Abstract:
BACKGROUND:It has been proposed that hepatitis C virus (HCV) antigens are involved in the pathogenesis of psoriasis and may contribute to severity of the disease. Increased expression of the apoptosis-regulating proteins p53 and tTG and decreased levels of bcl-2 in the keratinocytes of the skin of psoriatic patients have been reported. AIM:This study aims to identify the serum levels of apoptosis-regulating proteins in patients with psoriasis and without HCV infection and to study the relation between clinical severity of psoriasis and the presence of HCV infection. MATERIALS AND METHODS:Disease severity was assessed by psoriasis area severity index score (PASI) of 90 patients with psoriasis grouped as mild (n = 30), moderate (n = 30) and severe (n = 30); 20 healthy individuals were used as controls. All groups were subjected for complete history taking, clinical examination, and tests for liver function and HCV infection. The serum levels of apoptosis related proteins: p53, tTG and bcl-2 were estimated by enzyme linked immune sorbent assay (ELISA). RESULTS:There was a statistically significant (P < 0.001) correlation between clinical severity of psoriasis and presence of HCV antibodies and HCV-mRNA. In addition, significantly (P < 0.001) raised serum p53 and tTG, and reduced bcl-2 were observed among HCV-positive patients as compared to HCV-negative patients and control patients. CONCLUSION:These results conclude that clinical severity of psoriasis is affected by the presence of HCV antibodies and overexpression of apoptotic related proteins. In addition, altered serum levels of apoptosis-regulating proteins could be useful prognostic markers and therapeutic targets of psoriatic disease.
journal_name
Indian J Dermatoljournal_title
Indian journal of dermatologyauthors
Gabr SA,Berika MY,Alghadir AHdoi
10.4103/0019-5154.131377subject
Has Abstractpub_date
2014-05-01 00:00:00pages
230-6issue
3eissn
0019-5154issn
1998-3611pii
IJD-59-230journal_volume
59pub_type
杂志文章abstract:BACKGROUND:Seborrheic keratosis (SK) is a benign epidermal tumor of unknown etiology. Because of its wart-like morphology, Human papillomaviruses (HPVs) have been suggested as a possible causative agent. Viral involvement, however, has not been confirmed yet despite research and the association between HPVs and seborrh...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.113949
更新日期:2013-07-01 00:00:00
abstract::The incidence of nonmelanoma skin cancer (NMSC) continues to rise, partly because of aging, the frequency of early childhood sunburns, and sporadic extreme recreational sun exposure. A nonsurgical approach to selected cutaneous malignancy could possibly reduce the cost as well as morbidity of surgical treatment for NM...
journal_title:Indian journal of dermatology
pub_type: 杂志文章,评审
doi:10.4103/0019-5154.143503
更新日期:2014-11-01 00:00:00
abstract:Context:Androgenic alopecia (AGA) is a hereditary androgen-dependent disorder, characterized by gradual conversion of terminal hair into miniaturized hair and defined by various patterns. Common age group affected is between 30 and 50 years. Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors that inc...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/ijd.IJD_526_16
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:The mycological study of pityriasis versicolor is usually done by potassium hydroxide (KOH) mount and culture. However, KOH mount lacks a color contrast and requires a trained eye to interpret, while culture is difficult to perform, time consuming and has low sensitivity. Chicago Sky Blue 6B (CSB) is a new c...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.160476
更新日期:2015-07-01 00:00:00
abstract::Venereology-the study of venereal diseases or more recently, the sexually transmitted infections (STI) includes a variety of pathogens namely viruses, bacteria, fungi and protozoa for which the common factor is the mode of transmission and acquisition: Sexual relations between human beings. Medical and other historian...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.84713
更新日期:2011-07-01 00:00:00
abstract::Subcutaneous fat necrosis of infancy is a rare disorder of subcutaneous adipose tissue that is sometimes complicated by hypercalcemia. Complete resolution is common. From the pediatrician's point of view, the disease is a rare but important cause of inconsolable cry in a newborn. ...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.113983
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:The ability of steroids to reduce the histamine wheal was used to assess the efficacy of topical clobetasol propionate with varying dilutions of emollients. AIM:To determine the wheal-suppressing ability of topical clobetasol with varying dilutions of emollient. MATERIALS AND METHODS:It was a double-blinde...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.87146
更新日期:2011-09-01 00:00:00
abstract::Crohn's disease (CD) is a type of inflammatory bowel disease that can affect any part of the gut from mouth to anus. It also may occur at contiguous sites, like, lip, perineal or peristomal regions or may occur at sites separated from the bowel by normal tissue referred to as metastatic CD. The condition is relatively...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/ijd.IJD_389_16
更新日期:2018-07-01 00:00:00
abstract::Post-kala-azar dermal leishmaniasis (PKDL) is an unusual dermatosis occurring following an attack of visceral leishmaniasis (VL). There are only few reports of PKDL after successful treatment with miltefosine. We report two cases of PKDL that developed after successful treatment of VL with miltefosine. ...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.110848
更新日期:2013-05-01 00:00:00
abstract::Primary mucinous adenocarcinoma is a rare adnexal neoplasm of eccrine gland. Fewer than 200 cases are reported in literature. Clinically, it can be mistaken as a benign lesion. The primary challenge in these lesions is to differentiate these rare primary lesions from more frequent mucinous secondary deposits. Morpholo...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/ijd.IJD_619_16
更新日期:2018-03-01 00:00:00
abstract::Keratoacanthoma (KA) is a rapidly evolving tumor, composed of keratinizing squamous cells originating in pilosebaceous follicles and resolving spontaneously if left untreated. It is relatively uncommon in dark-skinned and occurs in middle aged individuals. Males are three times more affected than females. It presents ...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.105316
更新日期:2013-01-01 00:00:00
abstract::The various lesions seen in the clinical presentation of post kala-azar dermal leishmaniasis (PKDL) are reflected in the histopathology of the type of lesion biopsied. The cells that form the dermal infiltrate include lymphocytes, histiocytes, and plasma cells in varying proportions. The infiltrate, which is mild and ...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/ijd.IJD_307_19
更新日期:2020-11-01 00:00:00
abstract::The world of dermatology is pieced together by clinical conditions unique in their colors, morphology, and configuration. Dermatological signs and terms are influenced by etymology, language, and history. Eponyms also make dermatology a fascinating but linguistically challenging subject. This article reviews dermatolo...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.177799
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Existing remedies for controlling pseudofolliculitis barbae (PFB) are sometimes helpful; however the positive effects are often short lived. The only definitive cure for PFB is permanent removal of the hair follicle. AIMS:Our aim was to compare the efficacy of the Alexandrite laser with the intense pulsed l...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.57615
更新日期:2009-01-01 00:00:00
abstract::Acne vulgaris is one of the most commonly seen conditions and the immunological link is a topic of active research. Recently, the Th17 pathway has been found to play a pivotal role in acne. The adaptive immune response toward Propionibacterium acnes leads to activation of Th17 axis. Consequently, the Th17 cytokines (I...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/ijd.IJD_483_16
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Skin tags are common benign skin tumors usually occurring on the neck and major flexors of elder people. AIMS:The aim of this study is to perform quantitation of mast cells and collagen fibers in skin tags and normal skin in diabetics and nondiabetics, to find a possible correlation between mast cells and c...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.57605
更新日期:2009-01-01 00:00:00
abstract::Hidradenocarcinomas are very rare malignant sweat gland tumors that possess an infiltrative and/or low metastatic potential. Here we describe an interesting case of hidradenoma on the fronto-parietal region of the scalp of an elderly female, part of which had developed carcinomatous changes, infiltrating up to the per...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.160527
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Sertaconazole is a new, broad spectrum, fungicidal and fungistatic imidazole with added antipruritic and anti-inflammatory activity that would provide greater symptomatic relief and hence would be beneficial in improving the quality of life for the patient with dermatophytoses. AIMS AND OBJECTIVES:To compar...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.105284
更新日期:2013-01-01 00:00:00
abstract::Systemic retinoids such as isotretinoin and acitretin are associated with numerous side effects but are therapeutically valuable in dermatological practice. Several studies have reported the wound-healing effects of treatment with concurrent systemic retinoids in addition to surgical treatments. Herein, we describe tw...
journal_title:Indian journal of dermatology
pub_type:
doi:10.4103/ijd.IJD_148_18
更新日期:2019-01-01 00:00:00
abstract::Dyskeratosis congenita (DC) is a rare disease characterized by hyperpigmentation, nail dystrophy and mucous membrane abnormality. Commonly occurring in males, the patients die young usually due to bone marrow suppression. Malignancies of various descriptions have been reported in this disease, the commonest being soli...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.87167
更新日期:2011-09-01 00:00:00
abstract:AIM:To evaluate whether oxidative stress is implicated in melanocyte damage in vitiligo. BACKGROUND:Vitiligo is a complex disorder characterized by gradually enlarging areas of depigmentation. A new unifying hypothesis for the etiology of this pigment disorder is proposed, in which we postulate that the final destruct...
journal_title:Indian journal of dermatology
pub_type: 杂志文章,收录出版
doi:10.4103/0019-5154.55628
更新日期:2009-07-01 00:00:00
abstract::Cysticercosis is caused by cysticercus cellulose, which is the larva of Taenia solium, the pork tapeworm. The larvae are carried in the blood stream after penetrating the walls of the alimentary tract and they lodge in different tissues like the skin, skeletal muscles, brain, fundus and heart, to cause disseminated cy...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.48987
更新日期:2009-01-01 00:00:00
abstract::A 42-year-old male developed hemorrhagic bullae and erosions while in alcohol induced coma. The lesions were limited to areas of the body in prolonged contact with the ground in the comatose state. He developed rhabdomyolysis, progressing to acute renal failure (ARF). Histopathological examination of the skin showed s...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.143576
更新日期:2014-11-01 00:00:00
abstract::Angina bullosa hemorrhagic (ABH) describes the acute and sometimes painful onset of oral blood-filled vesicles and bullae, not attributable to blood dyscrasia, vesiculobullous disorders, systemic diseases or other known causes. The haemorrhagic bullae spontaneously burst after a short time resulting in ragged, often p...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.103083
更新日期:2012-11-01 00:00:00
abstract::Aquagenic keratoderma (AK) is a rare acquired skin condition characterized by recurrent and transient white papules and plaques associated with a burning sensation, pain, pruritus and/or hyperhidrosis on the palms and more rarely, soles triggered by sweat or contact with water. Often AK cause significant discomfort, t...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.152568
更新日期:2015-03-01 00:00:00
abstract::Dowling-Degos disease (DDD) is a late-onset genodermatosis characterized by hyperpigmented macules on the flexures along with scattered comedo-like lesions and pitted acneiform scars. Follicular Dowling-Degos is a rare type of DDD, with only two reports so far. It presents with follicular papules and comedo-like lesio...
journal_title:Indian journal of dermatology
pub_type:
doi:10.4103/ijd.IJD_260_18
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Warts are sometimes resistant or they tend to recur after every possible destructive therapy. Immunotherapy with skin-test antigens has been used as a viable therapeutic option in such recalcitrant cases. AIM:The aim of the study was to evaluate the response of resistant or recurrent warts to intralesional ...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.117301
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:Oxidative stress is considered as an initial pathogenic event in melanocyte destruction. These free radicals are scavenged by antioxidants, whose sum of activity in serum is measured by total antioxidant status (TAS). In addition, homocysteine (Hcy) may mediate melanocyte destruction via increased oxidative ...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.177764
更新日期:2016-03-01 00:00:00
abstract::Progressive nodular histiocytosis (PNH) is a rare normolipemic macrophage disorder and belongs to a subgroup of non-Langerhans cell histiocytosis (LCHs) which is characterized by a progressive course with no sign of spontaneous resolution but without systemic involvement. We report a 30-year-old gentleman who presente...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.160492
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Few clinical studies are found in the literature about patients hospitalized with a diagnosis of cutaneous drug eruption. AIMS:To determine the clinical types of drug eruptions and their causative agents in a hospital-based population. MATERIALS AND METHODS:This retrospective study was performed in the Der...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.96191
更新日期:2012-05-01 00:00:00