard to whether AD patients with psychosis (AD+P) have evidence of more severe neuropathologic findings at postmortem exam. We examined the...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610200006657
更新日期:2000-12-01 00:00:00
abstract:OBJECTIVES:People with dementia can face barriers when trying to access care after a diagnosis, particularly in young-onset dementia (YOD). Little is known about the effects of ethnicity on the use of anti-dementia medication and variations between age groups. The aim of this study was to analyze national data on varia...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610220000794
更新日期:2020-06-02 00:00:00
abstract:BACKGROUND:There is a paucity of simulation-based dementia education programmes for acute care settings that support the development of interpersonal skills pertinent to good care. Moreover, few studies measure the effectiveness of such programmes by evaluating the persistence of practice change beyond the immediate ti...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610218002193
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:There is increasing interest in identifying novel cognitive paradigms to help detect preclinical dementia. Promising results have been found in clinical settings using the Semantic Interference Test (SIT), a modification of an existing episodic memory test (Fuld Object Memory Evaluation) that exploits vulner...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610209991657
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Health services are encouraged to adopt a strong person-centered approach to the provision of care and services for older people. The aim of this project was to establish a user-friendly, psychometrically valid, and reliable measure of healthcare staff's practice, attitudes, and beliefs regarding person-cent...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610213000471
更新日期:2013-07-01 00:00:00
abstract::ABSTRACTBackground:Emerging genetic, ex-vivo, and clinical trial evidence indicates that calcium channel blockers (CCB) can improve mood and cognitive function. The objective of this study was to examine the effect of selective serotonin reuptake inhibitor (SSRI) therapy augmented with CCB on depression and cognitive ...
journal_title:International psychogeriatrics
pub_type: 杂志文章,多中心研究
doi:10.1017/S1041610217002903
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:Older Puerto Rican adults have particularly high risk of diabetes compared to the general US population. Diabetes is associated with both higher depressive symptoms and cognitive decline, but less is known about the longitudinal relationship between cognitive decline and incident depressive symptoms in those...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217000746
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Both anxiety disorders and subclinical anxiety symptoms are related to poorer health and functioning in later life. Because worry is an important component of anxiety, the accurate measurement of worry is crucial to studying the etiology, prevention and treatment of anxiety disorders. Assessment of the trait...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610206003450
更新日期:2007-02-01 00:00:00
abstract::Health-related quality of life (HRQL) was investigated in 211 inhabitants of five residential homes in The Netherlands and was assessed again 1 year later. It was examined (a) if HRQL was related to the presence of specific general medical illnesses, (b) if comorbidity resulted in poorer HRQL, independent of the type ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610299006067
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:In dementia, cognitive and psychological disorders might interfere with maintaining social interactions. We have little information about the nature of these interactions of people with dementia in nursing homes. The aim of this study is to investigate social interactions between people with dementia and to ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610215002483
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:The study aimed to evaluate the Cognitive Assessment Battery (CAB) in a specialist clinic setting in order to find out if it if it could be a supplement to the Mini-mental State Examination (MMSE) and distinguish between normal aging, mild cognitive impairment (MCI) and dementia, as well as MCI of different ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610210002334
更新日期:2011-09-01 00:00:00
abstract::The World Alzheimer Report 2016 estimated that 47 million people are living with dementia worldwide (Alzheimer's Disease International, 2016). In the inaugural World Health Organization Ministerial Conference on Global Action against Dementia, six of the top ten research priorities were focused on prevention, identifi...
journal_title:International psychogeriatrics
pub_type: 评论,杂志文章
doi:10.1017/S1041610218000042
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Little is known about the prevalence of, or associations with behavioral and psychological symptoms of dementia (BPSD) in developing countries. METHODS:Individuals diagnosed as having dementia according to DSM-IV criteria (mild and moderate cases as defined by the Clinical Dementia Rating scale only), toget...
journal_title:International psychogeriatrics
pub_type: 杂志文章,多中心研究
doi:10.1017/s1041610204000833
更新日期:2004-12-01 00:00:00
abstract::Most people who work in aged care have a fair idea of what is meant by cognitive impairment or decline, and we have some moderately robust instruments for detecting it and measuring change over time. Frailty is much more difficult to define, but like hard core pornography (Stewart, 1964), many of us "know it when we s...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217000060
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Alterations in iron metabolism have been suggested as potential pathological markers in patients with manifest depression. No data on the association between iron and depression exist from population-based studies, in which milder forms of depressive symptoms are much more common. The aim of this study was t...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610205002759
更新日期:2006-09-01 00:00:00
abstract::Dementia is defined as global cognitive impairment that interferes with function; however, function has been less well measured than cognition in anti-dementia drug trials. In the modern era of anti-dementia clinical trials, measurement of function has improved by differentiating between the aspects of function that h...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610207004966
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:Neuropsychiatric symptoms (NPS) are highly prevalent among nursing home patients with dementia. Several studies have investigated subsyndromes of NPS but the stability of these subsyndromes over time has rarely been examined. We have examined the stability over time of the factor structure of the Neuropsychi...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S104161021100086X
更新日期:2012-01-01 00:00:00
abstract::Neuroimaging has become part of the required investigations when assessing a patient with dementia. In this brief paper, we summarize the role of computed tomography (CT) in the routine work-up in dementia and provide some information about the role of the CT scan in the field of dementia research. Although CT is far ...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/S1041610211000950
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to give an in-depth description of the impact of disclosure of the diagnosis of dementia on a patient and the patient's partner. METHODS:Grounded theory interview study. RESULTS:Analysis of the interviews revealed that disclosure had an impact on three key domains: awareness of dem...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610205001316
更新日期:2005-06-01 00:00:00