Abstract:
BACKGROUND:Disease preventing effects gained by garlic consumption have been recognized since early period of history, making commercially available garlic supplements attractive to the general public. Possible pharmacokinetic interactions which could occur between applied drugs and aged garlic extract (AGE) are unknown. AIM:To test in vitro impact of some garlic phytochemicals on P-glycoprotein (Pgp), the most recognized efflux transporter, and the effect of AGE on passive membrane permeability, absorptive and secretory intestinal transporters. METHODS:Rat small intestine and Caco-2 cell monolayers, mounted in side-by-side diffusion chambers were used. RESULTS:Hydrophilic sulphur compounds increased Pgp mediated Rhodamine 123 (Rho123) efflux, whereas the lipophilic ones increased Pgp efflux through rat ileum but not through Caco-2 cell monolayers. Increased activities of secretory (Pgp, multidrug-resistance associated protein 2) and absorptive (monocarboxylate transporter 1, organic anion transporting polypeptide) transporters involved in drug absorption were observed in rat small intestine and Caco-2 cell monolayers in the presence of AGE. Transport of drugs mediated by breast cancer resistance protein and H(+)-oligopeptide transporter 1 was activated in rat intestine but inhibited through Caco-2 cells. Passive membrane permeability of tested compounds remained unaltered through rat small intestine, while significant changes were observed with Caco-2 cell monolayers. CONCLUSIONS:Due to the observed in vitro pharmacokinetic interactions between AGE and investigated cardiovascular, antidiabetic and antiviral drugs, in vivo absorption changes are possible, but the magnitude of change depends on the most profound process involved (influx, efflux, passive diffusion) in compounds permeability.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Berginc K,Žakelj S,Kristl Adoi
10.1007/s00394-010-0095-xsubject
Has Abstractpub_date
2010-09-01 00:00:00pages
373-84issue
6eissn
1436-6207issn
1436-6215journal_volume
49pub_type
杂志文章abstract:PURPOSE:Introduction of complementary food usually leads to decreasing intakes of long-chain n-3 polyunsaturated fatty acids (n-3 LC-PUFA), compared to full breastfeeding. In the randomised controlled PINGU intervention trial, we tested the effects of complementary foods with different contents of alpha-linolenic acid ...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-015-0982-2
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Mediterranean diet (MED) is associated with health benefits, yet scarce data exist regarding the role of MED in inflammatory bowel diseases (IBD). Herein, we aimed to evaluate the association between MED and inflammatory markers in patients with IBD after pouch surgery. METHODS:Consecutive patients after po...
journal_title:European journal of nutrition
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doi:10.1007/s00394-019-02158-3
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abstract:BACKGROUND/OBJECTIVES:Individuals with type 1 diabetes have a high risk of developing cardiovascular diseases, and it has been reported that they consume a high atherogenic diet. We examined how nutrient intake and adherence to current European nutritional recommendations evolved in a large cohort of European individua...
journal_title:European journal of nutrition
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doi:10.1007/s00394-012-0473-7
更新日期:2013-10-01 00:00:00
abstract:PURPOSE:Several studies in recent years have investigated the relationship between alcohol intake and melanoma risk, with conflicting results. To help clarify this issue, we conducted a literature review and dose-response meta-analysis of studies published until June 30th, 2017, that examined the association between al...
journal_title:European journal of nutrition
pub_type: 杂志文章,meta分析
doi:10.1007/s00394-018-1613-5
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:Considerable variation in 25-hydroxyvitamin D (25(OH)D) in populations worldwide that seems to be independent of latitude has been reported. Therefore, we aimed to assess vitamin D status of a mid-aged German general population and to identify its dietary, lifestyle, anthropometric, and genetic determinants. M...
journal_title:European journal of nutrition
pub_type: 杂志文章
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abstract:BACKGROUND:The prevalence of overweight/obesity and related manifestations such as metabolic syndrome (MetS) is increasing worldwide. High energy density diets, usually with low nutrient density, are among the main causes. Some high-quality dietary patterns like the Mediterranean diet (MedDiet) have been linked to the ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-019-02087-1
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abstract::The awareness is increasing that in the colon many metabolic processes take place in relation to the fermentation of our food, which might be relevant for health and disease. However, the relation between food, colon metabolism and health or disease is far from clear. In this overview, the physiology of colonic metabo...
journal_title:European journal of nutrition
pub_type: 杂志文章,评审
doi:10.1007/s00394-002-1101-8
更新日期:2002-11-01 00:00:00
abstract:PURPOSE:We examined whether high doses of folic acid and iron supplementation in early-to-mid pregnancy affect the risk of preterm birth, low birth weight, and small for gestational age neonates, in the mother-child cohort in Crete, Greece (Rhea study). METHODS:We included 1,279 women with singleton pregnancies with c...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-012-0339-z
更新日期:2013-02-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
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doi:10.1007/s00394-013-0542-6
更新日期:2014-01-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:Vegetables and fruits are rich sources of a variety of nutrients, including vitamins (E and C), trace minerals, and dietary fibers, and many other classes of biologically active compounds such as carotenoids and polyphenols, which are often assumed to protect against degenerative pathologies such as cardiova...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-006-0594-y
更新日期:2006-08-01 00:00:00
abstract:BACKGROUND:Flavonoids have physiological activity and a variety of pharmacological properties, including anticancer activity in vitro, but structure-anticancer activity relationships are unclear. AIM:The objectives of this work were to investigate the activity of dietary flavonol congeners against cell lines derived f...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-011-0204-5
更新日期:2012-03-01 00:00:00
abstract:PURPOSE:In vitro and in vivo studies suggested that flavonols, flavones, flavanones and flavan-3-ols have preventive effects on breast carcinogenesis. Epidemiological evidence about the associations between these flavonoid biomarkers and breast cancer risk is limited. This study aimed to investigate the association bet...
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-0931-0
更新日期:2016-04-01 00:00:00
abstract:INTRODUCTION:Breast cancer prevalence is growing worldwide. Many factors, such as diet and lifestyle could be determinants of the incidence of breast cancer. Coffee has been extensively studied in relation to several chronic diseases because of its multiple effects in health maintenance and its elevated consumption. We...
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doi:10.1007/s00394-020-02180-w
更新日期:2020-12-01 00:00:00
abstract:PURPOSE:The associations between specific carotenoid intake and colorectal cancer risk remain inconsistent. The aim of this study was to examine the association between specific dietary carotenoid intake with colorectal cancer risk in Chinese adults. METHOD:From July 2010 to October 2013, 845 eligible colorectal cance...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-014-0743-7
更新日期:2015-06-01 00:00:00
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abstract:PURPOSE:Alcoholic liver disease or non-alcoholic fatty liver disease/non-alcoholic steatohepatitis are well-known risk factors for liver fibrosis or cirrhosis and hepatocellular carcinoma; it is a major global health concern, but there are few effective and safe management options. Therefore, we aimed to investigate th...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章
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journal_title:European journal of nutrition
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2003-08-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-1036-5
更新日期:2016-10-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-013-0619-2
更新日期:2014-08-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-009-0047-5
更新日期:2010-02-01 00:00:00
abstract:PURPOSE:Ellagitannins are high molecular weight polyphenols present in high quantities in various food products. They are metabolized by human and animal gut microbiota to postbiotic metabolites-urolithins, bioavailable molecules of a low molecular weight. Following absorption in the gut, urolithins rapidly undergo pha...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-020-02386-y
更新日期:2020-09-22 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
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更新日期:2010-02-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2016-02-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2013-04-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章,评审
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更新日期:2017-03-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2008-09-01 00:00:00