Abstract:
:ABSTRACTBackground:Emerging genetic, ex-vivo, and clinical trial evidence indicates that calcium channel blockers (CCB) can improve mood and cognitive function. The objective of this study was to examine the effect of selective serotonin reuptake inhibitor (SSRI) therapy augmented with CCB on depression and cognitive decline in an elderly population with hypertension. METHODS:Prospective study of 296 persons treated with SSRI and antihypertensive drugs. Baseline and two year clinic assessments were used to categorize participants as users of SSRI + CCB (n = 53) or users of SSRI + other antihypertensives (n = 243). Clinic visits were performed up to four times in a ten-year period to assess depression and cognitive function. RESULTS:The sample mean age was 75.2 ± 5.47 years and 78% of participants were female. At two year follow-up there was a significant group by time interaction showing lower Center for Epidemiological Studies-Depression (CESD) scores in the SSRI + CCB group, F(1,291) = 4.13, p = 0.043, η2p = 0.014. Over ten-years follow-up, SSRI + CCB use was associated with improved general cognitive function (Mini-Mental State Examination: β = 0.97; 95% CI 0.14 to 1.81, p = 0.023) and immediate visual memory (Boston Visual Retention Test: β = 0.69; 95% CI 0.06 to 1.32, p = 0.033). CONCLUSION:The findings provide general population evidence that SSRI augmentation with CCB may improve depression and cognitive function.
journal_name
Int Psychogeriatrjournal_title
International psychogeriatricsauthors
Tully PJ,Peters R,Pérès K,Anstey KJ,Tzourio Cdoi
10.1017/S1041610217002903subject
Has Abstractpub_date
2018-09-01 00:00:00pages
1345-1354issue
9eissn
1041-6102issn
1741-203Xpii
S1041610217002903journal_volume
30pub_type
杂志文章,多中心研究abstract:OBJECTIVES:To evaluate the impact of external memory devices on the efficacy of a package of internal mnemonic techniques. Participants wrote two types of lists during the study phase: (a) a list of study words and/or (b) a loci list. At recall, participants were not allowed to refer to either of the lists they had wri...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610203008755
更新日期:2003-03-01 00:00:00
abstract::The objectives of this randomized clinical trial were to investigate the impact of the discontinuation of long-term antipsychotics in residents with dementia in chronic care institutions and to identify clinical predictors of safe discontinuation. Subjects included 34 residents with dementia who were on antipsychotics...
journal_title:International psychogeriatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/s1041610202008396
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:The clinical presentations in dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD) overlap considerably with that of Alzheimer's disease (AD) despite different pathological processes. Autopsy studies have also shown that multiple brain pathology occurs frequently, even in cases with a single cli...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610209009454
更新日期:2009-08-01 00:00:00
abstract::Current symptomatic treatments for dementia have only modest efficacy. Assessing meaningful benefits in this variably progressive syndrome is complex and difficult. This consensus statement was generated by an international group representing caregivers, organizations and professionals with expertise in dementia. We r...
journal_title:International psychogeriatrics
pub_type: 共识发展会议,杂志文章
doi:10.1017/S1041610207005145
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:Dementia in the elderly is associated with a greater risk of being subjected to abuse. More than half of those in Japan who abuse elderly relatives with dementia do not realize that their behavior corresponds to abuse. OBJECTIVE:This study sought to examine the effect of the presence of dementia in the elde...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610206004789
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:Apathy, characterized by diminished motivation, is a highly prevalent neuropsychiatric symptom in dementia. However, there is a substantial knowledge gap with regard to prevalence rates, neurobiological underpinnings, and effective treatments for apathy in pre-dementia states, including mild cognitive impair...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/S1041610217000527
更新日期:2018-02-01 00:00:00
abstract::Cholinergic deficits are a hallmark of Alzheimer's disease (AD) and Lewy body dementia (LBD). The nucleus basalis of Meynert (NBM) provides the major source of cortical cholinergic input; studying its functional connectivity might, therefore, provide a tool for probing the cholinergic system and its degeneration in ne...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610220003944
更新日期:2021-01-08 00:00:00
abstract::Few would argue that achieving the age of 100 years is extraordinary, but what about the quality of life at this extreme age? Is it worth it to live to 100 and beyond? The study by Araújo, Ribero, Teixeira, and Paúl (2015) in three ways provided an answer to this question substantiating and complementing recent findin...
journal_title:International psychogeriatrics
pub_type: 评论,杂志文章
doi:10.1017/S1041610215002021
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:The Family Group Conference (FGC) is an approach to partnership working which brings together service users, their support network and care professionals in a family-led decision making forum. Evidence, though limited, indicates that that FGC can enhance outcomes for service providers and their users. This s...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610215001507
更新日期:2016-02-01 00:00:00
abstract::Current approaches to the diagnosis of delirium are based upon the recognition of symptoms that emerge in the pathological state. As an alternative, we propose an approach to case identification for research purposes based on the recognition of significant changes in the cognitive or cerebral state of the individual p...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s104161029100073x
更新日期:1991-01-01 00:00:00
abstract::ABSTRACTBackground:Cognitive decline is an important complication of joint replacement surgeries in senior people. METHODS:We determined incidence rates of dementia diagnosis following endoprosthetic joint replacement surgery (upper and lower extremities). The observation period covered up to 28 quarters using German...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217002976
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:Vocally disruptive behavior (VDB) in the elderly is a common condition, especially in people with dementia, but difficult to treat. It may occur in as many as 40% of nursing home residents. This study is a review of the existing literature on this condition. METHOD:The literature review was conducted using ...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/S1041610208006728
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:Since its development, the Qualidem has had items that were considered unsuited for people with very severe dementia. This study attempted to investigate the applicability of all Qualidem items in people with all stages of dementia severity. METHODS:Four data sets that contained Qualidem observations on peo...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217001405
更新日期:2017-09-04 00:00:00
abstract:BACKGROUND:Previous studies have shown that the presence of depressive symptoms among older persons was evidently associated with subsequent physical and functional decline. However, few studies have directly examined the impact of changes in depressive symptoms or depressed mood on changes in functional ability. The p...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212000890
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Common sense suggests and research indicates relationships between staff factors in residential dementia care and quality of life (QOL) for residents, with poor care increasing suffering. However, we do not have a coherent picture of which staff interventions have an impact on quality of care (QOC) or reside...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610216001083
更新日期:2016-12-01 00:00:00
abstract:OBJECTIVES:While family caregivers (CGs) of persons with dementia are cost-effective for the health system, this form of caregiving leads to disproportionate vulnerability to physical, mental, and social adverse health consequences among CGs. The study goal was to determine the effect of the Reitman Centre CARERS progr...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610220004019
更新日期:2021-01-18 00:00:00
abstract::ABSTRACTBackground and Purpose:The impact of dementia-related stressors and strains have been examined for their potential to threaten the well-being of either the person with dementia or the family care partner, but rarely have studies considered the dyadic nature of well-being in dementia. The purpose of this study ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S104161021800203X
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Research with nondepressed adults suggests that social networks and social support are stable over the life course until very late age. This may not hold true for older adults with depression. We examined baseline status and trajectories of social networks and social support at the group and individual level...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610207005303
更新日期:2007-12-01 00:00:00
abstract::The Clinician Interview-Based Impression of Change, plus carer interview (CIBIC-Plus), is widely used in antidementia drug trials. It comprises Likert scales for disease severity and changes, and written accounts summarizing semistructured interviews evaluating behavior, cognition, and function. Studies using the CIBI...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610200006505
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to give an in-depth description of the impact of disclosure of the diagnosis of dementia on a patient and the patient's partner. METHODS:Grounded theory interview study. RESULTS:Analysis of the interviews revealed that disclosure had an impact on three key domains: awareness of dem...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610205001316
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:Research shows that lipid levels may be associated with cognitive function, particularly among women. We aimed to examine total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), high-density lipoprotein (HDL), and HDL/LDL ratio in relation to cognitive performance, measured w...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610215000320
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Acute exposure to sedative drugs may induce memory impairment, but there is mixed evidence that long-term sedative use may result in incident cognitive decline. The objective of this study was to investigate the use of sedative drugs and incident cognitive decline in a population-based sample of persons aged...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610211001359
更新日期:2012-01-01 00:00:00
abstract::Neuroimaging has become part of the required investigations when assessing a patient with dementia. In this brief paper, we summarize the role of computed tomography (CT) in the routine work-up in dementia and provide some information about the role of the CT scan in the field of dementia research. Although CT is far ...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/S1041610211000950
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:This review presents an overview of the published literature on the effectiveness of continuing professional education (CPE), which includes continuing medical education (CME) of different health care professionals in healthcare settings, for improving patient management and patient outcomes. This review sum...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/S1041610209008746
更新日期:2009-04-01 00:00:00
abstract::A brief review of classification in psychiatry from Kraepelin to ICD-10 and DSM-IV reveals that the categorical paradigm inherent in these nosological systems has certain inadequacies when applied to dementia specifically and cognitive impairment in general. There are "outcasts" from these two systems that, with the r...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/s1041610205001924
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Delirium is frequently observed in clinical practice, particularly in medical and surgical wards and more so among patients at risk, especially elderly with preexisting central nervous system impairments. OBJECTIVE:Despite the severe consequences of delirium, epidemiological data relating to incidence of de...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610202008499
更新日期:2002-09-01 00:00:00
abstract:BACKGROUND:Frailty is a complex health state of increased vulnerability associated with adverse outcomes such as disability, falls, hospitalization, and death. Along with physical impairments, cognition and quality of life may be affected in frail older adults. Yet, evidence is still lacking. The aim of this study was ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212000634
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Elder mistreatment, social ageism, and human rights are increasingly powerful discourses in positioning older people in society, yet the relationship between them has rarely been subjected to critical investigation. This perceived relationship will have implications for how mistreatment is understood and res...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212002372
更新日期:2013-08-01 00:00:00
abstract::Major depression in the elderly is often a relapsing, chronic illness with high risk for chronic invalidism, poor treatment compliance, and suicide. In most cases, maintenance treatment to prevent recurrence and to enhance the quality of life is thought to be indicated. We review recent data from our ongoing studies t...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/s104161029500233x
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:The Geriatric Anxiety Inventory (GAI) was developed for assessing anxiety in older adults. The objectives of this work were: (a) to analyze the psychometric properties of the Spanish version of the GAI, and (b) to explore the associations between anxiety and other variables related to emotional distress (dep...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610211001505
更新日期:2012-01-01 00:00:00