Abstract：
:In this study, we introduce a novel simulation technique to incorporate delineation errors into radiotherapy treatment margins and combine them with organ motion and set-up errors to investigate the cumulative dosimetric effects in different tumour sites. The effects of applying patient realignment correction protocols for radical treatments of prostate, lung and brain tumours were also modelled. Simulations were based on data from measurements using image-guidance techniques, including the use of fiducial markers in prostate and breathing correction techniques for the lung. The use of different sizes of planning target volume (PTV) margins was also evaluated. The prostate clinical target volumes' V99% showed up to 3.2% improvement with reduction in treatment uncertainties. For the lung plans, the V99% increased by up to an average of 10% with increase in treatment margin size from 0.5 to 1.5 cm. This improvement was, however, at the detriment of the dose delivered to the critical organs where the maximum dose received by the spinal cord increased by up to 0.5 Gy per fraction. These results were used to deduce the possible margin reductions and dose escalation achievable with reduced uncertainties.
journal_name
Med Biol Eng Computjournal_title
Medical & biological engineering & computingauthors
Mzenda B,Hosseini-Ashrafi M,Palmer A,Liu H,Brown DJdoi
10.1007/s11517-010-0616-zsubject
Has Abstractpub_date
2010-07-01 00:00:00pages
661-9issue
7eissn
0140-0118issn
1741-0444journal_volume
48pub_type
杂志文章abstract：:There is multiple evidence in the literature that a sub-threshold pre-pulse, delivered immediately prior to an electrical stimulation pulse, can alter the activation threshold of nerve fibers and motor unit recruitment characteristics. So far, previously published works combined monophasic stimuli with sub-threshold d...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-018-1851-y
更新日期：2018-12-01 00:00:00
abstract：:Many successful models to describe the biomechanical characteristics of planar biological soft tissues are based on strain energy function. However, the parameters in these models are determined by biaxial extension test, which might be difficult to exercise for certain types of soft tissue. This study presents a new ...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-013-1098-6
更新日期：2013-10-01 00:00:00
abstract：:The regulation of cerebral blood flow (CBF) following changes in arterial blood pressure (ABP) and end-tidal pCO2 (EtCO2) are of clinical interest in assessing cerebrovascular reserve capacity. Linear finite-impulse-response modelling is applied to ABP, EtCO2 and CBF velocity (CBFV, from transcranial Doppler measureme...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02345749
更新日期：2000-09-01 00:00:00
abstract：:A rapid-access but limited vocabulary communication aid for the non-vocal and speech impaired is useful in some well defined situations. The design and construction of such a device is described. Three distinct situations have been identified where an aid is essential and an initial evaluation has shown the Pocket Spe...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02441487
更新日期：1989-05-01 00:00:00
abstract：:The management of postprandial glucose excursions in type 1 diabetes has a major impact on overall glycaemic control. In this work, we propose and evaluate various mechanistic models to characterize the disposal of meal-attributable glucose. Sixteen young volunteers with type 1 diabetes were subject to a variable-targ...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-016-1509-6
更新日期：2017-02-01 00:00:00
abstract：:Architectural distortion is a subtle abnormality in mammograms, and a source of overlooking errors by radiologists. Computer-aided diagnosis (CAD) techniques can improve the performance of radiologists in detecting masses and calcifications; however, most CAD systems have not been designed to detect architectural dist...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-006-0088-3
更新日期：2006-10-01 00:00:00
abstract：:In cell-based research, the process of visually monitoring cells generates large image datasets that need to be evaluated for quantifiable information in order to track the effectiveness of treatments in vitro. With the traditional, end-point assay-based approach being error-prone, and existing computational approache...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-020-02177-x
更新日期：2020-07-01 00:00:00
abstract：: ...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章,撤回出版物
doi：10.1007/s11517-018-1933-x
更新日期：2019-03-01 00:00:00
abstract：:Portable biomedical instrumentation has become an important part of diagnostic and treatment instrumentation, including telemedicine applications. Low-voltage and low-power design tendencies prevail. Modern battery cell voltages in the range of 3-3.6 V require appropriate circuit solutions. A two-electrode biopotentia...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02344642
更新日期：2004-03-01 00:00:00
abstract：:A technique is proposed that allows automatic decomposition of electromyographic (EMG) signals into their constituent motor unit action potential trains (MUAPTs). A specific iterative algorithm with a classification method using fuzzy-logic techniques was developed. The proposed classification method takes into accoun...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02349972
更新日期：2003-11-01 00:00:00
abstract：:Neurofilaments are organised into parallel bundles in axons through crossbridges formed by lateral projections of neurofilament subunits. Pure neurofilaments form gels in vitro, consisting of interconnected parallel arrays of filaments regulated by the phosphorylation level of neurofilament subunits. Neurofilament-ass...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02522486
更新日期：1998-05-01 00:00:00
abstract：:Taking advantage of motion sensing technology, a quantitative assessment method for lower limbs motor function of cerebral palsy (CP) based on the gross motor function measurement (GMFM)-24 scale was explored in this study. According to the motion analysis on GMFM-24 scale, we translated the assessment problem of GMFM...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-019-02076-w
更新日期：2020-01-01 00:00:00
abstract：:The understanding of cardiac arrhythmia under genetic mutations has grown in interest among researchers. Previous studies focused on the effect of the D172N mutation on electrophysiological behavior. In this study, we analyzed not only the electrophysiological activity but also the mechanical responses during normal s...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-020-02124-w
更新日期：2020-05-01 00:00:00
abstract：:The development of an active implantable device for measuring electrocardiogram (ECG) is presented. The study is a part of a project which aims at developing implantable ECG instrumentation with wireless data and power transfer ( http://www.ele.tut.fi/tule ). The developed implant presented here has all the measuremen...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章,评审
doi：10.1007/s11517-007-0264-0
更新日期：2007-12-01 00:00:00
abstract：:Generation of a large number of cells belonging to the cardiac pacemaker system would constitute an important step towards their utilization as a biological cardiac pacemaker system. The aim of the present study was to identify factors, which might induce transformation of a heterogenous population of fetal cardiomyoc...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-007-0164-3
更新日期：2007-02-01 00:00:00
abstract：:This study analyzes the performance of knee extension and flexion of Taekwondo and Kickboxing athletes. The power values were extracted through electromyography obtained by an isokinetic dynamometer at 60 degrees per second. These values are resulted from the square of the electromyography signal. The analysis of kick...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-010-0608-z
更新日期：2010-06-01 00:00:00
abstract：:A continuous cardiac output monitoring system has been developed in the laboratory to allow the real-time measurement of the cardiac output. This form of continuous cardiac output measurement allows the doctor to view the beat-to-beat cardiac output and can be employed to measure artery constrictions as well. The sens...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02345272
更新日期：2001-01-01 00:00:00
abstract：:Marfan syndrome (MFS) is a genetic disorder that affects connective tissue, impairing cardiovascular structures and function, such as heart valves and aorta. Thus, patients with Marfan disease have a higher risk of developing circulatory problems associated with mitral and aortic valves prolapse, manifested as dilated...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-016-1524-7
更新日期：2017-03-01 00:00:00
abstract：:A bicuspid aortic valve (BAV) is a congenital cardiac disorder where the valve consists of only two cusps instead of three, as in a normal tricuspid valve (TAV). Although 97 % of BAVs include asymmetric cusps, little or no prior studies have investigated the blood flow through a three-dimensional BAV and root. The aim...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-013-1055-4
更新日期：2013-08-01 00:00:00
abstract：:A new transducer has been developed, based on an inductive principle, for recording fetal movements and sounds. The compliance of this transducer, the INductive PHOno-sensor (INPHO), can be matched to that of the maternal abdomen to provide an optimal transfer of displacement between maternal abdomen and transducer. I...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02441655
更新日期：1991-07-01 00:00:00
abstract：:Disappointing results for total ankle replacement have been explained by poor knowledge of the mechanics of the intact and replaced joints. Dynamic simulation tools have the capacity to simulate dynamic conditions that occur in human joints. The Working Model 2D tool was used to simulate the mechanics of the intact an...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02348124
更新日期：2002-03-01 00:00:00
abstract：:The CellDrum technology (The term 'CellDrum technology' includes a couple of slightly different technological setups for measuring lateral mechanical tension in various types of cell monolayers or 3D-tissue constructs) was designed to quantify the contraction rate and mechanical tension of self-exciting cardiac myocyt...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-009-0552-y
更新日期：2010-01-01 00:00:00
abstract：:Sino-aortic denervation (SAD) is employed in cats to evaluate the baroreflex influence on blood pressure (BP) and pulse interval (PI) spectral components from 0.00008 to 0.9 Hz as assessed by FFT wide-band spectra and their 1/f modelling; and the linear coupling between BP and PI and between systolic and diastolic BP ...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02520018
更新日期：1996-03-01 00:00:00
abstract：:Over a period of some years, the components of a system for discerning erosion on children's teeth have been progressively developed, for use in an extensive project seeking correlations between erosion and various perceived risk factors. The aim was the detection of minute levels of erosion, based on mappings of the ...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02348090
更新日期：2003-07-01 00:00:00
abstract：:An eye pointer was developed as a new line-of-sight displacement analyser. It analyses an observer's eye movements and superimposes their line of vision on a TV image which is the same as their view. A newly developed miniature colour field camera and very compact eye-movement sensors are attached to a translucent rei...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02446149
更新日期：1990-07-01 00:00:00
abstract：:Impedance cardiography is a low-cost noninvasive technique, based on monitoring of the thoracic impedance, for estimation of stroke volume (SV). Impedance cardiogram (ICG) is the negative of the first derivative of the impedance signal. A technique for beat-to-beat SV estimation using impedance cardiography and artifi...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-017-1752-5
更新日期：2018-06-01 00:00:00
abstract：:Performance evaluations of ion-selective field-effect transistors (ISFETs) have been carried out using both quality-control materials and whole arterial blood samples. Comparison of the results from these evaluations suggests that the whole blood evaluation may be more useful when assessing the value of particular sen...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02442678
更新日期：1990-05-01 00:00:00
abstract：:Monitoring upper-limb activity in a free-living environment is important for the evaluation of rehabilitation. This study is a validation of the Strathclyde Upper-Limb Activity Monitor (SULAM) which records the vertical movement and position of each wrist, and assesses bimanual movement. Agreement between the SULAM an...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-007-0233-7
更新日期：2007-10-01 00:00:00
abstract：:The reconstruction of bioluminescence tomography (BLT) is severely ill-posed due to the insufficient measurements and diffuses nature of the light propagation. Predefined permissible source region (PSR) combined with regularization terms is one common strategy to reduce such ill-posedness. However, the region of PSR i...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-018-1842-z
更新日期：2018-11-01 00:00:00
abstract：:Classification of cancerous genes from microarray data is an important research area in bioinformatics. Large amount of microarray data are available, but it is very costly to label them. This paper proposes an active learning model, a semi-supervised classification approach, to label the microarray data using which p...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-020-02238-1
更新日期：2020-10-01 00:00:00
