Prevalence, neurobiology, and treatments for apathy in prodromal dementia.

Abstract:

BACKGROUND:Apathy, characterized by diminished motivation, is a highly prevalent neuropsychiatric symptom in dementia. However, there is a substantial knowledge gap with regard to prevalence rates, neurobiological underpinnings, and effective treatments for apathy in pre-dementia states, including mild cognitive impairment (MCI) and mild behavioral impairment (MBI). METHODS:We conducted a comprehensive literature search using MEDLINE, Embase, and PsycINFO databases to identify available research on apathy in prodromal dementia. RESULTS:Apathy has consistently been detected in individuals with MCI with varying prevalence rates, and only recently has literature discussed the prevalence of apathy in MBI. Few pharmacological treatments have been utilized for apathy, with galantamine and risperidone showing mild reductions in apathetic behaviors. Non-pharmacological interventions in prodromal dementia are beginning to be explored and show promise, but few studies have replicated those results. DISCUSSION:More comprehensive guidelines for diagnosing apathy and further research investigating neurobiological mechanisms of apathy in MCI and MBI are required in order to effectively treat apathetic patients in prodromal dementia.

journal_name

Int Psychogeriatr

authors

Sherman C,Liu CS,Herrmann N,Lanctôt KL

doi

10.1017/S1041610217000527

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

177-184

issue

2

eissn

1041-6102

issn

1741-203X

pii

S1041610217000527

journal_volume

30

pub_type

杂志文章,评审
  • Midlife improvements in financial situation are associated with a reduced dementia risk later in life: the CAIDE 30-year study.

    abstract:OBJECTIVES:Perceived financial strain is associated with various health conditions, but it is unknown whether it is associated with an increased risk for dementia. The goal is to examine the associations between midlife perceptions of financial situation and dementia risk later in life. METHODS:Participants were deriv...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S104161021900173X

    authors: Sindi S,Darin-Mattsson A,Kåreholt I,Kulmala J,Ngandu T,Laatikainen T,Soininen H,Kivipelto M

    更新日期:2020-11-01 00:00:00

  • Healthcare utilization and monetary costs associated with agitation in UK care home residents with advanced dementia: a prospective cohort study.

    abstract:OBJECTIVE:Nearly half of care home residents with advanced dementia have clinically significant agitation. Little is known about costs associated with these symptoms toward the end of life. We calculated monetary costs associated with agitation from UK National Health Service, personal social services, and societal per...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610219002059

    authors: Buylova Gola A,Morris S,Candy B,Davis S,King M,Kupeli N,Leavey G,Moore K,Nazareth I,Omar R,Vickerstaff V,Jones L,Sampson EL

    更新日期:2020-03-01 00:00:00

  • Spirituality, social support, and flexibility among older adults: a five-year longitudinal study.

    abstract::ABSTRACTObjectives:The objectives of the study were to examine the trajectory of spirituality among older adults, to investigate the roles of gender and religion on the developmental trajectory of spirituality, and to explore whether the linear growth of spirituality accelerated or decelerated at time points at which ...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610218000029

    authors: Bailly N,Martinent G,Ferrand C,Agli O,Giraudeau C,Gana K,Roussiau N

    更新日期:2018-12-01 00:00:00

  • The course of neuropsychiatric symptoms in nursing-home patients with dementia over a 53-month follow-up period.

    abstract:BACKGROUND:Neuropsychiatric symptoms (NPS) are prevalent in nursing-home (NH) patients with dementia, but little is known about the long-term course of these symptoms. METHODS:In this study, 931 NH patients with dementia took part in a prospective cohort study with four assessments over a 53-month follow-up period. NP...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610213001609

    authors: Selbaek G,Engedal K,Benth JŠ,Bergh S

    更新日期:2014-01-01 00:00:00

  • Using sedatives-hypnotics or opioids in older adults: a narrow path.

    abstract::This issue of International Psychogeriatrics contains three papers from three continents that explore the use of sedatives-hypnotics and opioids in the treatment of older adults (Hamina et al., 2018; Machado-Duque et al., 2018; Tseng et al., 2018), and a fourth paper reporting on a qualitative study that addresses the...

    journal_title:International psychogeriatrics

    pub_type: 社论

    doi:10.1017/S104161021800087X

    authors: Davies SJC,Mulsant BH

    更新日期:2018-07-01 00:00:00

  • A retrospective, population-based cohort study of driving under the influence, Alzheimer's disease diagnosis, and survival.

    abstract::ABSTRACTIntroduction:The relationship between Alzheimer's Disease (AD) and alcohol addiction is poorly characterized. Arrests for driving under the influence (DUI) can serve as a proxy for alcohol addiction. Therefore, the potential association between DUI and AD could be helpful in understanding the relationship betw...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610218001151

    authors: Miller M,Orwat D,Rahimi G,Mintzer J

    更新日期:2019-04-01 00:00:00

  • "There isn't an easy way of finding the help that's available." Barriers and facilitators of service use among dementia family caregivers: a qualitative study.

    abstract:BACKGROUND:Family caregivers of people with dementia have significant unmet needs in regard to their caregiving role. Despite this, they are reluctant to utilize services to reduce their burden. The aim of this study was to examine the barriers and facilitators of service use among family caregivers of people with deme...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610216002532

    authors: Macleod A,Tatangelo G,McCabe M,You E

    更新日期:2017-05-01 00:00:00

  • The ABC of Alzheimer's disease: cognitive changes and their management in Alzheimer's disease and related dementias.

    abstract::Cognitive decline, commonly first recognized as memory impairment, is a typical feature of Alzheimer's disease (AD). Neuropathological changes in the cerebral cortex and limbic system lead to deficits in learning, memory, language, and visuospatial skills. The precise nature of cognitive dysfunction reflects the distr...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章,评审

    doi:10.1017/s1041610203008664

    authors: Corey-Bloom J

    更新日期:2002-01-01 00:00:00

  • Late life depression and dementia: a mental health literacy survey of Australian general practitioners.

    abstract:BACKGROUND:Whilst previous surveys of mental health literacy of general practitioners (GPs) have shown high rates of recognition of common mental disorders, few studies have been carried out into GPs' understanding of presentations in late life. This study aims to determine GPs' recognition of mental disorders in older...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610208008235

    authors: Wijeratne C,Harris P

    更新日期:2009-04-01 00:00:00

  • Suicide and aging in Japan: an examination of treated elderly suicide attempters.

    abstract::Although individuals aged 65 and over accounted for 12% of the total population of Japan in 1990, suicides in this age group consisted of 29% of all suicides. The elderly population of Japan is expected to grow rapidly to 24% of the total population by the year 2020, and suicide prevention for the elderly is an urgent...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/s1041610295002006

    authors: Takahashi Y,Hirasawa H,Koyama K,Asakawa O,Kido M,Onose H,Udagawa M,Ishikawa Y,Uno M

    更新日期:1995-07-01 00:00:00

  • Psychotherapy of an older adult with an avoidant personality disorder.

    abstract::This case describes the differential diagnosis and treatment of a 70-year-old man with an avoidant personality disorder. It illustrates that diagnostic assessment and treatment of personality problems in the elderly are possible in mental health care. It demonstrates that multiple stand-alone treatment modules can for...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610210001948

    authors: van Alphen SP

    更新日期:2011-05-01 00:00:00

  • Factors associated with long-term impact on informal caregivers during Alzheimer's disease dementia progression: 36-month results from GERAS.

    abstract:OBJECTIVE:To identify, in caregivers of patients with Alzheimer's disease (AD) dementia, factors associated with subjective (personal, physical, emotional, and social) and objective (informal caregiver time and costs) caregiver burden. DESIGN:Prospective longitudinal European observational study: post-hoc analysis. S...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610219000425

    authors: Reed C,Belger M,Scott Andrews J,Tockhorn-Heidenreich A,Jones RW,Wimo A,Dodel R,Haro JM

    更新日期:2020-02-01 00:00:00

  • Carer-held records for dementia: a controlled trial.

    abstract:BACKGROUND:A carer-held record (CHR) was developed to enable carers to contribute to care plans for their relatives with dementia, alongside other professionals. The aim of this study was to establish whether CHRs provide any measurable benefits for carers, in the areas of health, stress, knowledge of dementia and locu...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610205002565

    authors: Simpson R,Wakefield P,Spiers N,Jagger C,Lindesay J

    更新日期:2006-06-01 00:00:00

  • Use of benzodiazepines and cognitive performance in primary care patients with first cognitive complaints.

    abstract::ABSTRACTThe aim of the present study is to investigate the impact of benzodiazepine use on cognitive performance in primary care patients with first cognitive complaints. The association between the exposition to benzodiazepines (short and long half-life) and cognitive performance, evaluated through the Mini Mental St...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S104161021700223X

    authors: Grande G,Tramacere I,Vetrano DL,Pomati S,Mariani C,Filippini G

    更新日期:2018-04-01 00:00:00

  • Moving from the question of efficacy to the question of therapeutic relevance: an exploratory reanalysis of a controlled clinical study of 130 inpatients with dementia syndrome taking piracetam.

    abstract::The authors reanalyzed previously published data from a prospectively randomized, placebo-controlled, double-blind phase-III study of 130 inpatients with dementia syndrome. The patients in the study had been diagnosed as having suffered from organic brain syndrome (ICD 290), which is the core syndrome of dementia (so-...

    journal_title:International psychogeriatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1017/s1041610292000887

    authors: Herrmann WM,Stephan K

    更新日期:1992-07-01 00:00:00

  • Language use of older Italian-background persons with dementia in mainstream and ethno-specific residential care.

    abstract:BACKGROUND:Australia has a growing aging migrant population and rates of dementia in residential care are high. The communication of persons with dementia and limited English language proficiency in residential care is an area that has received little attention in the research literature. METHOD:Thirty-nine Italian-ba...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610205002309

    authors: Runci SJ,Redman JR,O'Connor DW

    更新日期:2005-12-01 00:00:00

  • Assessing the cumulative effects of exposure to selected benzodiazepines on the risk of fall-related injuries in the elderly.

    abstract:BACKGROUND:The use of benzodiazepines is associated with increased risk of fall-related injuries in the elderly. However, it is unclear if the risks vary across the products and how they depend on the pattern of use and dosage. Specifically, the possibility of cumulative effects of past benzodiazepine use has not been ...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610211002031

    authors: Sylvestre MP,Abrahamowicz M,Čapek R,Tamblyn R

    更新日期:2012-04-01 00:00:00

  • Neuropsychiatric symptom clusters of Alzheimer's disease in Hong Kong Chinese: prevalence and confirmatory factor analysis of the Neuropsychiatric Inventory.

    abstract:BACKGROUND:The aim of this study was to investigate the clustering of symptoms on the Neuropsychiatric Inventory (NPI) and the relative prevalence of symptom clusters in mild and moderate Alzheimer's disease (AD). METHODS:Confirmatory factor analysis (CFA) was performed on the polychoric correlation matrix of 12 NPI i...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610212000609

    authors: Cheng ST,Kwok T,Lam LC

    更新日期:2012-09-01 00:00:00

  • Sense of community in long-term care: the views of family caregivers of elderly military veterans.

    abstract:BACKGROUND:Family involvement in long-term care (LTC) is important but it can prove challenging and result in conflict with staff if families do not feel connected to the LTC facility or if they believe that their contributions are undervalued. According to McMillan & Chavis (1986), sense of community (SOC) refers to a...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610212001524

    authors: Petrovic-Poljak A,Konnert C

    更新日期:2013-03-01 00:00:00

  • Impact of socioeconomic status on the prevalence of dementia in an inner city memory disorders clinic.

    abstract:BACKGROUND:Socioeconomic status (SES) has been identified as a possible risk factor for the development of dementia, with low SES shown to be associated with a higher prevalence of dementia, increased psychiatric comorbidity and worse baseline cognitive functioning. Few studies have actually looked at the impact of SES...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610209990846

    authors: Fischer C,Yeung E,Hansen T,Gibbons S,Fornazzari L,Ringer L,Schweizer TA

    更新日期:2009-12-01 00:00:00

  • The experiences and needs of children living with a parent with young onset dementia: results from the NeedYD study.

    abstract:BACKGROUND:Children of patients with young onset dementia (YOD) who are confronted with a parent who has a progressive disease, often assist in caregiving tasks, which may have a great impact on their lives. The objective of the present study is to explore the experiences of children living with a young parent with dem...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610213001890

    authors: Millenaar JK,van Vliet D,Bakker C,Vernooij-Dassen MJ,Koopmans RT,Verhey FR,de Vugt ME

    更新日期:2014-12-01 00:00:00

  • Depression in the first year of stay for elderly long-term nursing home residents in the USA.

    abstract:BACKGROUND:Understanding the prevalence, incidence and cofactors of depression among long-term elderly nursing home (LTNH) residents domiciled for eight months or more may help optimize depression treatment in this vulnerable group. We quantified first year depression in American LTNH residents and the associations bet...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610210000578

    authors: Hoover DR,Siegel M,Lucas J,Kalay E,Gaboda D,Devanand DP,Crystal S

    更新日期:2010-11-01 00:00:00

  • Does bipolar disorder have a benign course?

    abstract::Written records have been describing extreme states of emotions since ancient Greece (Angst and Marneros, 2001), but Aretaeus of Cappadocia (which is geographically located in modern Turkey) was probably the first to outline the close relationship between depression and mania nearly 2000 years ago: "I think that melan...

    journal_title:International psychogeriatrics

    pub_type: 社论

    doi:10.1017/S1041610216001423

    authors: Almeida OP

    更新日期:2016-11-01 00:00:00

  • The Behavior Problems Checklist-Spanish: a preliminary study of a new scale for the assessment of depressive symptoms and disruptive behaviors in Hispanic patients with dementia.

    abstract::Few instruments are available with which to measure behavioral and psychological signs and symptoms in Hispanic patients with dementia. Therefore, the aim of the current study was to develop and evaluate a 17-item scale adapted from the Revised Memory and Behavior Problems Checklist. This measure, the Behavior Problem...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/s1041610201007438

    authors: Harwood DG,Barker WW,Ownby RL,Bravo M,Aguero H,Duara R

    更新日期:2001-03-01 00:00:00

  • The quality of the relationship perceived by spouses of people with young-onset dementia.

    abstract:BACKGROUND:Young-onset dementia (YOD) has a profound impact on spouses. However, little is known on how the quality of the relationship changes over time in YOD. This study aims to determine how the quality of the relationship changes over time and identify predictors of this change. METHODS:This study used data from ...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610220000332

    authors: Bruinsma J,Peetoom K,Millenaar J,Köhler S,Bakker C,Koopmans R,Pijnenburg Y,Verhey F,de Vugt M

    更新日期:2020-03-10 00:00:00

  • Subjective depressive mood and regional cerebral blood flow in mild Alzheimer's disease.

    abstract:BACKGROUND:Depressive symptoms are common in patients with Alzheimer's disease (AD) and increase the caregiver burden, although the etiology and pathologic mechanism of depressive symptoms in AD patients remain unclear. In this study, we tried to clarify the cerebral blood flow (CBF) correlates of subjective depressive...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610213002573

    authors: Honda H,Terada S,Sato S,Oshima E,Ikeda C,Nagao S,Yokota O,Uchitomi Y

    更新日期:2014-05-01 00:00:00

  • Global rating, symptoms, behavior, and cognitive performance as indicators of efficacy in clinical studies with nimodipine in elderly patients with cognitive impairment syndromes.

    abstract::Nimodipine is a calcium antagonist which improves learning and memory in brain-lesioned or aged animals (LeVere & Sandin, 1989; Schuurman & Traber, 1989). It also accelerates the recovery of experimentally damaged sciatic nerves (van der Zee et al., 1987) and reduces age-associated gait abnormalities in aging rats (Sc...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章,评审

    doi:

    authors: Schmage N,Bergener M

    更新日期:1992-01-01 00:00:00

  • Behavioral symptoms in vascular cognitive impairment and vascular dementia.

    abstract::Noncognitive or behavioral and psychological symptoms (BPSD) are common in vascular dementia. Many occur with the same frequency as in Alzheimer's disease, though depression, emotional lability, and apathy may be more common and psychosis less so. There is a particularly strong relationship between cerebrovascular dis...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/S1041610203009098

    authors: O'Brien J

    更新日期:2003-01-01 00:00:00

  • The GDS/FAST staging system.

    abstract::Staging methodologies are an essential tool in the assessment of disease severity in progressive dementing illness. Several different instruments have been developed for this purpose. One of the most widely used methodologies is the Global Deterioration Scale/Functional Assessment Staging (GDS/FAST) system. This syste...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章

    doi:10.1017/s1041610297004869

    authors: Auer S,Reisberg B

    更新日期:1997-01-01 00:00:00

  • The concept of quality of life in dementia in the different stages of the disease.

    abstract::In order to conceptually define quality of life (QOL) in dementia, the literature on QOL in the elderly population, in chronic disease and in dementia was studied. Dementia is a progressive, age-related, chronic condition and to avoid omissions within the dementia-specific concept of QOL, a broad orientation was the p...

    journal_title:International psychogeriatrics

    pub_type: 杂志文章,评审

    doi:10.1017/s1041610205002073

    authors: Ettema TP,Dröes RM,de Lange J,Ooms ME,Mellenbergh GJ,Ribbe MW

    更新日期:2005-09-01 00:00:00