12-Lipoxygenase and the regulation of hypoxia-inducible factor in prostate cancer cells.

abstract：:1,25-dihydroxyvitamin D(3) (VD(3)) induces differentiation in a number of leukemia cell lines and under various conditions is able to either stimulate or inhibit nuclear factor kappa B (NF-kappaB) activity. Here we report a time-dependent biphasic regulation of NF-kappaB in VD(3)-treated HL-60 leukemia cells. After VD...

journal_title：Experimental cell research

authors： Tse AK,Wan CK,Shen XL,Zhu GY,Cheung HY,Yang M,Fong WF

更新日期：2007-05-01 00:00:00

abstract：:Over the last decade there has been growing evidence that Brain Expressed X-Linked 2 (BEX2) has a significant role in the process of carcinogenesis. Collectively, available studies suggest a pro-oncogenic function for this gene in multiple malignancies, including breast, colorectal and hepatocellular cancers in additi...

journal_title：Experimental cell research

authors： Naderi A

更新日期：2019-03-15 00:00:00

abstract：:Lamin A is a component of the nuclear envelope that is synthesized as a precursor prelamin A molecule and then processed into mature lamin A through sequential steps of posttranslational modifications and proteolytic cleavages. Remarkably, over 400 distinct point mutations have been so far identified throughout the LM...

journal_title：Experimental cell research

authors： Reddy S,Comai L

更新日期：2012-01-01 00:00:00

abstract：:We investigated the ability of endocytosed activated epidermal growth factor receptors (EGFR) to induce expression of the cyclin-interacting protein p21/CIP1 in A431 cells. Transforming growth factor alpha (TGFalpha) and EGF both induced tyrosine phosphorylation, induction of p21/CIP1, and thereby inhibition of DNA sy...

journal_title：Experimental cell research

authors： Skarpen E,Johannessen LE,Bjerk K,Fasteng H,Guren TK,Lindeman B,Thoresen GH,Christoffersen T,Stang E,Huitfeldt HS,Madshus IH

更新日期：1998-08-25 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a progressive pulmonary vascular disease which is associated with pulmonary arterial endothelial cells (PAEC) dysfunction and pulmonary arterial smooth muscle cells proliferation. Moreover, inflammation is contributing a critical role in EC dysfunction and remains elusive. Nucl...

journal_title：Experimental cell research

authors： Li L,Kim IK,Chiasson V,Chatterjee P,Gupta S

更新日期：2017-10-01 00:00:00

abstract：:The localization of talin and vinculin in chicken embryo fibroblasts (CEF) during transformation was studied by immunoelectron microscopy. CEF cells were infected with a temperature-sensitive mutant of Rous sarcoma virus. After 16 h at 42 degrees C, transformation was induced by incubation at 37 degrees C for differen...

journal_title：Experimental cell research

authors： Brands R,de Boer A,Feltkamp CA,Roos E

更新日期：1990-01-01 00:00:00

abstract：:Although there have been many reports on the relationship between activation of telomerase and carcinogenesis, the role of telomerase in normal cellular growth is still unclear. In this study, we analyzed the relationship between upregulation of telomerase activity and cell cycle progression during the liver regenerat...

journal_title：Experimental cell research

authors： Inui T,Shinomiya N,Fukasawa M,Kobayashi M,Kuranaga N,Ohkura S,Seki S

更新日期：2002-02-15 00:00:00

abstract：:The subcellular distribution of tissue transglutaminase in human umbilical vein endothelial cells and human arterial and venous smooth muscle cells was examined. Double-immunofluorescence staining of smooth muscle cells and endothelial cells with anti-transglutaminase antisera and rhodamine-tagged phalloidin revealed ...

journal_title：Experimental cell research

authors： Chowdhury ZA,Barsigian C,Chalupowicz GD,Bach TL,Garcia-Manero G,Martinez J

更新日期：1997-02-25 00:00:00

abstract：:Overexpression of P-glycoprotein may cause increased efflux of a variety of anticancer drugs (ACD) leading to multidrug resistance (MDR) of tumor cells. Two sublines of murine monocytic leukemia P388 cells were used, one parental (Par-P388) and one multidrug resistant (MDR-P388). In cell growth inhibition assays in vi...

journal_title：Experimental cell research

authors： Boesch D,Muller K,Pourtier-Manzanedo A,Loor F

更新日期：1991-09-01 00:00:00

abstract：:Human T-cell leukemia/lymphotropic virus type I (HTLV-I) infection causes a variety of human diseases, including adult T-cell leukemia/lymphoma. The viral transactivator Tax has been implicated as a key factor in the HTLV-I-induced transformation pathway. To investigate the components of this pathway, we derived fibro...

journal_title：Experimental cell research

authors： Saggioro D,D'agostino DM,Chieco-Bianchi L

更新日期：1999-03-15 00:00:00

abstract：:Rat thyroid differentiated cells (PC Cl 3) are an excellent model system with which to study the interaction between differentiation and cell transformation. We previously demonstrated that PC Cl 3 cells expressing the adenovirus E1A gene no longer depend on thyrotropin for growth and do not express thyroid differenti...

journal_title：Experimental cell research

authors： Iuliano R,Trapasso F,Stella A,Le Pera I,Melillo RM,Bruni P,Baldassarre G,Chiariotti L,Santoro M,Viglietto G,Fusco A

更新日期：2000-11-01 00:00:00

abstract：:Insulin-like growth factor-1 (IGF-1) and its receptor (IGF-1R) are required for cell proliferation in vitro, raising the possibility that an autocrine IGF-1-IGF-1R system may be present in vivo and become activated in the viable ventricular myocytes shortly after infarction. Therefore, following the in vivo documentat...

journal_title：Experimental cell research

authors： Reiss K,Kajstura J,Zhang X,Li P,Szoke E,Olivetti G,Anversa P

更新日期：1994-08-01 00:00:00

abstract：:We have compared the rate of synthesis, half-life, and steady-state content of the oncoprotein p53 in logarithmically growing cultures of (a) primary embryo, (b) immortalized but untransformed, and (c) spontaneously transformed mouse fibroblasts. Steady-state p53 content derived from metabolic labeling and immunopreci...

journal_title：Experimental cell research

authors： Williams NW,Wynford-Thomas D

更新日期：1989-10-01 00:00:00

abstract：:DNA topoisomerase II (topo II) is the target of many anticancer drugs and is often altered in drug-resistant cell lines. In some tumor cell lines truncated isoforms of topo IIalpha are localized to the cytoplasm. To study the localization and function of individual enzyme domains, we have epitope-tagged several fragme...

journal_title：Experimental cell research

authors： Soltermann A,Ernst A,Leroy D,Stahel RA,Gasser SM

更新日期：1999-06-15 00:00:00

abstract：:Most developing lymphocytes spontaneously die in the thymus during positive and negative selection of the T cell repertoire. By evaluating the expression of the proliferation antigens Ki-67 and PCNA, we demonstrated here that more than 95% of thymocytes are potentially proliferating. The coincidence within the same ce...

journal_title：Experimental cell research

authors： Pellicciari C,Bottone MG,Schaack V,Barni S,Manfredi AA

更新日期：1996-12-15 00:00:00

abstract：:Rhodamine 123 (R 123) is a positively charged dye at physiological pH that accumulates specifically in the mitochondria of living cells without cytotoxic effect. In the present study, the uptake of R 123 by EL-4 lymphoma cells in culture with anticancer agents was measured by flow cytometry. Changes in R 123 uptake du...

journal_title：Experimental cell research

authors： Shinomiya N,Tsuru S,Katsura Y,Sekiguchi I,Suzuki M,Nomoto K

更新日期：1992-01-01 00:00:00

abstract：:Recently, SIRT5 was reported to be a predominant desuccinylase and demalonylase in mitochondria. Ablation of SIRT5 enhances the systemic succinylation and malonylation of mitochondrial proteins, including various metabolic enzymes; however, its function in pancreatic β cells has not yet been clarified. In this study, ...

journal_title：Experimental cell research

authors： Wang Y,Liu Q,Huan Y,Li R,Li C,Sun S,Guo N,Yang M,Liu S,Shen Z

更新日期：2018-10-01 00:00:00

abstract：:Murine embryonal carcinoma F9 cells can be induced to differentiate by 2-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase (ODC). The differentiated phenotype is similar to that of retinoic acid (RA)-treated F9 cells. In contrast to F9 cells the differentiated cells secrete plasminog...

journal_title：Experimental cell research

authors： Jetten AM,Shirley JE

更新日期：1985-01-01 00:00:00

abstract：:Mip130/LIN-9 is part of a large complex that includes homologs of the Drosophila dREAM (drosophila RB-like, E2F, and Myb) and C. elegans DRM complexes. This complex also includes proteins such as Mip40/LIN-37, Mip120/LIN-54, and LIN-52. In mammalian cells, Mip130/LIN-9 specifically associates with the p107/p130-E2F4 r...

journal_title：Experimental cell research

authors： Sandoval R,Pilkinton M,Colamonici OR

更新日期：2009-10-15 00:00:00

abstract：:Methylated amino acids inhibit lysosomal function in cultured rat heart myocytes more effectively than the classically employed lysosomotropic weak bases. Moreover, L-leucine methyl ester (L-Leu-OMe) or L-methionine methyl ester (L-Meth-OMe) do not alter lysosomal pH or inactivate lysosomal cysteine proteinases, but d...

journal_title：Experimental cell research

authors： Decker RS,Fuseler JF

更新日期：1984-09-01 00:00:00

abstract：:Tendinopathy is a common and disabling condition that is difficult to treat. The pathomolecular events behind tendinopathy remain uncertain. Micro-RNAs (miRNAs, miRs) are short non-coding RNAs that regulate gene expression and may play a role in tendinopathy development. Tenocytes were obtained from human patellar ten...

journal_title：Experimental cell research

authors： Xiao M,Iglinski-Benjamin KC,Sharpe O,Robinson WH,Abrams GD

更新日期：2019-05-15 00:00:00

abstract：:Treatment with ionic detergents of nuclei isolated from various continuously growing cell lines generally yields chromatin samples of high viscosity. Extensive treatment with nuclease-free proteinase K or pronase solubilized the viscous lysates with > 90% of the DNA migrating at approximately 50 kb. Freshly prepared h...

journal_title：Experimental cell research

authors： Szabó G Jr

更新日期：1995-12-01 00:00:00

abstract：:We have shown previously that the activity of the long myosin light chain kinase (MLCK) is cell cycle regulated with a decrease in specific activity during mitosis that can be restored following treatment with alkaline phosphatase. To better understand the role and significance of phosphorylation in regulating MLCK fu...

journal_title：Experimental cell research

authors： Dulyaninova NG,Bresnick AR

更新日期：2004-10-01 00:00:00

abstract：:In many systems, events participating in cell division are controlled by intracellular pH (pHi). In Xenopus eggs, fertilization is accompanied by an increase in pHi which occurs concomitantly with an increase in protein synthesis and a reinitiation of DNA synthesis, leading the embryo to cell division. In this paper, ...

journal_title：Experimental cell research

authors： Grandin N,Charbonneau M

更新日期：1989-12-01 00:00:00

abstract：:The glomerular capillary endothelium is highly specialized to support the selective filtration of massive volumes of plasma. Filtration is driven by Starling forces acting across the glomerular capillary wall, and depends on its large surface area and extremely high water permeability. Glomerular endothelial cells are...

journal_title：Experimental cell research

authors： Obeidat M,Obeidat M,Ballermann BJ

更新日期：2012-05-15 00:00:00

abstract：:In preceding studies, the IP3-sensitive Ca2+ store of the hamster insulinoma cell line, HIT, was detected in cell surface protrusions such as microvilli and related membrane structures [Lange, K., and Brandt, U. (1993) FEBS Lett. 320, 183-188; and (1993) FEBS Lett. 325, 205-209]. In this study, these experiments were ...

journal_title：Experimental cell research

authors： Lange J,Schlieps K,Lange K,Brandt U,Knoll-Köhler E

更新日期：1996-11-01 00:00:00

abstract：:Diabetic nephropathy (DN) is a major microvascular complication of diabetes that can lead to end-stage renal disease. Podocytes constitute the last barrier of glomerular filtration, whose damage are the direct cause of proteinuria. Dopamine receptors are involved in the regulation of diabetes-induced glomerular hyperf...

journal_title：Experimental cell research

authors： Shao X,Zhang X,Hu J,Gao T,Chen J,Xu C,Wei C

更新日期：2020-03-15 00:00:00

abstract：:Several species of Streptococcus, such as S. salivarius, S. mitis, and S. anginosus, are found to extensively colonize the oral cavity and the upper respiratory tract, and have been shown to increase in patients with oral squamous cell carcinoma (OSCC). Accumulating evidence have revealed that commensal bacteria are i...

journal_title：Experimental cell research

authors： Wang J,Sun F,Lin X,Li Z,Mao X,Jiang C

更新日期：2018-01-01 00:00:00

abstract：:Y-box binding protein-1 (YBX1) is a multifunctional protein and often acts as an indicator of poor prognosis in cancers. Increasing evidence has shown that the levels of YBX1 protein were closely associated with multidrug resistance, relapse, metastasis and poor prognosis in cancers. However, its role in nasopharyngea...

journal_title：Experimental cell research

authors： Zhou LL,Ni J,Feng WT,Yao R,Yue S,Zhu YN,Tang HY,Lv LY,Feng JF,Zhu WG

更新日期：2017-12-01 00:00:00

abstract：:Cytotoxic T lymphocyte (CTL)-mediated lysis is accompanied by fragmentation of target cell DNA into an oligonucleosome ladder, a hallmark of apoptosis. Is this a fortuitous coincidence, or could CTL be inducing lysis by activation of the suicide signal? In this report we demonstrate that CTL-mediated target cell death...

journal_title：Experimental cell research

authors： Helgason CD,Shi L,Greenberg AH,Shi Y,Bromley P,Cotter TG,Green DR,Bleackley RC

更新日期：1993-06-01 00:00:00