Psychotic symptoms in Alzheimer's disease are not associated with more severe neuropathologic features.

Abstract:

:Psychotic symptoms in Alzheimer's disease (AD) have been associated with increased rates of cognitive impairment and functional decline. Prior studies have been conflicting with regard to whether AD patients with psychosis (AD+P) have evidence of more severe neuropathologic findings at postmortem exam. We examined the severity of neuritic plaques and neurofibrillary tangles in six brain regions--middle frontal cortex, hippocampus, inferior parietal cortex, superior temporal cortex, occipital cortex, and transentorhinal cortex-in 24 AD+P subjects and 25 matched AD subjects without psychosis (AD-P). All analyses controlled for the presence of cortical Lewy bodies, and corrected for multiple comparisons. We found no significant associations between neuritic plaque and neurofibrillary tangle severity and AD+P, and no significant associations with any individual psychotic symptom. The association of AD+P with a more rapidly progressive course of AD appears to be mediated by a neuropathologic process other than increased severity of plaque and tangle formation.

journal_name

Int Psychogeriatr

authors

Sweet RA,Hamilton RL,Lopez OL,Klunk WE,Wisniewski SR,Kaufer DI,Healy MT,DeKosky ST

doi

10.1017/s1041610200006657

keywords:

subject

Has Abstract

pub_date

2000-12-01 00:00:00

pages

547-58

issue

4

eissn

1041-6102

issn

1741-203X

journal_volume

12

pub_type

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