Abstract:
:Using magnetic resonance imaging-based planimetry, we measured cortical and cerebral (cortical and ventricular) atrophy in 26 patients with Alzheimer's disease (AD) (age, 72.2 +/- 7.0) according to NINCDS-ADRDA criteria and 22 control subjects (age, 71.5 +/- 5.4). AD patients exhibited greater cerebral atrophy (p < .05) than control subjects. Cerebral atrophy was significantly correlated with age (r = .72, p < .0005) in healthy volunteers but not in AD patients. In AD patients, age of onset was negatively correlated with the estimated rate of disease-attributed cerebral degeneration ([observed atrophy--atrophy in normal aging calculated from the regression equation derived from the control group]/[duration of illness]) (r = -.54, p < .005). Multiple regression with interaction analysis demonstrated that age, age of onset, and their interaction successfully explained cerebral (R2 = .51, p < .05) and cortical (R2 = .64, p < .05) atrophy in patients with probable AD. Age of onset may be a strong predictor of the rate of cerebral degeneration in AD, and our results suggest that controlling age and the age of onset is essential in the quantitative study of AD.
journal_name
Int Psychogeriatrjournal_title
International psychogeriatricsauthors
Woo JI,Kim JH,Lee JHdoi
10.1017/s104161029700433xsubject
Has Abstractpub_date
1997-06-01 00:00:00pages
183-96issue
2eissn
1041-6102issn
1741-203Xjournal_volume
9pub_type
杂志文章abstract:BACKGROUND:Most studies examining psychotropic medication use on cognition in older persons with dementia include measures of global cognitive function. The present study examined the relationship between different types of psychotropic medication and specific cognitive functions in older people with dementia. METHODS...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610209008552
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:A single-item depression measure may not be adequate in capturing the complex entity of mental health, despite wide use of this indicator in community studies. This study evaluated the accuracy of a single-question depression measure in comparison to two composite indices-the Center for Epidemiologic Studies...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217001673
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Most research on family members' experience of dementia has focused on the time after diagnosis. Yet, once people reach clinical attention, families have already been living with the changes for some time. These pre-diagnosis experiences can influence later caregiving. We aimed to synthesize qualitative rese...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/S1041610217000862
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Australia has a growing aging migrant population and rates of dementia in residential care are high. The communication of persons with dementia and limited English language proficiency in residential care is an area that has received little attention in the research literature. METHOD:Thirty-nine Italian-ba...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610205002309
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:Preliminary evidence indicates that the quality of the carer-care recipient relationship predicts those carers most at risk from anxiety. Attachment style is related to higher carer burden, psychological morbidity and increased care recipient institutionalization. We tested, for the first time, the hypothesi...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S104161020700645X
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:The aim of this study was to test the association between anxiety at the time of hospitalization and falls occurring within one month of discharge, and to offer potential mechanisms for this association. METHODS:One-month, prospective cohort study of 556 older adults in two medical centers in Israel. Anxiet...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610215002306
更新日期:2016-06-01 00:00:00
abstract::Seventy-eight nondemented elderly depressed patients underwent an extensive battery of cognitive tests both before and after seven weeks of treatment with nortriptyline, phenelzine, or placebo. Clinical and cognitive evaluations of the patients were under double-blind conditions. Response to treatment did not appear t...
journal_title:International psychogeriatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/s1041610289000141
更新日期:1989-10-01 00:00:00
abstract:BACKGROUND:The use of benzodiazepines is associated with increased risk of fall-related injuries in the elderly. However, it is unclear if the risks vary across the products and how they depend on the pattern of use and dosage. Specifically, the possibility of cumulative effects of past benzodiazepine use has not been ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610211002031
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Qualitative research has suggested that spousal carers of someone with dementia differ in terms of whether they perceive their relationship with that person as continuous with the premorbid relationship or as radically different, and that a perception of continuity may be associated with more person-centered...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212001743
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND AND AIM:Previous research suggested caregiver singing could influence persons with severe dementia to communicate with increased competence, to cease aggression, and to cease disruptive screaming, while at the same time they seemed to understand what was going on when being cared for during morning care sess...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:
更新日期:2003-12-01 00:00:00
abstract::An extensive new caring program--including the introduction of Individual Care Plans and changes in ward organization, caring techniques, and caring philosophy--was introduced at two psychogeriatric wards with severely demented patients. The hypotheses were that the patients (n = 31) would improve in psychosocial capa...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610293001504
更新日期:1993-10-01 00:00:00
abstract:BACKGROUND:Eating disorders in the elderly are often overlooked. When they occur, significant morbidity and mortality result. In this study we review all existing literature on eating disorders in the elderly and provide practical guidelines for clinicians in recognizing and managing eating disorders in the elderly. M...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610210000104
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:The International Psychogeriatric Association (IPA) capacity taskforce was established to promote the autonomy, proper access to care, and dignity of persons with decision-making disabilities (DMDs) across nations. The Asia Consortium of the taskforce was established to pursue these goals in the Asia-Pacific...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S104161021400266X
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Research on the behavioral correlates of anxiety in older adults is sparse. The aim of this study was to explore the association of anxiety with behavioral patterns defined by health, activity, emotional and social variables. METHODS:A convenience sample of 395 older adults completed measures of health, act...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610214001148
更新日期:2015-07-01 00:00:00
abstract::ABSTRACTBackground:With increasing cultural diversity and growing elderly immigrant populations in Western European countries, the availability of brief cognitive screening instruments adequate for assessment of dementia in people from diverse backgrounds becomes increasingly important. The aim of the present study wa...
journal_title:International psychogeriatrics
pub_type: 杂志文章,多中心研究
doi:10.1017/S1041610218000832
更新日期:2019-02-01 00:00:00
abstract::ABSTRACTBackground:Cognitive decline is an important complication of joint replacement surgeries in senior people. METHODS:We determined incidence rates of dementia diagnosis following endoprosthetic joint replacement surgery (upper and lower extremities). The observation period covered up to 28 quarters using German...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217002976
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:It is necessary to continue to explore the psychometric characteristics of key cognitive screening tests such as the Montreal Cognitive Assessment (MoCA) to diagnose cognitive decline as early as possible and to attend to the growing need of clinical trials involving mild cognitive impairment (MCI) participa...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610215001982
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:The anxiety disorders are a prevalent mental health problem in older age with a considerable impact on quality of life. Until recently there have been few longitudinal studies on anxiety in this age group, consequently most of the evidence to date has been cross-sectional in nature. METHODS:We undertook a l...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/S1041610214001847
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Family involvement in long-term care (LTC) is important but it can prove challenging and result in conflict with staff if families do not feel connected to the LTC facility or if they believe that their contributions are undervalued. According to McMillan & Chavis (1986), sense of community (SOC) refers to a...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212001524
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Foreign home care services provided to frail older adults by individuals from the developing world are a global phenomenon. This study evaluated the challenges associated with live-in foreign home care from the perspective of older care recipients and their family members. METHODS:Qualitative interviews wer...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610209990421
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:There are difficulties in accurately defining patients with vascular dementia (VaD) and, therefore, little is known about the characteristics of this population. OBJECTIVE:To examine the population characteristics in patients with VaD enrolled in two randomized, double-blind, placebo-controlled, 24-week cli...
journal_title:International psychogeriatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/S1041610203009190
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:While the relationship of apolipoprotein E (APOE) to behavioral symptoms of dementia (BSD) has been studied in community-dwelling persons with AD, it has received limited attention within the nursing home (NH) population. The aim of this study was to examine the association between APOE genotype and BSD in N...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610209009235
更新日期:2009-08-01 00:00:00
abstract::ABSTRACTBackground:Psychological and social resources such as extraversion, optimism, social support, or social networks contribute to adaptation and to successful aging. Building on assumptions derived from successful aging and from the developmental adaptation models, this study aims to analyze the joint impact of d...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610218000388
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Global suicide rates among older adults are very high. Public attitudes towards older adults' suicide may affect older adults upon their contemplating such an act. Previous research has demonstrated that message framing affects persons' judgments and decision making. Thus, message framing may have particular...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610216000636
更新日期:2016-08-01 00:00:00
abstract::The onset of obsessive-compulsive disorder (OCD) for the first time in old age is uncommon and has been mostly related to cerebral abnormalities. We report a case of late-onset OCD in a 77-year-old woman following stressful life events but with a normal cerebral structure. The contribution of life events and vulnerabi...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610205002735
更新日期:2006-06-01 00:00:00
abstract:BACKGROUND:Studies indicate that diet may be related to the occurrence of brain lesions. The cross-sectional association between food intake and brain lesion volumes in late-life depression was examined in a cohort of elderly individuals with current or prior depression. METHODS:Food intake was assessed in 54 elderly ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610206004431
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the clustering of symptoms on the Neuropsychiatric Inventory (NPI) and the relative prevalence of symptom clusters in mild and moderate Alzheimer's disease (AD). METHODS:Confirmatory factor analysis (CFA) was performed on the polychoric correlation matrix of 12 NPI i...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212000609
更新日期:2012-09-01 00:00:00
abstract::Psychotic symptoms in Alzheimer's disease (AD) have been associated with increased rates of cognitive impairment and functional decline. Prior studies have been conflicting with regard to whether AD patients with psychosis (AD+P) have evidence of more severe neuropathologic findings at postmortem exam. We examined the...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610200006657
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND:People with Young Onset Dementia (YOD) have specific needs for care. These people eventually require institutional care, usually delivered by institutions designed for the elderly. The Dutch network of care organizations delivering specialized YOD care offers a unique opportunity to obtain more knowledge of ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610214001859
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:This article analyzes the natural history of wandering behavior throughout the course of dementia. DESIGN:Prospective, 10-year, longitudinal study of wandering behavior in dementia, with autopsy follow-up. SETTING:Participants with dementia, living at home with a carer. All lived in Oxfordshire, UK. PARTIC...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610201007542
更新日期:2001-06-01 00:00:00