Abstract:
Background:Deep venous thrombosis (DVT), even though resolved, may damage the valves and may lead to chronic venous insufficiency (CVI). We designed the present study to examine the thrombotic markers or other ultrasound features in the absence of active thrombosis in patients presenting with features suggestive of CVI. Materials and Methods:It was a cross-sectional study of 50 DVT patients. We collected a detailed history of presenting symptoms (onset, progression, and duration) and associated history of aggravating factors. After classifying the patients, color Doppler investigation for DVT and venous incompetence and blood investigations such as Factor V, D-Dimer, total cholesterol, total triglycerides, homocysteine, high-density lipoproteins, low-density lipoproteins (LDL), and very LDL were done. Results:We found a raised Factor V significantly more in patients classified as severe under clinical classification compared with nonsevere (19% and 0%; P = 0.05) and in patients with a high Venous Severity Clinical Score (VSCS) compared to those with a low VSCS score (17% and 0%; P = 0.03). We also found that perforators were significantly more in patients with a high VSCS score (88% and 58%; P = 0.02), in patients with a primary venous etiology compared with those without any venous etiology (97% and 1%; P < 0.0001), in patients with obstruction/reflux compared to those without any pathology (95% and 0%; P < 0.0001), and in patients with severe clinical classification compared with nonsevere patient (95% and 55%; P = 0.002). Conclusions:Clinical or subclinical DVT, an important cause of CVI, may not always be seen on ultrasound, especially after resolution. However, they may have the presence of blood parameters (Factor V and hyperhomocysteinemia) suggestive of DVT; these can be used as proxy markers for the current or previous DVT.
journal_name
Indian J Dermatoljournal_title
Indian journal of dermatologyauthors
Malkani RH,Karia R,Thadani Sdoi
10.4103/ijd.IJD_271_18subject
Has Abstractpub_date
2019-09-01 00:00:00pages
366-371issue
5eissn
0019-5154issn
1998-3611pii
IJD-64-366journal_volume
64pub_type
杂志文章abstract:AIM:To evaluate whether oxidative stress is implicated in melanocyte damage in vitiligo. BACKGROUND:Vitiligo is a complex disorder characterized by gradually enlarging areas of depigmentation. A new unifying hypothesis for the etiology of this pigment disorder is proposed, in which we postulate that the final destruct...
journal_title:Indian journal of dermatology
pub_type: 杂志文章,收录出版
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abstract::As researchers, we often collect data on a clinical record form or a questionnaire. It is an important part of study design. If the questionnaire is not well designed, the data collected will not be useful. In this section of the module, we have discussed some practical aspects of designing a questionnaire. It is usef...
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journal_title:Indian journal of dermatology
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journal_title:Indian journal of dermatology
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journal_title:Indian journal of dermatology
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pub_type: 杂志文章
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journal_title:Indian journal of dermatology
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2011-07-01 00:00:00
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journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.41649
更新日期:2008-01-01 00:00:00
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