Abstract:
:ABSTRACTIntroduction:The relationship between Alzheimer's Disease (AD) and alcohol addiction is poorly characterized. Arrests for driving under the influence (DUI) can serve as a proxy for alcohol addiction. Therefore, the potential association between DUI and AD could be helpful in understanding the relationship between alcohol abuse and AD. MATERIALS AND METHODS:A retrospective, population-based cohort study using state health and law enforcement data was performed. The study cross-referenced 141,281 South Carolina Alzheimer's Disease Registry cases with state law enforcement data. RESULTS:Of the 2,882 registry cases (1.4%) found to have a history of at least one DUI arrest, cases were predominantly White (58.7%) and male (77.4%). Results showed a correlation coefficient of 0.7 (p < 0.0001) between the age of first DUI arrest and the age of AD diagnosis. A dose-response relationship between the number of DUIs and age of AD onset was found to exist, where those with a history of DUI arrest were diagnosed an average of 9.1 years earlier, with a further 1.8 years earlier age at diagnosis in those with two or more arrests for DUI. A history of DUI arrest was also found to be negatively associated with survival after diagnosis, with a 10% decreased life expectancy in those with a DUI arrest history. CONCLUSIONS:Driving under the influence, a potential indicator of alcohol addiction, is associated with an earlier onset of AD registry diagnosis and shortened survival after diagnosis. This study contributes to the growing body of evidence suggesting that some cases of AD are alcohol related and, possibly, postponable or preventable.
journal_name
Int Psychogeriatrjournal_title
International psychogeriatricsauthors
Miller M,Orwat D,Rahimi G,Mintzer Jdoi
10.1017/S1041610218001151subject
Has Abstractpub_date
2019-04-01 00:00:00pages
571-577issue
4eissn
1041-6102issn
1741-203Xpii
S1041610218001151journal_volume
31pub_type
杂志文章abstract:BACKGROUND:Ageism, a form of prejudice in which one relates negatively to people due to their age, exists throughout life. However, no attempt has been made to compare ageist attitudes across the life cycle, from young adulthood to old age. Consequently, the current study examined age and gender differences in ageism t...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610211002936
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abstract:BACKGROUND:The objectives of this study were to examine the factors modifying the relationship between cortisol level and prevalent/incident cognitive impairment in older adults and to verify whether these relationships were non-linear. METHODS:Data were collected from 1,226 individuals aged 65 and older by two in-hom...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212001706
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Australia has a growing aging migrant population and rates of dementia in residential care are high. The communication of persons with dementia and limited English language proficiency in residential care is an area that has received little attention in the research literature. METHOD:Thirty-nine Italian-ba...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610205002309
更新日期:2005-12-01 00:00:00
abstract:OBJECTIVE:Cognitive impairment and negative signs are common in patients with schizophrenia. Up to 35% of elderly patients with schizophrenia fulfill the diagnostic criteria of dementia. Donepezil inhibits cholinesterase, thus enhancing cholinergic neurotransmission. We tested the efficacy of donepezil in elderly patie...
journal_title:International psychogeriatrics
pub_type: 杂志文章,随机对照试验
doi:10.1017/S1041610205003017
更新日期:2006-09-01 00:00:00
abstract::This paper provides a review of research issues and findings on the epidemiology of delirium. Despite the fact that research on this important geriatric syndrome has been conducted for many decades, several methodological issues make it difficult to compare findings across studies. In this paper we first discuss broad...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/s1041610291000625
更新日期:1991-01-01 00:00:00
abstract::Dementia is a neurodegenerative disorder with global impact, with the largest proportion of cases occurring in low- and middle-income countries. It is estimated that there are 46.8 million cases globally with approximately 10 million new cases each year or a new case occurring every 3 sec (Prince et al., 2015). For co...
journal_title:International psychogeriatrics
pub_type: 社论
doi:10.1017/S1041610217001685
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:This subanalysis of a large, double-blind, placebo-controlled trial examined the prevalence of behavioral symptoms in moderate to severe Alzheimer's disease (AD), and the effect of treatment with donepezil. METHODS:Two hundred ninety patients with moderate to severe AD (standardized Mini-Mental State Examina...
journal_title:International psychogeriatrics
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1017/s104161020200858x
更新日期:2002-12-01 00:00:00
abstract::The role of the physician is critical in the evaluation of cognitively impaired patients for two reasons: (a) The longitudinal relationship between the patient and physician provides a unique opportunity to observe changes over time, generating confidence that may encourage the patient and family to report any concern...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610297004729
更新日期:1997-01-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
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更新日期:2011-09-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/s1041610205002073
更新日期:2005-09-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610214000556
更新日期:2014-08-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
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更新日期:2016-12-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610211001803
更新日期:2012-02-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 信件
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更新日期:2018-06-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212000749
更新日期:2012-10-01 00:00:00
abstract::Depression is the most prevalent mental health problem among the elderly, including Chinese-American elderly. A Chinese-language version of the popular Geriatric Depression Scale Long Form (GDS-LF) and Short Form (GDS-SF) was developed. Based on the responses of 50 elderly Chinese immigrants to the U.S. (25 women and ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610296002803
更新日期:1996-10-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610214001161
更新日期:2015-01-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
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更新日期:2018-08-01 00:00:00
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journal_title:International psychogeriatrics
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更新日期:1992-07-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章,多中心研究
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journal_title:International psychogeriatrics
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更新日期:2020-06-30 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
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更新日期:2013-09-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610208007035
更新日期:2008-10-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610210000578
更新日期:2010-11-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章,多中心研究
doi:10.1017/S104161021600171X
更新日期:2017-02-01 00:00:00
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journal_title:International psychogeriatrics
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更新日期:2007-10-01 00:00:00
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journal_title:International psychogeriatrics
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更新日期:2013-03-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
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更新日期:2019-08-01 00:00:00
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journal_title:International psychogeriatrics
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doi:10.1017/s104161029700433x
更新日期:1997-06-01 00:00:00