Abstract:
OBJECTIVE:To review the currently available data on the use of ketamine in the treatment of depression among older adults from randomized controlled studies. DESIGN:Randomized controlled trials. SETTING:Variable. PARTICIPANTS:60 years and older with depression. INTERVENTION:Ketamine. MEASUREMENTS:Change in Montgomery-Asberg Depression Rating Scale (MADRS) scores. RESULTS:Two studies met the inclusion criteria. The first study showed a significant reduction in depression symptoms with use of repeated subcutaneous ketamine administration among older adults with depression. The second study failed to achieve significance on its primary outcome measure but did show a decrease in MADRS scores with intranasal ketamine along with a higher response and remission rates in esketamine group compared with the placebo group. The adverse effects from ketamine generally lasted only a few hours and abated spontaneously. No cognitive adverse effects were noted in either trial from the use of ketamine. CONCLUSIONS:The current evidence for use of ketamine among older adults with depression indicates some benefits with one positive and one negative trial. Although one of the trials did not achieve significance on the primary outcome measure, it still showed benefit of ketamine in reducing depressive symptoms. Ketamine was well tolerated in both studies with adverse effects being mild and transient.
journal_name
Int Psychogeriatrjournal_title
International psychogeriatricsauthors
Gupta A,Dhar R,Patadia P,Funaro M,Bhattacharya G,Farheen SA,Tampi RRdoi
10.1017/S1041610220000903subject
Has Abstractpub_date
2020-06-30 00:00:00pages
1-13eissn
1041-6102issn
1741-203Xpii
S1041610220000903pub_type
杂志文章abstract:BACKGROUND:The Geriatric Anxiety Inventory (GAI) was developed for assessing anxiety in older adults. The objectives of this work were: (a) to analyze the psychometric properties of the Spanish version of the GAI, and (b) to explore the associations between anxiety and other variables related to emotional distress (dep...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610211001505
更新日期:2012-01-01 00:00:00
abstract::Cholinergic deficits are a hallmark of Alzheimer's disease (AD) and Lewy body dementia (LBD). The nucleus basalis of Meynert (NBM) provides the major source of cortical cholinergic input; studying its functional connectivity might, therefore, provide a tool for probing the cholinergic system and its degeneration in ne...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610220003944
更新日期:2021-01-08 00:00:00
abstract:BACKGROUND:A careful characterization of behavioral abnormalities in corticobasal degeneration syndrome (CBDS) and progressive supranuclear palsy (PSP) by reliable tools is still lacking. Literature data provided evidence of the usefulness of the Frontal Behavioral Inventory (FBI) to operationalize such disturbances, p...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610209008862
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:This study aimed to examine the levels and rates of depression in Chinese residents living in ethno-specific nursing homes (NHs), and Chinese residents living in mainstream NHs in Sydney. Australia has a growing aging migrant population and rates of depression in NHs are high, but the prevalence of depressio...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S104161020999069X
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Family caregivers of people with dementia have significant unmet needs in regard to their caregiving role. Despite this, they are reluctant to utilize services to reduce their burden. The aim of this study was to examine the barriers and facilitators of service use among family caregivers of people with deme...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610216002532
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:Hospital-treated deliberate self harm and suicide among older adults have rarely been examined at a national level. METHODS:The Irish Central Statistics Office provided suicide and undetermined death data for 1980-2006. The National Registry of Deliberate Self Harm collected data relating to deliberate self...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610210001377
更新日期:2010-12-01 00:00:00
abstract::Dementia is defined as global cognitive impairment that interferes with function; however, function has been less well measured than cognition in anti-dementia drug trials. In the modern era of anti-dementia clinical trials, measurement of function has improved by differentiating between the aspects of function that h...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610207004966
更新日期:2007-06-01 00:00:00
abstract::ABSTRACTBackground:Evidence suggests that semantic interference may be a sensitive indicator of early dementia. We examined the utility of the Semantic Interference Test (SIT), a cognitive stress memory paradigm which taps proactive and retroactive semantic interference, for predicting progression from mild cognitive ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217002666
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:This study sought to conduct a comprehensive search for genetic risk of cognitive decline in the context of geriatric depression. DESIGN:A genome-wide association study (GWAS) analysis in the Neurocognitive Outcomes of Depression in the Elderly (NCODE) study. SETTING:Longitudinal, naturalistic follow-up stu...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610220001143
更新日期:2020-07-09 00:00:00
abstract::ABSTRACTAssociations between high body mass index (BMI) and subsequent cognitive decline, reported in elderly averaging below age 75, become less consistent at older ages. We compared the associations of BMI with cognition in moderately old (ages 75-84, N = 154) and oldest-old (85+, N = 93) samples. BMI and cognition ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610218001412
更新日期:2019-06-01 00:00:00
abstract::The Clinician Interview-Based Impression of Change, plus carer interview (CIBIC-Plus), is widely used in antidementia drug trials. It comprises Likert scales for disease severity and changes, and written accounts summarizing semistructured interviews evaluating behavior, cognition, and function. Studies using the CIBI...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610200006505
更新日期:2000-09-01 00:00:00
abstract::Delirium significantly increases morbidity and mortality in older people, especially those affected by other organic disorders, notably dementia (Siddiqi et al., 2006; Davis et al., 2012; Martins and Fernandes, 2012). Both delirium and dementia are characterized by cognitive decline through disintegration of brain fun...
journal_title:International psychogeriatrics
pub_type: 评论,杂志文章
doi:10.1017/S1041610216001988
更新日期:2017-01-01 00:00:00
abstract::ABSTRACTBackground:Walking ability recently emerged as a sub-clinical marker of cognitive decline. Hence, the relationship between baseline gait and future cognitive decline was examined in geriatric patients. Because a "loss of complexity" (LOC) is a key phenomenon of the aging process that exhibits in multiple syste...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217002770
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:Olfactory dysfunction, impaired smell identification in particular, is known as a diagnostic and a marker of conversion in Alzheimer's disease (AD). We aimed to evaluate the associations of olfactory identification impairments with cognition, illness severity, and progression in AD patients. METHODS:Fifty-s...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610213000446
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Depression in late life is a risk factor for cognitive decline. Depression is also associated with increased disability and social support deficits; these may precede conversion to dementia and inform risk. In this study, we examined if baseline or one-year change in disability and social support predicted l...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610214002543
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:The study of predeath grief is hampered by measures that are often lengthy and not clearly differentiated from other caregiving outcomes, most notably burden. We aimed to validate a new 11-item Caregiver Grief Questionnaire (CGQ) assessing two dimensions of predeath grief, namely relational deprivation and em...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610219000309
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:The growing and welcome interest in the issues leading to distress and impairment in younger doctors has not been mirrored by a focus on the similar issues in older doctors which is surprising given the aging medical workforce. OBJECTIVES:To improve understanding of impairment in older doctors and to facili...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610207005431
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:In old age, both apathy and depression have been associated with an increased cardiovascular disease (CVD) risk. This study evaluated the mediating role of cardiovascular risk factors in the relationship of apathy and mood symptoms with incident CVD. METHODS:Prospective cohort study of 1,790 community-dwell...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610215001751
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:The anxiety disorders are a prevalent mental health problem in older age with a considerable impact on quality of life. Until recently there have been few longitudinal studies on anxiety in this age group, consequently most of the evidence to date has been cross-sectional in nature. METHODS:We undertook a l...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/S1041610214001847
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:This study aimed to identify the nature and effects of implementation strategies to increase the use of evidence-based, non-pharmacological interventions designed to reduce the frequency and/or severity of behavioral and psychological symptoms associated with dementia, for people living in the community. DES...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610220001702
更新日期:2020-11-16 00:00:00
abstract::ABSTRACTBackground:Getting lost is a recognized complication in patients with dementia. Preventive measures are lacking. This study aims to investigate the effectiveness of a home-based missing incident prevention program (HMIPP) in reducing missing incidents, time of searching, and caregivers' stress. METHODS:The de...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610218000546
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:The impact of spousal bereavement on mental health varies among the widowed. More information is needed on factors influencing bereavement outcome. METHOD:We conducted a cross-sectional study on a sample of 216 widowed individuals. Initial non-response was high, with only 8% of all approached persons partic...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610206004248
更新日期:2007-10-01 00:00:00
abstract::Cognitive decline, commonly first recognized as memory impairment, is a typical feature of Alzheimer's disease (AD). Neuropathological changes in the cerebral cortex and limbic system lead to deficits in learning, memory, language, and visuospatial skills. The precise nature of cognitive dysfunction reflects the distr...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/s1041610203008664
更新日期:2002-01-01 00:00:00
abstract::ABSTRACTObjectives:The objectives of the study were to examine the trajectory of spirituality among older adults, to investigate the roles of gender and religion on the developmental trajectory of spirituality, and to explore whether the linear growth of spirituality accelerated or decelerated at time points at which ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610218000029
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Ageism, a form of prejudice in which one relates negatively to people due to their age, exists throughout life. However, no attempt has been made to compare ageist attitudes across the life cycle, from young adulthood to old age. Consequently, the current study examined age and gender differences in ageism t...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610211002936
更新日期:2012-06-01 00:00:00
abstract::ABSTRACTThe aim of the present study is to investigate the impact of benzodiazepine use on cognitive performance in primary care patients with first cognitive complaints. The association between the exposition to benzodiazepines (short and long half-life) and cognitive performance, evaluated through the Mini Mental St...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S104161021700223X
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:The delirium index (DI) is a valid measure of delirium severity. We proposed to describe longitudinal patterns of severity scores in older long-term care (LTC) residents. METHODS:A prospective cohort study of 280 residents in seven LTC facilities in Montreal and Quebec City, Canada, was conducted. DI, Barth...
journal_title:International psychogeriatrics
pub_type: 杂志文章,多中心研究
doi:10.1017/S104161021600137X
更新日期:2017-01-01 00:00:00
abstract::In order to conceptually define quality of life (QOL) in dementia, the literature on QOL in the elderly population, in chronic disease and in dementia was studied. Dementia is a progressive, age-related, chronic condition and to avoid omissions within the dementia-specific concept of QOL, a broad orientation was the p...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/s1041610205002073
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVES:Perceived financial strain is associated with various health conditions, but it is unknown whether it is associated with an increased risk for dementia. The goal is to examine the associations between midlife perceptions of financial situation and dementia risk later in life. METHODS:Participants were deriv...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S104161021900173X
更新日期:2020-11-01 00:00:00
abstract::Dementia is a neurodegenerative disorder with global impact, with the largest proportion of cases occurring in low- and middle-income countries. It is estimated that there are 46.8 million cases globally with approximately 10 million new cases each year or a new case occurring every 3 sec (Prince et al., 2015). For co...
journal_title:International psychogeriatrics
pub_type: 社论
doi:10.1017/S1041610217001685
更新日期:2017-11-01 00:00:00