Abstract:
AIM:To evaluate whether oxidative stress is implicated in melanocyte damage in vitiligo. BACKGROUND:Vitiligo is a complex disorder characterized by gradually enlarging areas of depigmentation. A new unifying hypothesis for the etiology of this pigment disorder is proposed, in which we postulate that the final destruction of melanocytes in vitiligo results from a cascade of reactions initiated by a disregulation of melanogenesis, as the result of a breakdown in free radical defense. METHODS:We evaluated 18 vitiligo mice and 12 controls that were age matched. Parameters of oxidative stress such as catalase (CAT), superoxide dismutase (SOD), and plasma malondialdehyde (MDA) were measured by spectrophotometry. RESULTS:MDA levels in vitiligo mice were significantly higher than in controls (P < 0.001). CAT, SOD, and glutathione peroxidase (GPx) activities in mice were significantly lower than controls (P < 0.05 and P < 0.001, respectively). CONCLUSION:Our results confirmed that oxidative stress plays an important role in the pathogenesis of vitiligo. Melanocyte damage in vitiligo might be linked to generalized oxidative stress. This study is the first report on antioxidant parameters in experimental vitiligo mice.
journal_name
Indian J Dermatoljournal_title
Indian journal of dermatologyauthors
Jalel A,Yassine M,Hamdaoui MHdoi
10.4103/0019-5154.55628subject
Has Abstractpub_date
2009-07-01 00:00:00pages
221-4issue
3eissn
0019-5154issn
1998-3611journal_volume
54pub_type
杂志文章,收录出版abstract:BACKGROUND:Alopecia areata (AA) is a common, chronic inflammatory disease characterized by nonscarring hair loss on the scalp or any hair-bearing area of the body. Recently, dermoscopy, a noninvasive diagnostic procedure, has been employed for the diagnosis of AA. AIM:To evaluate various dermoscopic patterns in AA and...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
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journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.174076
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journal_title:Indian journal of dermatology
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journal_title:Indian journal of dermatology
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.4103/0019-5154.70678
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pub_type: 杂志文章
doi:10.4103/0019-5154.156388
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2015-03-01 00:00:00
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pub_type: 杂志文章
doi:10.4103/0019-5154.74568
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.4103/0019-5154.80409
更新日期:2011-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00