The Evaluation of Endothelin-1 and Endothelin Receptor Type A Gene Polymorphisms in Patients with Vitiligo.

Abstract:

BACKGROUND:Endothelin-1 (EDN1) and EDN receptor type A (EDNRA) are implicated in melanocyte functions. AIM AND OBJECTIVES:This study examines the role of EDN1 (G5665T and T-1370G) and EDNRA (C + 70G and G-231A) polymorphisms as a risk factor for vitiligo, and evaluates the relationship between genotypes and clinical characteristics of vitiligo patients. MATERIALS AND METHODS:We analyzed genotype/allele distributions of EDN1 and EDNRA polymorphisms in 100 patients with vitiligo and 185 healthy controls by real-time polymerase chain reaction. RESULTS:There was no notable risk for vitiligo afflicted by studied polymorphisms. However, the presence of EDNRA +70 variant G allele was found to be related with decreased risk for development of generalized type of vitiligo (odds ratio [OR]: 0.42, 95% confidence interval [CI] = 0.21-0.86, pcorr = 0.03) and showed protective effect against associated diseases seen in vitiligo (OR: 0.49, 95% CI = 0.27-0.88, pcorr = 0.034). Haplotype analysis demonstrated a strong (disequilibrium coefficient = 0.73, r (2) = 0.405) linkage disequilibrium between EDN1 G5665T and T-1370G polymorphisms. The EDN1 5665/-1330 TT haplotype was over represented significantly in controls than in patients (P = 0.04). CONCLUSION:The studied polymorphisms do not seem to be a major risk for vitiligo. Haplotype analysis denoting protective effects against vitiligo may indicate an indirect interaction in the course of vitiligo. In addition, EDNRA + 70 polymorphism is protective against generalized type of vitiligo and associated diseases.

journal_name

Indian J Dermatol

authors

Bingül İ,Aydıngöz İE,Vural P,Doğru-Abbasoğlu S,Uysal M

doi

10.4103/0019-5154.174076

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

118

issue

1

eissn

0019-5154

issn

1998-3611

pii

IJD-61-118b

journal_volume

61

pub_type

杂志文章
  • Aquagenic keratoderma treated with tap water iontophoresis.

    abstract::Aquagenic keratoderma (AK) is a rare acquired skin condition characterized by recurrent and transient white papules and plaques associated with a burning sensation, pain, pruritus and/or hyperhidrosis on the palms and more rarely, soles triggered by sweat or contact with water. Often AK cause significant discomfort, t...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.152568

    authors: Errichetti E,Piccirillo A

    更新日期:2015-03-01 00:00:00

  • Olmsted Syndrome: Rare Occurrence in Four Siblings.

    abstract::Olmsted syndrome is a very rare and severe cicatrizing keratoderma associated with periorificial lesion. Most cases are sporadic but familial occurrence has been also seen. Till now around 73 cases have been reported and none of the reported cases have 4 siblings affected from this disease. We are reporting cases of 4...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.182467

    authors: Bukharia A,Komal S,Sudhanan VM,Chaudhary SS

    更新日期:2016-05-01 00:00:00

  • Atypical fibroxanthoma: an unusual skin neoplasm in xeroderma pigmentosum.

    abstract::Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder related to defective deoxyribonucleic acid (DNA) repair. Various cutaneous manifestations related to ultraviolet (UV) damage characterize the clinical course. Primary malignant cutaneous neoplasms like squamous cell carcinoma, basal cell carcinoma and m...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.100493

    authors: Bandyopadhyay R,Nag D,Bandyopadhyay S,Sinha SK

    更新日期:2012-09-01 00:00:00

  • Mucocutaneous manifestations of chikungunya Fever: a study from an epidemic in coastal karnataka.

    abstract:BACKGROUND:Chikungunya fever (CF) epidemic has recently re-emerged in India affecting large population. Mucocutaneous manifestations are an important clinical feature of the disease. We have reviewed mucocutaneous manifestations of the disease during a recent epidemic in coastal Karnataka. PATIENTS AND METHODS:Seventy...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.82483

    authors: Bhat RM,Rai Y,Ramesh A,Nandakishore B,Sukumar D,Martis J,Kamath GH

    更新日期:2011-05-01 00:00:00

  • Hirsutism in Kashmir: an etiological study.

    abstract:BACKGROUND:Hirsutism refers to the presence of terminal hairs at the body sites under androgenic control. Various factors, including genetic makeup and hormonal status, influence the rate and pattern of hair growth at these sites. PURPOSE:To study the pattern of hirsutism in Kashmir. MATERIALS AND METHODS:Thirty five...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.48997

    authors: Ahmad QM,Shah IH,Sameem F,Kamili QU,Sultan J

    更新日期:2009-01-01 00:00:00

  • Generalized eruptive syringoma.

    abstract::Eruptive syringoma is a very rare variant of syringoma. It is a benign adnexal tumor of the intraepidermal portion of eccrine sweat ducts. Here we report a 32-year-old female presented with classical asymptomatic eruptive syringomas involving her face and extremities. ...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.152586

    authors: Avhad G,Ghuge P,Jerajani HR

    更新日期:2015-03-01 00:00:00

  • Skin as a marker of internal disease: a case of sarcoidosis.

    abstract::A 52-year-old female presented to our out patient department with asymptomatic, hypopigmented lesions on the neck and back since 2 months. There was a history of taking antitubercular treatment for suspected pulmonary tuberculosis 2 years back. On blood investigations, the serum angiotensin converting enzyme levels we...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.84756

    authors: Gautam M,Patil S,Munde P

    更新日期:2011-07-01 00:00:00

  • POEMS Syndrome with Extensive Calciphylaxis: A Case Report and Literature Review.

    abstract::POEMS syndrome, a paraneoplastic disorder, caused by plasma cell dyscrasia, is characterized by polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes. Calciphylaxis is a vasculopathy of subcutaneous arteries with calcification and skin ulceration, most commonly associated with end-stage renal disea...

    journal_title:Indian journal of dermatology

    pub_type:

    doi:10.4103/ijd.IJD_492_18

    authors: Liu CH,Chen YC,Chen TY,Huang HW,Lee JY

    更新日期:2020-11-01 00:00:00

  • Acrokeratosis verruciformis of hopf along lines of blaschko.

    abstract::Acrokeratosis verruciformis of Hopf (AKV) is a rare genodermatosis presenting as multiple plane wart-like lesions symmetrically distributed on dorsum of hands and feet. Its pathogenesis is unknown. A case of 24 years old female is described with multiple hyperpigmented, hyperkeratotic papules on the left side of body ...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.117324

    authors: Nair PA

    更新日期:2013-09-01 00:00:00

  • No Evidence of Human Papillomaviruses in Non-genital Seborrheic Keratosis.

    abstract:BACKGROUND:Seborrheic keratosis (SK) is a benign epidermal tumor of unknown etiology. Because of its wart-like morphology, Human papillomaviruses (HPVs) have been suggested as a possible causative agent. Viral involvement, however, has not been confirmed yet despite research and the association between HPVs and seborrh...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.113949

    authors: Meibodi NT,Nahidi Y,Meshkat Z,Esmaili H,Gharib M,Gholoobi A

    更新日期:2013-07-01 00:00:00

  • Punctate vascular papules on the tongue and scrotum.

    abstract::We report a 60-year-old man who presented with a 2-year history of painless red raised lesions involving the tongue and scrotum. Histopathology was suggestive of angiokeratoma. Oral angiokeratomas are most commonly found as a component of the generalized systemic disorder in Fabry's disease or fucosidosis. Our patient...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.96207

    authors: Pahwa P,Meena D,Tanveer N,Sharma VK,Sethuraman G

    更新日期:2012-05-01 00:00:00

  • Tender skin nodules in a newborn.

    abstract::Subcutaneous fat necrosis of infancy is a rare disorder of subcutaneous adipose tissue that is sometimes complicated by hypercalcemia. Complete resolution is common. From the pediatrician's point of view, the disease is a rare but important cause of inconsolable cry in a newborn. ...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.113983

    authors: Coondoo A,Lahiry R,Choudhury A,Sengupta S

    更新日期:2013-07-01 00:00:00

  • Methodology Series Module 8: Designing Questionnaires and Clinical Record Forms.

    abstract::As researchers, we often collect data on a clinical record form or a questionnaire. It is an important part of study design. If the questionnaire is not well designed, the data collected will not be useful. In this section of the module, we have discussed some practical aspects of designing a questionnaire. It is usef...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/ijd.IJD_76_17

    authors: Setia MS

    更新日期:2017-03-01 00:00:00

  • Kindler'S syndrome: a case series of three Indian children.

    abstract::Kindler's syndrome is a very rare genodermatosis characterized by acral blistering starting in infancy, photosensitivity, progressive poikiloderma, cutaneous atrophy, and various forms of mucosal involvement. A large number of other cutaneous and extracutaneous features have also been described. We report here three c...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.74568

    authors: Ghosh SK,Bandyopadhyay D,Das J,Chatterjee G,Sarkar S

    更新日期:2010-10-01 00:00:00

  • Transient idiopathic primary penoscrotal edema.

    abstract::We present the case of a male born prematurely at 32 weeks gestation by cesarean section following overt symptoms of maternal preeclampsia. He developed severe penoscrotal edema anew one month from birth. No remarkable exposure or trauma was identified. This unexplained swelling remained uniform till 4 months of age, ...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.117340

    authors: Namir SA,Trattner A

    更新日期:2013-09-01 00:00:00

  • Phenytoin Induced Cutaneous B Cell Pseudolymphoma.

    abstract::Cutaneous pseudolymphomas are benign lymphoproliferative processes mimicking lymphomas clinically and histologically. One of the precipitating factors for pseudolymphoma is drugs like anticonvulsants, antidepressants and angiotensin-converting enzyme inhibitors. According to existing literature phenytoin-induced cutan...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.164437

    authors: Riyaz N,Sasidharanpillai S,Aravindan KP,Nobin BK,Raghavan NT,Nikhila PK

    更新日期:2015-09-01 00:00:00

  • Bilateral Multisegmental Zosteriform Leiomyoma Cutis: A Rare Entity.

    abstract::Cutaneous leiomyomas are benign tumors derived from the smooth muscles of the skin. They are firm, skin-colored to brownish, frequently painful papules and nodules presenting either as a solitary tumor or multiple clustered lesions. Uncommon patterns of multiple leiomyoma cutis include linear, zosteriform, or dermatom...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.156388

    authors: Bandyopadhyay D,Saha A,Bhattacharya S

    更新日期:2015-05-01 00:00:00

  • Oxidative stress level and tyrosinase activity in vitiligo patients.

    abstract:BACKGROUND:Vitiligo is an acquired pigmentary disorder of the skin. Genetic factors, oxidative stress, autoimmunity, and neurochemical agents might be contributing factors for the development of the disease. AIMS:To evaluate the oxidative stress level and tyrosinase activity in vitiligo patients and to compare them wi...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.60344

    authors: Eskandani M,Golchai J,Pirooznia N,Hasannia S

    更新日期:2010-01-01 00:00:00

  • Idiopathic calcinosis cutis of the vulva.

    abstract:BACKGROUND:In the present study, calcinosis cutis (CC) is defined as the deposition of amorphous calcium and phosphate salts under epidermis and it may be caused by a pre-existing event such as extravasation injury or hypercalcemic conditions. Idiopathic CC cases have no underlying disease or pre-existing cause. AIM:A...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.119960

    authors: Coban YK,Aytekin AH,Aydin EN

    更新日期:2013-11-01 00:00:00

  • Stamping a Case of Cutaneous Adverse Drug Reaction: Proving Beyond Causality Assessment.

    abstract::Different types of skin testing with a suspected drug have been reported to be helpful in determining the cause of cutaneous adverse drug reactions (CADRs). It is of utmost importance for practicing dermatologists to have a first hand knowledge of different types of skin tests available in a case of CADR. In each susp...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/ijd.IJD_580_17

    authors: Das S,Biswas P,Pal D,De A

    更新日期:2018-03-01 00:00:00

  • Increased Plasma Levels of S100A8, S100A9, and S100A12 in Chronic Spontaneous Urticaria.

    abstract:Background:Chronic spontaneous urticaria (CSU) is a skin disorder with an important immunologic profile. S100A8, S100A9, and S100A12 are the members of S100 family that have been reported to play important role in autoimmune diseases, but the characteristics of these three S100 members have not been defined in CSU. Ai...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/ijd.IJD_375_18

    authors: Zhou QY,Lin W,Zhu XX,Xu SL,Ying MX,Shi L,Lin BJ

    更新日期:2019-11-01 00:00:00

  • Concurrent hand-foot skin reaction and hair depigmentation with sunitinib: report of a case and literature review of kinase inhibitors and blocking antibodies.

    abstract::Kinase inhibitors have revolutionized cancer therapy by becoming the first-line agents for advanced solid malignancies replacing the traditional chemotherapeutic agents. Cutaneous side-effects with these drugs are common, but owing to their infrequent use in Indian patients, our current knowledge of toxicity is scanty...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.143525

    authors: Bansal S,Sardana K,Singh K,Garg VK

    更新日期:2014-11-01 00:00:00

  • Clinical and investigative assessment of patients with positive versus negative autologous serum skin test: a study of 80 South Indian patients.

    abstract:BACKGROUND:Chronic urticaria (CU) is defined as urticaria persisting daily as or almost daily for more than 6 weeks and affecting 0.1% of the population. Mast cell degranulation and histamine release is of central importance in the pathogenesis of CU. About 40-50% of the patients with chronic idiopathic urticaria demon...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.103061

    authors: Krupashankar DS,Shashikala K,Madala R

    更新日期:2012-11-01 00:00:00

  • Topical Corticosteroids Abuse: A Clinical Study of Cutaneous Adverse Effects.

    abstract:Background:Topical corticosteroids (TC) are one of the most widely used agents in dermatology practice. Misuse of these agents may lead to a wide range of adverse effects. Aim:This study was conducted to assess the magnitude of abuse of topical corticosteroids (TC) and clinical patterns of cutaneous adverse effects am...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/ijd.IJD_110_17

    authors: Meena S,Gupta LK,Khare AK,Balai M,Mittal A,Mehta S,Bhatri G

    更新日期:2017-11-01 00:00:00

  • Subcutaneous rhinosporidiosis masquerading as soft tissue tumor: diagnosed by fine-needle aspiration cytology.

    abstract::Rhinosporidiosis is a chronic granulomatous lesion caused by Rhinosporidium seeberi. It frequently involves nasopharynx and ocular region. Presenting as cutaneous and subcutaneous mass is extremely rare. This report describes the FNA cytology of rhinosporidiosis occurring as a soft tissue mass in the right mid thigh r...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.152606

    authors: Kishan Prasad HL,Rao C,Girisha BS,Shetty V,Permi HS,Jayakumar M,Kiran HS

    更新日期:2015-03-01 00:00:00

  • Mometasone-based triple combination therapy in melasma: is it really safe?

    abstract:BACKGROUND:Kligman's triple combination formula has been one of the most popular treatment options in melasma over the last three decades. The original Kligman's formula has been modified in many ways over the years and the most recent modification that has been introduced is a triple combination of 2% hydroquinone, 0....

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.74545

    authors: Majid I

    更新日期:2010-10-01 00:00:00

  • Systemic Retinoids and Scar Dehiscence.

    abstract::Systemic retinoids such as isotretinoin and acitretin are associated with numerous side effects but are therapeutically valuable in dermatological practice. Several studies have reported the wound-healing effects of treatment with concurrent systemic retinoids in addition to surgical treatments. Herein, we describe tw...

    journal_title:Indian journal of dermatology

    pub_type:

    doi:10.4103/ijd.IJD_148_18

    authors: Aksoy HM,Aksoy B,Çalikoglu E

    更新日期:2019-01-01 00:00:00

  • Is frictional lichenoid dermatitis a minor variant of atopic dermatitis or a photodermatosis.

    abstract:CONTEXT:Frictional lichenoid dermatitis. BACKGROUND:Frictional lichenoid dermatitis (FLE) is an entity that is probably under diagnosed and has been variably associated with either friction and/or atopy with a distinctive seasonal variation. AIMS AND OBJECTIVES:To study correlation of FLE with UV index and to assess ...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.147797

    authors: Sardana K,Goel K,Garg VK,Goel A,Khanna D,Grover C,Khurana N

    更新日期:2015-01-01 00:00:00

  • Pattern of Childhood Onset Vitiligo at a Tertiary Care Centre in South- West Rajasthan.

    abstract:CONTEXT:Onset of vitiligo during childhood is not uncommon but the data is limited on this subject. AIMS:This study was planned to assess the magnitude of childhood onset vitiligo (COV) and adulthood onset vitiligo (AOV), and compare their clinical pattern. SETTINGS AND DESIGN:A cross sectional hospital based clinica...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.164423

    authors: Kayal A,Gupta LK,Khare AK,Mehta S,Mittal A,Kuldeep CM

    更新日期:2015-09-01 00:00:00

  • Disseminated cysticercosis with huge muscle hypertrophy.

    abstract::Cysticercosis is caused by cysticercus cellulose, which is the larva of Taenia solium, the pork tapeworm. The larvae are carried in the blood stream after penetrating the walls of the alimentary tract and they lodge in different tissues like the skin, skeletal muscles, brain, fundus and heart, to cause disseminated cy...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.48987

    authors: Bandyopadhyay D,Sen S

    更新日期:2009-01-01 00:00:00