Abstract:
:Psychotic symptoms in Alzheimer's disease (AD) have been associated with increased rates of cognitive impairment and functional decline. Prior studies have been conflicting with regard to whether AD patients with psychosis (AD+P) have evidence of more severe neuropathologic findings at postmortem exam. We examined the severity of neuritic plaques and neurofibrillary tangles in six brain regions--middle frontal cortex, hippocampus, inferior parietal cortex, superior temporal cortex, occipital cortex, and transentorhinal cortex-in 24 AD+P subjects and 25 matched AD subjects without psychosis (AD-P). All analyses controlled for the presence of cortical Lewy bodies, and corrected for multiple comparisons. We found no significant associations between neuritic plaque and neurofibrillary tangle severity and AD+P, and no significant associations with any individual psychotic symptom. The association of AD+P with a more rapidly progressive course of AD appears to be mediated by a neuropathologic process other than increased severity of plaque and tangle formation.
journal_name
Int Psychogeriatrjournal_title
International psychogeriatricsauthors
Sweet RA,Hamilton RL,Lopez OL,Klunk WE,Wisniewski SR,Kaufer DI,Healy MT,DeKosky STdoi
10.1017/s1041610200006657keywords:
subject
Has Abstractpub_date
2000-12-01 00:00:00pages
547-58issue
4eissn
1041-6102issn
1741-203Xjournal_volume
12pub_type
杂志文章abstract:BACKGROUND:Symptoms of complicated grief are associated with a traumatic death. However, the subjective experience of whether or not the death was considered traumatic has not been substantially explored. This study first examined the difference between objective and subjective traumatic death, and then investigated th...
journal_title:International psychogeriatrics
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journal_title:International psychogeriatrics
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journal_title:International psychogeriatrics
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journal_title:International psychogeriatrics
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:International psychogeriatrics
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:1992-01-01 00:00:00
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更新日期:2007-06-01 00:00:00
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journal_title:International psychogeriatrics
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更新日期:2010-08-01 00:00:00
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journal_title:International psychogeriatrics
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更新日期:1994-04-01 00:00:00
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journal_title:International psychogeriatrics
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更新日期:1998-12-01 00:00:00
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更新日期:2009-02-01 00:00:00
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更新日期:2009-04-01 00:00:00
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更新日期:2013-11-01 00:00:00
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更新日期:2015-12-01 00:00:00
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更新日期:2016-04-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to determine levels, rates and progression of apathy in healthy older persons and to investigate factors associated with its progression. METHODS:Seventy-six healthy elderly subjects, aged 58-85 years (mean 69.9), who were recruited by general advertisement and through local commun...
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更新日期:2010-05-01 00:00:00
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journal_title:International psychogeriatrics
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更新日期:1999-03-01 00:00:00
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更新日期:2007-10-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:International psychogeriatrics
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更新日期:2013-02-01 00:00:00
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