Abstract:
BACKGROUND:Skin tags are common benign skin tumors usually occurring on the neck and major flexors of elder people. AIMS:The aim of this study is to perform quantitation of mast cells and collagen fibers in skin tags and normal skin in diabetics and nondiabetics, to find a possible correlation between mast cells and collagen fibers in the pathogenesis of skin tags. METHODS:Thirty participants with skin tags were divided into two groups (15 diabetic and 15 nondiabetic). Three biopsies were obtained from one anatomical site: A large skin tag, a small skin tag, and adjacent normal skin. Mast cells stained with Bismarck brown were counted manually in ten different fields of each section with magnification x1000 and the average count was correlated with the percentage of mean collagen area in five fields done by the image analyzer. RESULTS:A statistically significant correlation between mast cell count and percentage of collagen mean area was detected in both studied groups (except in large skin tags of the nondiabetic group). CONCLUSION:The positive correlation between mast cell count and percentage of collagen mean area suggests the critical role of mast cells in the etiogenesis of skin tags through its interaction with fibroblasts.
journal_name
Indian J Dermatoljournal_title
Indian journal of dermatologyauthors
El Safoury OS,Fawzy MM,El Maadawa ZM,Mohamed DHdoi
10.4103/0019-5154.57605subject
Has Abstractpub_date
2009-01-01 00:00:00pages
319-22issue
4eissn
0019-5154issn
1998-3611journal_volume
54pub_type
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journal_title:Indian journal of dermatology
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journal_title:Indian journal of dermatology
pub_type: 杂志文章
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journal_title:Indian journal of dermatology
pub_type: 杂志文章
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journal_title:Indian journal of dermatology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Indian journal of dermatology
pub_type: 杂志文章
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journal_title:Indian journal of dermatology
pub_type: 杂志文章
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journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/ijd.IJD_668_16
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journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.117354
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journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.156360
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pub_type: 杂志文章,评审
doi:10.4103/0019-5154.147778
更新日期:2015-01-01 00:00:00
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journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.152606
更新日期:2015-03-01 00:00:00
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journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.147883
更新日期:2015-01-01 00:00:00
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journal_title:Indian journal of dermatology
pub_type: 杂志文章
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journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.147844
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journal_title:Indian journal of dermatology
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.70665
更新日期:2010-07-01 00:00:00
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journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.190128
更新日期:2016-09-01 00:00:00
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journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.60365
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journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.174093
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journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.169139
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journal_title:Indian journal of dermatology
pub_type:
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pub_type: 杂志文章
doi:10.4103/0019-5154.113949
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