当前位置： SCI文献检索 > International Journal of Immunogenetics期刊下所有文献 > Study on VNTR polymorphism of gene IL-1RA in 19 Chinese populations.

Study on VNTR polymorphism of gene IL-1RA in 19 Chinese populations.

Abstract：

:Earlier studies suggested that a variable number tandem repeat (VNTR) polymorphism in intron 2 of the interleukin-1 receptor antagonist (IL-1RA) gene might be associated with some chronic inflammatory diseases, autoimmune diseases and solid tumours. To study the distribution of this polymorphism in China, 1352 samples were collected from 19 widely distributed Chinese populations. PCR was used to genotype the VNTR. The overall frequencies of allele 1 and allele 2 were 0.913 and 0.064 respectively. The frequency of the allele 2 was significantly different between the northeastern and the northwestern populations. Moreover, the allele frequencies at this locus in three Chinese Han populations were different from that in minority populations. When compared with other populations worldwide, the frequencies of the two alleles in China were not significantly different from those in the Asian and Pacific Islands. However, the prevalence of allele 1 in China was significantly higher, and the prevalence of allele 2 was significantly lower, than those in American and European Caucasians, and the pairwise Fst values reinforced this observation. The differences of the allele frequencies between different regions and within the same region showed that geography and race have important roles in the population differentiation for the IL-1RA gene. In summary, our results provide a valuable reference for population genetic information and future disease association studies in Chinese populations.

journal_name

Int J Immunogenet

journal_title

International journal of immunogenetics

authors

Jiang J,Zhang X,Sun D,Jin Y,Bai J,Chen F,Fu S

doi

10.1111/j.1744-313X.2009.00891.x

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

73-7

issue

2

eissn

1744-3121

issn

1744-313X

pii

EJI891

journal_volume

37

pub_type

杂志文章

相关文献

International Journal of Immunogenetics文献大全
  • TLR9 gene polymorphism (rs187084, rs352140): association with acute rejection and estimated glomerular filtration rate in renal transplant recipients.

    abstract：:The Toll-like receptors (TLRs) are related to innate immunity. TLR9, a member of TLRs, is expressed in immune cell-rich tissues and mediates cellular response. We investigated the association between TLR9 polymorphisms and kidney allograft outcomes. To investigate whether TLR9 polymorphisms are associated with acute r...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章,多中心研究

    doi：10.1111/iji.12069

    authors： Kim TH,Jeong KH,Kim SK,Lee SH,Ihm CG,Lee TW,Moon JY,Yoon YC,Chung JH,Park SJ,Kang SW,Kim YH

    更新日期：2013-12-01 00:00:00

  • Characterization of a novel DRB1*14 allele (DRB1*1449) in the Han-Chinese population.

    abstract：:We report here a novel human leukocyte antigen (HLA) allele, DRB1*1449, in the Han-Chinese population. The nature of the new allele was confirmed by the sequencing-based typing (SBT) method. Genomic DNA and six subclones containing DNA fragment of DRB1 exon 2 were sequenced in both forward and reverse directions. The ...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2005.00557.x

    authors： Miao KR,Xue M,Zhou XY,Xu R,Fei XM,Pan QQ,Zhang JW,Zhao X,Fan S,KuKuruga D,Xu AL,Wang CY

    更新日期：2006-02-01 00:00:00

  • Frequency of P2RX7 A1513C and TLR2 -196 to -174 ins/del in healthy Polish individuals.

    abstract：:Polymorphisms within genes coding innate immune response proteins are involved in genetic susceptibility to various conditions. We investigated the frequency of P2RX7 A1513C and TLR2 -196 to -174 ins/del polymorphisms in healthy Polish population. Frequency of minor alleles was relatively similar to the pattern presen...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12185

    authors： Lewandowska M,Garczyńska P,Jędrychowska-Dańska K,Kopczyńska P,Masłowska A,Witas H

    更新日期：2015-06-01 00:00:00

  • Analysis of polymorphic sites in the promoter of the nitric oxide synthase 2 gene in Brazilian patients with leprosy.

    abstract：:Leprosy is one of the most neglected infectious tropical diseases of the skin and the nerves caused by the intracellular pathogen Mycobacterium leprae. The inducible NOS isoform encoded by NOS2A plays a vital role in host defence against bacterial infections. The functional promoter polymorphisms in NOS2A are associat...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12108

    authors： Messias-Reason IJ,van Tong H,Velavan TP

    更新日期：2014-06-01 00:00:00

  • Study on the polymorphisms of HLA-ABCDQB1DRB1 alleles and haplotypes in Hubei Han population of China.

    abstract：:The present study aimed to analyse the frequencies of human leukocyte antigen HLA-ABCDQB1 and HLA-DRB1 alleles and haplotypes in a subset of 3,732 Han population from Hubei of China. All samples were typed in the HLA-ABCDQB1 and HLA-DRB1 loci using the sequence-based typing method; subsequently, the HLA polymorphisms ...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12516

    authors： Zou J,Shen G,Qiang W,Zhu YY,Li WX

    更新日期：2021-02-01 00:00:00

  • HLA gene and haplotype frequencies in Russians, Bashkirs and Tatars, living in the Chelyabinsk Region (Russian South Urals).

    abstract：:We have characterized the HLA-A, -B, -DRB1, -DQA1 and -DQB1 profiles of three major ethnic groups living in Chelyabinsk Region of Russian South Urals, viz., Russians (n = 207), Bashkirs (n = 146) and Tatars (n = 135). First field level typing was performed by PCR using sequence-specific primers. Estimates included car...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2012.01117.x

    authors： Suslova TA,Burmistrova AL,Chernova MS,Khromova EB,Lupar EI,Timofeeva SV,Devald IV,Vavilov MN,Darke C

    更新日期：2012-10-01 00:00:00

  • The molecular characterization of a catalase from Chinese mitten crab Eriocheir sinensis.

    abstract：:Catalase (CAT) is an antioxidant enzyme and plays a significant role in the protection against oxidative stress by reducing hydrogen peroxide. The CAT cDNA of Eriocheir sinensis (EsCAT) was cloned via RACE technique. The complete sequence of EsCAT cDNA consisted of a 5' untranslated regions (UTR) of 224 bp, a 3' UTR o...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12019

    authors： Wang M,Wang L,Zhou Z,Gao Y,Wang L,Shi X,Gai Y,Mu C,Song L

    更新日期：2013-06-01 00:00:00

  • cDNA cloning, genomic structure and mRNA expression pattern of porcine type I interferons receptor 2 gene.

    abstract：:Type I interferons (IFN) are important mediators of the host defence against viruses through binding to the cell surface receptors, among which the binding to type I IFN receptor 2 (IFNAR2) is the very first step initiating a complex signal transduction cascade. By using RT-PCR and 5' RACE approaches, we obtained porc...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2011.01018.x

    authors： Xing F,Li Y,Liang S,Liu D,Jiang C,Zhang Y,Kang L,Jiang Y

    更新日期：2011-08-01 00:00:00

  • IFN-γ +874T/A polymorphism increases susceptibility to post-traumatic osteomyelitis.

    abstract：:Immunological inflammatory reaction is one of the key links in the occurrence and development of post-traumatic osteomyelitis after microbial invasion. Growing evidence suggests complex interactions between IFN-γ and bone remodelling cells. However, potential association of IFN-γ gene polymorphism with susceptibility ...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12462

    authors： Zhao XQ,Jiang N,Hu YJ,Yu B

    更新日期：2020-04-01 00:00:00

  • Association between CCL2 haplotypes and knee osteoarthritis.

    abstract：:We examined five single nucleotide polymorphisms (SNPs) and reconstructed 5-locus haplotypes of the CCL2 gene, in knee osteoarthritis (OA) cases and in controls. The CCL2 rs2857657 variant (G) allele was observed more frequently in female knee OA cases than in controls. One haplotype (H5) was observed exclusively in t...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12015

    authors： Hulin-Curtis SL,Bidwell JL,Perry MJ

    更新日期：2013-08-01 00:00:00

  • Influence of HLA-DR2 on perforin-positive cells in pulmonary tuberculosis.

    abstract：:Perforin is one of the key effector molecules of cytotoxic T cells and natural killer cells. The influence of HLA-DRB1 alleles on peripheral blood perforin-positive CD4, CD8, CD16 and CD 56 cells was studied by flow cytometry. HLA-DRB1 typing was done in normal healthy subjects (NHS: n = 156) and patients with pulmona...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2007.00703.x

    authors： Rajeswari DN,Selvaraj P,Raghavan S,Jawahar MS,Narayanan PR

    更新日期：2007-10-01 00:00:00

  • Genetic association of interleukin-2, interleukin-4, interleukin-6, transforming growth factor-β, tumour necrosis factor-α and blood concentrations of calcineurin inhibitors in Turkish renal transplant patients.

    abstract：:Cytokines are essential for the control of the immune response as most of the immunosuppressive drugs target cytokine production or their action. The calcineurin inhibitors (CNIs) cyclosporine (CsA) and tacrolimus are immunosuppressive drugs widely used after renal transplantation to prevent allograft rejection. They ...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12192

    authors： Seyhun Y,Ciftci HS,Kekik C,Karadeniz MS,Tefik T,Nane I,Turkmen A,Oguz FS,Aydin F

    更新日期：2015-06-01 00:00:00

  • Reliability of HLA-Cw data collected in unrelated bone marrow registry and their usefulness for preliminary donor selection.

    abstract：:In the present study, we addressed the question of how often HLA-DRB1-matched donors can be found by further typing of AB-matched donors and whether Cw preselection can be helpful. Sixty-eight patients and 174 donors were enrolled in the study. In all donors, confirmatory DNA Cw typing was performed to check reliabili...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2005.00533.x

    authors： Nowak J,Mika-Witkowska R,Zajko M,Łopacz P

    更新日期：2005-10-01 00:00:00

  • New genes associated with rheumatoid arthritis identified by gene expression profiling.

    abstract：:In this study, we aimed to find new genes associated with rheumatoid arthritis (RA) so that more comprehensive genes would be used for monitoring and/or diagnosing patients. Illumina digital gene expression profiling was applied in two sample types - peripheral blood mononuclear cells (PBMCs) and synovial cells to com...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12313

    authors： Wang H,Guo J,Jiang J,Wu W,Chang X,Zhou H,Li Z,Zhao J

    更新日期：2017-06-01 00:00:00

  • Investigation of JAK2, STAT3 and CCR6 polymorphisms and their gene-gene interactions in inflammatory bowel disease.

    abstract：:Genome-wide association studies identified many loci associated with the two forms of inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative colitis (UC). Components of the interleukin-23 signalling pathway, such as IL23R, JAK2 and STAT3, have been implicated in both diseases. In addition, emerging evid...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2012.01084.x

    authors： Polgar N,Csongei V,Szabo M,Zambo V,Melegh BI,Sumegi K,Nagy G,Tulassay Z,Melegh B

    更新日期：2012-06-01 00:00:00

  • HLA class II eplet mismatch load improves prediction of dnDSA development after living donor kidney transplantation.

    abstract：:HLA donor-specific antibodies developed de novo after transplant remain a major cause of chronic allograft dysfunction. Our study main purpose was to determine whether HLA MM, assessed traditionally and by HLA total and AbVer eplet mismatch load (EptMM and EpvMM) assessed with HLAMatchMaker, had impact on dnDSA develo...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12519

    authors： Tafulo S,Malheiro J,Santos S,Dias L,Almeida M,Martins S,Pedroso S,Mendes C,Lobato L,Castro-Henriques A

    更新日期：2021-02-01 00:00:00

  • Association of tumour necrosis factor-alpha -308 G/A promoter polymorphism with susceptibility and disease profile of rheumatoid arthritis.

    abstract：:The objective was to analyze the possible involvement of tumour necrosis factor-alpha (TNF-α) -308 G/A promoter polymorphism in the susceptibility and/or the disease profile of rheumatoid arthritis (RA) in Egyptian patients. TNF-α-308 G/promoter polymorphism detection by amplification refractory mutation system (ARMS)...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2011.01028.x

    authors： Mosaad YM,Abdelsalam A,El-Bassiony SR

    更新日期：2011-10-01 00:00:00

  • HLA-B*15 subtypes distribution in Han population in Beijing, China, as compared with those of other populations.

    abstract：:To identify HLA-B*15 subtypes distribution in Han population in Beijing, People's Republic of China, 826 unrelated healthy individuals were typed using the polymerase chain reaction-sequence-based typing method. Within the 246 HLA-B*15 positive individuals, 29 HLA-B*15 alleles were identified, the most predominant of ...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2010.00910.x

    authors： Yang G,Deng YJ,Qin H,Zhu BF,Chen F,Shen CM,Sun ZM,Chen LP,Wu J,Mu HF,Lucas R

    更新日期：2010-06-01 00:00:00

  • A chromosomal event resulting in possession and expression of multiple HLA-B and Cw genes in a renal patient.

    abstract：:Routine HLA typing of a renal patient for purposes of registration for transplantation revealed an unusual human leucocyte antigen (HLA)-B and Cw genotype, with three specificities detected. Results were confirmed in a second sample, and in a second laboratory. The possibility of these results reflecting a chimaeric s...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2006.00610.x

    authors： Poole K,Montague B,Roberts R,Stoves J,Bendukidze N,Clark B

    更新日期：2006-08-01 00:00:00

  • Solid phase testing in the HLA laboratory: implications for organ allocation.

    abstract：:This piece was originally requested as a white paper from the Scientific and Clinical Affairs Committee of the American Society for Histocompatibility and Immunogenetics (ASHI), of which the author was then Chairman. Upon review by the ASHI Board of Directors and the Editors of their journal, it was considered too con...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章,评审

    doi：10.1111/j.1744-313X.2008.00768.x

    authors： Eckels DD

    更新日期：2008-08-01 00:00:00

  • Frequency of ABO/Rhesus (D) blood groupings and ethnic distribution in the Greater-Accra region of Ghana, towards effective blood bank inventory.

    abstract：:Knowledge on blood group phenotypes is of key importance in clinical practice. It used in blood transfusion practice to determine the direction of recruitment of voluntary donors as required for each population within a country, and for disease association and population genetics studies. This study aimed at reporting...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12412

    authors： Doku GN,Agbozo WK,Annor RA,Kisseh GD,Owusu MA

    更新日期：2019-04-01 00:00:00

  • Characterization of tumour necrosis factor-alpha genetic variants and mRNA expression in patients with severe sepsis.

    abstract：:Tumour necrosis factor-alpha (TNFalpha) has been implicated in the pathogenicity of severe sepsis by both genetic association studies and animal models. Conflicting functional data have emerged in relation to genetic variants and TNFalpha protein production. Therefore, we assessed the functionality of TNFalpha genetic...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2008.00773.x

    authors： O'Dwyer MJ,Mankan AK,Ryan AW,Lawless MW,Stordeur P,Kelleher D,McManus R,Ryan T

    更新日期：2008-08-01 00:00:00

  • FcγRIIB-nt645+25A/G gene polymorphism and periodontitis in Japanese women with preeclampsia.

    abstract：:FcγRIIB contains a unique immunoreceptor tyrosine-based inhibition motif (ITIM) and functions as a negative feedback regulator of leucocyte activation and antibody production. We have previously reported FcγRIIB-nt645+25A/G gene polymorphism to be associated with prevalence and severity of periodontitis, FcγRIIB expre...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2012.01124.x

    authors： Wang Y,Sugita N,Kikuchi A,Iwanaga R,Hirano E,Shimada Y,Sasahara J,Tanaka K,Yoshie H

    更新日期：2012-12-01 00:00:00

  • Killer cell immunoglobulin-like receptors on NK cells: the how, where and why.

    abstract：:Natural killer (NK) cells have killer cell immunoglobulin-like receptors (KIR) that recognize and interact with HLA class I antigen. The KIRs are a multigene family and its members are often highly polymorphic. Evidence is emerging from disease-association studies that KIR receptors can play beneficial roles in viral ...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章,评审

    doi：10.1111/j.1744-313X.2007.00739.x

    authors： Gardiner CM

    更新日期：2008-02-01 00:00:00

  • HLA haplotypes in recurrent aphthous stomatitis: a mode of inheritance?

    abstract：:The aim of this study was to investigate the genetic association between recurrent aphthous stomatitis (RAS) and human leucocyte antigen (HLA) class I and II alleles and HLA haplotypes. Families selected had at least one child suffering from recurrent aphthous stomatitis in addition to one or both of the parents. HLA-...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2008.00801.x

    authors： Albanidou-Farmaki E,Deligiannidis A,Markopoulos AK,Katsares V,Farmakis K,Parapanissiou E

    更新日期：2008-12-01 00:00:00

  • The distributions of HLA-A, HLA-B, HLA-C, HLA-DRB1 and HLA-DQB1 allele and haplotype at high-resolution level in Zhejiang Han population of China.

    abstract：:The distributions of HLA allele and haplotype are variable in different ethnic populations and the data for some populations have been published. However, the data on HLA-C and HLA-DQB1 loci and the haplotype of HLA-A, HLA-B, HLA-C, HLA-DRB1 and HLA-DQB1 loci at a high-resolution level are limited in Zhejiang Han popu...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12411

    authors： Chen N,Wang W,Wang F,Dong L,Zhao S,Zhang W,He J,Huang H,Zhu F

    更新日期：2019-02-01 00:00:00

  • Intron 4 polymorphism of the endothelial nitric oxide synthase eNOS gene and early microangiopathy in type 1 diabetes.

    abstract：:Nitric oxide (NO) is an endogenous vasodilator involved in inflammatory and autoimmune response, and in the pathophysiology of diabetic vascular disease. Endothelium-derived NO is formed from L-arginine by endothelial NO synthase (eNOS), and earlier studies have provided evidence for altered NO metabolism and impaired...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2009.00839.x

    authors： Mamoulakis D,Bitsori M,Galanakis E,Vazgiourakis V,Panierakis C,Goulielmos GN

    更新日期：2009-06-01 00:00:00

  • Using ESTs database to predict and validate single polymorphisms at the HLA system.

    abstract：:We propose a bioinformatics pipeline in which we use an ESTs database to predict and validate single-nucleotide polymorphisms (SNPs) directly linked to gene-coding regions at the HLA class I genes (HLA-A, HLA-B and HLA-C). Annotation originated from our analysis revealed various classes of possible new variations that...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2011.01076.x

    authors： Figueiredo TC,de Oliveira JR

    更新日期：2012-06-01 00:00:00

  • Th-1 cytokines gene polymorphism in human brucellosis.

    abstract：:Brucellosis is a worldwide zoonosis. Infection with Brucella species results in the activation of cell-mediated immune response. The interaction between Th1and Th2 cytokines determines the outcome of disease. Production of each cytokine is in turn affected by genetic factors. In this study, we investigated the possibl...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2006.00626.x

    authors： Davoudi S,Amirzargar AA,Hajiabdolbaghi M,Rasoolinejad M,Soodbakhsh A,Jafari S,Piri H,Maleknejad P,Bagherian H,Madadi N,Nikbin B

    更新日期：2006-10-01 00:00:00

  • Molecular approaches to transfusion medicine in Polynesians and Maori in New Zealand.

    abstract：:In recent years, with the application of genotyping technology, there has been a substantial increase in the number of reported blood group alleles. This survey was designed to evaluate new molecular blood group genotyping methods and compile reference blood group data sets for Polynesian and Maori subjects. Subsequen...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12073

    authors： Edinur HA,Dunn PP,Lea RA,Chambers GK

    更新日期：2013-12-01 00:00:00