Head circumference as a useful surrogate for intracranial volume in older adults.

Abstract:

BACKGROUND:Intracranial volume (ICV) has been proposed as a measure of maximum lifetime brain size. Accurate ICV measures require neuroimaging which is not always feasible for epidemiologic investigations. We examined head circumference as a useful surrogate for ICV in older adults. METHODS:99 older adults underwent Magnetic Resonance Imaging (MRI). ICV was measured by Statistical Parametric Mapping 8 (SPM8) software or Functional MRI of the Brain Software Library (FSL) extraction with manual editing, typically considered the gold standard. Head circumferences were determined using standardized tape measurement. We examined estimated correlation coefficients between head circumference and the two MRI-based ICV measurements. RESULTS:Head circumference and ICV by SPM8 were moderately correlated (overall r = 0.73, men r = 0.67, women r = 0.63). Head circumference and ICV by FSL were also moderately correlated (overall r = 0.69, men r = 0.63, women r = 0.49). CONCLUSIONS:Head circumference measurement was strongly correlated with MRI-derived ICV. Our study presents a simple method to approximate ICV among older patients, which may prove useful as a surrogate for cognitive reserve in large scale epidemiologic studies of cognitive outcomes. This study also suggests the stability of head circumference correlation with ICV throughout the lifespan.

journal_name

Int Psychogeriatr

authors

Hshieh TT,Fox ML,Kosar CM,Cavallari M,Guttmann CR,Alsop D,Marcantonio ER,Schmitt EM,Jones RN,Inouye SK

doi

10.1017/S104161021500037X

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

157-62

issue

1

eissn

1041-6102

issn

1741-203X

pii

S104161021500037X

journal_volume

28

pub_type

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