Systemic Retinoids and Scar Dehiscence.

Abstract:

:Systemic retinoids such as isotretinoin and acitretin are associated with numerous side effects but are therapeutically valuable in dermatological practice. Several studies have reported the wound-healing effects of treatment with concurrent systemic retinoids in addition to surgical treatments. Herein, we describe two patients with scar dehiscence that developed after initiation of systemic retinoid treatment following cutaneous surgery. In Case 1, isotretinoin was thought to decrease collagen production to a greater degree than did degradation during the wound remodeling phase, which resulted in wound dehiscence. In Case 2, acitretin was thought to decrease fibroblast proliferation and collagen production during the proliferation phase of wound healing, which resulted in wound dehiscence. Based on the two presented cases, it is advisable to postpone systemic retinoid treatment for 6 months to 1 year following cutaneous surgery, located especially in cosmetically important sites.

journal_name

Indian J Dermatol

authors

Aksoy HM,Aksoy B,Çalikoglu E

doi

10.4103/ijd.IJD_148_18

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

68-70

issue

1

eissn

0019-5154

issn

1998-3611

pii

IJD-64-68

journal_volume

64

pub_type

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