The measuring, meaning and importance of activities of daily living (ADLs) as an outcome.

Abstract:

:Dementia is defined as global cognitive impairment that interferes with function; however, function has been less well measured than cognition in anti-dementia drug trials. In the modern era of anti-dementia clinical trials, measurement of function has improved by differentiating between the aspects of function that have been impaired--for example, impaired initiative versus ineffective performance, as is evaluated by the Disability Assessment for Dementia. Obstacles remain, including how best to distinguish the concepts of functional impairment and disability, how broad to make the range of functional impairment (e.g. whether it should include impaired performance of hobbies, or withdrawal from leisure activities) to individualize assessment, and to distinguish cognitive from non-cognitive causes of impaired function. Even though it appears that improved function is commonly related to improved executive function, and that the latter, more than other aspects of improved cognition, is the effect most prized by patients, families and physicians, functional assessment measures are often less sensitive to change than other outcome measures. How best to improve sensitivity to change of functional measurements is controversial, but it is necessary to do so in order to evaluate the full effects of treatment.

journal_name

Int Psychogeriatr

authors

Rockwood K

doi

10.1017/S1041610207004966

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

467-82

issue

3

eissn

1041-6102

issn

1741-203X

pii

S1041610207004966

journal_volume

19

pub_type

杂志文章
  • Changes in depressive symptoms and functional disability among community-dwelling depressive older adults.

    abstract:BACKGROUND:Previous studies have shown that the presence of depressive symptoms among older persons was evidently associated with subsequent physical and functional decline. However, few studies have directly examined the impact of changes in depressive symptoms or depressed mood on changes in functional ability. The p...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610212000890

    authors: Nyunt MS,Lim ML,Yap KB,Ng TP

    更新日期:2012-10-01 00:00:00

  • A dynamic long-term care system for the demented elderly.

    abstract::The dynamic processes and the way they interact in shaping a care system for demented patients are analyzed and discussed. The development of disability/dependency, interpreted in a simulation model based on Katz's index of ADL and Berger's scale "Rating the severity of senility," gave insight into the interplay of fo...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/s1041610296002888

    authors: Annerstedt L,Sanada J,Gustafson L

    更新日期:1996-01-01 00:00:00

  • A brief measure of predeath grief in dementia caregivers: the Caregiver Grief Questionnaire.

    abstract:OBJECTIVE:The study of predeath grief is hampered by measures that are often lengthy and not clearly differentiated from other caregiving outcomes, most notably burden. We aimed to validate a new 11-item Caregiver Grief Questionnaire (CGQ) assessing two dimensions of predeath grief, namely relational deprivation and em...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610219000309

    authors: Cheng ST,Ma DY,Lam LCW

    更新日期:2019-08-01 00:00:00

  • Modern technology to support carers of care recipients with dementia or functional mental illness: promising progress, but a long road ahead.

    abstract::There is no doubt that family carers who look after a family member with dementia or with a functional mental illness fulfill an important role, not only for their loved one, but also for the health and aged care systems of the countries they live in. Due to increasing life expectancy, but also improved healthcare the...

    journal_title:International psychogeriatrics

    pub_type: 社论

    doi:10.1017/S1041610217002150

    authors: Lautenschlager NT,Diehl-Schmid J,Loi SM,Mayer J,Tensil M,Kurz AF

    更新日期:2017-12-01 00:00:00

  • Factors associated with long-term impact on informal caregivers during Alzheimer's disease dementia progression: 36-month results from GERAS.

    abstract:OBJECTIVE:To identify, in caregivers of patients with Alzheimer's disease (AD) dementia, factors associated with subjective (personal, physical, emotional, and social) and objective (informal caregiver time and costs) caregiver burden. DESIGN:Prospective longitudinal European observational study: post-hoc analysis. S...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610219000425

    authors: Reed C,Belger M,Scott Andrews J,Tockhorn-Heidenreich A,Jones RW,Wimo A,Dodel R,Haro JM

    更新日期:2020-02-01 00:00:00

  • Sense of community in long-term care: the views of family caregivers of elderly military veterans.

    abstract:BACKGROUND:Family involvement in long-term care (LTC) is important but it can prove challenging and result in conflict with staff if families do not feel connected to the LTC facility or if they believe that their contributions are undervalued. According to McMillan & Chavis (1986), sense of community (SOC) refers to a...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610212001524

    authors: Petrovic-Poljak A,Konnert C

    更新日期:2013-03-01 00:00:00

  • Association of cognitive impairment and grip strength trajectories with mortality among middle-aged and elderly adults.

    abstract::ABSTRACTBackground:This study investigates whether maintaining high levels of cognitive impairment and weak grip strength will predict a higher risk for mortality. METHODS:Data from the Korean Longitudinal Study of Aging (KLoSA) from 2006 to 2014 was assessed using longitudinal data analysis and included 5,812 resear...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610218001175

    authors: Kim JH,Kim JM

    更新日期:2019-05-01 00:00:00

  • The course of neuropsychiatric symptoms in nursing-home patients with dementia over a 53-month follow-up period.

    abstract:BACKGROUND:Neuropsychiatric symptoms (NPS) are prevalent in nursing-home (NH) patients with dementia, but little is known about the long-term course of these symptoms. METHODS:In this study, 931 NH patients with dementia took part in a prospective cohort study with four assessments over a 53-month follow-up period. NP...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610213001609

    authors: Selbaek G,Engedal K,Benth JŠ,Bergh S

    更新日期:2014-01-01 00:00:00

  • Development and initial testing of the Person-Centred Health Care for Older Adults Survey.

    abstract:BACKGROUND:Health services are encouraged to adopt a strong person-centered approach to the provision of care and services for older people. The aim of this project was to establish a user-friendly, psychometrically valid, and reliable measure of healthcare staff's practice, attitudes, and beliefs regarding person-cent...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610213000471

    authors: Dow B,Fearn M,Haralambous B,Tinney J,Hill K,Gibson S

    更新日期:2013-07-01 00:00:00

  • Does a cognitive stress test predict progression from mild cognitive impairment to dementia equally well in clinical versus population-based settings?

    abstract::ABSTRACTBackground:Evidence suggests that semantic interference may be a sensitive indicator of early dementia. We examined the utility of the Semantic Interference Test (SIT), a cognitive stress memory paradigm which taps proactive and retroactive semantic interference, for predicting progression from mild cognitive ...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610217002666

    authors: Beer JC,Snitz BE,Chang CH,Loewenstein DA,Ganguli M

    更新日期:2018-10-01 00:00:00

  • A test of the measurement invariance of a brief version of the Penn State Worry Questionnaire between American and Spanish older adults.

    abstract:BACKGROUND:Both anxiety disorders and subclinical anxiety symptoms are related to poorer health and functioning in later life. Because worry is an important component of anxiety, the accurate measurement of worry is crucial to studying the etiology, prevention and treatment of anxiety disorders. Assessment of the trait...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610206003450

    authors: Nuevo R,Mackintosh MA,Gatz M,Montorio I,Wetherell JL

    更新日期:2007-02-01 00:00:00

  • Large intracranial volume accelerates conversion to dementia in males and APOE4 non-carriers with mild cognitive impairment.

    abstract:BACKGROUND:It is unclear how brain reserve interacts with gender and apolipoprotein E4 (APOE4) genotype, and how this influences the progression of Alzheimer's disease (AD). The association between intracranial volume (ICV) and progression to AD in subjects with mild cognitive impairment (MCI), and differences accordin...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S104161021500229X

    authors: An H,Son SJ,Cho S,Cho EY,Choi B,Kim SY,Alzheimer's Disease Neuroimaging Initiative.

    更新日期:2016-05-01 00:00:00

  • Successful aging in Spanish older adults: the role of psychosocial resources.

    abstract::ABSTRACTBackground:Psychological and social resources such as extraversion, optimism, social support, or social networks contribute to adaptation and to successful aging. Building on assumptions derived from successful aging and from the developmental adaptation models, this study aims to analyze the joint impact of d...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610218000388

    authors: Dumitrache CG,Rubio L,Cordón-Pozo E

    更新日期:2019-02-01 00:00:00

  • A study of the effectiveness of MP3 players to support family carers of people living with dementia at home.

    abstract:BACKGROUND:Music can be therapeutic to people with dementia; however, little is known about its effect on the family carers. This project aimed to (1) assess the effects of MP3 player use by a person with dementia on caregivers' mental health and wellbeing, including their self-care and health-promoting behavior and (2...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610214001999

    authors: Lewis V,Bauer M,Winbolt M,Chenco C,Hanley F

    更新日期:2015-03-01 00:00:00

  • A pilot study: comparative research of social functioning, circadian rhythm parameters, and cognitive function among institutional inpatients, and outpatients with chronic schizophrenia and healthy elderly people.

    abstract:BACKGROUND:Irregular circadian rhythm and cognitive impairment are frequently observed in patients with chronic schizophrenia. However, their effects in different living environments or with aging remain unclear. The aim of this study was to clarify the characteristics of circadian rhythm and cognition function in the ...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610214001604

    authors: Kume Y,Sugita T,Oga K,Kagami K,Igarashi H

    更新日期:2015-01-01 00:00:00

  • Contribution of self-reported health ratings to predicting frailty, institutionalization, and death over a 5-year period.

    abstract::Cross-sectional data from Phase 1 of the Canadian Study of Health and Aging was used to examine the relationship between two self-report health measures: "How would you say your health is these days?"(HEALTH) and "How much do your health troubles stand in the way of your doing the things you want to do?"(TROUBLE). The...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1017/s1041610202008165

    authors: Gutman GM,Stark A,Donald A,Beattie BL

    更新日期:2001-01-01 00:00:00

  • Sleep/wake cycle disturbance in Alzheimer's disease: how much is due to an inherent trait?

    abstract::Major advances in understanding the physiology and genetics of circadian rhythm in the past decade challenge the researcher of sleep/wake disorders in Alzheimer's disease (AD) to distinguish patient characteristics stable across the course of illness ("traits") from characteristics that vary with stage of illness ("st...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/s1041610202008293

    authors: Yesavage JA,Taylor JL,Kraemer H,Noda A,Friedman L,Tinklenberg JR

    更新日期:2002-03-01 00:00:00

  • Reduced beta-amyloid sensitivity for platelet-monocyte aggregates in EDTA blood of alzheimer patients.

    abstract::Alzheimer´s disease (AD) is a severe neurodegenerative brain disorder characterized by beta-amyloid plaques, Tau pathology, inflammation, neurodegeneration, and cerebrovascular dysfunction. Besides that, alterations in monocytes and platelets have been reported in the blood of Alzheimer patients. In the present study,...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610217001612

    authors: Defrancesco M,Marksteiner J,Humpel C

    更新日期:2018-01-01 00:00:00

  • Engagement in social activities and progression from mild to severe cognitive impairment: the MYHAT study.

    abstract:BACKGROUND:It is of considerable public health importance to prevent or delay the progression of mild cognitive impairment (MCI) to more severely impaired cognitive states. This study examines the risk of progression from mild to severe cognitive impairment in relation to engagement in social activities while mildly im...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610212002086

    authors: Hughes TF,Flatt JD,Fu B,Chang CC,Ganguli M

    更新日期:2013-04-01 00:00:00

  • Alcohol use disorder is a risk factor for mortality among older public housing residents.

    abstract::Epidemiologic survey data were used to examine relationships between alcohol use and abuse and the physical and mental health status of elderly public housing residents (weighted n = 865) and to determine the influence that drinking behavior had on mortality. Residents with a current alcohol disorder (4%) were more li...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/s1041610298005407

    authors: Black BS,Rabins PV,McGuire MH

    更新日期:1998-09-01 00:00:00

  • Economic outcomes and levers: impacts for individuals and society.

    abstract::The pervasive scarcity of resources relative to the demands upon them makes it necessary for decision makers to think carefully about choices. Evidence from economics can help to inform such choices, particularly as it relates to costs, outcomes, the efficiency with which resources are used, the distribution of benefi...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610207005157

    authors: Knapp M

    更新日期:2007-06-01 00:00:00

  • Clinical and economic characteristics associated with direct costs of Alzheimer's, frontotemporal and vascular dementia in Argentina.

    abstract:BACKGROUND:The economic cost of dementia is high and can be predicted by cognitive and neuropsychiatric profiles. The differential costs of the various subtypes of dementia are unknown in Argentina, and this study therefore aimed to compare these costs. METHODS:Patients with a diagnosis of dementia of Alzheimer-type (...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610210002012

    authors: Rojas G,Bartoloni L,Dillon C,Serrano CM,Iturry M,Allegri RF

    更新日期:2011-05-01 00:00:00

  • Neuropathology of vascular cognitive impairment and vascular dementia.

    abstract::Understanding of vascular substrates of cognitive decline in the elderly is evolving to include a major emphasis on the impact of small vessel disease (SVD). While existing concepts of multi-infarct dementia and strategic infarct dementia remain valid, they present difficulty in generalizing clinicopathological correl...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610203008998

    authors: Ince PG,Fernando MS

    更新日期:2003-01-01 00:00:00

  • Attachment anxiety, depression, and perceived social support: a moderated mediation model of suicide ideation among the elderly.

    abstract:OBJECTIVES:Issues concerning the association among attachment anxiety, depression and suicidal ideation among the elderly have rarely been explored. The present study investigated the relationship among attachment anxiety, depression and perceived support concerning suicidal ideation among older people. DESIGN:Cross-s...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S104161022000054X

    authors: Oonarom A,Wongpakaran T,Kuntawong P,Wongpakaran N

    更新日期:2020-05-07 00:00:00

  • Visual analogue mood scale scores in healthy young versus older adults.

    abstract::ABSTRACTBackground:The current research sought to characterize current mood state profiles in healthy young versus older adults using 100-point visual analogue mood scales (VAMS), provide within-sample and new sample replication of age-group differences, assess sex differences, and compare with commonly used standardi...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610218000996

    authors: Machado L,Thompson LM,Brett CHR

    更新日期:2019-03-01 00:00:00

  • Behavioral symptoms in vascular cognitive impairment and vascular dementia.

    abstract::Noncognitive or behavioral and psychological symptoms (BPSD) are common in vascular dementia. Many occur with the same frequency as in Alzheimer's disease, though depression, emotional lability, and apathy may be more common and psychosis less so. There is a particularly strong relationship between cerebrovascular dis...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610203009098

    authors: O'Brien J

    更新日期:2003-01-01 00:00:00

  • The development and evaluation of the DK-20: a knowledge of dementia measure.

    abstract:BACKGROUND:Raising understanding of dementia has become a key focus of international health and social care. An up-to-date, psychometrically sound measure of dementia knowledge that embraces a biopsychosocial perspective is lacking. The aim of this study is to develop and evaluate the psychometric properties of the DK-...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610213001142

    authors: Shanahan N,Orrell M,Schepers AK,Spector A

    更新日期:2013-11-01 00:00:00

  • Efficacy of risperidone for treating patients with behavioral and psychological symptoms of dementia.

    abstract:BACKGROUND:Large randomized controlled trials have shown that risperidone reduces the frequency and severity of behavioral and psychological symptoms of dementia (BPSD) in patients with dementia. Since such trials are obliged to use very strict inclusion and exclusion criteria, their information about the efficacy is l...

    journal_title:International psychogeriatrics

    pub_type: 临床试验,杂志文章

    doi:10.1017/s1041610204000122

    authors: Wancata J

    更新日期:2004-03-01 00:00:00

  • Sleep-wake disorders in Alzheimer's disease: further genetic analyses in relation to objective sleep measures.

    abstract::This paper presents updated analyses on the genetic associations of sleep disruption in individuals with Alzheimer's disease (AD). We published previously a study of the association between single nucleotide polymorphisms (SNPs) found in eight genes related to circadian rhythms and objective measures of sleep-wake dis...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610219001777

    authors: Yesavage JA,Noda A,Heath A,McNerney MW,Domingue BW,Hernandez Y,Benson G,Hallmayer J,O'Hara R,Williams LM,Goldstein-Piekarski AN,Zeitzer JM,Fairchild JK

    更新日期:2020-07-01 00:00:00

  • The effects of mood changes and antidepressants on the cognitive capacity of elderly depressed patients.

    abstract::Seventy-eight nondemented elderly depressed patients underwent an extensive battery of cognitive tests both before and after seven weeks of treatment with nortriptyline, phenelzine, or placebo. Clinical and cognitive evaluations of the patients were under double-blind conditions. Response to treatment did not appear t...

    journal_title:International psychogeriatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1017/s1041610289000141

    authors: Georgotas A,McCue RE,Reisberg B,Ferris SH,Nagachandran N,Chang I,Mir P

    更新日期:1989-10-01 00:00:00