Abstract:
:The authors reanalyzed previously published data from a prospectively randomized, placebo-controlled, double-blind phase-III study of 130 inpatients with dementia syndrome. The patients in the study had been diagnosed as having suffered from organic brain syndrome (ICD 290), which is the core syndrome of dementia (so-called dementia syndrome) for at least two years. They were treated with piracetam for three months at a dose level of 4,800 mg/d. These data were reexamined in order both to survey the extent of drug-related improvement and response rates when assessed at different levels and to investigate the comparability of efficacy in subgroups suffering from either senile dementia of the Alzheimer type or multi-infarct dementia. Three scales were used for the assessment of efficacy. They were the CGI, or Clinical Global Impression, completed by the physicians; the SCAG, or Sandoz Clinical Assessment Geriatric, used by clinical psychologists; and the BGP, or Beurteilungsskala für Geriatrische Patienten (Evaluation Scale for Geriatric Patients), employed by the nursing staff. The Syndrome-Kurztest (SKT) and Benton tests served to measure performance. The items and subscores of the SCAG and the SKT were highly intercorrelated at baseline, forming a common factor fairly independent of the information gained by BGP. This suggests that merely using different kinds of information-gathering methods, i.e., clinical scales and performance tests, completed by different groups of observers, does not automatically result in nonredundant comprehensive information. When using the most conservative response criterion of individual improvement, i.e., at least one baseline standard deviation, treatment with piracetam showed statistically significant (pe less than .001) explorative response rates of 50% and above in three out of four target variables, as compared to the 0 to 6% obtained with placebo. CGI was used as descriptive variable. Again, using this response criterion from a separate analysis of diagnostic subgroups, as matched by the median of the patients' Hachinski Ischemic Scale scores, it does not appear that piracetam's efficacy for patients with senile dementia of the Alzheimer type (SDAT) varies with its efficacy for patients with multi-infarct dementia (MID).
journal_name
Int Psychogeriatrjournal_title
International psychogeriatricsauthors
Herrmann WM,Stephan Kdoi
10.1017/s1041610292000887keywords:
subject
Has Abstractpub_date
1992-07-01 00:00:00pages
25-44issue
1eissn
1041-6102issn
1741-203Xjournal_volume
4pub_type
临床试验,杂志文章,随机对照试验abstract:OBJECTIVES:To evaluate the impact of external memory devices on the efficacy of a package of internal mnemonic techniques. Participants wrote two types of lists during the study phase: (a) a list of study words and/or (b) a loci list. At recall, participants were not allowed to refer to either of the lists they had wri...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610203008755
更新日期:2003-03-01 00:00:00
abstract::ABSTRACTObjectives:The objectives of the study were to examine the trajectory of spirituality among older adults, to investigate the roles of gender and religion on the developmental trajectory of spirituality, and to explore whether the linear growth of spirituality accelerated or decelerated at time points at which ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610218000029
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Patient and carer participation in old age psychiatry is less developed than in other areas of mental health. What can we learn from the historical context about increasing participation and how can it be conceptualized? METHODS:The historical and policy context of patient and carer participation in the Nat...
journal_title:International psychogeriatrics
pub_type: 历史文章,杂志文章,评审
doi:10.1017/S1041610211001864
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:Eating disorders in the elderly are often overlooked. When they occur, significant morbidity and mortality result. In this study we review all existing literature on eating disorders in the elderly and provide practical guidelines for clinicians in recognizing and managing eating disorders in the elderly. M...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610210000104
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:The objectives of this study were to examine the factors modifying the relationship between cortisol level and prevalent/incident cognitive impairment in older adults and to verify whether these relationships were non-linear. METHODS:Data were collected from 1,226 individuals aged 65 and older by two in-hom...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212001706
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:The study aimed to evaluate the Cognitive Assessment Battery (CAB) in a specialist clinic setting in order to find out if it if it could be a supplement to the Mini-mental State Examination (MMSE) and distinguish between normal aging, mild cognitive impairment (MCI) and dementia, as well as MCI of different ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610210002334
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Previous studies have shown that the presence of depressive symptoms among older persons was evidently associated with subsequent physical and functional decline. However, few studies have directly examined the impact of changes in depressive symptoms or depressed mood on changes in functional ability. The p...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212000890
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Australia has a growing aging migrant population and rates of dementia in residential care are high. The communication of persons with dementia and limited English language proficiency in residential care is an area that has received little attention in the research literature. METHOD:Thirty-nine Italian-ba...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610205002309
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:We examine the association between leisure-time activities and the risk of developing cognitive impairment among Chinese older people, and further investigate whether the association varies by educational level. METHODS:This follow-up study included 6,586 participants (aged 79.5 ± 9.8 years, range 65-105 ye...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610216001769
更新日期:2017-05-01 00:00:00
abstract::I read with great interest the study of Petrazzuoli et al. (2017) on exploring dementia management attitudes in primary care. The authors made a laudable effort to evaluate this important issue, which certainly needs timely attention. The high response rate from 25 member countries of the European General Practice Res...
journal_title:International psychogeriatrics
pub_type: 评论,信件
doi:10.1017/S1041610217003003
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:The field of geriatric medicine has identified a need for an evaluative tool that can rapidly quantify global cognitive ability and accurately monitor change over time in patients with a wide range of impairments. We hypothesized that the development of an adaptive test approach to cognitive measurement woul...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610211000615
更新日期:2011-09-01 00:00:00
abstract::ABSTRACTObjectives:Centenarians have survived into very late life, but whether they reach very old age in good health remains unclear. The purpose of this study was to compare the cardiovascular health status and cognitive functioning of centenarians in the United States with centenarians in Japan. DESIGN, SETTING, A...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610218001813
更新日期:2019-04-01 00:00:00
abstract::Backround: Night-time agitation is a frequent symptom of dementia. It often causes nursing home admission and has been linked to circadian rhythm disturbances. A positive influence of light interventions on night-time agitation was shown in several studies. The aim of our study was to investigate whether there is a lo...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217001235
更新日期:2017-12-01 00:00:00
abstract::ABSTRACT Background: Mild cognitive impairment (MCI) is a diagnostic classification used to describe patients experiencing cognitive decline but without a corresponding impairment in daily functioning. Over the years, MCI diagnostic criteria have undergone major changes that correspond to advancements in research. Des...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610214002270
更新日期:2014-11-05 00:00:00
abstract:OBJECTIVE:To identify, in caregivers of patients with Alzheimer's disease (AD) dementia, factors associated with subjective (personal, physical, emotional, and social) and objective (informal caregiver time and costs) caregiver burden. DESIGN:Prospective longitudinal European observational study: post-hoc analysis. S...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610219000425
更新日期:2020-02-01 00:00:00
abstract::Cross-sectional data from Phase 1 of the Canadian Study of Health and Aging was used to examine the relationship between two self-report health measures: "How would you say your health is these days?"(HEALTH) and "How much do your health troubles stand in the way of your doing the things you want to do?"(TROUBLE). The...
journal_title:International psychogeriatrics
pub_type: 杂志文章,多中心研究
doi:10.1017/s1041610202008165
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Older Puerto Ricans belong to two rapidly growing demographic groups known to have high rates of depression: the aging and Hispanic populations. Studies of depression in Puerto Ricans have primarily focused on the impact of demographic factors and health. This study expands previous research, examining the r...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610203009505
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND:An association between metabolic syndrome (MetS) and disturbances in neurocognitive function has been identified in Caucasians but the nature and extent of impaired cognition in Asian MetS patients, who may be at greater risk of degenerative cognitive decline, remains unspecified. METHODS:A cross-sectional ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S104161021400057X
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:In dementia, cognitive and psychological disorders might interfere with maintaining social interactions. We have little information about the nature of these interactions of people with dementia in nursing homes. The aim of this study is to investigate social interactions between people with dementia and to ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610215002483
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Understanding the prevalence, incidence and cofactors of depression among long-term elderly nursing home (LTNH) residents domiciled for eight months or more may help optimize depression treatment in this vulnerable group. We quantified first year depression in American LTNH residents and the associations bet...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610210000578
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:It is currently not known whether elderly men and women present with different subtypes of depression and mania/bipolar disorder. The aim of this study was to compare the prevalence of subtypes of a single depressive episode and mania/bipolar disorder according to the ICD-10 for elderly men and women in a na...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S104161020600319X
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:While the relationship of apolipoprotein E (APOE) to behavioral symptoms of dementia (BSD) has been studied in community-dwelling persons with AD, it has received limited attention within the nursing home (NH) population. The aim of this study was to examine the association between APOE genotype and BSD in N...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610209009235
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:Both anxiety disorders and subclinical anxiety symptoms are related to poorer health and functioning in later life. Because worry is an important component of anxiety, the accurate measurement of worry is crucial to studying the etiology, prevention and treatment of anxiety disorders. Assessment of the trait...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610206003450
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND:The elderly are at high risk of developing tuberculosis. The prevalence and incidence of depression and anxiety are higher in those with tuberculosis than in the general population. A positive correlation between national suicide rates and rates of mortality due to tuberculosis has been reported. METHODS:Th...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610209990378
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Whether perceived changes in memory parallel changes in brain pathology is uncertain. Positron emission tomography (PET) scans using 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile (FDDNP) can measure levels of amyloid plaques and tau neurofibrillary tangles in vivo. Here we ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212000051
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:Older migrants with dementia and limited English language proficiency in residential care may have unmet needs for social interaction. This project compared verbal communication and prescribed psychiatric medication of Greek and Italian residents with dementia in ethno-specific and mainstream residential car...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610211002134
更新日期:2012-05-01 00:00:00
abstract::ABSTRACTBackground:Little is known about the combined use of benzodiazepines and antidepressants in older psychiatric patients. This study examined the prescription pattern of concurrent benzodiazepines in older adults treated with antidepressants in Asia, and explored its demographic and clinical correlates. METHODS...
journal_title:International psychogeriatrics
pub_type: 杂志文章,多中心研究
doi:10.1017/S1041610217002563
更新日期:2019-05-01 00:00:00
abstract::Current approaches to the diagnosis of delirium are based upon the recognition of symptoms that emerge in the pathological state. As an alternative, we propose an approach to case identification for research purposes based on the recognition of significant changes in the cognitive or cerebral state of the individual p...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s104161029100073x
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Previous studies have shown that the verbal fluency test (VFT) is a sensitive measure of cognitive dysfunction in Alzheimer's disease (AD). However, other studies have shown that the performances were significantly influenced by education in the normal elderly population. In order to examine the utility of t...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610210000839
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:Behavioral and psychological symptoms of dementia (BPSD) cause caregiver distress and earlier institutionalization. We compared the prevalence and characteristics of BPSD between institution residents and memory clinic outpatients with Alzheimer's disease (AD) to test the hypothesis that there is more BPSD a...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610209990767
更新日期:2009-12-01 00:00:00