Experience of Varied Presentation of Chronic Progressive Disseminated Histoplasmosis in Immunocompetent Patients: A Diagnostic Conundrum.

Abstract:

:We report two cases of chronic progressive disseminated histoplasmosis with unusual and rare clinical picture in a patient with no underlying risk factor. One 50-year-old male, presented with hoarseness of voice, chronic cough, with a history of nonresponding anti-tubercular therapy, revealed mucocutaneous lesions on examination. Fungating vocal cord lesions were visualized on bronchoscopy, raised suspicion of carcinoma. The second case, a 22-year-old female, referred to hospital with suspected vasculitis, with complaints of "off and on" fever with decreased oral intake, arthralgia, who later developed generalized nodular skin eruptions. On investigation, human immunodeficiency virus test was found to be negative in both the cases. Histopathological findings of skin biopsy, adrenal and bone marrow aspirates raised suspicion, whereas fungal cultures confirmed Histoplasma infection. Although diagnosis was delayed, but both of them were successfully treated with amphotericin B.

journal_name

Indian J Dermatol

authors

Ghosh R,Mishra P,Sen S,Maiti PK,Chatterjee G

doi

10.4103/0019-5154.190128

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

580

issue

5

eissn

0019-5154

issn

1998-3611

pii

IJD-61-580c

journal_volume

61

pub_type

杂志文章
  • Zinc-responsive acral hyperkeratotic dermatosis-A novel entity or a subset of some well-known dermatosis?

    abstract:BACKGROUND:We are reporting a series of interesting cases, which presented to us with psoriasiform lesions distributed over the acral regions of the body. The cases are unusual because they were resistant to conventional treatment modalities like topical corticosteroids, tacrolimus and oral methotrexate but showed sign...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.152507

    authors: Ghosh A,Aggarwal I,De A,Samanta A,Chatterjee G,Bala S,Biswas P,Chowdhary N

    更新日期:2015-03-01 00:00:00

  • Chloroma of perianal region masquerading as perianal abscess.

    abstract::Chloroma, also called granulocytic sarcoma (GS) or Myeloid Sarcoma, is a rare malignant extra-medullary neoplasm of myeloid precursor cells. It is usually associated with myeloproliferative disorders but its appearance may precede the onset of leukaemia. The presence of a chloroma is certainly a sign of poor prognosis...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.105326

    authors: Sen R,Singh S,Qury MS,Marwah S,Aggarwal G,Singla S

    更新日期:2013-01-01 00:00:00

  • Limits of fine-needle aspiration cytology in diagnosing pilomatrixoma: a series of 25 cases with clinico-pathologic correlations.

    abstract:BACKGROUND:Pilomatrixoma (PMX) is a benign, quite uncommon, skin neoplasm, which is frequently misdiagnosed by clinicians. AIM:We have analyzed 25 PMX to determine the agreement between clinical diagnosis, preoperative FNA characteristics, and corresponding histopathological specimens; moreover, reliable cytologic cri...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.94295

    authors: Ieni A,Todaro P,Bonanno AM,Catalano F,Catalano A,Tuccari G

    更新日期:2012-03-01 00:00:00

  • Psoriasiform dermatoses: microscopic approach.

    abstract::Psoriasiform dermatoses often pose challenges to both dermatologists and pathologists alike. With proper clinicopathologic correlation and a systematic approach, it is possible to arrive at a specific diagnosis in most cases. This article attempts to outline a practical, step-wise method of looking at these cases and ...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.113945

    authors: Tirumalae R

    更新日期:2013-07-01 00:00:00

  • Counseling in Pemphigus.

    abstract::Pemphigus is a chronic, potentially life threatening, autoimmune intraepidermal blistering disease affecting the skin and the mucous membrane. Pemphigus may have profound impact on the quality of life in the affected patients. Counselling and adjuvant psychotherapy may be beneficial at least in few patients and should...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/ijd.IJD_198_17

    authors: Rao R,Srinivas CR

    更新日期:2017-05-01 00:00:00

  • Wolf's Isotopic Response: Report of a Case and Review of Literature.

    abstract::"Wolf's isotopic response" refers to the occurrence of a new dermatosis at the site of previously healed dermatosis. A number of factors including viral, neural, vascular, and immunologic factors have been implicated in the causation of this peculiar response but none has been proven conclusively. Here, we report a ca...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.131401

    authors: Mahajan R,De D,Saikia UN

    更新日期:2014-05-01 00:00:00

  • Lichen Simplex Chronicus Secondary to Scald Injury and Skin Flap Transplantation.

    abstract::A 50-year-old woman had suffered from chronic pruritic plaque located on right retroauricular area for around 16 years, which was diagnosed as lichen simplex chronicus. Seventeen years ago, patient had multiple scalded areas distributed throughout the body and underwent autologous skin flap transplantation for the rig...

    journal_title:Indian journal of dermatology

    pub_type:

    doi:10.4103/ijd.IJD_88_19

    authors: Xu JL,Song GX,Yin ZQ

    更新日期:2020-01-01 00:00:00

  • Quantitation of mast cells and collagen fibers in skin tags.

    abstract:BACKGROUND:Skin tags are common benign skin tumors usually occurring on the neck and major flexors of elder people. AIMS:The aim of this study is to perform quantitation of mast cells and collagen fibers in skin tags and normal skin in diabetics and nondiabetics, to find a possible correlation between mast cells and c...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.57605

    authors: El Safoury OS,Fawzy MM,El Maadawa ZM,Mohamed DH

    更新日期:2009-01-01 00:00:00

  • Acquired multifocal tufted angiomas in an immunocompetent young adult.

    abstract::Tufted angioma (TA) is a rare benign vascular neoplasm, localized to the skin and subcutaneous tissues, occurring primarily on the trunk and extremities of children. The lesions are usually asymptomatic but, rarely, paroxysmal painful episodes may be associated. The occurrence of eruptive TA is still rarer and had bee...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.84741

    authors: Ghosh SK,Bandyopadhyay D,Ghosh A,Biswas SK,Barma KD

    更新日期:2011-07-01 00:00:00

  • Dermatitis Artefacta: A Review of Five Cases: A Diagnostic and Therapeutic Challenge.

    abstract::Dermatitis artefacta (DA) is a self-inflicted dermatological condition where the underlying motive is to assume a sick role. The act of self-harm is to discharge the inner sense of isolation and emotional distress, which is too great to endure. We, hereby, report five interesting cases of DA with varied presentations,...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.169139

    authors: Saha A,Seth J,Gorai S,Bindal A

    更新日期:2015-11-01 00:00:00

  • Atypical fibroxanthoma: an unusual skin neoplasm in xeroderma pigmentosum.

    abstract::Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder related to defective deoxyribonucleic acid (DNA) repair. Various cutaneous manifestations related to ultraviolet (UV) damage characterize the clinical course. Primary malignant cutaneous neoplasms like squamous cell carcinoma, basal cell carcinoma and m...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.100493

    authors: Bandyopadhyay R,Nag D,Bandyopadhyay S,Sinha SK

    更新日期:2012-09-01 00:00:00

  • Dermatitis neglecta -- a dirty dermatosis: report of three cases.

    abstract::Dermatitis neglecta is a condition that results from inadequate frictional cleansing leading to accumulation of corneocytes, sebum and sweat ultimately resulting in hyper-pigmented patch or verrucous plaque. Recognizing this condition avoids unnecessary, aggressive diagnostic and therapeutic procedures. Here we report...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.152525

    authors: Saha A,Seth J,Sharma A,Biswas D

    更新日期:2015-03-01 00:00:00

  • Extensive presentation of verruca plana in a healthy individual.

    abstract::A 27-year-old healthy man presented with non-itchy hyperpigmented skin lesions involving the trunk of duration 3 years. Examination revealed numerous coalescing, rough, slightly elevated brownish papules involving large areas of back, chest, and abdomen. There were no other cutaneous or systemic findings. Cutaneous bi...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.82495

    authors: Pavithra S,Mallya H,Pai GS

    更新日期:2011-05-01 00:00:00

  • Primary Mucinous Adenocarcinoma of Skin: Myoepithelial Cells are a Clue to its Diagnosis.

    abstract::Primary mucinous adenocarcinoma is a rare adnexal neoplasm of eccrine gland. Fewer than 200 cases are reported in literature. Clinically, it can be mistaken as a benign lesion. The primary challenge in these lesions is to differentiate these rare primary lesions from more frequent mucinous secondary deposits. Morpholo...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/ijd.IJD_619_16

    authors: Sistla R,Afroz T,Narayanswamy J

    更新日期:2018-03-01 00:00:00

  • Subcutaneous rhinosporidiosis masquerading as soft tissue tumor: diagnosed by fine-needle aspiration cytology.

    abstract::Rhinosporidiosis is a chronic granulomatous lesion caused by Rhinosporidium seeberi. It frequently involves nasopharynx and ocular region. Presenting as cutaneous and subcutaneous mass is extremely rare. This report describes the FNA cytology of rhinosporidiosis occurring as a soft tissue mass in the right mid thigh r...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.152606

    authors: Kishan Prasad HL,Rao C,Girisha BS,Shetty V,Permi HS,Jayakumar M,Kiran HS

    更新日期:2015-03-01 00:00:00

  • Post-kala-azar dermal leishmaniasis developing in miltefosine-treated visceral leishmaniasis.

    abstract::Post-kala-azar dermal leishmaniasis (PKDL) is an unusual dermatosis occurring following an attack of visceral leishmaniasis (VL). There are only few reports of PKDL after successful treatment with miltefosine. We report two cases of PKDL that developed after successful treatment of VL with miltefosine. ...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.110848

    authors: Koley S,Mandal RK,Choudhary S,Bandyopadhyay A

    更新日期:2013-05-01 00:00:00

  • A family with leukonychia totalis.

    abstract::A family presented to our dermatology clinic with a complaint of white nails. Physical examination revealed clinical feature of leukonychia totalis and the presence of sensorineural hearing loss, palmo plantar keratoderma and knuckle pads (four essential criteria for the diagnosis of Bart Pumphrey syndrome).Three cons...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.60365

    authors: Balighi K,Moeineddin F,Lajevardi V,Ahmadreza R

    更新日期:2010-01-01 00:00:00

  • Cellular grafts in management of leucoderma.

    abstract::Cellular grafting methods constitute important advances in the surgical management of leucoderma. Different methods such as noncultured epidermal suspensions, melanocyte cultures, and melanocyte-keratinocyte cultures have all been shown to be effective. This article reviews these methods. ...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.53194

    authors: Mysore V,Salim T

    更新日期:2009-01-01 00:00:00

  • Role of Adjuvant Narrow Band Ultraviolet B Phototherapy in the Treatment of Chronic Urticaria.

    abstract:Background:Chronic urticaria is a common dermatological disorder that causes a great deal of distress in patients and affects daily life. Narrow band ultraviolet B (NBUVB) has been shown to be an effective treatment in chronic urticaria in few studies. However, the data regarding its role in chronic urticaria are limit...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/ijd.IJD_475_16

    authors: Sheikh G,Latif I,Lone KS,Hassan I,Jabeen Y,Keen A

    更新日期:2019-05-01 00:00:00

  • Disease Pattern among Sexually Transmitted Infection Clinic Attendees: A Hospital-Based Study.

    abstract:Background:Sexually transmitted infections (STIs) have a definite role in the facilitation of HIV infection, which, in turn, also increases susceptibility to other STIs. Further, the social stigma and secrecy surrounding STIs create difficulty in estimating its true incidence and prevalence. Objective:The objective of...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/ijd.IJD_640_16

    authors: Talukdar K,Chopra A,Mitra D,Mitra B

    更新日期:2018-11-01 00:00:00

  • Effectiveness of Paint Psoralen and Ultraviolet-A in Alopecia Areata - Our Experience in the National Skin Center.

    abstract:Background:Alopecia areata (AA) is usually a benign cause of patchy hair loss that often resolves within a few weeks to months. Most treatment modalities are ineffective in the treatment of severe AA. The use of paint psoralen and ultraviolet-A (PUVA) in the treatment of patients with severe forms of AA has been report...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/ijd.IJD_400_18

    authors: Tan LS,Chan MMH,Tan DJA,Lee JSS,Chong WS

    更新日期:2020-05-01 00:00:00

  • Mal de Meleda with Congenital Cataract: A Novel Case Report.

    abstract::Mal de meleda (MdM), a rare autosomal recessive genodermatosis is characterized by erythema and hyperkeratosis of the palms and soles with a sharp demarcation and that progress with age (progrediens) and extend to the dorsal aspects of the hands and feet (transgrediens). It has been associated with various conditions ...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.159655

    authors: Sethi A,Janda JK,Sharma N,Malhotra SK

    更新日期:2015-09-01 00:00:00

  • Malignant Eccrine Poroma of the Vulva: An Intriguing Case of a Rare Tumor at an Unusual Site.

    abstract::Malignant eccrine poroma is a rare malignancy of the eccrine sweat glands, occurring most frequently on the lower extremities. It affects both sexes equally usually in the 6(th) to 7(th) decade of life. Metastasis to regional lymph nodes may occur in 20% that may be fatal in 60% cases. Its aggressive nature, rarity of...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.185713

    authors: Mishra P,Sen S,Sharma N,Sen D

    更新日期:2016-07-01 00:00:00

  • Disseminated cysticercosis with huge muscle hypertrophy.

    abstract::Cysticercosis is caused by cysticercus cellulose, which is the larva of Taenia solium, the pork tapeworm. The larvae are carried in the blood stream after penetrating the walls of the alimentary tract and they lodge in different tissues like the skin, skeletal muscles, brain, fundus and heart, to cause disseminated cy...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.48987

    authors: Bandyopadhyay D,Sen S

    更新日期:2009-01-01 00:00:00

  • Topical Corticosteroids Abuse: A Clinical Study of Cutaneous Adverse Effects.

    abstract:Background:Topical corticosteroids (TC) are one of the most widely used agents in dermatology practice. Misuse of these agents may lead to a wide range of adverse effects. Aim:This study was conducted to assess the magnitude of abuse of topical corticosteroids (TC) and clinical patterns of cutaneous adverse effects am...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/ijd.IJD_110_17

    authors: Meena S,Gupta LK,Khare AK,Balai M,Mittal A,Mehta S,Bhatri G

    更新日期:2017-11-01 00:00:00

  • Keratoacanthoma centrifugum marginatum at an unusual site.

    abstract::Keratoacanthoma (KA) is a rapidly evolving tumor, composed of keratinizing squamous cells originating in pilosebaceous follicles and resolving spontaneously if left untreated. It is relatively uncommon in dark-skinned and occurs in middle aged individuals. Males are three times more affected than females. It presents ...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.105316

    authors: Phiske MM,Avhad G,Jerajani H

    更新日期:2013-01-01 00:00:00

  • A Pilot Study Evaluating Therapeutic Response of Different Dosage of Oral Glucocorticoid in Two Children with Familial Glucocorticoid Deficiency Presenting with Diffuse Mucocutaneous Hyperpigmentation.

    abstract:INTRODUCTION:Familial glucocorticoid deficiency (FGD) is a rare autosomal recessive potentially life-threatening condition, characterized by glucocorticoid deficiency, preserved aldosterone/renin secretion, and secondary rise in plasma adrenocorticotropic hormone level. This occurs due to either mutation in adrenocorti...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/ijd.IJD_716_16

    authors: Sarkar UK,Sarma N,Debbarma S,Mandal AK,Bala AK

    更新日期:2017-03-01 00:00:00

  • Apoptosis and clinical severity in patients with psoriasis and HCV infection.

    abstract:BACKGROUND:It has been proposed that hepatitis C virus (HCV) antigens are involved in the pathogenesis of psoriasis and may contribute to severity of the disease. Increased expression of the apoptosis-regulating proteins p53 and tTG and decreased levels of bcl-2 in the keratinocytes of the skin of psoriatic patients ha...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.131377

    authors: Gabr SA,Berika MY,Alghadir AH

    更新日期:2014-05-01 00:00:00

  • Mucocutaneous manifestations of chikungunya Fever: a study from an epidemic in coastal karnataka.

    abstract:BACKGROUND:Chikungunya fever (CF) epidemic has recently re-emerged in India affecting large population. Mucocutaneous manifestations are an important clinical feature of the disease. We have reviewed mucocutaneous manifestations of the disease during a recent epidemic in coastal Karnataka. PATIENTS AND METHODS:Seventy...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.82483

    authors: Bhat RM,Rai Y,Ramesh A,Nandakishore B,Sukumar D,Martis J,Kamath GH

    更新日期:2011-05-01 00:00:00

  • Mutilating keratoderma--a case report.

    abstract::A 19 year old girl had mutilating palmoplantar keratoderma with generalised ichthyosiform dermatosis and linear verrucous plaques in popliteal fossae. Her mother had similar disorder. ...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:

    authors: Thappa DM,Sharma R,Kumar B,Radotra BD

    更新日期:1989-03-01 00:00:00