Abstract:
:Cutaneous pseudolymphomas are benign lymphoproliferative processes mimicking lymphomas clinically and histologically. One of the precipitating factors for pseudolymphoma is drugs like anticonvulsants, antidepressants and angiotensin-converting enzyme inhibitors. According to existing literature phenytoin-induced cutaneous pseudolymphomas are usually T-cell predominant. Most often withdrawal of the drug with or without short-course systemic steroids can attain a cure. Rarely malignant transformation has been reported years later despite withdrawal of the offending drug, which necessitates a long-term follow up of the affected. We report an 80-year-old male patient who was receiving phenytoin sodium and who presented with diffuse erythema and infiltrated skin lesions which histologically resembled cutaneous B-cell lymphoma. Substituting phenytoin with levetiracetam achieved resolution of symptoms. Further evaluation was suggestive of a reactive process. A detailed drug history is of paramount importance in differentiating drug-induced pseudolymphoma from lymphoma. Searching literature we could not find any previous reports of phenytoin-induced cutaneous B-cell pseudolymphoma.
journal_name
Indian J Dermatoljournal_title
Indian journal of dermatologyauthors
Riyaz N,Sasidharanpillai S,Aravindan KP,Nobin BK,Raghavan NT,Nikhila PKdoi
10.4103/0019-5154.164437subject
Has Abstractpub_date
2015-09-01 00:00:00pages
522issue
5eissn
0019-5154issn
1998-3611pii
IJD-60-522cjournal_volume
60pub_type
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