Abstract:
BACKGROUND:Sertaconazole is a new, broad spectrum, fungicidal and fungistatic imidazole with added antipruritic and anti-inflammatory activity that would provide greater symptomatic relief and hence would be beneficial in improving the quality of life for the patient with dermatophytoses. AIMS AND OBJECTIVES:To compare efficacy and safety of sertaconazole, terbinafine and luliconazole in patients with dermatophytoses. MATERIALS AND METHODS:83 patients with tinea corporis and tinea cruris infections were enrolled in this multicentre, randomized, open label parallel study. The initial 'Treatment Phase' involved three groups receiving either sertaconazole 2% cream applied topically twice daily for four weeks, terbinafine 1% cream once daily for two weeks, luliconazole 1% cream once daily for two weeks. At the end of treatment phase, there was a 'Follow-up Phase' at end of 2 weeks, where the patients were assessed clinically and mycologically for relapse. RESULTS:Of the 83 patients, 62 completed the study, sertaconazole (n = 20), terbinafine (n = 22) and luliconazole (n = 20). The primary efficacy variables including change in pruritus, erythema, vesicle, desquamation and mycological cure were significantly improved in all the three groups, as compared to baseline, in the Treatment and Follow-up phase. Greater proportion of patients in sertaconazole group (85%) showed resolution of pruritus as compared to terbinafine (54.6%); and luliconazole (70%), (P < 0.05 sertaconazole vs terbinafine). There was a greater reduction in mean total composite score (pruritus, erythema, vesicle and desquamation) in sertaconazole group (97.1%) as compared to terbinafine (91.2%) and luliconazole (92.9%). All groups showed equal negative mycological assessment without any relapses. All three study drugs were well tolerated. Only one patient in sertaconazole group withdrew from the study due to suspected allergic contact dermatitis. CONCLUSION:Sertaconazole was better than terbinafine and luliconazole in relieving signs and symptoms during study and follow up period. At the end of 'Treatment Phase' and 'Follow-up' Phase, all patients showed negative mycological assessment in all three treatment groups suggesting no recurrence of the disease.
journal_name
Indian J Dermatoljournal_title
Indian journal of dermatologyauthors
Jerajani H,Janaki C,Kumar S,Phiske Mdoi
10.4103/0019-5154.105284subject
Has Abstractpub_date
2013-01-01 00:00:00pages
34-8issue
1eissn
0019-5154issn
1998-3611pii
IJD-58-34journal_volume
58pub_type
杂志文章abstract::A 42-year-old male developed hemorrhagic bullae and erosions while in alcohol induced coma. The lesions were limited to areas of the body in prolonged contact with the ground in the comatose state. He developed rhabdomyolysis, progressing to acute renal failure (ARF). Histopathological examination of the skin showed s...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.143576
更新日期:2014-11-01 00:00:00
abstract::Psoriasiform dermatoses often pose challenges to both dermatologists and pathologists alike. With proper clinicopathologic correlation and a systematic approach, it is possible to arrive at a specific diagnosis in most cases. This article attempts to outline a practical, step-wise method of looking at these cases and ...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.113945
更新日期:2013-07-01 00:00:00
abstract::POEMS syndrome, a paraneoplastic disorder, caused by plasma cell dyscrasia, is characterized by polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes. Calciphylaxis is a vasculopathy of subcutaneous arteries with calcification and skin ulceration, most commonly associated with end-stage renal disea...
journal_title:Indian journal of dermatology
pub_type:
doi:10.4103/ijd.IJD_492_18
更新日期:2020-11-01 00:00:00
abstract::Erythema annulare centrifugum (EAC) is characterised by slowly enlarging annular erythematous lesions and is thought to represent a clinical reaction pattern to infections, medications, and rarely, underlying malignancy. Causative drugs include chloroquine, cimetidine, gold sodium thiomalate, amitriptyline, finasterid...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/ijd.IJD_728_16
更新日期:2018-01-01 00:00:00
abstract::Familial atypical multiple mole melanoma syndrome (FAMMMS) is an autosomal dominant genodermatosis characterized by multiple melanocytic nevi, usually more than 50, and a family history of melanoma. It is known to be associated with carcinoma of pancreas and other malignancies involving gastrointestinal tract, breast,...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.152585
更新日期:2015-03-01 00:00:00
abstract::Acanthosis nigricans (AN) is a dermatosis characterized by velvety, papillomatous, brownish-black, hyperkeratotic plaques, typically on the intertriginous surfaces and neck. The majority (80%) of AN occurs idiopathically or in benign conditions such as endocrinopathies like diabetes mellitus, polycystic ovary syndrome...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.160540
更新日期:2015-07-01 00:00:00
abstract:Background:Sun exposure causes extensive intrinsic as well as extrinsic changes in the skin. Pathogenic effects of sun exposure such as tanning, melasma, skin cancer, and aggravation of various photodermatoses such as systemic lupus erythematosus (SLE) may be prevented by the use of sunscreens. We conducted the present...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/ijd.IJD_609_17
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:We are reporting a series of interesting cases, which presented to us with psoriasiform lesions distributed over the acral regions of the body. The cases are unusual because they were resistant to conventional treatment modalities like topical corticosteroids, tacrolimus and oral methotrexate but showed sign...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.152507
更新日期:2015-03-01 00:00:00
abstract::Dermatitis neglecta is a condition that results from inadequate frictional cleansing leading to accumulation of corneocytes, sebum and sweat ultimately resulting in hyper-pigmented patch or verrucous plaque. Recognizing this condition avoids unnecessary, aggressive diagnostic and therapeutic procedures. Here we report...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.152525
更新日期:2015-03-01 00:00:00
abstract::Cutaneous pseudolymphomas are benign lymphoproliferative processes mimicking lymphomas clinically and histologically. One of the precipitating factors for pseudolymphoma is drugs like anticonvulsants, antidepressants and angiotensin-converting enzyme inhibitors. According to existing literature phenytoin-induced cutan...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.164437
更新日期:2015-09-01 00:00:00
abstract::A 27-year-old healthy man presented with non-itchy hyperpigmented skin lesions involving the trunk of duration 3 years. Examination revealed numerous coalescing, rough, slightly elevated brownish papules involving large areas of back, chest, and abdomen. There were no other cutaneous or systemic findings. Cutaneous bi...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.82495
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:Few clinical studies are found in the literature about patients hospitalized with a diagnosis of cutaneous drug eruption. AIMS:To determine the clinical types of drug eruptions and their causative agents in a hospital-based population. MATERIALS AND METHODS:This retrospective study was performed in the Der...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.96191
更新日期:2012-05-01 00:00:00
abstract::We present the case of a male born prematurely at 32 weeks gestation by cesarean section following overt symptoms of maternal preeclampsia. He developed severe penoscrotal edema anew one month from birth. No remarkable exposure or trauma was identified. This unexplained swelling remained uniform till 4 months of age, ...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.117340
更新日期:2013-09-01 00:00:00
abstract::Immune reconstitution inflammatory syndrome (IRIS) occurs as an acute symptomatic expression of a latent infection during the recovery of immune system in response to antiretroviral therapy in HIV patients. IRIS triggers both opportunistic and non-opportunistic infections. We report a case of IRIS in a patient with HI...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.147883
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Pityriasis versicolor is a mild, chronic, usually asymptomatic superficial fungal infection of the stratum corneum, caused by Malassezia yeasts. The purpose of the present study is to assess the clinical profile of a group of patients with pityriasis versicolor and to find out the epidemiological characteris...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.44791
更新日期:2008-01-01 00:00:00
abstract:Background:Deep venous thrombosis (DVT), even though resolved, may damage the valves and may lead to chronic venous insufficiency (CVI). We designed the present study to examine the thrombotic markers or other ultrasound features in the absence of active thrombosis in patients presenting with features suggestive of CVI...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/ijd.IJD_271_18
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Kligman's triple combination formula has been one of the most popular treatment options in melasma over the last three decades. The original Kligman's formula has been modified in many ways over the years and the most recent modification that has been introduced is a triple combination of 2% hydroquinone, 0....
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.74545
更新日期:2010-10-01 00:00:00
abstract::The world of dermatology is pieced together by clinical conditions unique in their colors, morphology, and configuration. Dermatological signs and terms are influenced by etymology, language, and history. Eponyms also make dermatology a fascinating but linguistically challenging subject. This article reviews dermatolo...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.177799
更新日期:2016-03-01 00:00:00
abstract::Granuloma annulare (GA) is a disease characterized by granulomatous inflammation of the dermis. A variant form of the disease, generalized granuloma annulare (GGA), can be observed in 15% of affected patients. Localized GA is likely to resolve spontaneously within months or a few years, whereas GGA can persist for dec...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.110828
更新日期:2013-05-01 00:00:00
abstract::Dermatitis artefacta (DA) is a self-inflicted dermatological condition where the underlying motive is to assume a sick role. The act of self-harm is to discharge the inner sense of isolation and emotional distress, which is too great to endure. We, hereby, report five interesting cases of DA with varied presentations,...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.169139
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Acne vulgaris causes erythematous papulopustular lesions in active stage and often leave behind residual scarring and pigmentation. Its onset in adolescence may add to the emotional and psychological challenges experienced during this period. AIMS:To assess the impact of acne on the various psychosocial dom...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.190102
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Atopy-related illnesses such as atopic dermatitis and asthma are chronic illnesses, and children suffering from such illnesses are subjected to frequent absenteeism from school. Studies have shown that the performance of children with asthma was comparable to their healthy counterparts despite their absentee...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.70665
更新日期:2010-07-01 00:00:00
abstract::Aquagenic keratoderma (AK) is a rare acquired skin condition characterized by recurrent and transient white papules and plaques associated with a burning sensation, pain, pruritus and/or hyperhidrosis on the palms and more rarely, soles triggered by sweat or contact with water. Often AK cause significant discomfort, t...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.152568
更新日期:2015-03-01 00:00:00
abstract:INTRODUCTION:It is a functional peripheral vascular disorder characterized by bluish discoloration of skin and mucous membrane due to diminished oxyhemoglobin. It may be due to central or local tissue oxygenation defects. It is a painful episodic disorder, where trophic changes and ulceration are very rare except in ne...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.119946
更新日期:2013-11-01 00:00:00
abstract::Dowling-Degos disease (DDD) is a late-onset genodermatosis characterized by hyperpigmented macules on the flexures along with scattered comedo-like lesions and pitted acneiform scars. Follicular Dowling-Degos is a rare type of DDD, with only two reports so far. It presents with follicular papules and comedo-like lesio...
journal_title:Indian journal of dermatology
pub_type:
doi:10.4103/ijd.IJD_260_18
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Oxidative stress is considered as an initial pathogenic event in melanocyte destruction. These free radicals are scavenged by antioxidants, whose sum of activity in serum is measured by total antioxidant status (TAS). In addition, homocysteine (Hcy) may mediate melanocyte destruction via increased oxidative ...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.177764
更新日期:2016-03-01 00:00:00
abstract::A 55-year-old woman presented with a 5-year history of livedo racemosa on her limbs. Histology showed vasculitis of medium-sized arteries with a circumferential, hyalinised, intraluminal fibrin ring. Her laboratory investigations did not indicate any underlying systemic disease. The findings were consistent with lymph...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.139907
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:The metabolic complications and pathologic changes that occur in diabetes mellitus (DM) influence the occurrence of various dermatoses. AIM:To study the impact of control of diabetes on the pattern of cutaneous disorders. MATERIALS AND METHODS:A cross-sectional descriptive study of patients attending diabe...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.80409
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:It has been proposed that hepatitis C virus (HCV) antigens are involved in the pathogenesis of psoriasis and may contribute to severity of the disease. Increased expression of the apoptosis-regulating proteins p53 and tTG and decreased levels of bcl-2 in the keratinocytes of the skin of psoriatic patients ha...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.131377
更新日期:2014-05-01 00:00:00
abstract::The true existence of naevoid psoriasis and inflammatory linear verrucous naevus as distinct entities has been a debatable issue. Each has been opined to be a variant of the other. Considerable clinical and histological resemblance is seen between the two conditions. We describe three cases which attempt to throw more...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.103072
更新日期:2012-11-01 00:00:00