当前位置： SCI文献检索 > INDIAN JOURNAL OF DERMATOLOGY期刊下所有文献 > Clinical and investigative assessment of patients with positive versus negative autologous serum skin test: a study of 80 South Indian patients.

Clinical and investigative assessment of patients with positive versus negative autologous serum skin test: a study of 80 South Indian patients.

Abstract：

BACKGROUND:Chronic urticaria (CU) is defined as urticaria persisting daily as or almost daily for more than 6 weeks and affecting 0.1% of the population. Mast cell degranulation and histamine release is of central importance in the pathogenesis of CU. About 40-50% of the patients with chronic idiopathic urticaria demonstrate an immediate wheal and flare response to intra-dermal injected autologous serum. This led to the concept of autoimmune urticaria. AIMS:To determine the occurrence, clinical features, associated clinical conditions, comorbidities of autoimmune urticaria and to compare this with chronic spontaneous urticaria. This study aimed to find the frequency of autologous serum skin test (ASST) positive patients among patients with CU and to identify the clinical and laboratory parameters associated with positive ASST. MATERIALS AND METHODS:Prospective correlation study was done on 80 chronic urticaria patients, more than 6 weeks duration, attending outpatient department of dermatology during a period of November 2007 to January 2010. Patients were subjected to ASST, complete blood count, urine routine examination, liver function tests, renal function tests, thyroid function tests, H. pylori antibody tests, C3 and C4 complement level estimation, antinuclear antibody, and urine analysis. RESULTS:ASST was positive in 58.75% and negative in 41.25% of the patients, respectively. Out of 33 patients with history of angioedema, 9 (27.3%) patients were in ASST negative group and 24 were in positive group, this was statistically significant. Both groups showed no statistically significant difference for epidemiological details. CONCLUSION:ASST is considered a screening test for an autoimmune urticaria, which decreases the rate of diagnosis of "idiopathic" form of chronic urticaria. Patients with an autoimmune urticaria have more severe urticaria, more prolonged duration, more frequent attacks, and angioedema. Identification of autoimmune urticaria may permit the use of an immunotherapy in severe disease unresponsive to anti-histamine therapy.

journal_name

Indian J Dermatol

journal_title

Indian journal of dermatology

authors

Krupashankar DS,Shashikala K,Madala R

doi

10.4103/0019-5154.103061

subject

Has Abstract

pub_date

2012-11-01 00:00:00

pages

434-8

issue

eissn

0019-5154

issn

1998-3611

pii

IJD-57-434

journal_volume

pub_type

杂志文章

在线工具

Clinical and investigative assessment of patients with positive versus negative autologous serum skin test: a study of 80 South Indian patients.