Regulation of subcellular localization of the antiproliferative protein Tob by its nuclear export signal and bipartite nuclear localization signal sequences.

abstract：:The HRP-1 cell line is derived from normal rat placenta and appears morphologically similar to and retains characteristic expression of cellular markers of labyrinthine trophoblast cells. In this study, monolayers of HRP-1 cells grown on permeable supports were evaluated as a potential in vitro system to study trophob...

journal_title：Experimental cell research

authors： Shi F,Soares MJ,Avery M,Liu F,Zhang X,Audus KL

更新日期：1997-07-10 00:00:00

abstract：:Hypoxia/reoxygenation (H/R) injury is characterized by microfilament reorganization in cardiomyocytes. Previous studies have shown that myofibrillogenesis regulator-1 (MR-1) is expressed in the myocardium and promotes actin organization in cardiomyocytes. The purpose of this study was to investigate the role of MR-1 i...

journal_title：Experimental cell research

authors： Tao T,Wang X,Liu M,Liu X

更新日期：2015-10-01 00:00:00

abstract：:The cell cycle of the P388D 1 murine macrophage line was delineated and suspensions of exponentially growing cells were separated by centrifugal elutriation into subpopulations enriched in the various phases of the cycle. Analysis of both growth and labelled mitoses curves disclosed that the doubling and cell-cycle ti...

journal_title：Experimental cell research

authors： Gandour DM,Walker WS

更新日期：1983-02-01 00:00:00

abstract：:Hereditary transthyretin amyloidosis (ATTR) is caused by amyloid deposition of misfolded transthyretin (TTR) in various tissues. Recently, reduction of circulating serum TTR, achieved via silencing oligonucleotides, was introduced as therapy of ATTR amyloidosis. We explored the impact of Serpin Family A Member 1 (SERP...

journal_title：Experimental cell research

authors： Niemietz C,Bezerra F,Almeida MR,Guo S,Monia BP,Saraiva MJ,Schütz P,Schmidt HH,Zibert A

更新日期：2020-10-15 00:00:00

abstract：:The enzyme activity hydrolysing diadenosine 5,5'-P1, P4-tetraphosphate (AP4A) was demonstrated in the embryonic extract of sea urchin. The enzyme activity was preferentially inhibited by ZnCl2 and by high concentrations of isobutylmethylxanthine, indicating that two types of the enzyme, (AP4A) hydrolase and non-specif...

journal_title：Experimental cell research

authors： Morioka M,Shimada H

更新日期：1987-03-01 00:00:00

abstract：:Human diploid fibroblasts, arrested following serum or mevalonate depletion, were restimulated to a maximal rate of DNA synthesis within 24 h after the addition of serum or mevalonate, respectively. In both cases the initiation of DNA synthesis was preceded by a 12-h prereplicative phase. Upon the stimulation with ser...

journal_title：Experimental cell research

authors： Carlberg M,Hjertman M,Wejde J,Larsson O

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND/AIMS:The NOD-like receptor, pyrin domain containing-3 (NLRP3) inflammasome is involved in the progression of chronic kidney disease in several rodent models. Here, we investigated whether a specific inhibitor of NLRP3 inflammasome, MCC950, can attenuate cisplatin-induced renal fibrosis. MATERIALS:Renal fibr...

journal_title：Experimental cell research

authors： Li S,Lin Q,Shao X,Mou S,Gu L,Wang L,Zhang Z,Shen J,Zhou Y,Qi C,Jin H,Pang H,Ni Z

更新日期：2019-10-01 00:00:00

abstract：:This study was designed to elucidate the mechanisms involved in elevated cell death arising from an altered endogenous oxidant state. Increased levels of cell death were detected in cells lacking Gpx1 following the addition of exogenous H2O2. This increased apoptosis correlated with a down-regulation in the activation...

journal_title：Experimental cell research

authors： Taylor JM,Crack PJ,Gould JA,Ali U,Hertzog PJ,Iannello RC

更新日期：2004-11-01 00:00:00

abstract：:Mutations in PKHD1 (polycystic kidney and hepatic disease gene 1) gene cause the autosomal recessive polycystic kidney disease (ARPKD). Fibrocystin/polyductin (FPC), encoded by PKHD1, is a membrane-associated receptor-like protein. Although it is widely accepted that cystogenesis is mostly due to aberrant cell prolife...

journal_title：Experimental cell research

authors： Sun L,Wang S,Hu C,Zhang X

更新日期：2011-04-15 00:00:00

abstract：:Recent studies report mitochondrial carrier homolog 2 (MTCH2) as a novel and uncharacterized protein that acts as a receptor-like protein for the truncated BH3-interacting domain death agonist (tBID) protein in the outer membrane of mitochondria. These studies, using mouse embryonic stem cells and fibroblasts as well ...

journal_title：Experimental cell research

authors： Robinson AJ,Kunji ER,Gross A

更新日期：2012-07-01 00:00:00

abstract：:The replication kinetics and cytological changes of normal human oral keratinocytes (NHOK) isolated from the basal surface of oral epithelial sheet and cultured as dispersed cells in low (0.15 mM) Ca(2+) medium without serum were analyzed. Replicating NHOK were quantitated by cell count and identified by [(3)H]thymidi...

journal_title：Experimental cell research

authors： Kang MK,Bibb C,Baluda MA,Rey O,Park NH

更新日期：2000-08-01 00:00:00

abstract：:The non-alpha-helical head domains of cytoskeletal intermediate filaments (IFs) are considered to play an important role in IF assembly and stability. We have investigated the fate of a "headless" mutant vimentin protein in cell types that either lack cytoplasmic IFs or contain preexisting IF networks (keratin and vim...

journal_title：Experimental cell research

authors： Andreoli JM,Trevor KT

更新日期：1994-09-01 00:00:00

abstract：:The process of tumor cell invasion of the basement membrane is proposed to consist of three steps: attachment, local proteolysis and migration. 12-(S)-HETE, a 12-lipoxygenase metabolite of arachidonic acid, upregulates surface expression of integrin cytoadhesins and an autocrine motility factor receptor, suggesting th...

journal_title：Experimental cell research

authors： Honn KV,Timár J,Rozhin J,Bazaz R,Sameni M,Ziegler G,Sloane BF

更新日期：1994-09-01 00:00:00

abstract：:Skeletal muscles cope with a large range of activities, from being able to support the body weight during long periods of upright standing to perform explosive movements in response to an unexpected threat. This requires systems for energy metabolism that can provide energy during long periods of moderately increased ...

journal_title：Experimental cell research

authors： Westerblad H,Bruton JD,Katz A

更新日期：2010-11-01 00:00:00

abstract：:The dynamics of lamin disassembly and reassembly during sea urchin male pronuclear development in vitro was investigated. Using five anti-lamin antibodies, we monitored by immunofluorescence and immunoblotting the changes in lamins during sperm chromatin decondensation, nuclear envelope (NE) formation, and male pronuc...

journal_title：Experimental cell research

authors： Collas P,Pinto-Correia C,Poccia DL

更新日期：1995-08-01 00:00:00

abstract：:We have previously demonstrated that transient blocking of DNA synthesis with drugs such as 1-beta-D-arabinofuranosylcytosine results in some segments of the chromosomal DNA being replicated more than once in a single cell cycle. One explanation for this phenomenon might be that it is due to a perturbation of the cell...

journal_title：Experimental cell research

authors： Woodcock DM,Crowther PJ,Allan G,Cooper IA

更新日期：1983-08-01 00:00:00

abstract：:Resistance of cancer cells to apoptosis is dependent on a balance of multiple genetic and epigenetic mechanisms, which up-regulate efficacy of the surviving growth factor-receptor signaling pathways and suppress death-receptor signaling pathways. The Insulin-like Growth Factor-1 Receptor (IGF-1R) signaling pathway is ...

journal_title：Experimental cell research

authors： Karasic TB,Hei TK,Ivanov VN

更新日期：2010-07-15 00:00:00

abstract：:Autophagy has been reported to have a pivotal role in maintaining stemness, regulating immunomodulation and enhancing the survival of mesenchymal stem cells (MSCs). However, the effect of autophagy on MSC metabolism is largely unknown. Here, we report a workflow for examining the impact of autophagy on human placenta-...

journal_title：Experimental cell research

authors： Sun Y,Chen D,Liu J,Xu Y,Shi X,Luo X,Pan Q,Yu J,Yang J,Cao H,Li L,Li L

更新日期：2018-11-01 00:00:00

abstract：:Developmental studies have demonstrated that the vascular smooth muscle cells (VSMC) present within the elastic arteries are differentiated from two definitive origins, the neural crest and the mesoderm. Cells from these distinct progenitors differ in their ability to determine long-range spatial order of the extracel...

journal_title：Experimental cell research

authors： Thieszen SL,Dalton M,Gadson PF,Patterson E,Rosenquist TH

更新日期：1996-08-25 00:00:00

abstract：:Allograft Inflammatory Factor-1 (AIF-1) is a cytoplasmic calcium-binding protein expressed in vascular smooth muscle cells (VSMC) in response to injury or cytokine stimulation. AIF-1 contains a partially conserved EF-hand calcium-binding domain, and participates in VSMC activation by activation of Rac1 and induction o...

journal_title：Experimental cell research

authors： Autieri MV,Chen X

更新日期：2005-07-01 00:00:00

abstract：:p75NTR is a member of the tumor necrosis superfamily of proteins which is variably associated with induction of apoptosis and proliferation. Cyclin D2 is one of the mediators of cellular progression through G1 phase of the cell cycle. The present study demonstrates the inverse relationship between expression of cyclin...

journal_title：Experimental cell research

authors： Fritz MD,Mirnics ZK,Nylander KD,Schor NF

更新日期：2006-10-15 00:00:00

abstract：:Sertoli cell lines have been established from H-2K(b)-tsA58 transgenic mice carrying an inducible temperature-sensitive SV40 T antigen in their germline. All cell lines tested for expression of Sertoli cell products by reverse transcription-polymerase chain reaction were shown to express mRNAs for alpha-inhibin, Steel...

journal_title：Experimental cell research

authors： Walther N,Jansen M,Ergün S,Kascheike B,Ivell R

更新日期：1996-06-15 00:00:00

abstract：:Tubular epithelial-to-mesenchymal transition (EMT) plays a crucial role in the progression of renal tubular interstitial fibrosis (TIF), which subsequently leads to chronic kidney disease (CKD) and eventually, end-stage renal disease (ESRD). We propose that augmenter of liver regeneration (ALR), a member of the newly ...

journal_title：Experimental cell research

authors： Liao XH,Zhang L,Chen GT,Yan RY,Sun H,Guo H,Liu Q

更新日期：2014-10-01 00:00:00

abstract：:In small oocytes of Xenopus laevis, the three most abundant proteins are isolated as basic polypeptides with molecular weights of 48 kD (P48), 43 kD (P43) and 40 kD (P40, also known as transcription factor IIIA). All three proteins share common properties in being able to bind specifically ribosomal 5S RNA molecules a...

journal_title：Experimental cell research

authors： Barrett P,Johnson RM,Sommerville J

更新日期：1984-08-01 00:00:00

abstract：:Integrin beta 4 subunit is present in association with alpha 6 chain on both normal and transformed epithelial cells. Recently alpha 6 beta 4 heterodimer was found on the endothelium of medium-sized blood vessels and on immature thymocytes. In this report we show, by Northern blotting, indirect immunofluorescence, imm...

journal_title：Experimental cell research

authors： Scardigli R,Soddu S,Falcioni R,Crescenzi M,Cimino L,Sacchi A

更新日期：1996-09-15 00:00:00

abstract：:An implantation-competent blastocyst, several hours prior to its attachment on the uterine wall, transmits signals to surrounding uterine cells and vice-versa to initiate a two-way interaction. The language of this precocious dialogue is versatile, taking advantage of secreted molecules for long-range interactions and...

journal_title：Experimental cell research

authors： Lim HJ,Dey SK

更新日期：2009-02-15 00:00:00

abstract：:The growth rate of malignant F9 embryonal carcinoma cells slows considerably following all-trans-retinoic acid-induced differentiation into benign parietal endoderm. To determine the mechanism of this process, we examined the expression of cyclins D1, D2, and D3 and the activity of their associated kinases. Cyclin D1 ...

journal_title：Experimental cell research

authors： Li Y,Glozak MA,Smith SM,Rogers MB

更新日期：1999-12-15 00:00:00

abstract：:Transferrin (Tf), an iron-binding protein, was investigated in the cultured human fibroblast which is a major cell type in connective tissues. Tf is a major iron-transporting protein and has an important role in iron metabolism. Using two-dimensional gel electrophoresis, we demonstrated the eight subtypes of Tf produc...

journal_title：Experimental cell research

authors： Kondo T,Sakaguchi M,Namba M

更新日期：1998-07-10 00:00:00

abstract：:Cell-CAM 105 is involved in intercellular adhesion of isolated rat hepatocytes in vitro. In addition to liver, cell-CAM 105 occurs in several different epithelia, in platelets, and in granulocytes. In this paper we present a detailed analysis of cell-CAM 105 in the small intestinal mucosa. Isolated rat intestinal epit...

journal_title：Experimental cell research

authors： Hansson M,Blikstad I,Obrink B

更新日期：1989-03-01 00:00:00

abstract：:The first angiogenesis inhibitors for cancer have now been approved by the F.D.A. in the U.S. and in 28 other countries, including China. The majority of these are monotherapies that block VEGF. However, mutant tumor cells may over time produce redundant angiogenic factors. Therefore, for long-term use in cancer, comb...

journal_title：Experimental cell research

authors： Folkman J

更新日期：2006-03-10 00:00:00