Comorbidity of leishmania major with cutaneous sarcoidosis.

Abstract:

BACKGROUND:leishmaniasis infection might manifest as sarcoidosis; on the other hand, some evidences propose an association between sarcoidosis and leishmaniasis. Most of the times, it is impossible to discriminate idiopathic sarcoidosis from leishmaniasis by conventional histopathologic exam. AIM:We performed a cross-sectional study to examine the association of sarcoidosis with leishmaniasis in histopathologically diagnosed sarcoidal granuloma biopsy samples by polymerase chain reaction (PCR). MATERIALS AND METHODS:We examined paraffin-embedded skin biopsy samples obtained from patients with clinical and histopathological diagnosis as naked sarcoidal granuloma, referred to Skin Research Center of Shaheed Beheshti Medical University from January 2001 to March 2010, in order to isolate Leishmania parasite. The samples were reassessed by an independent dermatopathologist. DNA extracted from all specimens was analyzed by the commercially available PCR kits (DNPTM Kit, CinnaGen, Tehran, Iran) to detect endemic Leishmania species, namely leishmania major (L. major). RESULTS:L. major was positive in PCR of Eight out of twenty-five examined samples. CONCLUSION:Cutaneous leishmaniasis may be misinterpreted as sarcoidosis; in endemic areas, when conventional methods fail to detect Leishmania parasite, PCR should be utilized in any granulomatous skin disease compatible with sarcoidosis, regardless of the clinical presentation or histopathological interpretation.

journal_name

Indian J Dermatol

authors

Moravvej H,Vesal P,Abolhasani E,Nahidi S,Mahboudi F

doi

10.4103/0019-5154.131453

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

316

issue

3

eissn

0019-5154

issn

1998-3611

pii

IJD-59-316b

journal_volume

59

pub_type

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