Abstract:
BACKGROUND:Depressive symptoms are common in patients with Alzheimer's disease (AD) and increase the caregiver burden, although the etiology and pathologic mechanism of depressive symptoms in AD patients remain unclear. In this study, we tried to clarify the cerebral blood flow (CBF) correlates of subjective depressive symptoms in AD. METHODS:Seventy-six consecutive patients with AD were recruited from outpatient units of the Memory Clinic of Okayama University Hospital. Subjective depressive symptoms were evaluated using the short version of the Geriatric Depression Scale (GDS). All patients underwent brain SPECT with 99mTc-ethylcysteinate dimer, and the SPECT images were analyzed by the Statistical Parametric Mapping 8 program. RESULTS:No significant differences between groups with high and low GDS scores were found with respect to age, sex, years of education, and revised Addenbrooke's Cognitive Examination scores. Compared to patients with low scores on GDS, patients with high scores showed significant hypoperfusion in the left inferior frontal region. CONCLUSIONS:The left inferior frontal region may be significantly involved in the pathogenesis of subjective depressive symptoms in AD. Subjective and objective depressive symptoms may have somewhat different neural substrates in AD.
journal_name
Int Psychogeriatrjournal_title
International psychogeriatricsauthors
Honda H,Terada S,Sato S,Oshima E,Ikeda C,Nagao S,Yokota O,Uchitomi Ydoi
10.1017/S1041610213002573subject
Has Abstractpub_date
2014-05-01 00:00:00pages
817-23issue
5eissn
1041-6102issn
1741-203Xpii
S1041610213002573journal_volume
26pub_type
杂志文章abstract:BACKGROUND:Recognizing and diagnosing early onset dementia (EOD) can be complex and often takes longer than for late onset dementia. The objectives of this study are to investigate the barriers to diagnosis and to develop a typology of the diagnosis pathway for EOD caregivers. METHODS:Semi-structured interviews with 9...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610211001013
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:Mild cognitive impairment (MCI) is proposed to describe the transitional stage between normal cognitive aging and dementia. It has had significant impact in the field of dementia research, but it remains controversial whether or not it should be used as a diagnostic category in clinical practice. METHODS:Se...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610208007126
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:Elderly people living in residential homes are at high risk for developing major depressive and anxiety disorders, and therefore deserve attention in terms of preventive interventions. We evaluated the feasibility and effectiveness of a guided self-help intervention for the prevention of depression and anxie...
journal_title:International psychogeriatrics
pub_type: 杂志文章,随机对照试验
doi:10.1017/S1041610211000202
更新日期:2011-08-01 00:00:00
abstract::ABSTRACTBackground:Walking ability recently emerged as a sub-clinical marker of cognitive decline. Hence, the relationship between baseline gait and future cognitive decline was examined in geriatric patients. Because a "loss of complexity" (LOC) is a key phenomenon of the aging process that exhibits in multiple syste...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217002770
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:Cognitive impairment and negative signs are common in patients with schizophrenia. Up to 35% of elderly patients with schizophrenia fulfill the diagnostic criteria of dementia. Donepezil inhibits cholinesterase, thus enhancing cholinergic neurotransmission. We tested the efficacy of donepezil in elderly patie...
journal_title:International psychogeriatrics
pub_type: 杂志文章,随机对照试验
doi:10.1017/S1041610205003017
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:The objectives of this study were to examine the factors modifying the relationship between cortisol level and prevalent/incident cognitive impairment in older adults and to verify whether these relationships were non-linear. METHODS:Data were collected from 1,226 individuals aged 65 and older by two in-hom...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212001706
更新日期:2013-02-01 00:00:00
abstract::Noisemaking is one of the most disturbing behavior disorders associated with dementia. Standard management practices, including pharmacological interventions, are not very successful in treating the behavior. Very little research has been carried out to evaluate innovative treatments or to determine the etiology of no...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610297004547
更新日期:1997-12-01 00:00:00
abstract:BACKGROUND:Seeking medical advice for dementia involves an understanding of norms, values and attitudes towards care-giving and inter-dependency, which are culturally bounded. We hypothesize that local culture and socioeconomic structure affect our Chinese patients who present with forgetfulness to our memory clinic. ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S104161020800817X
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:The aim of the study was to determine the amount of trauma impact and significant post-traumatic stress symptoms, which can indicate a possible post-traumatic stress disorder (PTSD), in a sample of former German child soldiers of World War II. METHODS:103 participants were recruited through the press, then ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610208007035
更新日期:2008-10-01 00:00:00
abstract::Psychotic symptoms in Alzheimer's disease (AD) have been associated with increased rates of cognitive impairment and functional decline. Prior studies have been conflicting with regard to whether AD patients with psychosis (AD+P) have evidence of more severe neuropathologic findings at postmortem exam. We examined the...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610200006657
更新日期:2000-12-01 00:00:00
abstract::A brief review of classification in psychiatry from Kraepelin to ICD-10 and DSM-IV reveals that the categorical paradigm inherent in these nosological systems has certain inadequacies when applied to dementia specifically and cognitive impairment in general. There are "outcasts" from these two systems that, with the r...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/s1041610205001924
更新日期:2005-01-01 00:00:00
abstract::Major advances in understanding the physiology and genetics of circadian rhythm in the past decade challenge the researcher of sleep/wake disorders in Alzheimer's disease (AD) to distinguish patient characteristics stable across the course of illness ("traits") from characteristics that vary with stage of illness ("st...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610202008293
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND:Most research on family members' experience of dementia has focused on the time after diagnosis. Yet, once people reach clinical attention, families have already been living with the changes for some time. These pre-diagnosis experiences can influence later caregiving. We aimed to synthesize qualitative rese...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/S1041610217000862
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Vocally disruptive behavior (VDB) in the elderly is a common condition, especially in people with dementia, but difficult to treat. It may occur in as many as 40% of nursing home residents. This study is a review of the existing literature on this condition. METHOD:The literature review was conducted using ...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/S1041610208006728
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVE:This study sought to conduct a comprehensive search for genetic risk of cognitive decline in the context of geriatric depression. DESIGN:A genome-wide association study (GWAS) analysis in the Neurocognitive Outcomes of Depression in the Elderly (NCODE) study. SETTING:Longitudinal, naturalistic follow-up stu...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610220001143
更新日期:2020-07-09 00:00:00
abstract::The focus of this report is the treatment of persons with dementia who are of a non-English-speaking background (NESB). Noisemaking is one behavioral manifestation associated with severe dementia. It can have devastating effects on persons with dementia by limiting their access to activity programs and social interact...
journal_title:International psychogeriatrics
pub_type: 临床试验,杂志文章
doi:10.1017/s1041610299005864
更新日期:1999-09-01 00:00:00
abstract::The onset of obsessive-compulsive disorder (OCD) for the first time in old age is uncommon and has been mostly related to cerebral abnormalities. We report a case of late-onset OCD in a 77-year-old woman following stressful life events but with a normal cerebral structure. The contribution of life events and vulnerabi...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610205002735
更新日期:2006-06-01 00:00:00
abstract::ABSTRACTBackground:With increasing cultural diversity and growing elderly immigrant populations in Western European countries, the availability of brief cognitive screening instruments adequate for assessment of dementia in people from diverse backgrounds becomes increasingly important. The aim of the present study wa...
journal_title:International psychogeriatrics
pub_type: 杂志文章,多中心研究
doi:10.1017/S1041610218000832
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Community care workers' experience of delivering support to people with dementia is less researched than that of residential workers. The purpose of the study is to explore community-based dementia care workers' perspectives about their roles and the contextual variables that impact upon their work experienc...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212002323
更新日期:2013-05-01 00:00:00
abstract::Alzheimer´s disease (AD) is a severe neurodegenerative brain disorder characterized by beta-amyloid plaques, Tau pathology, inflammation, neurodegeneration, and cerebrovascular dysfunction. Besides that, alterations in monocytes and platelets have been reported in the blood of Alzheimer patients. In the present study,...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217001612
更新日期:2018-01-01 00:00:00
abstract::Depression is the most prevalent mental health problem among the elderly, including Chinese-American elderly. A Chinese-language version of the popular Geriatric Depression Scale Long Form (GDS-LF) and Short Form (GDS-SF) was developed. Based on the responses of 50 elderly Chinese immigrants to the U.S. (25 women and ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610296002803
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND:Neuropsychiatric symptoms (NPS) are highly prevalent among nursing home patients with dementia. Several studies have investigated subsyndromes of NPS but the stability of these subsyndromes over time has rarely been examined. We have examined the stability over time of the factor structure of the Neuropsychi...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S104161021100086X
更新日期:2012-01-01 00:00:00
abstract::In this editorial, we challenge the current understanding of "Living Well with Dementia." Such discourse introduces the possibility of not living well with the condition or even of "living badly with dementia." Numerous words might be relevant here - grief, pain, anguish, depression - but in this editorial we consciou...
journal_title:International psychogeriatrics
pub_type: 社论
doi:10.1017/S104161021600199X
更新日期:2017-02-01 00:00:00
abstract::Cross-sectional data from Phase 1 of the Canadian Study of Health and Aging was used to examine the relationship between two self-report health measures: "How would you say your health is these days?"(HEALTH) and "How much do your health troubles stand in the way of your doing the things you want to do?"(TROUBLE). The...
journal_title:International psychogeriatrics
pub_type: 杂志文章,多中心研究
doi:10.1017/s1041610202008165
更新日期:2001-01-01 00:00:00
abstract::Dementia is a neurodegenerative disorder with global impact, with the largest proportion of cases occurring in low- and middle-income countries. It is estimated that there are 46.8 million cases globally with approximately 10 million new cases each year or a new case occurring every 3 sec (Prince et al., 2015). For co...
journal_title:International psychogeriatrics
pub_type: 社论
doi:10.1017/S1041610217001685
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Frailty in older adults is a multifactorial syndrome defined by low metabolic reserve, less resistance to stressors, and difficulty in maintaining organic homeostasis due to cumulative decline of multiple physiological systems. The relationship between frailty and cognition remains unclear and studies about ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212000907
更新日期:2012-11-01 00:00:00
abstract:UNLABELLED:This article reports the findings of a 3-year epidemiological survey for dementia in an urban community-resident population in Mumbai (Bombay), India, wherein the prevalence of all types of dementia was determined. METHOD:The study was conducted in three stages. Stage 1: From a potential pool of 30,000 subj...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610201007852
更新日期:2001-12-01 00:00:00
abstract::ABSTRACTBackground:Little is known about the combined use of benzodiazepines and antidepressants in older psychiatric patients. This study examined the prescription pattern of concurrent benzodiazepines in older adults treated with antidepressants in Asia, and explored its demographic and clinical correlates. METHODS...
journal_title:International psychogeriatrics
pub_type: 杂志文章,多中心研究
doi:10.1017/S1041610217002563
更新日期:2019-05-01 00:00:00
abstract::With now over 50 million people worldwide with dementia (Prince et al., 2013), there are almost certainly well over 100 million people with cognitive concerns and many of these will attend their health professional keen to know what is going on. We need those without intensive training in this field to be more confide...
journal_title:International psychogeriatrics
pub_type: 评论,杂志文章
doi:10.1017/S1041610217001818
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Quality of Life-Alzheimer's Disease (QOL-AD) is a widely used scale for the study of quality of life in patients with dementia. The aim of this study is the transcultural adaptation and validation of the QOL-AD scale in Portugal. METHODS:Translation and transcultural adaptation was performed according to st...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610213000379
更新日期:2013-07-01 00:00:00