Abstract:
:One hundred and seven newly diagnosed, untreated patients with Parkinson's disease (PD) were divided into two groups according to their age at reported onset of symptoms. Of these, 79 patients were under age 70 (early-onset) and 28 patients were age 70 and over (late-onset). The group of 50 control subjects comprised spouses, friends of the PD patients, and community volunteers. The patients were participants in a multicenter drug study of Parkinson's disease. Each had received a detailed neurological and neuropsychological assessment in the baseline placebo phases of the study. Thirty-4 patients with early-onset and 12 patients with late-onset were reassessed 3 years after treatment with low-dose levodopa, with bromocriptine, or with a combination of the two drugs. The results of the baseline phase of the study revealed that 8% of the early-onset group and 32% of the late-onset group were classified as demented. The 3-year follow-up revealed that the prevalence of dementia had increased to 17% in the early-onset group and to 83% in the late-onset group. This study confirms that at least two distinct subtypes of Parkinson's disease exist. The subtypes differ both clinically and neuropsychologically. The age at onset of symptoms is a critical determinant of the rate and type of cognitive decline in Parkinson's disease.
journal_name
Int Psychogeriatrjournal_title
International psychogeriatricsauthors
Reid WGkeywords:
subject
Has Abstractpub_date
1992-01-01 00:00:00pages
147-60eissn
1041-6102issn
1741-203Xjournal_volume
4 Suppl 2pub_type
临床试验,杂志文章,多中心研究,随机对照试验abstract:BACKGROUND:Seeking medical advice for dementia involves an understanding of norms, values and attitudes towards care-giving and inter-dependency, which are culturally bounded. We hypothesize that local culture and socioeconomic structure affect our Chinese patients who present with forgetfulness to our memory clinic. ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S104161020800817X
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVES:To evaluate the impact of external memory devices on the efficacy of a package of internal mnemonic techniques. Participants wrote two types of lists during the study phase: (a) a list of study words and/or (b) a loci list. At recall, participants were not allowed to refer to either of the lists they had wri...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610203008755
更新日期:2003-03-01 00:00:00
abstract:BACKGROUND:Family involvement in long-term care (LTC) is important but it can prove challenging and result in conflict with staff if families do not feel connected to the LTC facility or if they believe that their contributions are undervalued. According to McMillan & Chavis (1986), sense of community (SOC) refers to a...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212001524
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:The International Psychogeriatric Association (IPA) capacity taskforce was established to promote the autonomy, proper access to care, and dignity of persons with decision-making disabilities (DMDs) across nations. The Asia Consortium of the taskforce was established to pursue these goals in the Asia-Pacific...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S104161021400266X
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:A careful characterization of behavioral abnormalities in corticobasal degeneration syndrome (CBDS) and progressive supranuclear palsy (PSP) by reliable tools is still lacking. Literature data provided evidence of the usefulness of the Frontal Behavioral Inventory (FBI) to operationalize such disturbances, p...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610209008862
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:It is necessary to continue to explore the psychometric characteristics of key cognitive screening tests such as the Montreal Cognitive Assessment (MoCA) to diagnose cognitive decline as early as possible and to attend to the growing need of clinical trials involving mild cognitive impairment (MCI) participa...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610215001982
更新日期:2016-05-01 00:00:00
abstract::Although individuals aged 65 and over accounted for 12% of the total population of Japan in 1990, suicides in this age group consisted of 29% of all suicides. The elderly population of Japan is expected to grow rapidly to 24% of the total population by the year 2020, and suicide prevention for the elderly is an urgent...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610295002006
更新日期:1995-07-01 00:00:00
abstract:BACKGROUND:Overlap between neuropsychiatric symptoms of dementia and delirium complicates diagnosis of delirium superimposed on dementia (DSD). This study sought to examine differences in delirium presentation and outcomes between DSD patients with and without pre-existing behavioral and psychological symptoms of demen...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610216001836
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:There is suggestion that self-reported depressive syndromes can independently manifest in the general population as cognitive/affective or somatic/vegetative. The Beck Depression Inventory, 2nd edition (BDI-II), a self-report measure of depressive symptoms, has been shown to support this two-factor structure...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212001676
更新日期:2013-03-01 00:00:00
abstract::Alzheimer´s disease (AD) is a severe neurodegenerative brain disorder characterized by beta-amyloid plaques, Tau pathology, inflammation, neurodegeneration, and cerebrovascular dysfunction. Besides that, alterations in monocytes and platelets have been reported in the blood of Alzheimer patients. In the present study,...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217001612
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Qualitative research has suggested that spousal carers of someone with dementia differ in terms of whether they perceive their relationship with that person as continuous with the premorbid relationship or as radically different, and that a perception of continuity may be associated with more person-centered...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212001743
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Elderly suicide rates are associated with the elderly population size, the proportion of elderly in the general population and the elderly dependency ratio. METHODS:A cross-national study examining the "a priori" hypothesis that the relationship between elderly suicide rates and average annual population gr...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610208007953
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Concerns about suicide risk in people with dementia have been increasing in recent years along with a discourse about rational suicide and assisted suicide. METHODS:A systematic narrative literature review of suicidal behavior and assisted suicide in persons with dementia. RESULTS:Most studies that have ex...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/S1041610215000629
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:It is unclear how brain reserve interacts with gender and apolipoprotein E4 (APOE4) genotype, and how this influences the progression of Alzheimer's disease (AD). The association between intracranial volume (ICV) and progression to AD in subjects with mild cognitive impairment (MCI), and differences accordin...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S104161021500229X
更新日期:2016-05-01 00:00:00
abstract::ABSTRACT Background: The consequences of co-occurring persistent loneliness and late life depression are yet unknown. The aim of this study was to get a deeper insight into the mental health consequences of loneliness in older persons with depressive symptoms and their perspectives of emotional distress by using a mix...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610214000581
更新日期:2014-04-09 00:00:00
abstract:BACKGROUND:The growing and welcome interest in the issues leading to distress and impairment in younger doctors has not been mirrored by a focus on the similar issues in older doctors which is surprising given the aging medical workforce. OBJECTIVES:To improve understanding of impairment in older doctors and to facili...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610207005431
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:The aim of this survey is to investigate professional attitudes to the presence and value of spiritual care from Old Age Psychiatrists. METHOD:All registered members of the Faculty of the Psychiatry of Old Age in the United Kingdom were asked to complete a 21-question semi-structured questionnaire. The firs...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610206004339
更新日期:2007-10-01 00:00:00
abstract::This paper provides a review of research issues and findings on the epidemiology of delirium. Despite the fact that research on this important geriatric syndrome has been conducted for many decades, several methodological issues make it difficult to compare findings across studies. In this paper we first discuss broad...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/s1041610291000625
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVE:This study sought to conduct a comprehensive search for genetic risk of cognitive decline in the context of geriatric depression. DESIGN:A genome-wide association study (GWAS) analysis in the Neurocognitive Outcomes of Depression in the Elderly (NCODE) study. SETTING:Longitudinal, naturalistic follow-up stu...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610220001143
更新日期:2020-07-09 00:00:00
abstract:OBJECTIVE:Despite delirium being common in older hospitalized people, little is known about its management. The aims of this study are (1) to describe the pharmacological management of delirium in an acute care setting as a baseline measure prior to the implementation of newly developed Australian guidelines; and (2) t...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610208008028
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:Suicide is a major public health concern. The elderly have the highest rate of suicide and they make more lethal suicide attempts and have fewer psychiatric interventions than young people. Furthermore, they have old-age specific psychosocial difficulties. The present study investigated psychosocial risk fac...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610211000263
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Previous studies have shown that the presence of depressive symptoms among older persons was evidently associated with subsequent physical and functional decline. However, few studies have directly examined the impact of changes in depressive symptoms or depressed mood on changes in functional ability. The p...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212000890
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:The length of stay and bed usage on acute psychogeriatric admission wards are influenced by several factors. The impact of a dedicated specialist social worker working exclusively with acutely ill psychogeriatric inpatients and with a dedicated budget for domiciliary care packages on the length of stay, bed ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610201007724
更新日期:2001-09-01 00:00:00
abstract::ABSTRACTBackground:The current research sought to characterize current mood state profiles in healthy young versus older adults using 100-point visual analogue mood scales (VAMS), provide within-sample and new sample replication of age-group differences, assess sex differences, and compare with commonly used standardi...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610218000996
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:Despite the high prevalence and morbidity of minor and subsyndromal depression in primary care elderly people, there are few data to identify those at highest risk of poor outcomes. The goal of this observational cohort study was to characterize the one-year outcomes of minor and subsyndromal depression, exa...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610208007746
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:We assessed eight-year mortality rates and predictors in a rural cohort of elderly individuals with cognitive impairment. METHODS:A total of 1,035 individuals, including 155 (15.0%) individuals with cognitive impairment, no dementia (CIND), and 69 (6.7%) individuals with clinically diagnosed dementia were f...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610214000556
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Previous studies have thoroughly investigated the prevalence and risk factors for completed suicide. In marked contrast is the lack of a better understanding of attempted suicide in the elderly. The aim of this study was to estimate the prevalence of attempted suicide in the elderly and examine the associate...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610216002283
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:Few current studies explore psychological well-being among older Chinese immigrants in Australia. The study addressed this gap and provided preliminary data on psychological well-being among this group. Four indicators, namely depression, anxiety, loneliness, and quality of life, were used to present a compr...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610216001010
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Depressive symptoms are common in patients with Alzheimer's disease (AD) and increase the caregiver burden, although the etiology and pathologic mechanism of depressive symptoms in AD patients remain unclear. In this study, we tried to clarify the cerebral blood flow (CBF) correlates of subjective depressive...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610213002573
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Older people have a higher risk of drug-related problems (DRPs). However, little is known about the prevalence of DRPs in community-dwelling people who screened positive for dementia. Our study aimed to determine (1) the prevalence and types of DRPs and (2) the socio-demographic and clinical variables associ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217001442
更新日期:2017-11-01 00:00:00