Phenytoin Induced Cutaneous B Cell Pseudolymphoma.

Abstract:

:Cutaneous pseudolymphomas are benign lymphoproliferative processes mimicking lymphomas clinically and histologically. One of the precipitating factors for pseudolymphoma is drugs like anticonvulsants, antidepressants and angiotensin-converting enzyme inhibitors. According to existing literature phenytoin-induced cutaneous pseudolymphomas are usually T-cell predominant. Most often withdrawal of the drug with or without short-course systemic steroids can attain a cure. Rarely malignant transformation has been reported years later despite withdrawal of the offending drug, which necessitates a long-term follow up of the affected. We report an 80-year-old male patient who was receiving phenytoin sodium and who presented with diffuse erythema and infiltrated skin lesions which histologically resembled cutaneous B-cell lymphoma. Substituting phenytoin with levetiracetam achieved resolution of symptoms. Further evaluation was suggestive of a reactive process. A detailed drug history is of paramount importance in differentiating drug-induced pseudolymphoma from lymphoma. Searching literature we could not find any previous reports of phenytoin-induced cutaneous B-cell pseudolymphoma.

journal_name

Indian J Dermatol

authors

Riyaz N,Sasidharanpillai S,Aravindan KP,Nobin BK,Raghavan NT,Nikhila PK

doi

10.4103/0019-5154.164437

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

522

issue

5

eissn

0019-5154

issn

1998-3611

pii

IJD-60-522c

journal_volume

60

pub_type

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