Statistical analysis, trial design and duration in Alzheimer's disease clinical trials: a review.

abstract：:ABSTRACTBackground:Psychosocial models suggest that the lived experience of dementia is affected by interpersonal factors such as the ways in which others view, talk about, and behave toward the person with dementia. This review aimed to illuminate how informal, everyday interpersonal relationships are experienced by ...

journal_title：International psychogeriatrics

authors： Patterson KM,Clarke C,Wolverson EL,Moniz-Cook ED

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Both anxiety disorders and subclinical anxiety symptoms are related to poorer health and functioning in later life. Because worry is an important component of anxiety, the accurate measurement of worry is crucial to studying the etiology, prevention and treatment of anxiety disorders. Assessment of the trait...

journal_title：International psychogeriatrics

authors： Nuevo R,Mackintosh MA,Gatz M,Montorio I,Wetherell JL

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Mental capacity has been little studied among older general hospital inpatients. METHODS:A retrospective analysis was undertaken of routinely collected data (age, gender, ethnicity, admission diagnosis, psychiatric diagnosis, Mini-mental State Examination score, whether capacity was assessed, the outcome of...

journal_title：International psychogeriatrics

authors： Mujic F,Von Heising M,Stewart RJ,Prince MJ

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:Behavioral and psychological symptoms of dementia (BPSD) cause caregiver distress and earlier institutionalization. We compared the prevalence and characteristics of BPSD between institution residents and memory clinic outpatients with Alzheimer's disease (AD) to test the hypothesis that there is more BPSD a...

journal_title：International psychogeriatrics

authors： Cheng TW,Chen TF,Yip PK,Hua MS,Yang CC,Chiu MJ

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:To examine the effects of complex cognitive (mahjong) and physical (Tai Chi) activities on dementia severity in nursing home residents with dementia. METHODS:Cluster-randomized open-label controlled design. 110 residents were randomized by nursing home into three conditions: mahjong, Tai Chi, and simple han...

journal_title：International psychogeriatrics

authors： Cheng ST,Chow PK,Song YQ,Yu EC,Lam JH

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:This study aimed to determine: (1) the prevalence of depression, anxiety, and depression associated with anxiety (DA); (2) the risk factor profile of depression, anxiety, and DA; (3) the course of depression, anxiety, and DA over 24 months. METHODS:Two-year longitudinal study of 20,036 adults aged 60+ years...

journal_title：International psychogeriatrics

authors： Almeida OP,Draper B,Pirkis J,Snowdon J,Lautenschlager NT,Byrne G,Sim M,Stocks N,Kerse N,Flicker L,Pfaff JJ

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:This study determined the reliability, validity, and factor structure of self-report emotions in persons with mild Alzheimer's disease (AD) and mild cognitive impairment (MCI) relative to controls. METHODS:Participants (mild AD, n = 73; MCI, n = 159; controls, n = 96) rated current emotions with the Visual ...

journal_title：International psychogeriatrics

authors： Ready RE,Carvalho JO,Green RC,Gavett BE,Stern RA

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Preliminary evidence indicates that the quality of the carer-care recipient relationship predicts those carers most at risk from anxiety. Attachment style is related to higher carer burden, psychological morbidity and increased care recipient institutionalization. We tested, for the first time, the hypothesi...

journal_title：International psychogeriatrics

authors： Cooper C,Owens C,Katona C,Livingston G

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVE:Clinical syndromes such as amnestic mild cognitive impairment (MCI) are highly predictive of future development of Alzheimer's disease (AD), but it is not known how many of the individuals that develop the disease can be identified with these syndromes. This study aims to determine how many individuals with A...

journal_title：International psychogeriatrics

authors： Palmer K,Bäckman L,Winblad B,Fratiglioni L

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Depressive symptoms are common in patients with Alzheimer's disease (AD) and increase the caregiver burden, although the etiology and pathologic mechanism of depressive symptoms in AD patients remain unclear. In this study, we tried to clarify the cerebral blood flow (CBF) correlates of subjective depressive...

journal_title：International psychogeriatrics

authors： Honda H,Terada S,Sato S,Oshima E,Ikeda C,Nagao S,Yokota O,Uchitomi Y

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:There is suggestion that self-reported depressive syndromes can independently manifest in the general population as cognitive/affective or somatic/vegetative. The Beck Depression Inventory, 2nd edition (BDI-II), a self-report measure of depressive symptoms, has been shown to support this two-factor structure...

journal_title：International psychogeriatrics

authors： Carvalho JO,Tan JE,Springate BA,Davis JD

更新日期：2013-03-01 00:00:00

abstract：:This article reviews longitudinal data collected from patients with Alzheimer's disease (AD) that are relevant to the design and interpretation of clinical treatment trials. Longitudinal data from patients tested with the Alzheimer's Disease Assessment Scale demonstrate that cognitive symptoms, including memory loss, ...

journal_title：International psychogeriatrics

authors： Mohs RC

更新日期：1996-07-01 00:00:00

abstract：:This community-based epidemiological survey concerns relationships between social and health factors and depression in a Finnish population aged 60 years or over. A multivariate analysis based on log-linear models is used in this study. The log-linear model showed five interactions for the depressed men and eight for ...

journal_title：International psychogeriatrics

authors： Pahkala K,Kivelä SL,Laippala P

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:Multifactorial strategies that prevent or delay the onset or progress of cognitive decline and dementia are needed, and should include education regarding recognized risk factors. The current study sought to investigate whether older adults "at risk" of cognitive decline benefit from psychoeducation targetin...

journal_title：International psychogeriatrics

authors： Norrie LM,Diamond K,Hickie IB,Rogers NL,Fearns S,Naismith SL

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:The IPA Taskforce on Mental Health Issues in Long-Term Care Homes seeks to improve mental health care in long-term care (LTC) homes. The aim of this paper is to provide recommendations on comprehensive assessment of depression and behavioral problems in order to further stimulate countries and professionals ...

journal_title：International psychogeriatrics

authors： Koopmans RT,Zuidema SU,Leontjevas R,Gerritsen DL

更新日期：2010-11-01 00:00:00

abstract：:Delirium significantly increases morbidity and mortality in older people, especially those affected by other organic disorders, notably dementia (Siddiqi et al., 2006; Davis et al., 2012; Martins and Fernandes, 2012). Both delirium and dementia are characterized by cognitive decline through disintegration of brain fun...

journal_title：International psychogeriatrics

authors： Suh GH,Gega L

更新日期：2017-01-01 00:00:00

abstract：:ABSTRACTBackground:Evidence suggests that semantic interference may be a sensitive indicator of early dementia. We examined the utility of the Semantic Interference Test (SIT), a cognitive stress memory paradigm which taps proactive and retroactive semantic interference, for predicting progression from mild cognitive ...

journal_title：International psychogeriatrics

authors： Beer JC,Snitz BE,Chang CH,Loewenstein DA,Ganguli M

更新日期：2018-10-01 00:00:00

abstract：:Observed cognitive decline in the elderly has been widely reported in the literature. The relation of experimental cognitive ability measures to real-world cognitive competence has been questioned. This research examines the validity of English-language versions of two measures of everyday competency: the Memory in Re...

journal_title：International psychogeriatrics

authors： Goodman CR,Zarit SH

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND:Cognitive impairment places older adults at increased risk of functional decline, injuries, and hospitalization. Assessments to determine whether older persons are still capable of meeting the cognitive challenges of everyday living are crucial to ensure their safe and independent living in the community. Th...

journal_title：International psychogeriatrics

authors： Law LL,Barnett F,Gray MA,Yau MK,Siu AM

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:To validate a shorter version of the Geriatric Depression Scale (GDS) for older, visually impaired patients. PARTICIPANTS:Subjects were 70 visually impaired adults over age 65 who were presenting for services at a low vision clinic. METHOD:Subjects were interviewed by a geriatric nurse practitioner. A struc...

journal_title：International psychogeriatrics

authors： Galaria II,Casten RJ,Rovner BW

更新日期：2000-12-01 00:00:00

abstract：:Backround: Night-time agitation is a frequent symptom of dementia. It often causes nursing home admission and has been linked to circadian rhythm disturbances. A positive influence of light interventions on night-time agitation was shown in several studies. The aim of our study was to investigate whether there is a lo...

journal_title：International psychogeriatrics

authors： Wahnschaffe A,Nowozin C,Rath A,Floessner T,Appelhoff S,Münch M,Kunz D

更新日期：2017-12-01 00:00:00

abstract：:Epidemiologic survey data were used to examine relationships between alcohol use and abuse and the physical and mental health status of elderly public housing residents (weighted n = 865) and to determine the influence that drinking behavior had on mortality. Residents with a current alcohol disorder (4%) were more li...

journal_title：International psychogeriatrics

authors： Black BS,Rabins PV,McGuire MH

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVE:Despite delirium being common in older hospitalized people, little is known about its management. The aims of this study are (1) to describe the pharmacological management of delirium in an acute care setting as a baseline measure prior to the implementation of newly developed Australian guidelines; and (2) t...

journal_title：International psychogeriatrics

authors： Tropea J,Slee J,Holmes AC,Gorelik A,Brand CA

更新日期：2009-02-01 00:00:00

abstract：:Staging methodologies are an essential tool in the assessment of disease severity in progressive dementing illness. Several different instruments have been developed for this purpose. One of the most widely used methodologies is the Global Deterioration Scale/Functional Assessment Staging (GDS/FAST) system. This syste...

journal_title：International psychogeriatrics

authors： Auer S,Reisberg B

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:Nearly half of care home residents with advanced dementia have clinically significant agitation. Little is known about costs associated with these symptoms toward the end of life. We calculated monetary costs associated with agitation from UK National Health Service, personal social services, and societal per...

journal_title：International psychogeriatrics

authors： Buylova Gola A,Morris S,Candy B,Davis S,King M,Kupeli N,Leavey G,Moore K,Nazareth I,Omar R,Vickerstaff V,Jones L,Sampson EL

更新日期：2020-03-01 00:00:00

abstract：:Cholinergic deficits are a hallmark of Alzheimer's disease (AD) and Lewy body dementia (LBD). The nucleus basalis of Meynert (NBM) provides the major source of cortical cholinergic input; studying its functional connectivity might, therefore, provide a tool for probing the cholinergic system and its degeneration in ne...

journal_title：International psychogeriatrics

authors： Schumacher J,Thomas AJ,Peraza LR,Firbank M,O'Brien JT,Taylor JP

更新日期：2021-01-08 00:00:00

abstract：OBJECTIVES:To quantitatively synthesize data on the accuracy of the Rowland Universal Dementia Assessment Scale (RUDAS) in different sociocultural settings and compare its performance to other brief screening instruments for the detection of dementia. DESIGN:Systematic review and meta-analysis. Literature searches wer...

journal_title：International psychogeriatrics

authors： Nielsen TR,Jørgensen K

更新日期：2020-09-01 00:00:00

abstract：:Older widowers have high rates of completed suicide but have rarely been the subject of systematic inquiry. We investigated the prevalence of depressive symptoms and major depressive episodes (MDEs) in recently widowed older men over the first 13 months after bereavement. We employed a matched-pair longitudinal design...

journal_title：International psychogeriatrics

authors： Byrne GJ,Raphael B

更新日期：1999-03-01 00:00:00

abstract：:The focus of this report is the treatment of persons with dementia who are of a non-English-speaking background (NESB). Noisemaking is one behavioral manifestation associated with severe dementia. It can have devastating effects on persons with dementia by limiting their access to activity programs and social interact...

journal_title：International psychogeriatrics

authors： Runci S,Doyle C,Redman J

更新日期：1999-09-01 00:00:00

abstract：:ABSTRACTBackground:Cognition is multidimensional, and each domain plays a unique and crucial part in successful daily life engagement. However, less attention has been paid to multi-domain cognitive health for the elderly, and the role of lifestyle factors in each domain remains unclear. METHODS:We conducted a cross-...

journal_title：International psychogeriatrics

authors： Yuan M,Chen J,Han Y,Wei X,Ye Z,Zhang L,Hong YA,Fang Y

更新日期：2018-10-01 00:00:00