Current concepts in the pathogenesis of psoriasis.

Abstract:

:Psoriasis is a multi-factorial skin disease with a complex pathogenesis. Various factors which have been suggested to play a key role in the pathogenesis are T cells, antigen presenting cells (APC's), keratinocytes, Langerhans' cells, macrophages, natural killer cells, an array of Th1 type cytokines, certain growth factors like vascular endothelial growth factor (VEGF), keratinocyte growth factor (KGF), and others. It has been hypothesized that the disease starts with the activation of T cell by an unknown antigen, which leads to secretion of an array of cytokines by activated T cells, inflammatory cells, and keratinocytes. The characteristic lesion of psoriasis is due to the hyper-proliferation of the keratinocyte. Activated Langerhans' cells migrate from skin to lymph nodes presenting the antigen to nodal naïve T cells (cells that have not been activated by antigen previously). The T cells activated by non-antigen-dependent mechanism may, however, become antigen-specific memory cells that react with a cross-reactive auto-antigen such as keratin (molecular mimicry). The genetic background of the disease may be suggested from the fact that concordance rate is 63-73% in monozygotic twins, as compared to 17-20% in dizygotic twins. Several disease susceptibility loci have been suggested as predisposing factors, PSORS1-PSORS9.

journal_name

Indian J Dermatol

authors

Das RP,Jain AK,Ramesh V

doi

10.4103/0019-5154.48977

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

7-12

issue

1

eissn

0019-5154

issn

1998-3611

journal_volume

54

pub_type

杂志文章
  • Adult Onset Langerhans Cell Histiocytosis Limited to the Skin.

    abstract::Langerhans cell histiocytosis (LCH) is a proliferative disease commonly seen in the pediatric population but rarely encountered in the adult population. The exact etiology remains unclear. It has various clinical features and is very likely to be misdiagnosed. Histopathology and immunohistochemistry are very important...

    journal_title:Indian journal of dermatology

    pub_type:

    doi:10.4103/ijd.IJD_504_18

    authors: Gurung I,Gao Y,Han K,Peng XB

    更新日期:2019-09-01 00:00:00

  • Skin as a marker of internal disease: a case of sarcoidosis.

    abstract::A 52-year-old female presented to our out patient department with asymptomatic, hypopigmented lesions on the neck and back since 2 months. There was a history of taking antitubercular treatment for suspected pulmonary tuberculosis 2 years back. On blood investigations, the serum angiotensin converting enzyme levels we...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.84756

    authors: Gautam M,Patil S,Munde P

    更新日期:2011-07-01 00:00:00

  • POEMS Syndrome with Extensive Calciphylaxis: A Case Report and Literature Review.

    abstract::POEMS syndrome, a paraneoplastic disorder, caused by plasma cell dyscrasia, is characterized by polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes. Calciphylaxis is a vasculopathy of subcutaneous arteries with calcification and skin ulceration, most commonly associated with end-stage renal disea...

    journal_title:Indian journal of dermatology

    pub_type:

    doi:10.4103/ijd.IJD_492_18

    authors: Liu CH,Chen YC,Chen TY,Huang HW,Lee JY

    更新日期:2020-11-01 00:00:00

  • Subcutaneous pheohyphomycosis presenting as a innocuous pustule.

    abstract::Pheohyphomycosis is a rare heterogeneous group of mycotic infections caused by dematiaceous (phaeoid) fungi affecting the skin, subcutaneous tissue, and central nervous system. Herein, we report a case of 29-year-old man with innocuous pustule over the right index finger. Examination revealed a subcutaneous swelling w...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.108083

    authors: Pai VV,Naveen KN,Hanumanthayya K,Dinesh US

    更新日期:2013-03-01 00:00:00

  • Xanthelasma Palpebrarum with Arcus Cornea: A Clinical and Biochemical Study.

    abstract:BACKGROUND:Xanthelasma palpebrarum (XP) is characterized by sharply demarcated yellowish flat plaques on upper and lower eyelids. It is commonly seen in women with a peak incidence at 30-50 years. It is also considered as the cutaneous marker of underlying atherosclerosis along with the disturbed lipid metabolism. XP a...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.182426

    authors: Nair PA,Patel CR,Ganjiwale JD,Diwan NG,Jivani NB

    更新日期:2016-05-01 00:00:00

  • A Novel Contrast Stain for the Rapid Diagnosis of Pityriasis Versicolor: A Comparison of Chicago Sky Blue 6B Stain, Potassium Hydroxide Mount and Culture.

    abstract:BACKGROUND:The mycological study of pityriasis versicolor is usually done by potassium hydroxide (KOH) mount and culture. However, KOH mount lacks a color contrast and requires a trained eye to interpret, while culture is difficult to perform, time consuming and has low sensitivity. Chicago Sky Blue 6B (CSB) is a new c...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.160476

    authors: Lodha N,Poojary SA

    更新日期:2015-07-01 00:00:00

  • Distant Skin Metastases from Carcinoma Buccal Mucosa: A Rare Presentation.

    abstract::Cancer of the oral cavity makes up approximately 30% of all head and neck region tumors. Skin metastasis is rare with an incidence ranging between 0.7% and 2.4%. Skin metastasis usually occurs in the neck, scalp, and over the skin near the primary site. We report a patient with carcinoma left buccal mucosa who present...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.185764

    authors: Srinivasan S,Leekha N,Gupta S,Mithal U,Arora V,De S

    更新日期:2016-07-01 00:00:00

  • Generalized eruptive syringoma.

    abstract::Eruptive syringoma is a very rare variant of syringoma. It is a benign adnexal tumor of the intraepidermal portion of eccrine sweat ducts. Here we report a 32-year-old female presented with classical asymptomatic eruptive syringomas involving her face and extremities. ...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.152586

    authors: Avhad G,Ghuge P,Jerajani HR

    更新日期:2015-03-01 00:00:00

  • Propionibacterium acnes and the Th1/Th17 Axis, Implications in Acne Pathogenesis and Treatment.

    abstract::Acne vulgaris is one of the most commonly seen conditions and the immunological link is a topic of active research. Recently, the Th17 pathway has been found to play a pivotal role in acne. The adaptive immune response toward Propionibacterium acnes leads to activation of Th17 axis. Consequently, the Th17 cytokines (I...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/ijd.IJD_483_16

    authors: Sardana K,Verma G

    更新日期:2017-07-01 00:00:00

  • Chloroma of perianal region masquerading as perianal abscess.

    abstract::Chloroma, also called granulocytic sarcoma (GS) or Myeloid Sarcoma, is a rare malignant extra-medullary neoplasm of myeloid precursor cells. It is usually associated with myeloproliferative disorders but its appearance may precede the onset of leukaemia. The presence of a chloroma is certainly a sign of poor prognosis...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.105326

    authors: Sen R,Singh S,Qury MS,Marwah S,Aggarwal G,Singla S

    更新日期:2013-01-01 00:00:00

  • SCEDOSPORIUM INFECTION IN A PATIENT WITH ANTI-TNFα THERAPY.

    abstract::Patients on anti-TNFα therapy are at increased risk for rare opportunistic infections. Here we are reporting a case of Scedosporium apiospermum infection in a patient treated with anti-TNF for 5 years. Patients on anti-TNFα need close follow-up and clinicians should be suspicious for atypical infections in these immun...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.77560

    authors: Nguyen CT,Raychaudhuri SP

    更新日期:2011-01-01 00:00:00

  • Cutaneous disorders in 500 diabetic patients attending diabetic clinic.

    abstract:BACKGROUND:The metabolic complications and pathologic changes that occur in diabetes mellitus (DM) influence the occurrence of various dermatoses. AIM:To study the impact of control of diabetes on the pattern of cutaneous disorders. MATERIALS AND METHODS:A cross-sectional descriptive study of patients attending diabe...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.80409

    authors: Ragunatha S,Anitha B,Inamadar AC,Palit A,Devarmani SS

    更新日期:2011-03-01 00:00:00

  • Clinical and investigative assessment of patients with positive versus negative autologous serum skin test: a study of 80 South Indian patients.

    abstract:BACKGROUND:Chronic urticaria (CU) is defined as urticaria persisting daily as or almost daily for more than 6 weeks and affecting 0.1% of the population. Mast cell degranulation and histamine release is of central importance in the pathogenesis of CU. About 40-50% of the patients with chronic idiopathic urticaria demon...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.103061

    authors: Krupashankar DS,Shashikala K,Madala R

    更新日期:2012-11-01 00:00:00

  • Giant pedunculated seborrheic keratosis of penis.

    abstract::Seborrheic keratosis of the penis is a rare entity. It has been mistaken as genital warts and differentiation is only made on histopathology. We are reporting a case presenting as multiple giant polypoidal lesions on the penile skin for the last 20 years. Seborrheic keratosis should be considered in the differential d...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.39743

    authors: Thakur JS,Thakur A,Chauhan CG,Diwana VK,Chauhan DC

    更新日期:2008-01-01 00:00:00

  • Immunohistochemistry: relevance in dermatology.

    abstract::Use of immunohistochemical technique is increasing in diagnosing various diseases. In many situations it may not be possible to differentiate entities with overlapping clinical and histopathological features. Immunostaining of cellular antigens is immensely helpful in such cases. Immunohistochemistry (IHC) has also be...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.91818

    authors: Palit A,Inamadar AC

    更新日期:2011-11-01 00:00:00

  • Hirsutism in Kashmir: an etiological study.

    abstract:BACKGROUND:Hirsutism refers to the presence of terminal hairs at the body sites under androgenic control. Various factors, including genetic makeup and hormonal status, influence the rate and pattern of hair growth at these sites. PURPOSE:To study the pattern of hirsutism in Kashmir. MATERIALS AND METHODS:Thirty five...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.48997

    authors: Ahmad QM,Shah IH,Sameem F,Kamili QU,Sultan J

    更新日期:2009-01-01 00:00:00

  • Chronic Arsenicosis: Cases from a Nonendemic Area of South Rajasthan.

    abstract::Two adult patients from a village of district Bhilwara, Rajasthan, consulted Skin Department of R. N. T. Medical College and Hospital, Udaipur, with complaints of thickening of the palms and soles and pigmentation of skin with a nonhealing ulcer on the palm. They also had complaints of loss of appetite, abdominal pain...

    journal_title:Indian journal of dermatology

    pub_type:

    doi:10.4103/ijd.IJD_704_16

    authors: Mehta S,Goyal U,Gupta LK,Mittal A,Khare AK,Balai M,Chapperwal M

    更新日期:2019-03-01 00:00:00

  • Pattern of Childhood Onset Vitiligo at a Tertiary Care Centre in South- West Rajasthan.

    abstract:CONTEXT:Onset of vitiligo during childhood is not uncommon but the data is limited on this subject. AIMS:This study was planned to assess the magnitude of childhood onset vitiligo (COV) and adulthood onset vitiligo (AOV), and compare their clinical pattern. SETTINGS AND DESIGN:A cross sectional hospital based clinica...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.164423

    authors: Kayal A,Gupta LK,Khare AK,Mehta S,Mittal A,Kuldeep CM

    更新日期:2015-09-01 00:00:00

  • Bilateral Multisegmental Zosteriform Leiomyoma Cutis: A Rare Entity.

    abstract::Cutaneous leiomyomas are benign tumors derived from the smooth muscles of the skin. They are firm, skin-colored to brownish, frequently painful papules and nodules presenting either as a solitary tumor or multiple clustered lesions. Uncommon patterns of multiple leiomyoma cutis include linear, zosteriform, or dermatom...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.156388

    authors: Bandyopadhyay D,Saha A,Bhattacharya S

    更新日期:2015-05-01 00:00:00

  • Comparative assessment of the efficacy and safety of sertaconazole (2%) cream versus terbinafine cream (1%) versus luliconazole (1%) cream in patients with dermatophytoses: a pilot study.

    abstract:BACKGROUND:Sertaconazole is a new, broad spectrum, fungicidal and fungistatic imidazole with added antipruritic and anti-inflammatory activity that would provide greater symptomatic relief and hence would be beneficial in improving the quality of life for the patient with dermatophytoses. AIMS AND OBJECTIVES:To compar...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.105284

    authors: Jerajani H,Janaki C,Kumar S,Phiske M

    更新日期:2013-01-01 00:00:00

  • Rare case of phenytoin induced acute generalized exanthematous pustulosis with cerebellar syndrome.

    abstract::Acute generalized exanthematous pustulosis (AGEP) is a rare drug induced cutaneous hypersensitivity reaction characterized by sudden onset of fever with sterile pustules overlying an erythematous skin occurring all over the body. The offending drugs are usually B-lactams and macrolides. Among anticonvulsants carbamaze...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.127715

    authors: Shingade PU,Wankhede V,Kataria PS,Sonone N

    更新日期:2014-03-01 00:00:00

  • Knowledge and Attitude of General Population toward Effects of Sun Exposure and Use of Sunscreens.

    abstract:Background:Sun exposure causes extensive intrinsic as well as extrinsic changes in the skin. Pathogenic effects of sun exposure such as tanning, melasma, skin cancer, and aggravation of various photodermatoses such as systemic lupus erythematosus (SLE) may be prevented by the use of sunscreens. We conducted the present...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/ijd.IJD_609_17

    authors: Agarwal SB,Godse K,Patil S,Nadkarni N

    更新日期:2018-07-01 00:00:00

  • Comparison of the activities of four antifungal agents in an in vitro model of dermatophyte nail infection.

    abstract:BACKGROUND:Onychomycosis is a difficult condition to treat and cure rates are disappointing. Moreover fungicidal action of antifungal agents in NCCLS assays and their rapid accumulation in nails in vivo are not compatible with the duration of treatment. AIMS:This study aimed to find the effectiveness of 4 different an...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.43216

    authors: Nowrozi H,Nazeri G,Adimi P,Bashashati M,Emami M

    更新日期:2008-01-01 00:00:00

  • Generalized granuloma annulare treated with monthly rifampicin, ofloxacin, and minocycline combination therapy.

    abstract::Granuloma annulare (GA) is a disease characterized by granulomatous inflammation of the dermis. A variant form of the disease, generalized granuloma annulare (GGA), can be observed in 15% of affected patients. Localized GA is likely to resolve spontaneously within months or a few years, whereas GGA can persist for dec...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.110828

    authors: Garg S,Baveja S

    更新日期:2013-05-01 00:00:00

  • Systemic Retinoids and Scar Dehiscence.

    abstract::Systemic retinoids such as isotretinoin and acitretin are associated with numerous side effects but are therapeutically valuable in dermatological practice. Several studies have reported the wound-healing effects of treatment with concurrent systemic retinoids in addition to surgical treatments. Herein, we describe tw...

    journal_title:Indian journal of dermatology

    pub_type:

    doi:10.4103/ijd.IJD_148_18

    authors: Aksoy HM,Aksoy B,Çalikoglu E

    更新日期:2019-01-01 00:00:00

  • Acetaminophen-induced cellulitis-like fixed drug eruption.

    abstract::Acetaminophen is a widely used analgesic drug. Its adverse reactions are rare but severe. An 89-year-old man developed an indurated edematous and erythematous plaque on his left arm 1 day after acetaminophen ingestion. Cellulitis was suspected and antibiotictherapy was started but there was no improvement of the rash;...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.80419

    authors: Fathallah N,Ben Salem C,Slim R,Boussofara L,Ghariani N,Bouraoui K

    更新日期:2011-03-01 00:00:00

  • Dermoscopy of Follicular Dowling-Degos Disease.

    abstract::Dowling-Degos disease (DDD) is a late-onset genodermatosis characterized by hyperpigmented macules on the flexures along with scattered comedo-like lesions and pitted acneiform scars. Follicular Dowling-Degos is a rare type of DDD, with only two reports so far. It presents with follicular papules and comedo-like lesio...

    journal_title:Indian journal of dermatology

    pub_type:

    doi:10.4103/ijd.IJD_260_18

    authors: Dabas G,Mahajan R,Afra TP,De D,Handa S,Aggarwal D,Radotra BD

    更新日期:2020-07-01 00:00:00

  • Artificial Intelligence: How is It Changing Medical Sciences and Its Future?

    abstract::Artificially intelligent computer systems are used extensively in medical sciences. Common applications include diagnosing patients, end-to-end drug discovery and development, improving communication between physician and patient, transcribing medical documents, such as prescriptions, and remotely treating patients. W...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/ijd.IJD_421_20

    authors: Basu K,Sinha R,Ong A,Basu T

    更新日期:2020-09-01 00:00:00

  • Genital Ulcerative Pyoderma Gangrenosum in Behçet's Disease: A Case Report and Review of the Literature.

    abstract::Behçet's disease (BD), first described by Hulusi Behcet, is a multisystemic disease characterized by recurrent oral and genital ulcerations, ocular and cutaneous lesions, arthritis and vascular disease. Pyoderma gangrenosum (PG) is a rare, chronic, sterile pustular and progressive ulcerative process of unknown cause; ...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.147866

    authors: Ozuguz P,Kacar SD,Manav V,Karaca S,Aktepe F,Ulu S

    更新日期:2015-01-01 00:00:00

  • Eccrine poroma on the face: an atypical presentation.

    abstract::An eccrine poroma is a solitary tumor arising from the eccrine duct epithelium in the epidermis. The lesions commonly occur on the sole of the foot, the hands, and occasionally on the nose, eyelids, neck, and chest. We report a patient who presented with a slow-growing nodular lesion over her left cheek, prompting a d...

    journal_title:Indian journal of dermatology

    pub_type: 杂志文章

    doi:10.4103/0019-5154.123515

    authors: Mahajan RS,Parikh AA,Chhajlani NP,Bilimoria FE

    更新日期:2014-01-01 00:00:00