Abstract:
OBJECTIVES:The aim of this study was to investigate survival time and life-expectancy in people with young-onset dementia (YOD) and to examine the relationship with age, sex, dementia subtype and comorbidity. DESIGN, SETTING AND PARTICIPANTS:Survival was examined in 198 participants in the Needs in Young-onset Dementia study, including participants with Alzheimer's dementia (AD), vascular dementia (VaD) and frontotemporal dementia (FTD). MEASURES:The primary outcomes were survival time after symptom onset and after date of diagnosis. Cox proportional hazards models were used to explore the relationship between survival and age, sex, dementia subtype and comorbidity. Additionally, the impact on remaining life expectancy was explored. RESULTS:During the six-year follow-up, 77 of the participants died (38.9%), 78 participants survived (39.4%) and 43 were lost to follow-up (21.7%). The mean survival time after symptom onset and diagnosis was 209 months (95% CI 185-233) and 120 months (95% CI 110-130) respectively. Participants with AD had a statistically significant shorter survival compared with VaD participants, both regarding survival after symptom onset (p = 0.047) as well as regarding survival after diagnosis (p = 0.049). Younger age at symptom onset or at diagnosis was associated with longer survival times. The remaining life expectancy, after diagnosis, was reduced with 51% for males and 59% for females compared to the life expectancy of the general population in the same age groups. CONCLUSION/IMPLICATIONS:It is important to consider the dementia subtype when persons with YOD and their families are informed about the prognosis of survival. Our study suggests longer survival times compared to other studies on YOD, and survival is prolonged compared to studies on LOD. Younger age at symptom onset or at diagnosis was positively related to survival but diagnosis at younger ages, nevertheless, still diminishes life expectancy dramatically.
journal_name
Int Psychogeriatrjournal_title
International psychogeriatricsauthors
Gerritsen AAJ,Bakker C,Verhey FRJ,Pijnenburg YAL,Millenaar JK,de Vugt ME,Koopmans RTCMdoi
10.1017/S1041610219000152subject
Has Abstractpub_date
2019-12-01 00:00:00pages
1781-1789issue
12eissn
1041-6102issn
1741-203Xpii
S1041610219000152journal_volume
31pub_type
杂志文章,多中心研究abstract:BACKGROUND:Research on the behavioral correlates of anxiety in older adults is sparse. The aim of this study was to explore the association of anxiety with behavioral patterns defined by health, activity, emotional and social variables. METHODS:A convenience sample of 395 older adults completed measures of health, act...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610214001148
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:There is a paucity of simulation-based dementia education programmes for acute care settings that support the development of interpersonal skills pertinent to good care. Moreover, few studies measure the effectiveness of such programmes by evaluating the persistence of practice change beyond the immediate ti...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610218002193
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Official health organizations have established the dose of physical activity needed for preserving both physical and psychological health in old age. The objective of this study was to explore whether adherence to the recommended criterion of physical activity accounted for better psychological functioning i...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212001299
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Patient and carer participation in old age psychiatry is less developed than in other areas of mental health. What can we learn from the historical context about increasing participation and how can it be conceptualized? METHODS:The historical and policy context of patient and carer participation in the Nat...
journal_title:International psychogeriatrics
pub_type: 历史文章,杂志文章,评审
doi:10.1017/S1041610211001864
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:It remains unclear so far whether the role of cognitive reserve may differ between physically frail compared to less frail individuals. Therefore, the present study set out to investigate the relation of key markers of cognitive reserve to cognitive status in old age and its interplay with physical frailty i...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217000795
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Delirium is frequently observed in clinical practice, particularly in medical and surgical wards and more so among patients at risk, especially elderly with preexisting central nervous system impairments. OBJECTIVE:Despite the severe consequences of delirium, epidemiological data relating to incidence of de...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610202008499
更新日期:2002-09-01 00:00:00
abstract::Few would argue that achieving the age of 100 years is extraordinary, but what about the quality of life at this extreme age? Is it worth it to live to 100 and beyond? The study by Araújo, Ribero, Teixeira, and Paúl (2015) in three ways provided an answer to this question substantiating and complementing recent findin...
journal_title:International psychogeriatrics
pub_type: 评论,杂志文章
doi:10.1017/S1041610215002021
更新日期:2016-02-01 00:00:00
abstract::ABSTRACTBackground:The aim of this study is to identify the prevalence and risk factors of documented delirium in general practices in Germany. METHODS:The present study includes 2,194 patients over the age of 65 years with delirium and 2,194 controls without delirium from a sample of 6,180,042 patients from 1,262 ge...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217002587
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVES:Social reserve such as having close friends helps promoting activity engagement in old age. Activity engagement in turn contributes to the accumulation of cognitive reserve and is a key predictor for maintaining executive functioning in aging. We investigated the mediating role of leisure activity engagement...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610219001789
更新日期:2019-12-23 00:00:00
abstract:OBJECTIVE:Cognitive impairment and negative signs are common in patients with schizophrenia. Up to 35% of elderly patients with schizophrenia fulfill the diagnostic criteria of dementia. Donepezil inhibits cholinesterase, thus enhancing cholinergic neurotransmission. We tested the efficacy of donepezil in elderly patie...
journal_title:International psychogeriatrics
pub_type: 杂志文章,随机对照试验
doi:10.1017/S1041610205003017
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:Vocally disruptive behavior (VDB) in the elderly is a common condition, especially in people with dementia, but difficult to treat. It may occur in as many as 40% of nursing home residents. This study is a review of the existing literature on this condition. METHOD:The literature review was conducted using ...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/S1041610208006728
更新日期:2008-08-01 00:00:00
abstract::Seventy-eight nondemented elderly depressed patients underwent an extensive battery of cognitive tests both before and after seven weeks of treatment with nortriptyline, phenelzine, or placebo. Clinical and cognitive evaluations of the patients were under double-blind conditions. Response to treatment did not appear t...
journal_title:International psychogeriatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/s1041610289000141
更新日期:1989-10-01 00:00:00
abstract:OBJECTIVES:Geriatric depression complicates cognitive health in older adults. This study aims to investigate the impact of depressive symptoms on cognitive impairment in community-dwelling older adults, depending on whether cognitive dysfunction accompanied. DESIGN:A community-based longitudinal cohort study. SETTING...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610220003622
更新日期:2020-11-16 00:00:00
abstract::The focus of this report is the treatment of persons with dementia who are of a non-English-speaking background (NESB). Noisemaking is one behavioral manifestation associated with severe dementia. It can have devastating effects on persons with dementia by limiting their access to activity programs and social interact...
journal_title:International psychogeriatrics
pub_type: 临床试验,杂志文章
doi:10.1017/s1041610299005864
更新日期:1999-09-01 00:00:00
abstract:OBJECTIVES:While family caregivers (CGs) of persons with dementia are cost-effective for the health system, this form of caregiving leads to disproportionate vulnerability to physical, mental, and social adverse health consequences among CGs. The study goal was to determine the effect of the Reitman Centre CARERS progr...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610220004019
更新日期:2021-01-18 00:00:00
abstract::Over 20 years ago, the Australian Liberal/National Party Federal Opposition had a set of policies with which it hoped to persuade the Australian people to return it to government in the election due in 1996. This particular collection of proposed initiatives was called "The things that matter". When the then leader of...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610216000387
更新日期:2016-06-01 00:00:00
abstract:UNLABELLED:This article reports the findings of a 3-year epidemiological survey for dementia in an urban community-resident population in Mumbai (Bombay), India, wherein the prevalence of all types of dementia was determined. METHOD:The study was conducted in three stages. Stage 1: From a potential pool of 30,000 subj...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610201007852
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND:In old age, both apathy and depression have been associated with an increased cardiovascular disease (CVD) risk. This study evaluated the mediating role of cardiovascular risk factors in the relationship of apathy and mood symptoms with incident CVD. METHODS:Prospective cohort study of 1,790 community-dwell...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610215001751
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVES:Issues concerning the association among attachment anxiety, depression and suicidal ideation among the elderly have rarely been explored. The present study investigated the relationship among attachment anxiety, depression and perceived support concerning suicidal ideation among older people. DESIGN:Cross-s...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S104161022000054X
更新日期:2020-05-07 00:00:00
abstract:BACKGROUND:It is of considerable public health importance to prevent or delay the progression of mild cognitive impairment (MCI) to more severely impaired cognitive states. This study examines the risk of progression from mild to severe cognitive impairment in relation to engagement in social activities while mildly im...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212002086
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:A past history of self-harm is a significant risk factor for suicide in older people. The aims of this study are to (i) characterize older people who present with self-harm to emergency departments (EDs); and (ii) determine the predictors for repeat self-harm and suicide. METHODS:Demographic and clinical da...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217000308
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Most research on family members' experience of dementia has focused on the time after diagnosis. Yet, once people reach clinical attention, families have already been living with the changes for some time. These pre-diagnosis experiences can influence later caregiving. We aimed to synthesize qualitative rese...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/S1041610217000862
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:The purpose of the study was to examine the attention deficit hyperactivity disorder (ADHD) symptomatology across the lifespan by comparing older individuals' self-reports about current ADHD symptoms and symptoms in childhood. METHODS:The 25-item Wender Utah Rating Scale (WURS) was initially administered in...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212002050
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:Religious and spiritual issues are clearly important to the older adult population and may play a positive role in maintaining health and recovering from illness. This study systematically reviewed the literature examining the effects of religion and spirituality on health outcomes such as cognitive function...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/S1041610214001665
更新日期:2015-05-01 00:00:00
abstract::In this review, we explore the relationship between epilepsy and cognition and between epilepsy and dementia. Chronic epilepsy, particularly mesial temporal lobe epilepsy (MTLE) with hippocampal sclerosis, may be associated with impaired cognition, which can be secondary to uncontrolled seizures, to adverse effects of...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/s1041610205002024
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Aggressive behavior (AB) is common in institutional settings. It is an important issue because of its consequences on both the person manifesting such behaviors and their caregivers. Although there are numerous studies assessing non-pharmacologic strategies to manage AB in older adults, no extensive review o...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610205002929
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND:Verbal fluency (VF) tasks are simple and efficient clinical tools to detect executive dysfunction and lexico-semantic impairment. VF tasks are widely used in patients with suspected dementia, but their accuracy for detection of mild cognitive impairment (MCI) is still under investigation. Schooling in partic...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610209990639
更新日期:2009-12-01 00:00:00
abstract::Few instruments are available with which to measure behavioral and psychological signs and symptoms in Hispanic patients with dementia. Therefore, the aim of the current study was to develop and evaluate a 17-item scale adapted from the Revised Memory and Behavior Problems Checklist. This measure, the Behavior Problem...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610201007438
更新日期:2001-03-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the clustering of symptoms on the Neuropsychiatric Inventory (NPI) and the relative prevalence of symptom clusters in mild and moderate Alzheimer's disease (AD). METHODS:Confirmatory factor analysis (CFA) was performed on the polychoric correlation matrix of 12 NPI i...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212000609
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:The aim of this study was to examine the impact of residential respite care on disruptive behavior displayed by older people, particularly those with dementia. METHODS:A quasi-experimental, repeated-measures, single-group design was used. The participants were a consecutive series of 100 older people with a...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610205002553
更新日期:2006-03-01 00:00:00