Abstract:
:Progressive nodular histiocytosis (PNH) is a rare normolipemic macrophage disorder and belongs to a subgroup of non-Langerhans cell histiocytosis (LCHs) which is characterized by a progressive course with no sign of spontaneous resolution but without systemic involvement. We report a 30-year-old gentleman who presented with skin lesions all over the body associated with gradual bilateral painless loss of vision. On examination, approximately 30 to 40, skin-colored, firm, non-tender papules and nodules were noted over the body especially on the face and trunk. A skin biopsy revealed a cellular tumor in the dermis composed of oval to spindle-shaped cells, positive for CD68 but negative for S-100, CD34, CD21, CD35 and HMB45, supporting a diagnosis of spindle cell histiocytic tumor. Ophthalmic examination revealed a generalized arteriolar attenuation in both eyes. He received Tab Imatinib 400 mg OD for 5 months followed by Tab Pazopanib 800 mg OD for 4 months and both the drugs were stopped due to lack of any response in the skin lesions. We report this case due to its rarity, characteristic clinical presentation, and its association with Eale's disease. Primary treatment remains surgical excision of bothersome lesions and optimal systemic treatment is still unknown.
journal_name
Indian J Dermatoljournal_title
Indian journal of dermatologyauthors
Williams A,Thomas AG,Kwatra KS,Jain Kdoi
10.4103/0019-5154.160492subject
Has Abstractpub_date
2015-07-01 00:00:00pages
388-90issue
4eissn
0019-5154issn
1998-3611pii
IJD-60-388journal_volume
60pub_type
杂志文章abstract::A 48-year-old man presented with acute abdominal pain underwent laparotomy that revealed two perforated ulcers in jejunum. He had skin lesions with porcelain white atrophic scar which were ignored for 3 years, whereas the disease revealed own malignant nature and progressed to nervous, gastrointestinal, and cardiopulm...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.87157
更新日期:2011-09-01 00:00:00
abstract::Trichoepithelioma is a rare benign adnexal tumor which may be of solitary nonfamilial type or multiple familial trichoepitheliomas. Here, we describe a rare presentation of nonfamilial case of trichoepithelioma in a 50-year-old female with multiple skin colored facial papules and nodules over the face, upper back, and...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.174030
更新日期:2016-01-01 00:00:00
abstract::Systemic retinoids such as isotretinoin and acitretin are associated with numerous side effects but are therapeutically valuable in dermatological practice. Several studies have reported the wound-healing effects of treatment with concurrent systemic retinoids in addition to surgical treatments. Herein, we describe tw...
journal_title:Indian journal of dermatology
pub_type:
doi:10.4103/ijd.IJD_148_18
更新日期:2019-01-01 00:00:00
abstract::Use of immunohistochemical technique is increasing in diagnosing various diseases. In many situations it may not be possible to differentiate entities with overlapping clinical and histopathological features. Immunostaining of cellular antigens is immensely helpful in such cases. Immunohistochemistry (IHC) has also be...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.91818
更新日期:2011-11-01 00:00:00
abstract::Psoriasis is a multi-factorial skin disease with a complex pathogenesis. Various factors which have been suggested to play a key role in the pathogenesis are T cells, antigen presenting cells (APC's), keratinocytes, Langerhans' cells, macrophages, natural killer cells, an array of Th1 type cytokines, certain growth fa...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.48977
更新日期:2009-01-01 00:00:00
abstract::Crohn's disease (CD) is a type of inflammatory bowel disease that can affect any part of the gut from mouth to anus. It also may occur at contiguous sites, like, lip, perineal or peristomal regions or may occur at sites separated from the bowel by normal tissue referred to as metastatic CD. The condition is relatively...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/ijd.IJD_389_16
更新日期:2018-07-01 00:00:00
abstract::Sturge-Weber syndrome is a rare sporadic condition of mesodermal phakomatosis, characterized by purple-colored flat cutaneous cranial (face) hemangiomas (most commonly along the trigeminal nerve), glaucoma and vascular lesions in the ipsilateral brain and meninges. Klippel-Trenaunay syndrome is also an uncommon mesode...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.91848
更新日期:2011-11-01 00:00:00
abstract::Seborrheic keratosis of the penis is a rare entity. It has been mistaken as genital warts and differentiation is only made on histopathology. We are reporting a case presenting as multiple giant polypoidal lesions on the penile skin for the last 20 years. Seborrheic keratosis should be considered in the differential d...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.39743
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:Facial angiofibromas (FA) are the most visible cutaneous manifestations in patients with tuberous sclerosis (TS), often resulting in stigmatization of the affected individuals. Recent studies have suggested that topical rapamycin may be an effective treatment for angiofibromas. AIM:To study the safety and...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.174087
更新日期:2016-01-01 00:00:00
abstract::Dowling-Degos disease (DDD) is a late-onset genodermatosis characterized by hyperpigmented macules on the flexures along with scattered comedo-like lesions and pitted acneiform scars. Follicular Dowling-Degos is a rare type of DDD, with only two reports so far. It presents with follicular papules and comedo-like lesio...
journal_title:Indian journal of dermatology
pub_type:
doi:10.4103/ijd.IJD_260_18
更新日期:2020-07-01 00:00:00
abstract::Psoriasiform dermatoses often pose challenges to both dermatologists and pathologists alike. With proper clinicopathologic correlation and a systematic approach, it is possible to arrive at a specific diagnosis in most cases. This article attempts to outline a practical, step-wise method of looking at these cases and ...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.113945
更新日期:2013-07-01 00:00:00
abstract::Melanoma is a rare form of cutaneous malignancy encountered in the dark skin population. Epidermotropic metastatic melanoma is a rare form of cutaneous metastatic melanoma which can mimic primary melanoma on histopathology. Hence its differentiation is of immense prognostic importance. The occurrence of rim of depigme...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.117323
更新日期:2013-09-01 00:00:00
abstract:Background:Acitretin is a widely used systemic retinoid in the treatment of psoriasis. Dosage of acitretin in not weight adjusted due to certain interindividual variations. Objective:To evaluate the clinical efficacy and effects on biochemical parameters of fixed tapering dosage of acitretin in patients with psoriasis...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/ijd.IJD_300_18
更新日期:2019-05-01 00:00:00
abstract:Introduction:Mycobacterium leprae has a small genome and a tendency of persisting as a very low-grade infection. The authors have shown earlier, that the changes in TTC repeats, in M. leprae genome may contribute to the restriction of the pathogenicity of the bacterium and its survival strategy in case of pure neural H...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/ijd.IJD_90_18
更新日期:2018-11-01 00:00:00
abstract::We report two cases of chronic progressive disseminated histoplasmosis with unusual and rare clinical picture in a patient with no underlying risk factor. One 50-year-old male, presented with hoarseness of voice, chronic cough, with a history of nonresponding anti-tubercular therapy, revealed mucocutaneous lesions on ...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.190128
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Xanthelasma palpebrarum (XP) is characterized by sharply demarcated yellowish flat plaques on upper and lower eyelids. It is commonly seen in women with a peak incidence at 30-50 years. It is also considered as the cutaneous marker of underlying atherosclerosis along with the disturbed lipid metabolism. XP a...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.182426
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:A combination of topical retinoid and antibacterial therapy is often advocated for acne to enhance therapeutic efficacy. AIMS:A preliminary study to evaluate the efficacy and tolerability of a topical fixed combination of nadifloxacin (1%) and adapalene (0.1%) in the treatment of mild to moderate acne in In...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.135492
更新日期:2014-07-01 00:00:00
abstract::Keratoacanthoma (KA) is a rapidly evolving tumor, composed of keratinizing squamous cells originating in pilosebaceous follicles and resolving spontaneously if left untreated. It is relatively uncommon in dark-skinned and occurs in middle aged individuals. Males are three times more affected than females. It presents ...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.105316
更新日期:2013-01-01 00:00:00
abstract::Tufted angioma (TA) is a rare benign vascular neoplasm, localized to the skin and subcutaneous tissues, occurring primarily on the trunk and extremities of children. The lesions are usually asymptomatic but, rarely, paroxysmal painful episodes may be associated. The occurrence of eruptive TA is still rarer and had bee...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.84741
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:Pityriasis versicolor is a mild, chronic, usually asymptomatic superficial fungal infection of the stratum corneum, caused by Malassezia yeasts. The purpose of the present study is to assess the clinical profile of a group of patients with pityriasis versicolor and to find out the epidemiological characteris...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.44791
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:The evaluation for skin disorders forms an important component of primary health care practice for all including children. The prevalence of certain skin diseases in children can reflect status of health, hygiene, and personal cleanliness of a community. AIMS:This study was planned to evaluate the magnitude...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.97665
更新日期:2012-07-01 00:00:00
abstract:INTRODUCTION:Familial glucocorticoid deficiency (FGD) is a rare autosomal recessive potentially life-threatening condition, characterized by glucocorticoid deficiency, preserved aldosterone/renin secretion, and secondary rise in plasma adrenocorticotropic hormone level. This occurs due to either mutation in adrenocorti...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/ijd.IJD_716_16
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Chikungunya fever (CF) epidemic has recently re-emerged in India affecting large population. Mucocutaneous manifestations are an important clinical feature of the disease. We have reviewed mucocutaneous manifestations of the disease during a recent epidemic in coastal Karnataka. PATIENTS AND METHODS:Seventy...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.82483
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:Alopecia areata (AA) is a common, chronic inflammatory disease characterized by nonscarring hair loss on the scalp or any hair-bearing area of the body. Recently, dermoscopy, a noninvasive diagnostic procedure, has been employed for the diagnosis of AA. AIM:To evaluate various dermoscopic patterns in AA and...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.193668
更新日期:2016-11-01 00:00:00
abstract::A 40-year-old lady presented with history of multiple red raised painful lesions over her body of 10 days duration. Lesions spread from forearms to arms and back of trunk during the progress of the disease. Associated pain and burning sensation in the lesions was present while working in the sun. Mild to moderate grad...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.127682
更新日期:2014-03-01 00:00:00
abstract:Background:Sun exposure causes extensive intrinsic as well as extrinsic changes in the skin. Pathogenic effects of sun exposure such as tanning, melasma, skin cancer, and aggravation of various photodermatoses such as systemic lupus erythematosus (SLE) may be prevented by the use of sunscreens. We conducted the present...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/ijd.IJD_609_17
更新日期:2018-07-01 00:00:00
abstract::Post-kala-azar dermal leishmaniasis (PKDL) is an unusual dermatosis occurring following an attack of visceral leishmaniasis (VL). There are only few reports of PKDL after successful treatment with miltefosine. We report two cases of PKDL that developed after successful treatment of VL with miltefosine. ...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.110848
更新日期:2013-05-01 00:00:00
abstract::Chloroma, also called granulocytic sarcoma (GS) or Myeloid Sarcoma, is a rare malignant extra-medullary neoplasm of myeloid precursor cells. It is usually associated with myeloproliferative disorders but its appearance may precede the onset of leukaemia. The presence of a chloroma is certainly a sign of poor prognosis...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.105326
更新日期:2013-01-01 00:00:00
abstract::A case of tuberculosis verrucosa cutis in an unusual site is being reported. The patient had presented with recurrence of a perianal growth which had been excised in the past. A histopathological study done during the recurrence confirmed tuberculosis. The patient's chest X-ray showed pulmonary tuberculosis, though he...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:
更新日期:1989-03-01 00:00:00
abstract::Erythema multiforme is an acute muco-cutaneous hypersensitivity reaction with a variety of etiologies. It is characterized by a skin eruption, with or without oral or other mucous membrane lesions. General characteristics and treatmet have been described, but nail findings are rarely reported Here we present a 26-year...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.169157
更新日期:2015-11-01 00:00:00