A systematic review of ketamine for the treatment of depression among older adults.

Abstract:

OBJECTIVE:To review the currently available data on the use of ketamine in the treatment of depression among older adults from randomized controlled studies. DESIGN:Randomized controlled trials. SETTING:Variable. PARTICIPANTS:60 years and older with depression. INTERVENTION:Ketamine. MEASUREMENTS:Change in Montgomery-Asberg Depression Rating Scale (MADRS) scores. RESULTS:Two studies met the inclusion criteria. The first study showed a significant reduction in depression symptoms with use of repeated subcutaneous ketamine administration among older adults with depression. The second study failed to achieve significance on its primary outcome measure but did show a decrease in MADRS scores with intranasal ketamine along with a higher response and remission rates in esketamine group compared with the placebo group. The adverse effects from ketamine generally lasted only a few hours and abated spontaneously. No cognitive adverse effects were noted in either trial from the use of ketamine. CONCLUSIONS:The current evidence for use of ketamine among older adults with depression indicates some benefits with one positive and one negative trial. Although one of the trials did not achieve significance on the primary outcome measure, it still showed benefit of ketamine in reducing depressive symptoms. Ketamine was well tolerated in both studies with adverse effects being mild and transient.

journal_name

Int Psychogeriatr

authors

Gupta A,Dhar R,Patadia P,Funaro M,Bhattacharya G,Farheen SA,Tampi RR

doi

10.1017/S1041610220000903

subject

Has Abstract

pub_date

2020-06-30 00:00:00

pages

1-13

eissn

1041-6102

issn

1741-203X

pii

S1041610220000903

pub_type

杂志文章
  • Psychometric properties of the Spanish version of the Geriatric Anxiety Inventory.

    abstract:BACKGROUND:The Geriatric Anxiety Inventory (GAI) was developed for assessing anxiety in older adults. The objectives of this work were: (a) to analyze the psychometric properties of the Spanish version of the GAI, and (b) to explore the associations between anxiety and other variables related to emotional distress (dep...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610211001505

    authors: Márquez-González M,Losada A,Fernández-Fernández V,Pachana NA

    更新日期:2012-01-01 00:00:00

  • Functional connectivity of the nucleus basalis of Meynert in Lewy body dementia and Alzheimer's disease.

    abstract::Cholinergic deficits are a hallmark of Alzheimer's disease (AD) and Lewy body dementia (LBD). The nucleus basalis of Meynert (NBM) provides the major source of cortical cholinergic input; studying its functional connectivity might, therefore, provide a tool for probing the cholinergic system and its degeneration in ne...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610220003944

    authors: Schumacher J,Thomas AJ,Peraza LR,Firbank M,O'Brien JT,Taylor JP

    更新日期:2021-01-08 00:00:00

  • Pattern of behavioral disturbances in corticobasal degeneration syndrome and progressive supranuclear palsy.

    abstract:BACKGROUND:A careful characterization of behavioral abnormalities in corticobasal degeneration syndrome (CBDS) and progressive supranuclear palsy (PSP) by reliable tools is still lacking. Literature data provided evidence of the usefulness of the Frontal Behavioral Inventory (FBI) to operationalize such disturbances, p...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610209008862

    authors: Borroni B,Alberici A,Agosti C,Cosseddu M,Padovani A

    更新日期:2009-06-01 00:00:00

  • Levels and rates of depression among Chinese people living in Chinese ethno-specific and mainstream residential care in Sydney.

    abstract:BACKGROUND:This study aimed to examine the levels and rates of depression in Chinese residents living in ethno-specific nursing homes (NHs), and Chinese residents living in mainstream NHs in Sydney. Australia has a growing aging migrant population and rates of depression in NHs are high, but the prevalence of depressio...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S104161020999069X

    authors: Goh I,Low LF,Brodaty H

    更新日期:2010-03-01 00:00:00

  • "There isn't an easy way of finding the help that's available." Barriers and facilitators of service use among dementia family caregivers: a qualitative study.

    abstract:BACKGROUND:Family caregivers of people with dementia have significant unmet needs in regard to their caregiving role. Despite this, they are reluctant to utilize services to reduce their burden. The aim of this study was to examine the barriers and facilitators of service use among family caregivers of people with deme...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610216002532

    authors: Macleod A,Tatangelo G,McCabe M,You E

    更新日期:2017-05-01 00:00:00

  • Suicide and deliberate self harm in older Irish adults.

    abstract:BACKGROUND:Hospital-treated deliberate self harm and suicide among older adults have rarely been examined at a national level. METHODS:The Irish Central Statistics Office provided suicide and undetermined death data for 1980-2006. The National Registry of Deliberate Self Harm collected data relating to deliberate self...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610210001377

    authors: Corcoran P,Reulbach U,Perry IJ,Arensman E

    更新日期:2010-12-01 00:00:00

  • The measuring, meaning and importance of activities of daily living (ADLs) as an outcome.

    abstract::Dementia is defined as global cognitive impairment that interferes with function; however, function has been less well measured than cognition in anti-dementia drug trials. In the modern era of anti-dementia clinical trials, measurement of function has improved by differentiating between the aspects of function that h...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610207004966

    authors: Rockwood K

    更新日期:2007-06-01 00:00:00

  • Does a cognitive stress test predict progression from mild cognitive impairment to dementia equally well in clinical versus population-based settings?

    abstract::ABSTRACTBackground:Evidence suggests that semantic interference may be a sensitive indicator of early dementia. We examined the utility of the Semantic Interference Test (SIT), a cognitive stress memory paradigm which taps proactive and retroactive semantic interference, for predicting progression from mild cognitive ...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610217002666

    authors: Beer JC,Snitz BE,Chang CH,Loewenstein DA,Ganguli M

    更新日期:2018-10-01 00:00:00

  • Genome-wide screen to identify genetic loci associated with cognitive decline in late-life depression.

    abstract:OBJECTIVE:This study sought to conduct a comprehensive search for genetic risk of cognitive decline in the context of geriatric depression. DESIGN:A genome-wide association study (GWAS) analysis in the Neurocognitive Outcomes of Depression in the Elderly (NCODE) study. SETTING:Longitudinal, naturalistic follow-up stu...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610220001143

    authors: Steffens DC,Garrett ME,Soldano KL,McQuoid DR,Ashley-Koch AE,Potter GG

    更新日期:2020-07-09 00:00:00

  • Distinct age-related associations for body mass index and cognition in cognitively healthy very old veterans.

    abstract::ABSTRACTAssociations between high body mass index (BMI) and subsequent cognitive decline, reported in elderly averaging below age 75, become less consistent at older ages. We compared the associations of BMI with cognition in moderately old (ages 75-84, N = 154) and oldest-old (85+, N = 93) samples. BMI and cognition ...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610218001412

    authors: Schmeidler J,Mastrogiacomo CN,Beeri MS,Rosendorff C,Silverman JM

    更新日期:2019-06-01 00:00:00

  • Qualitative analysis of the clinician interview-based impression of change (Plus): methodological issues and implications for clinical research.

    abstract::The Clinician Interview-Based Impression of Change, plus carer interview (CIBIC-Plus), is widely used in antidementia drug trials. It comprises Likert scales for disease severity and changes, and written accounts summarizing semistructured interviews evaluating behavior, cognition, and function. Studies using the CIBI...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/s1041610200006505

    authors: Joffres C,Graham J,Rockwood K

    更新日期:2000-09-01 00:00:00

  • Understanding delirium trajectory and its importance in care provision for older people.

    abstract::Delirium significantly increases morbidity and mortality in older people, especially those affected by other organic disorders, notably dementia (Siddiqi et al., 2006; Davis et al., 2012; Martins and Fernandes, 2012). Both delirium and dementia are characterized by cognitive decline through disintegration of brain fun...

    journal_title:International psychogeriatrics

    pub_type: 评论,杂志文章

    doi:10.1017/S1041610216001988

    authors: Suh GH,Gega L

    更新日期:2017-01-01 00:00:00

  • The relationship between gait dynamics and future cognitive decline: a prospective pilot study in geriatric patients.

    abstract::ABSTRACTBackground:Walking ability recently emerged as a sub-clinical marker of cognitive decline. Hence, the relationship between baseline gait and future cognitive decline was examined in geriatric patients. Because a "loss of complexity" (LOC) is a key phenomenon of the aging process that exhibits in multiple syste...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610217002770

    authors: Kikkert LHJ,Vuillerme N,van Campen JP,Appels BA,Hortobágyi T,Lamoth CJC

    更新日期:2018-09-01 00:00:00

  • Smell identification function as a severity and progression marker in Alzheimer's disease.

    abstract:BACKGROUND:Olfactory dysfunction, impaired smell identification in particular, is known as a diagnostic and a marker of conversion in Alzheimer's disease (AD). We aimed to evaluate the associations of olfactory identification impairments with cognition, illness severity, and progression in AD patients. METHODS:Fifty-s...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610213000446

    authors: Velayudhan L,Pritchard M,Powell JF,Proitsi P,Lovestone S

    更新日期:2013-07-01 00:00:00

  • Disability but not social support predicts cognitive deterioration in late-life depression.

    abstract:BACKGROUND:Depression in late life is a risk factor for cognitive decline. Depression is also associated with increased disability and social support deficits; these may precede conversion to dementia and inform risk. In this study, we examined if baseline or one-year change in disability and social support predicted l...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610214002543

    authors: Riddle M,McQuoid DR,Potter GG,Steffens DC,Taylor WD

    更新日期:2015-05-01 00:00:00

  • A brief measure of predeath grief in dementia caregivers: the Caregiver Grief Questionnaire.

    abstract:OBJECTIVE:The study of predeath grief is hampered by measures that are often lengthy and not clearly differentiated from other caregiving outcomes, most notably burden. We aimed to validate a new 11-item Caregiver Grief Questionnaire (CGQ) assessing two dimensions of predeath grief, namely relational deprivation and em...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610219000309

    authors: Cheng ST,Ma DY,Lam LCW

    更新日期:2019-08-01 00:00:00

  • Physician don't heal thyself: a descriptive study of impaired older doctors.

    abstract:BACKGROUND:The growing and welcome interest in the issues leading to distress and impairment in younger doctors has not been mirrored by a focus on the similar issues in older doctors which is surprising given the aging medical workforce. OBJECTIVES:To improve understanding of impairment in older doctors and to facili...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610207005431

    authors: Peisah C,Wilhelm K

    更新日期:2007-10-01 00:00:00

  • The mediating role of cardiovascular risk factors in the relationship between symptoms of apathy and incident cardiovascular disease in community-dwelling older individuals.

    abstract:BACKGROUND:In old age, both apathy and depression have been associated with an increased cardiovascular disease (CVD) risk. This study evaluated the mediating role of cardiovascular risk factors in the relationship of apathy and mood symptoms with incident CVD. METHODS:Prospective cohort study of 1,790 community-dwell...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610215001751

    authors: Eurelings LS,Jaccard J,Moll van Charante EP,Eikelenboom P,Ligthart SA,van Gool WA,Richard E

    更新日期:2016-04-01 00:00:00

  • The natural course of anxiety disorders in the elderly: a systematic review of longitudinal trials.

    abstract:BACKGROUND:The anxiety disorders are a prevalent mental health problem in older age with a considerable impact on quality of life. Until recently there have been few longitudinal studies on anxiety in this age group, consequently most of the evidence to date has been cross-sectional in nature. METHODS:We undertook a l...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章,评审

    doi:10.1017/S1041610214001847

    authors: Sami MB,Nilforooshan R

    更新日期:2015-07-01 00:00:00

  • Implementation of evidence-based, non-pharmacological interventions addressing behavior and psychological symptoms of dementia: a systematic review focused on implementation strategies.

    abstract:OBJECTIVE:This study aimed to identify the nature and effects of implementation strategies to increase the use of evidence-based, non-pharmacological interventions designed to reduce the frequency and/or severity of behavioral and psychological symptoms associated with dementia, for people living in the community. DES...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610220001702

    authors: Bennett S,Laver K,MacAndrew M,Beattie E,Clemson L,Runge C,Richardson L

    更新日期:2020-11-16 00:00:00

  • Effectiveness of a home-based missing incident prevention program for community-dwelling elderly patients with dementia.

    abstract::ABSTRACTBackground:Getting lost is a recognized complication in patients with dementia. Preventive measures are lacking. This study aims to investigate the effectiveness of a home-based missing incident prevention program (HMIPP) in reducing missing incidents, time of searching, and caregivers' stress. METHODS:The de...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610218000546

    authors: Lau WM,Chan TY,Szeto SL

    更新日期:2019-01-01 00:00:00

  • Predictors of psychological adjustment after bereavement.

    abstract:BACKGROUND:The impact of spousal bereavement on mental health varies among the widowed. More information is needed on factors influencing bereavement outcome. METHOD:We conducted a cross-sectional study on a sample of 216 widowed individuals. Initial non-response was high, with only 8% of all approached persons partic...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610206004248

    authors: Onrust S,Cuijpers P,Smit F,Bohlmeijer E

    更新日期:2007-10-01 00:00:00

  • The ABC of Alzheimer's disease: cognitive changes and their management in Alzheimer's disease and related dementias.

    abstract::Cognitive decline, commonly first recognized as memory impairment, is a typical feature of Alzheimer's disease (AD). Neuropathological changes in the cerebral cortex and limbic system lead to deficits in learning, memory, language, and visuospatial skills. The precise nature of cognitive dysfunction reflects the distr...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章,评审

    doi:10.1017/s1041610203008664

    authors: Corey-Bloom J

    更新日期:2002-01-01 00:00:00

  • Spirituality, social support, and flexibility among older adults: a five-year longitudinal study.

    abstract::ABSTRACTObjectives:The objectives of the study were to examine the trajectory of spirituality among older adults, to investigate the roles of gender and religion on the developmental trajectory of spirituality, and to explore whether the linear growth of spirituality accelerated or decelerated at time points at which ...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610218000029

    authors: Bailly N,Martinent G,Ferrand C,Agli O,Giraudeau C,Gana K,Roussiau N

    更新日期:2018-12-01 00:00:00

  • Different dimensions of ageist attitudes among men and women: a multigenerational perspective.

    abstract:BACKGROUND:Ageism, a form of prejudice in which one relates negatively to people due to their age, exists throughout life. However, no attempt has been made to compare ageist attitudes across the life cycle, from young adulthood to old age. Consequently, the current study examined age and gender differences in ageism t...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610211002936

    authors: Bodner E,Bergman YS,Cohen-Fridel S

    更新日期:2012-06-01 00:00:00

  • Use of benzodiazepines and cognitive performance in primary care patients with first cognitive complaints.

    abstract::ABSTRACTThe aim of the present study is to investigate the impact of benzodiazepine use on cognitive performance in primary care patients with first cognitive complaints. The association between the exposition to benzodiazepines (short and long half-life) and cognitive performance, evaluated through the Mini Mental St...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S104161021700223X

    authors: Grande G,Tramacere I,Vetrano DL,Pomati S,Mariani C,Filippini G

    更新日期:2018-04-01 00:00:00

  • Longitudinal patterns of delirium severity scores in long-term care settings.

    abstract:BACKGROUND:The delirium index (DI) is a valid measure of delirium severity. We proposed to describe longitudinal patterns of severity scores in older long-term care (LTC) residents. METHODS:A prospective cohort study of 280 residents in seven LTC facilities in Montreal and Quebec City, Canada, was conducted. DI, Barth...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1017/S104161021600137X

    authors: Ciampi A,Bai C,Dyachenko A,McCusker J,Cole MG,Belzile E

    更新日期:2017-01-01 00:00:00

  • The concept of quality of life in dementia in the different stages of the disease.

    abstract::In order to conceptually define quality of life (QOL) in dementia, the literature on QOL in the elderly population, in chronic disease and in dementia was studied. Dementia is a progressive, age-related, chronic condition and to avoid omissions within the dementia-specific concept of QOL, a broad orientation was the p...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章,评审

    doi:10.1017/s1041610205002073

    authors: Ettema TP,Dröes RM,de Lange J,Ooms ME,Mellenbergh GJ,Ribbe MW

    更新日期:2005-09-01 00:00:00

  • Midlife improvements in financial situation are associated with a reduced dementia risk later in life: the CAIDE 30-year study.

    abstract:OBJECTIVES:Perceived financial strain is associated with various health conditions, but it is unknown whether it is associated with an increased risk for dementia. The goal is to examine the associations between midlife perceptions of financial situation and dementia risk later in life. METHODS:Participants were deriv...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S104161021900173X

    authors: Sindi S,Darin-Mattsson A,Kåreholt I,Kulmala J,Ngandu T,Laatikainen T,Soininen H,Kivipelto M

    更新日期:2020-11-01 00:00:00

  • Joining forces to prevent dementia: The International Research Network On Dementia Prevention (IRNDP).

    abstract::Dementia is a neurodegenerative disorder with global impact, with the largest proportion of cases occurring in low- and middle-income countries. It is estimated that there are 46.8 million cases globally with approximately 10 million new cases each year or a new case occurring every 3 sec (Prince et al., 2015). For co...

    journal_title:International psychogeriatrics

    pub_type: 社论

    doi:10.1017/S1041610217001685

    authors: Anstey KJ,Peters R,Clare L,Lautenschlager NT,Dodge HH,Barnes DE,Shahar S,Brodaty H,Rees G

    更新日期:2017-11-01 00:00:00