Abstract:
Background:Acitretin is a widely used systemic retinoid in the treatment of psoriasis. Dosage of acitretin in not weight adjusted due to certain interindividual variations. Objective:To evaluate the clinical efficacy and effects on biochemical parameters of fixed tapering dosage of acitretin in patients with psoriasis administered over a period of 4 weeks. Materials and Methods:This was an observational study. The study included patients of psoriasis vulgaris in the age group of 18 and 65 years with a psoriasis area severity index (PASI) score of >10 which was not responsive to topical therapy and phototherapy. Patients were given oral acitretin daily at a dose of 25 mg BD for 2 weeks, which was later tapered to 25 mg OD for another 2 weeks. The clinical efficacy and biochemical parameters were assessed. Results:Out of the 18 patients, PASI 75 was achieved in 66% of the patients by the end of the third week. Significant elevations were noted in serum lipids during 4 weeks, which returned to normal limits or near baseline levels at the end of 4 weeks. Conclusion:Fixed tapering dose of acitretin is effective in psoriasis with minimal clinical and biochemical adverse events.
journal_name
Indian J Dermatoljournal_title
Indian journal of dermatologyauthors
Pai VV,Phadke D,Shukla P,Naik Kdoi
10.4103/ijd.IJD_300_18subject
Has Abstractpub_date
2019-05-01 00:00:00pages
213-216issue
3eissn
0019-5154issn
1998-3611pii
IJD-64-213journal_volume
64pub_type
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journal_title:Indian journal of dermatology
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pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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