The effects of mood changes and antidepressants on the cognitive capacity of elderly depressed patients.

Abstract:

:Seventy-eight nondemented elderly depressed patients underwent an extensive battery of cognitive tests both before and after seven weeks of treatment with nortriptyline, phenelzine, or placebo. Clinical and cognitive evaluations of the patients were under double-blind conditions. Response to treatment did not appear to significantly affect cognitive capacity; neither did treatment with an active substance as compared to placebo. In addition, the baseline level of cognitive functioning did not appear related to whether a patient responded to treatment. The authors conclude that under optimal conditions neither antidepressant produces measurable changes in the cognitive capacity of nondemented elderly patients.

journal_name

Int Psychogeriatr

authors

Georgotas A,McCue RE,Reisberg B,Ferris SH,Nagachandran N,Chang I,Mir P

doi

10.1017/s1041610289000141

subject

Has Abstract

pub_date

1989-10-01 00:00:00

pages

135-43

issue

2

eissn

1041-6102

issn

1741-203X

journal_volume

1

pub_type

临床试验,杂志文章,随机对照试验
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