Abstract:
BACKGROUND:Oral isotretinoin treatment might influence the levels of vitamin B12 and folic acid. AIMS AND OBJECTIVES:The aim of this study is to compare vitamin B12 and folic acid levels in patients with moderate and severe acne vulgaris with those of the healthy control group and to investigate the effect of isotretinoin treatment on these vitamins. MATERIALS AND METHODS:Patients who completed 6 months of isotretinoin therapy for moderate and severe forms of acne vulgaris and a control group consisting of healthy individuals between February 2011 and March 2012 were included in the study. Before isotretinoin therapy and at 6.- months of the therapy, serum vitamin B12 and folic acid levels were measured. In the healthy control group, vitamin B12 and folic acid levels were assessed only once. RESULTS:In total, 120 patients with moderate and severe acne vulgaris who completed 6 months isotretinoin therapy and 100 healthy individuals who constituted the control group were included in the study. Pre-treatment vitamin B12 values of the patient group were found to be statistically significantly higher (P = 0.002), but any statistically significant difference was not detected in folic acid measurements (P = 0.566). A statistically significant decrease was detected in post-treatment vitamin B12 and folic acid levels (P < 0.05). CONCLUSION:Vitamin B12/folic acid treatment should be given under medical surveillance before and during isotretinoin therapy. Supplementation of these vitamins should be recommended in cases of their deficiency, so as to decrease the risks of neuropsychiatric and occlusive vascular diseases.
journal_name
Indian J Dermatoljournal_title
Indian journal of dermatologyauthors
Gökalp H,Bulur I,Gürer Mdoi
10.4103/0019-5154.143533subject
Has Abstractpub_date
2014-11-01 00:00:00pages
630issue
6eissn
0019-5154issn
1998-3611pii
IJD-59-630bjournal_volume
59pub_type
杂志文章abstract:Context:Androgenic alopecia (AGA) is a hereditary androgen-dependent disorder, characterized by gradual conversion of terminal hair into miniaturized hair and defined by various patterns. Common age group affected is between 30 and 50 years. Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors that inc...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/ijd.IJD_526_16
更新日期:2019-01-01 00:00:00
abstract::A systematic review is a summary of existing evidence that answers a specific clinical question, contains a thorough, unbiased search of the relevant literature, explicit criteria for assessing studies and structured presentation of the results. A systematic review that incorporates quantitative pooling of similar stu...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.127671
更新日期:2014-03-01 00:00:00
abstract:Background:Lichen planus (LP) is an inflammatory skin disease of unknown etiology associated with chronic inflammation, oxidative stress induction, and cardiovascular risk factors. Objectives:To document the prevalence of metabolic syndrome (MetS), dyslipidemia, and associated factors in Nigerian patients with LP. Me...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/ijd.IJD_111_18
更新日期:2019-07-01 00:00:00
abstract::Rhinosporidiosis is a chronic granulomatous lesion caused by Rhinosporidium seeberi. It frequently involves nasopharynx and ocular region. Presenting as cutaneous and subcutaneous mass is extremely rare. This report describes the FNA cytology of rhinosporidiosis occurring as a soft tissue mass in the right mid thigh r...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.152606
更新日期:2015-03-01 00:00:00
abstract::As researchers, we often collect data on a clinical record form or a questionnaire. It is an important part of study design. If the questionnaire is not well designed, the data collected will not be useful. In this section of the module, we have discussed some practical aspects of designing a questionnaire. It is usef...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/ijd.IJD_76_17
更新日期:2017-03-01 00:00:00
abstract::Cutaneous larva migrans (CLM) is characterized by the formation of distinctive, tortuous, and serpentine skin lesions occurring as a result of epidermal burrowing by certain helminthic larvae. Although this condition is usually uneventful, rarely it may result in patchy pulmonary infiltration with peripheral eosinophi...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.177753
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abstract:BACKGROUND:Pilomatrixoma (PMX) is a benign, quite uncommon, skin neoplasm, which is frequently misdiagnosed by clinicians. AIM:We have analyzed 25 PMX to determine the agreement between clinical diagnosis, preoperative FNA characteristics, and corresponding histopathological specimens; moreover, reliable cytologic cri...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.94295
更新日期:2012-03-01 00:00:00
abstract::A family presented to our dermatology clinic with a complaint of white nails. Physical examination revealed clinical feature of leukonychia totalis and the presence of sensorineural hearing loss, palmo plantar keratoderma and knuckle pads (four essential criteria for the diagnosis of Bart Pumphrey syndrome).Three cons...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.60365
更新日期:2010-01-01 00:00:00
abstract::Kindler's syndrome is a very rare genodermatosis characterized by acral blistering starting in infancy, photosensitivity, progressive poikiloderma, cutaneous atrophy, and various forms of mucosal involvement. A large number of other cutaneous and extracutaneous features have also been described. We report here three c...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.74568
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:Atopy-related illnesses such as atopic dermatitis and asthma are chronic illnesses, and children suffering from such illnesses are subjected to frequent absenteeism from school. Studies have shown that the performance of children with asthma was comparable to their healthy counterparts despite their absentee...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.70665
更新日期:2010-07-01 00:00:00
abstract::Dermatitis artefacta (DA) is a self-inflicted dermatological condition where the underlying motive is to assume a sick role. The act of self-harm is to discharge the inner sense of isolation and emotional distress, which is too great to endure. We, hereby, report five interesting cases of DA with varied presentations,...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.169139
更新日期:2015-11-01 00:00:00
abstract::A 48-year-old man presented with acute abdominal pain underwent laparotomy that revealed two perforated ulcers in jejunum. He had skin lesions with porcelain white atrophic scar which were ignored for 3 years, whereas the disease revealed own malignant nature and progressed to nervous, gastrointestinal, and cardiopulm...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.87157
更新日期:2011-09-01 00:00:00
abstract::Cancer metastases represent the most devastating aspect of malignancy, since the mortality of cancer patients is mainly related to the metastatic behavior of the primary neoplasm. Skin metastases are usually late events in the course of tumor progression. Excluding melanoma, the most common tumor to metastasize to the...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.91838
更新日期:2011-11-01 00:00:00
abstract::Dowling-Degos disease (DDD) is a late-onset genodermatosis characterized by hyperpigmented macules on the flexures along with scattered comedo-like lesions and pitted acneiform scars. Follicular Dowling-Degos is a rare type of DDD, with only two reports so far. It presents with follicular papules and comedo-like lesio...
journal_title:Indian journal of dermatology
pub_type:
doi:10.4103/ijd.IJD_260_18
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Seborrheic keratosis (SK) is a benign epidermal tumor of unknown etiology. Because of its wart-like morphology, Human papillomaviruses (HPVs) have been suggested as a possible causative agent. Viral involvement, however, has not been confirmed yet despite research and the association between HPVs and seborrh...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.113949
更新日期:2013-07-01 00:00:00
abstract::Kinase inhibitors have revolutionized cancer therapy by becoming the first-line agents for advanced solid malignancies replacing the traditional chemotherapeutic agents. Cutaneous side-effects with these drugs are common, but owing to their infrequent use in Indian patients, our current knowledge of toxicity is scanty...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.143525
更新日期:2014-11-01 00:00:00
abstract::A 39-year-old female with a pruritic verrucous plaque over dorsal aspect of great toe was treated with 4 intralesional corticosteroid injections each at an interval of 2 weeks. Three months later, she developed depigmentation at the injection site and in a network-like distribution radiating away from the site. The de...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.44805
更新日期:2008-01-01 00:00:00
abstract::Chloroma, also called granulocytic sarcoma (GS) or Myeloid Sarcoma, is a rare malignant extra-medullary neoplasm of myeloid precursor cells. It is usually associated with myeloproliferative disorders but its appearance may precede the onset of leukaemia. The presence of a chloroma is certainly a sign of poor prognosis...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.105326
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Skin tags are common benign skin tumors usually occurring on the neck and major flexors of elder people. AIMS:The aim of this study is to perform quantitation of mast cells and collagen fibers in skin tags and normal skin in diabetics and nondiabetics, to find a possible correlation between mast cells and c...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.57605
更新日期:2009-01-01 00:00:00
abstract::Crohn's disease (CD) is a type of inflammatory bowel disease that can affect any part of the gut from mouth to anus. It also may occur at contiguous sites, like, lip, perineal or peristomal regions or may occur at sites separated from the bowel by normal tissue referred to as metastatic CD. The condition is relatively...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/ijd.IJD_389_16
更新日期:2018-07-01 00:00:00
abstract::Cancer of the oral cavity makes up approximately 30% of all head and neck region tumors. Skin metastasis is rare with an incidence ranging between 0.7% and 2.4%. Skin metastasis usually occurs in the neck, scalp, and over the skin near the primary site. We report a patient with carcinoma left buccal mucosa who present...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.185764
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:The evaluation for skin disorders forms an important component of primary health care practice for all including children. The prevalence of certain skin diseases in children can reflect status of health, hygiene, and personal cleanliness of a community. AIMS:This study was planned to evaluate the magnitude...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.97665
更新日期:2012-07-01 00:00:00
abstract::Two adult patients from a village of district Bhilwara, Rajasthan, consulted Skin Department of R. N. T. Medical College and Hospital, Udaipur, with complaints of thickening of the palms and soles and pigmentation of skin with a nonhealing ulcer on the palm. They also had complaints of loss of appetite, abdominal pain...
journal_title:Indian journal of dermatology
pub_type:
doi:10.4103/ijd.IJD_704_16
更新日期:2019-03-01 00:00:00
abstract::Palmo-plantar keratodermas (PPKD) are a diverse group of acquired and hereditary disorders, characterized by excessive thickening of the skin of palms and soles. Here, we report a case of Type I or Buschke-Fischer-Brauer variant of punctate palmo-plantar keratoderma, in a 66-year-old gentleman. The association of our ...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.156452
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Few clinical studies are found in the literature about patients hospitalized with a diagnosis of cutaneous drug eruption. AIMS:To determine the clinical types of drug eruptions and their causative agents in a hospital-based population. MATERIALS AND METHODS:This retrospective study was performed in the Der...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.96191
更新日期:2012-05-01 00:00:00
abstract:INTRODUCTION:Cutaneous leishmaniasis (CL) is a parasitic disease which has different clinical forms. The aim of this study is to compare the response to leishmanin skin test (LST) in three forms of CL including plaque type, lupoid type, and sporotrichoid type. MATERIALS AND METHODS:This was a descriptive cross-section...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.110838
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Alopecia areata (AA) is a common, chronic inflammatory disease characterized by nonscarring hair loss on the scalp or any hair-bearing area of the body. Recently, dermoscopy, a noninvasive diagnostic procedure, has been employed for the diagnosis of AA. AIM:To evaluate various dermoscopic patterns in AA and...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.193668
更新日期:2016-11-01 00:00:00
abstract:Introduction:Mycobacterium leprae has a small genome and a tendency of persisting as a very low-grade infection. The authors have shown earlier, that the changes in TTC repeats, in M. leprae genome may contribute to the restriction of the pathogenicity of the bacterium and its survival strategy in case of pure neural H...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/ijd.IJD_90_18
更新日期:2018-11-01 00:00:00
abstract::A 42-year-old male developed hemorrhagic bullae and erosions while in alcohol induced coma. The lesions were limited to areas of the body in prolonged contact with the ground in the comatose state. He developed rhabdomyolysis, progressing to acute renal failure (ARF). Histopathological examination of the skin showed s...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.143576
更新日期:2014-11-01 00:00:00
abstract:INTRODUCTION:Facial angiofibromas (FA) are the most visible cutaneous manifestations in patients with tuberous sclerosis (TS), often resulting in stigmatization of the affected individuals. Recent studies have suggested that topical rapamycin may be an effective treatment for angiofibromas. AIM:To study the safety and...
journal_title:Indian journal of dermatology
pub_type: 杂志文章
doi:10.4103/0019-5154.174087
更新日期:2016-01-01 00:00:00