Abstract:
:Dementia is defined as global cognitive impairment that interferes with function; however, function has been less well measured than cognition in anti-dementia drug trials. In the modern era of anti-dementia clinical trials, measurement of function has improved by differentiating between the aspects of function that have been impaired--for example, impaired initiative versus ineffective performance, as is evaluated by the Disability Assessment for Dementia. Obstacles remain, including how best to distinguish the concepts of functional impairment and disability, how broad to make the range of functional impairment (e.g. whether it should include impaired performance of hobbies, or withdrawal from leisure activities) to individualize assessment, and to distinguish cognitive from non-cognitive causes of impaired function. Even though it appears that improved function is commonly related to improved executive function, and that the latter, more than other aspects of improved cognition, is the effect most prized by patients, families and physicians, functional assessment measures are often less sensitive to change than other outcome measures. How best to improve sensitivity to change of functional measurements is controversial, but it is necessary to do so in order to evaluate the full effects of treatment.
journal_name
Int Psychogeriatrjournal_title
International psychogeriatricsauthors
Rockwood Kdoi
10.1017/S1041610207004966subject
Has Abstractpub_date
2007-06-01 00:00:00pages
467-82issue
3eissn
1041-6102issn
1741-203Xpii
S1041610207004966journal_volume
19pub_type
杂志文章abstract:BACKGROUND:Previous studies have shown that the presence of depressive symptoms among older persons was evidently associated with subsequent physical and functional decline. However, few studies have directly examined the impact of changes in depressive symptoms or depressed mood on changes in functional ability. The p...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212000890
更新日期:2012-10-01 00:00:00
abstract::The dynamic processes and the way they interact in shaping a care system for demented patients are analyzed and discussed. The development of disability/dependency, interpreted in a simulation model based on Katz's index of ADL and Berger's scale "Rating the severity of senility," gave insight into the interplay of fo...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610296002888
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVE:The study of predeath grief is hampered by measures that are often lengthy and not clearly differentiated from other caregiving outcomes, most notably burden. We aimed to validate a new 11-item Caregiver Grief Questionnaire (CGQ) assessing two dimensions of predeath grief, namely relational deprivation and em...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610219000309
更新日期:2019-08-01 00:00:00
abstract::There is no doubt that family carers who look after a family member with dementia or with a functional mental illness fulfill an important role, not only for their loved one, but also for the health and aged care systems of the countries they live in. Due to increasing life expectancy, but also improved healthcare the...
journal_title:International psychogeriatrics
pub_type: 社论
doi:10.1017/S1041610217002150
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVE:To identify, in caregivers of patients with Alzheimer's disease (AD) dementia, factors associated with subjective (personal, physical, emotional, and social) and objective (informal caregiver time and costs) caregiver burden. DESIGN:Prospective longitudinal European observational study: post-hoc analysis. S...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610219000425
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Family involvement in long-term care (LTC) is important but it can prove challenging and result in conflict with staff if families do not feel connected to the LTC facility or if they believe that their contributions are undervalued. According to McMillan & Chavis (1986), sense of community (SOC) refers to a...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212001524
更新日期:2013-03-01 00:00:00
abstract::ABSTRACTBackground:This study investigates whether maintaining high levels of cognitive impairment and weak grip strength will predict a higher risk for mortality. METHODS:Data from the Korean Longitudinal Study of Aging (KLoSA) from 2006 to 2014 was assessed using longitudinal data analysis and included 5,812 resear...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610218001175
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Neuropsychiatric symptoms (NPS) are prevalent in nursing-home (NH) patients with dementia, but little is known about the long-term course of these symptoms. METHODS:In this study, 931 NH patients with dementia took part in a prospective cohort study with four assessments over a 53-month follow-up period. NP...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610213001609
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Health services are encouraged to adopt a strong person-centered approach to the provision of care and services for older people. The aim of this project was to establish a user-friendly, psychometrically valid, and reliable measure of healthcare staff's practice, attitudes, and beliefs regarding person-cent...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610213000471
更新日期:2013-07-01 00:00:00
abstract::ABSTRACTBackground:Evidence suggests that semantic interference may be a sensitive indicator of early dementia. We examined the utility of the Semantic Interference Test (SIT), a cognitive stress memory paradigm which taps proactive and retroactive semantic interference, for predicting progression from mild cognitive ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217002666
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Both anxiety disorders and subclinical anxiety symptoms are related to poorer health and functioning in later life. Because worry is an important component of anxiety, the accurate measurement of worry is crucial to studying the etiology, prevention and treatment of anxiety disorders. Assessment of the trait...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610206003450
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND:It is unclear how brain reserve interacts with gender and apolipoprotein E4 (APOE4) genotype, and how this influences the progression of Alzheimer's disease (AD). The association between intracranial volume (ICV) and progression to AD in subjects with mild cognitive impairment (MCI), and differences accordin...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S104161021500229X
更新日期:2016-05-01 00:00:00
abstract::ABSTRACTBackground:Psychological and social resources such as extraversion, optimism, social support, or social networks contribute to adaptation and to successful aging. Building on assumptions derived from successful aging and from the developmental adaptation models, this study aims to analyze the joint impact of d...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610218000388
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Music can be therapeutic to people with dementia; however, little is known about its effect on the family carers. This project aimed to (1) assess the effects of MP3 player use by a person with dementia on caregivers' mental health and wellbeing, including their self-care and health-promoting behavior and (2...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610214001999
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Irregular circadian rhythm and cognitive impairment are frequently observed in patients with chronic schizophrenia. However, their effects in different living environments or with aging remain unclear. The aim of this study was to clarify the characteristics of circadian rhythm and cognition function in the ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610214001604
更新日期:2015-01-01 00:00:00
abstract::Cross-sectional data from Phase 1 of the Canadian Study of Health and Aging was used to examine the relationship between two self-report health measures: "How would you say your health is these days?"(HEALTH) and "How much do your health troubles stand in the way of your doing the things you want to do?"(TROUBLE). The...
journal_title:International psychogeriatrics
pub_type: 杂志文章,多中心研究
doi:10.1017/s1041610202008165
更新日期:2001-01-01 00:00:00
abstract::Major advances in understanding the physiology and genetics of circadian rhythm in the past decade challenge the researcher of sleep/wake disorders in Alzheimer's disease (AD) to distinguish patient characteristics stable across the course of illness ("traits") from characteristics that vary with stage of illness ("st...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610202008293
更新日期:2002-03-01 00:00:00
abstract::Alzheimer´s disease (AD) is a severe neurodegenerative brain disorder characterized by beta-amyloid plaques, Tau pathology, inflammation, neurodegeneration, and cerebrovascular dysfunction. Besides that, alterations in monocytes and platelets have been reported in the blood of Alzheimer patients. In the present study,...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217001612
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:It is of considerable public health importance to prevent or delay the progression of mild cognitive impairment (MCI) to more severely impaired cognitive states. This study examines the risk of progression from mild to severe cognitive impairment in relation to engagement in social activities while mildly im...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212002086
更新日期:2013-04-01 00:00:00
abstract::Epidemiologic survey data were used to examine relationships between alcohol use and abuse and the physical and mental health status of elderly public housing residents (weighted n = 865) and to determine the influence that drinking behavior had on mortality. Residents with a current alcohol disorder (4%) were more li...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610298005407
更新日期:1998-09-01 00:00:00
abstract::The pervasive scarcity of resources relative to the demands upon them makes it necessary for decision makers to think carefully about choices. Evidence from economics can help to inform such choices, particularly as it relates to costs, outcomes, the efficiency with which resources are used, the distribution of benefi...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610207005157
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:The economic cost of dementia is high and can be predicted by cognitive and neuropsychiatric profiles. The differential costs of the various subtypes of dementia are unknown in Argentina, and this study therefore aimed to compare these costs. METHODS:Patients with a diagnosis of dementia of Alzheimer-type (...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610210002012
更新日期:2011-05-01 00:00:00
abstract::Understanding of vascular substrates of cognitive decline in the elderly is evolving to include a major emphasis on the impact of small vessel disease (SVD). While existing concepts of multi-infarct dementia and strategic infarct dementia remain valid, they present difficulty in generalizing clinicopathological correl...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610203008998
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVES:Issues concerning the association among attachment anxiety, depression and suicidal ideation among the elderly have rarely been explored. The present study investigated the relationship among attachment anxiety, depression and perceived support concerning suicidal ideation among older people. DESIGN:Cross-s...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S104161022000054X
更新日期:2020-05-07 00:00:00
abstract::ABSTRACTBackground:The current research sought to characterize current mood state profiles in healthy young versus older adults using 100-point visual analogue mood scales (VAMS), provide within-sample and new sample replication of age-group differences, assess sex differences, and compare with commonly used standardi...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610218000996
更新日期:2019-03-01 00:00:00
abstract::Noncognitive or behavioral and psychological symptoms (BPSD) are common in vascular dementia. Many occur with the same frequency as in Alzheimer's disease, though depression, emotional lability, and apathy may be more common and psychosis less so. There is a particularly strong relationship between cerebrovascular dis...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610203009098
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Raising understanding of dementia has become a key focus of international health and social care. An up-to-date, psychometrically sound measure of dementia knowledge that embraces a biopsychosocial perspective is lacking. The aim of this study is to develop and evaluate the psychometric properties of the DK-...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610213001142
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Large randomized controlled trials have shown that risperidone reduces the frequency and severity of behavioral and psychological symptoms of dementia (BPSD) in patients with dementia. Since such trials are obliged to use very strict inclusion and exclusion criteria, their information about the efficacy is l...
journal_title:International psychogeriatrics
pub_type: 临床试验,杂志文章
doi:10.1017/s1041610204000122
更新日期:2004-03-01 00:00:00
abstract::This paper presents updated analyses on the genetic associations of sleep disruption in individuals with Alzheimer's disease (AD). We published previously a study of the association between single nucleotide polymorphisms (SNPs) found in eight genes related to circadian rhythms and objective measures of sleep-wake dis...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610219001777
更新日期:2020-07-01 00:00:00
abstract::Seventy-eight nondemented elderly depressed patients underwent an extensive battery of cognitive tests both before and after seven weeks of treatment with nortriptyline, phenelzine, or placebo. Clinical and cognitive evaluations of the patients were under double-blind conditions. Response to treatment did not appear t...
journal_title:International psychogeriatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/s1041610289000141
更新日期:1989-10-01 00:00:00