Abstract:
INTRODUCTION:Facial angiofibromas (FA) are the most visible cutaneous manifestations in patients with tuberous sclerosis (TS), often resulting in stigmatization of the affected individuals. Recent studies have suggested that topical rapamycin may be an effective treatment for angiofibromas. AIM:To study the safety and efficacy of topical rapamycin in treatment of FA in Type IV-VI skin type. MATERIALS AND METHODS:Five female patients with FA were included in the study, four of whom had TS, whereas one had isolated angiofibromas without systemic involvement. The age of the patients varied from 6 to 44 years. After baseline evaluation, they were advised to apply topical rapamycin (0.1-1%) in white soft paraffin base twice daily. Follow-up varied from 1 month to 6 months and is ongoing. RESULTS:A sustained improvement was observed with respect to erythema, size as well as extent of the lesions as early as within 2 weeks of starting treatment. No side effects were observed. A correlation between duration of angiofibromas and effectiveness of treatment was noted. CONCLUSION:Topical rapamycin appears to be a safe and effective alternative to surgical or laser-based treatments in patients with FA. This treatment shows potential to be a first-line management for FA and appears safe to start in early childhood.
journal_name
Indian J Dermatoljournal_title
Indian journal of dermatologyauthors
Viswanath V,Thakur P,Pund Pdoi
10.4103/0019-5154.174087subject
Has Abstractpub_date
2016-01-01 00:00:00pages
119issue
1eissn
0019-5154issn
1998-3611pii
IJD-61-119djournal_volume
61pub_type
杂志文章abstract:INTRODUCTION:Dermatology is primarily a non-acute, outpatient-centered clinical specialty, but substantial number of patients need indoor admission for adequate management. Over the years, the need for inpatient facilities in Dermatology has grown manifold; however, these facilities are available only in some tertiary ...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
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abstract:BACKGROUND:Acanthosis nigricans (AN) is a dermatosis characterized by thickened, hyperpigmented plaques, typically on the intertriginous surfaces and neck. Common in some populations, its prevalence depends on race. Clinicians should recognize AN; it heralds disorders ranging from endocrinologic disturbances to maligna...
journal_title:Indian journal of dermatology
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journal_title:Indian journal of dermatology
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journal_title:Indian journal of dermatology
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journal_title:Indian journal of dermatology
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journal_title:Indian journal of dermatology
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journal_title:Indian journal of dermatology
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journal_title:Indian journal of dermatology
pub_type: 杂志文章
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journal_title:Indian journal of dermatology
pub_type: 杂志文章
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journal_title:Indian journal of dermatology
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journal_title:Indian journal of dermatology
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doi:10.4103/ijd.IJD_580_17
更新日期:2018-03-01 00:00:00
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journal_title:Indian journal of dermatology
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journal_title:Indian journal of dermatology
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journal_title:Indian journal of dermatology
pub_type: 杂志文章
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更新日期:2019-11-01 00:00:00
abstract::Crohn's disease (CD) is a type of inflammatory bowel disease that can affect any part of the gut from mouth to anus. It also may occur at contiguous sites, like, lip, perineal or peristomal regions or may occur at sites separated from the bowel by normal tissue referred to as metastatic CD. The condition is relatively...
journal_title:Indian journal of dermatology
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journal_title:Indian journal of dermatology
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journal_title:Indian journal of dermatology
pub_type: 杂志文章
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journal_title:Indian journal of dermatology
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更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Pityriasis versicolor is a mild, chronic, usually asymptomatic superficial fungal infection of the stratum corneum, caused by Malassezia yeasts. The purpose of the present study is to assess the clinical profile of a group of patients with pityriasis versicolor and to find out the epidemiological characteris...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.44791
更新日期:2008-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:Indian journal of dermatology
pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.152586
更新日期:2015-03-01 00:00:00