Abstract:
:Langerhans cell histiocytosis (LCH) is a proliferative disease commonly seen in the pediatric population but rarely encountered in the adult population. The exact etiology remains unclear. It has various clinical features and is very likely to be misdiagnosed. Histopathology and immunohistochemistry are very important for the diagnosis of LCH. Treatment protocols remain controversial. Herein, we report a rare adult onset LCH, which is confined to the skin. A 50-year-old Chinese man presented with a nodule with itchy rashes on the left lower leg, which gradually grew in size for the last 6 months. He also had multiple scattered rashes on the right lower leg. The skin biopsy demonstrated Langerhans cells infiltrating the superficial dermis, and the tumor cells were positive for CD1a and S-100 expression. The diagnosis was LCH based on the histopathological and immunohistochemistry results.
journal_name
Indian J Dermatoljournal_title
Indian journal of dermatologyauthors
Gurung I,Gao Y,Han K,Peng XBdoi
10.4103/ijd.IJD_504_18subject
Has Abstractpub_date
2019-09-01 00:00:00pages
414-416issue
5eissn
0019-5154issn
1998-3611pii
IJD-64-414journal_volume
64pub_type
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