Age of onset and brain atrophy in Alzheimer's disease.

Abstract:

:Using magnetic resonance imaging-based planimetry, we measured cortical and cerebral (cortical and ventricular) atrophy in 26 patients with Alzheimer's disease (AD) (age, 72.2 +/- 7.0) according to NINCDS-ADRDA criteria and 22 control subjects (age, 71.5 +/- 5.4). AD patients exhibited greater cerebral atrophy (p < .05) than control subjects. Cerebral atrophy was significantly correlated with age (r = .72, p < .0005) in healthy volunteers but not in AD patients. In AD patients, age of onset was negatively correlated with the estimated rate of disease-attributed cerebral degeneration ([observed atrophy--atrophy in normal aging calculated from the regression equation derived from the control group]/[duration of illness]) (r = -.54, p < .005). Multiple regression with interaction analysis demonstrated that age, age of onset, and their interaction successfully explained cerebral (R2 = .51, p < .05) and cortical (R2 = .64, p < .05) atrophy in patients with probable AD. Age of onset may be a strong predictor of the rate of cerebral degeneration in AD, and our results suggest that controlling age and the age of onset is essential in the quantitative study of AD.

journal_name

Int Psychogeriatr

authors

Woo JI,Kim JH,Lee JH

doi

10.1017/s104161029700433x

subject

Has Abstract

pub_date

1997-06-01 00:00:00

pages

183-96

issue

2

eissn

1041-6102

issn

1741-203X

journal_volume

9

pub_type

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