Abstract:
BACKGROUND:Vitiligo is an acquired pigmentary disorder of the skin. Genetic factors, oxidative stress, autoimmunity, and neurochemical agents might be contributing factors for the development of the disease. AIMS:To evaluate the oxidative stress level and tyrosinase activity in vitiligo patients and to compare them with healthy volunteers. MATERIALS AND METHODS:We used Comet assay to evaluate DNA strand breaks in peripheral blood cells of active vitiligo patients. We then extracted total protein from lesional and nonlesional skin of ten selected patients. Tyrosinase activity was found to play a crucial role in melanogenesis. RESULTS:The basal level of systemic oxidative DNA strand breaks in leukocytes increased in vitiligo patients compared to healthy participants. We observed that tyrosinase activity in lesional skin was lower than in nonlesional skin. CONCLUSION:Our finding suggests that increased levels of oxidative stress might impact tyrosinase activity and eumelanin synthesis via anabolism pathway of melanin synthesis. In sum, we observed a negative correlation between levels of systemic oxidative stress and of tyrosinase activity.
journal_name
Indian J Dermatoljournal_title
Indian journal of dermatologyauthors
Eskandani M,Golchai J,Pirooznia N,Hasannia Sdoi
10.4103/0019-5154.60344subject
Has Abstractpub_date
2010-01-01 00:00:00pages
15-9issue
1eissn
0019-5154issn
1998-3611journal_volume
55pub_type
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