当前位置： SCI文献检索 > International Journal of Immunogenetics期刊下所有文献 > The distributions of HLA-A, HLA-B, HLA-C, HLA-DRB1 and HLA-DQB1 allele and haplotype at high-resolution level in Zhejiang Han population of China.

The distributions of HLA-A, HLA-B, HLA-C, HLA-DRB1 and HLA-DQB1 allele and haplotype at high-resolution level in Zhejiang Han population of China.

Abstract：

:The distributions of HLA allele and haplotype are variable in different ethnic populations and the data for some populations have been published. However, the data on HLA-C and HLA-DQB1 loci and the haplotype of HLA-A, HLA-B, HLA-C, HLA-DRB1 and HLA-DQB1 loci at a high-resolution level are limited in Zhejiang Han population, China. In this study, the frequencies of the HLA-A, HLA-B, HLA-C, HLA-DRB1 and HLA-DQB1 loci and haplotypes were analysed among 3,548 volunteers from the Zhejiang Han population using polymerase chain reaction sequencing-based typing method. Totals of 51 HLA-A, 97 HLA-B, 45 HLA-C, 53 HLA-DRB1 and 27 HLA-DQB1 alleles were observed. The top three frequent alleles of HLA-A, HLA-B, HLA-C, HLA-DRB1 and HLA-DQB1 loci were A*11:01 (23.83%), A*24:02 (17.16%), A*02:01 (11.36%); B*40:01 (14.08%), B*46:01 (12.20%), B*58:01 (8.50%); C*07:02 (18.25%), C*01:02:01G (18.15%), C*03:04 (9.88%); DRB1*09:01 (17.52%), DRB1*12:02 (10.57%), DRB1*15:01 (9.70%); DQB1*03:01 (22.63%), DQB1*03:03 (18.26%) and DQB1*06:01 (10.88%), respectively. A total of 141 HLA-A-C-B-DRB1-DQB1 haplotypes with a frequency of ≥0.1% were found and the haplotypes with frequency greater than 3% were A*02:07-C*01:02:01G-B*46:01-DRB1*09:01-DQB1*03:03 (4.20%), A*33:03-C*03:02-B*58:01-DRB1*03:01-DQB1*02:01 (4.15%), A*30:01-C*06:02-B*13:02-DRB1*07:01-DQB1*02:02 (3.20%). The likelihood ratios test for the linkage disequilibrium of two loci haplotypes was revealed that the majority of the pairwise associations were statistically significant. The data presented in this study will be useful for searching unrelated HLA-matched donor, planning donor registry and for anthropology studies in China.

journal_name

Int J Immunogenet

journal_title

International journal of immunogenetics

authors

Chen N,Wang W,Wang F,Dong L,Zhao S,Zhang W,He J,Huang H,Zhu F

doi

10.1111/iji.12411

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

7-16

issue

1

eissn

1744-3121

issn

1744-313X

journal_volume

46

pub_type

杂志文章

相关文献

International Journal of Immunogenetics文献大全
  • Heme oxygenase 1 gene polymorphisms and outcome of renal transplantation.

    abstract：:Heme oxygenase isoenzyme HO-1 has been linked to several cytoprotective functions with a potentially beneficial role in transplantation. In the present study, the effect of genetic variation in HO-1 on renal allograft outcome was investigated. Six hundred and eighty patients subject to renal transplantation in a singl...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2007.00688.x

    authors： Turpeinen H,Kyllönen LE,Parkkinen J,Laine J,Salmela KT,Partanen J

    更新日期：2007-08-01 00:00:00

  • Characterization of a novel MICB variant in an individual from the Chinese Uyghur population, MICB*005:09, by cloning and sequencing.

    abstract：:A new allelic variant in MICB*005 lineage, MICB*005:09, has been identified in a male Uyghur individual recruited from Xinjiang Uyghur Autonomous Region, China by PCR-sequence-based typing (Sanger sequencing) and confirmed by cloning and sequencing. Aligned with MICB*005:03, this new allelic variant shows a synonymous...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12410

    authors： Tursun M,Wang Z,Guo W,Hasim A,Tian W

    更新日期：2019-02-01 00:00:00

  • Speed and selection in the evolution of killer-cell immunoglobulin-like receptors.

    abstract：:The killer-cell immunoglobulin-like receptors (KIR) form a diverse family of receptors that control the functions of natural killer cells. Sequencing of KIR from primates has revealed the unexpected extent to which this gene family has diversified mostly likely in response to pathogens and to pathogen-mediated selecti...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章,评审

    doi：10.1111/j.1744-313X.2008.00756.x

    authors： Martinez-Borra J,Khakoo SI

    更新日期：2008-04-01 00:00:00

  • Cytokine typing: SNP allele frequencies in the Iranian population.

    abstract：:Single nucleotide polymorphisms within the promoter or other regulatory sequences of cytokine genes were evaluated and compared between an Iranian population and populations of different ethnic/geographical background. In 40 healthy Iranian subjects, cytokine typing was performed by polymerase chain reaction-sequence-...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章,收录出版

    doi：10.1111/j.1744-313X.2006.00595.x

    authors： Bagheri M,Abdi-Rad I,Omrani D,Khalkhali HR

    更新日期：2006-06-01 00:00:00

  • Discovery of the novel HLA-DRB1*09:01:08 allele in a Taiwanese volunteer bone marrow donor and identification of the probable HLA-A, HLA-B and HLA-DRB1 haplotype in association with DRB1*09:01:08.

    abstract：:We report here the novel variant of HLA-DRB1*09:01, DRB1*09:01:08, discovered in a Taiwanese volunteer bone marrow donor by a sequence-based typing (SBT) method. The DNA sequence of DRB1*09:01:08 is identical to the sequence of DRB1*09:01:02 in exon 2 except a silent mutation at nucleotide position 261(C→T) (GCC→GCT a...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2012.01143.x

    authors： Yang KL,Lee SK,Yang SY,Kao RH,Lin CL,Lin PY

    更新日期：2013-04-01 00:00:00

  • Characterization of HLA-F polymorphism in four distinct populations in Mainland China.

    abstract：:Currently, there is a lack of information on polymorphism of human leucocyte antigen-F (HLA-F) gene in ethnically diverse human populations. In this study, HLA-F allelic typing was performed for 690 individuals representing two southern Chinese Han populations (Hunan Han and Guangdong Han) and two northern Chinese pop...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12047

    authors： Pan FH,Liu XX,Tian W

    更新日期：2013-10-01 00:00:00

  • Study on the polymorphisms of HLA-ABCDQB1DRB1 alleles and haplotypes in Hubei Han population of China.

    abstract：:The present study aimed to analyse the frequencies of human leukocyte antigen HLA-ABCDQB1 and HLA-DRB1 alleles and haplotypes in a subset of 3,732 Han population from Hubei of China. All samples were typed in the HLA-ABCDQB1 and HLA-DRB1 loci using the sequence-based typing method; subsequently, the HLA polymorphisms ...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12516

    authors： Zou J,Shen G,Qiang W,Zhu YY,Li WX

    更新日期：2021-02-01 00:00:00

  • Molecular cloning and characterization of Th1 and Th2 cytokines of African buffalo (Syncerus caffer).

    abstract：:The African buffalo (Syncerus caffer) has been implicated as the reservoir of several bovine infectious agents. However, there is insufficient information on the protective immune responses in the African buffalo, particularly in infected animals. In this study, we analysed Th1 cytokines IL-2 and IFN-γ, and Th2 cytoki...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2011.01062.x

    authors： Suzuki S,Konnai S,Okagawa T,Githaka NW,Kariuki E,Gakuya F,Kanduma E,Shirai T,Ikebuchi R,Ikenaka Y,Ishizuka M,Murata S,Ohashi K

    更新日期：2012-04-01 00:00:00

  • Association of tumour necrosis factor-alpha -308 G/A promoter polymorphism with susceptibility and disease profile of rheumatoid arthritis.

    abstract：:The objective was to analyze the possible involvement of tumour necrosis factor-alpha (TNF-α) -308 G/A promoter polymorphism in the susceptibility and/or the disease profile of rheumatoid arthritis (RA) in Egyptian patients. TNF-α-308 G/promoter polymorphism detection by amplification refractory mutation system (ARMS)...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2011.01028.x

    authors： Mosaad YM,Abdelsalam A,El-Bassiony SR

    更新日期：2011-10-01 00:00:00

  • Association between interferon lambda 3 rs12979860 polymorphism and clinical outcome in dengue virus-infected children.

    abstract：:Single nucleotide polymorphisms (SNPs) in immune-related genes have been shown to play a role in driving the development of the severe phenotypes of dengue virus (DENV) infection. We assessed the association between IFNL3 gene SNP (rs12979860) and dengue clinical outcomes in children. Patients with dengue-related symp...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12477

    authors： da Silva Cezar RD,da Silva Castanha PM,Matos Freire N,Mola C,Feliciano do Carmo R,Tenório Cordeiro M,Baptista P,Silva Vasconcelos LR,Moura P,da Silva Teixeira VG

    更新日期：2020-08-01 00:00:00

  • The clinical implications of HLA mismatches in unrelated donor haematopoietic cell transplantation.

    abstract：:Haematopoietic stem cell transplantation (HSCT), using unrelated donors (UD), is now a common modality of treatment for individuals with a variety of different diseases. HLA matching has been shown to have a significant impact on patient outcome. This study includes 423 unrelated UK patient/donor pairs. The patients a...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2008.00793.x

    authors： Shaw BE

    更新日期：2008-08-01 00:00:00

  • No evidence for association of the TP53 12139 and the BAX-248 polymorphisms with endemic pemphigus foliaceus (fogo selvagem).

    abstract：:Pemphigus foliaceus (PF) is an autoimmune bullous epidermal disease, characterized by autoantibodies specific to the desmosomal protein desmoglein 1 (dsg1) and by acantholysis, the rupture of the cellular junctions among keratinocytes. Known also as fogo selvagem (wild fire) in Brazil, the disease has distinct epidemi...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2006.00585.x

    authors： Köhler KF,Petzl-Erler ML

    更新日期：2006-04-01 00:00:00

  • HLA genotyping using the Illumina HLA TruSight next-generation sequencing kits: A comparison.

    abstract：:Illumina first introduced their TruSight human leucocyte antigen (HLA) next-generation sequencing (NGS) typing kit in 2015 and subsequently followed up with a new version in 2016. Here we report on our experience comparing the two versions of the Illumina HLA NGS kits. ...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12322

    authors： Profaizer T,Lázár-Molnár E,Pole A,Delgado JC,Kumánovics A

    更新日期：2017-08-01 00:00:00

  • Identification of a novel MICB allele, MICB*030, by cloning and sequencing.

    abstract：:A novel MICB allele, MICB*030, has been identified in a healthy Chinese individual of Mongol ethnicity residing in northern China by polymerase chain reaction sequence-based typing (PCR-SBT) and confirmed by cloning and sequencing. MICB*030 was linked to HLA-B*35. Aligned with MICB*005:02, MICB*030 has a nonsynonymous...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12207

    authors： Wang WY,Wang F,Tian W

    更新日期：2015-08-01 00:00:00

  • Analysis of polymorphic sites in the promoter of the nitric oxide synthase 2 gene in Brazilian patients with leprosy.

    abstract：:Leprosy is one of the most neglected infectious tropical diseases of the skin and the nerves caused by the intracellular pathogen Mycobacterium leprae. The inducible NOS isoform encoded by NOS2A plays a vital role in host defence against bacterial infections. The functional promoter polymorphisms in NOS2A are associat...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12108

    authors： Messias-Reason IJ,van Tong H,Velavan TP

    更新日期：2014-06-01 00:00:00

  • Dominant, non-MHC genetic control of food allergy in an adjuvant-free mouse model.

    abstract：:Food allergy is a potentially fatal immune-mediated disorder with incompletely understood mechanisms. We studied the genetic control of food allergy using major histocompatibility complex-identical mice (H2(s)) and an adjuvant-free method of sensitization. Whereas, transdermal exposure to hazelnut - a model allergenic...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2009.00860.x

    authors： Parvataneni S,Birmingham NP,Gonipeta B,Gangur V

    更新日期：2009-10-01 00:00:00

  • Presence of the functional CASPASE-12 allele in Indian subpopulations.

    abstract：:Most humans lack a functional CASP12 gene, with the nonfunctional variant (CASP12p1), found in 100% of the Caucasian and east Asian population, and in approximately 80% of people of African descent. However, 20% of Africans carry an intact allele of CASP12, which produces a full-length pro-enzyme and increases the ris...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2012.01107.x

    authors： Yavari M,Brinkley G,Klapstein KD,Hartwig WC,Rao R,Hermel E

    更新日期：2012-10-01 00:00:00

  • Frequencies of MICA alleles in patients from southern Brazil with multibacillary and paucibacillary leprosy.

    abstract：:Leprosy is a chronic infectious disease caused by Mycobacterium leprae, which mainly affects the skin and nervous system. The disease has several clinical forms. This study investigated the MICA and HLA-B genes in 223 samples from leprosy patients and 201 samples from healthy individuals matched for age, gender and et...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2011.01074.x

    authors： do Sacramento WS,Mazini PS,Franceschi DA,de Melo FC,Braga MA,Sell AM,Tsuneto LT,Visentainer JE

    更新日期：2012-06-01 00:00:00

  • The -1541 C>T and +4259 G>T of TIM-3 polymorphisms are associated with rheumatoid arthritis susceptibility in a Chinese Hui population.

    abstract：:The T-cell immunoglobulin and mucin domain 3 (TIM-3) has been shown to be associated with susceptibility to rheumatoid arthritis (RA). In this study, we investigated the association of four single-nucleotide polymorphisms (SNPs) of the TIM-3 gene with RA susceptibility in Chinese Hui and Han groups. Using restriction ...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2011.01046.x

    authors： Xu J,Yang Y,Liu X,Wang Y

    更新日期：2011-12-01 00:00:00

  • Study on VNTR polymorphism of gene IL-1RA in 19 Chinese populations.

    abstract：:Earlier studies suggested that a variable number tandem repeat (VNTR) polymorphism in intron 2 of the interleukin-1 receptor antagonist (IL-1RA) gene might be associated with some chronic inflammatory diseases, autoimmune diseases and solid tumours. To study the distribution of this polymorphism in China, 1352 samples...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2009.00891.x

    authors： Jiang J,Zhang X,Sun D,Jin Y,Bai J,Chen F,Fu S

    更新日期：2010-04-01 00:00:00

  • The first report of the human platelet alloantigen 4b allele in a Brazilian.

    abstract：:The human platelet alloantigen (HPA) 4b allele is rarely observed in Caucasians and the observed incidence in Asians is usually lower than 1.0%. We report the first Brazilian with the allele HPA-4b, and were able to determined that he inherited it from his father. ...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2005.00511.x

    authors： Toralles-Pereira C,de M C Pardini MI,Deffune E,Machado PE

    更新日期：2005-06-01 00:00:00

  • Evaluation of Toll-like receptor and adaptor molecule polymorphisms for susceptibility to tuberculosis in a Colombian population.

    abstract：:Immunological studies have supported the idea that innate immunity is critical for the control of Mycobacterium tuberculosis (Mtb) infection in humans. Despite the overwhelming evidence showing the critical role of Toll-like receptors (TLRs) in the in vitro recognition of Mtb, the in vivo significance of individual TL...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2011.01077.x

    authors： Sánchez D,Lefebvre C,Rioux J,García LF,Barrera LF

    更新日期：2012-06-01 00:00:00

  • Role of TLR4 C>1196T (Thr399Ile) and TLR4 A>896G (Asp299Gly) polymorphisms in a North Indian population with asthma: a case-control study.

    abstract：:Toll-like receptor 4 (TLR4) is the most important TLR among the pattern recognition receptors which recognizes lipopolysaccharide of gram-negative bacteria. They identify a highly conserved structure of microbes called pathogen-associated molecular patterns and activate immune and inflammatory responses that have been...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12115

    authors： Sinha S,Singh J,Jindal SK,Birbian N,Singla N

    更新日期：2014-12-01 00:00:00

  • Polymorphism in the proximal promoter region of the perforin gene and its impact on the course of HIV infection.

    abstract：:Cytotoxic T lymphocytes (CTLs) play an essential role in the control of viral replication during human immunodeficiency virus (HIV) infection. However, the efficacy of the CTL response varies between individuals. We tested the hypothesis that genetic polymorphisms in the lytic effector molecule perforin could influenc...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2006.00571.x

    authors： McIlroy D,Meyer L,Dudoit Y,Samri A,Delfraissy JF,Autran B,Debré P,Theodorou I

    更新日期：2006-04-01 00:00:00

  • Discrimination of FCGR2B polymorphism without coamplification of FCGR2A and FCGR2C genes.

    abstract：:The FCGR locus is characterized by high polymorphism and sequence homology. In particular, the Ile232Thr polymorphism in the FCGR2B gene results in inaccurate genotyping in most published papers. The purpose of the study was to develop an accurate genotyping assay able to discriminate this polymorphism. ...

    journal_title：International journal of immunogenetics

    pub_type： 临床试验,杂志文章

    doi：10.1111/iji.12351

    authors： Bonatti F,Adorni A,Percesepe A,Martorana D

    更新日期：2018-02-01 00:00:00

  • HLA haplotypes in recurrent aphthous stomatitis: a mode of inheritance?

    abstract：:The aim of this study was to investigate the genetic association between recurrent aphthous stomatitis (RAS) and human leucocyte antigen (HLA) class I and II alleles and HLA haplotypes. Families selected had at least one child suffering from recurrent aphthous stomatitis in addition to one or both of the parents. HLA-...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2008.00801.x

    authors： Albanidou-Farmaki E,Deligiannidis A,Markopoulos AK,Katsares V,Farmakis K,Parapanissiou E

    更新日期：2008-12-01 00:00:00

  • Frequency of P2RX7 A1513C and TLR2 -196 to -174 ins/del in healthy Polish individuals.

    abstract：:Polymorphisms within genes coding innate immune response proteins are involved in genetic susceptibility to various conditions. We investigated the frequency of P2RX7 A1513C and TLR2 -196 to -174 ins/del polymorphisms in healthy Polish population. Frequency of minor alleles was relatively similar to the pattern presen...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12185

    authors： Lewandowska M,Garczyńska P,Jędrychowska-Dańska K,Kopczyńska P,Masłowska A,Witas H

    更新日期：2015-06-01 00:00:00

  • Association study of polymorphisms within matrix metalloproteinase 9 with bronchial asthma.

    abstract：:Matrix metalloproteinase 9 plays an important role in the development of bronchial asthma. We were interested in whether the polymorphisms -T1702A, -C1562T, R279Q and +C6T within the matrix metalloproteinase 9 (MMP-9) gene were associated with asthma in a population of 231 asthmatic children. However, we found no asso...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2005.00516.x

    authors： Ganter K,Deichmann KA,Heinzmann A

    更新日期：2005-08-01 00:00:00

  • Th-1 cytokines gene polymorphism in human brucellosis.

    abstract：:Brucellosis is a worldwide zoonosis. Infection with Brucella species results in the activation of cell-mediated immune response. The interaction between Th1and Th2 cytokines determines the outcome of disease. Production of each cytokine is in turn affected by genetic factors. In this study, we investigated the possibl...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2006.00626.x

    authors： Davoudi S,Amirzargar AA,Hajiabdolbaghi M,Rasoolinejad M,Soodbakhsh A,Jafari S,Piri H,Maleknejad P,Bagherian H,Madadi N,Nikbin B

    更新日期：2006-10-01 00:00:00

  • Molecular diversity of HLA-A, -B and -C alleles in a North Indian population as determined by PCR-SSOP.

    abstract：:We have used molecular methods to determine the frequencies of human leukocyte antigen (HLA)-A, -B and -C alleles in normal, healthy, unrelated individuals from North India using polymerase chain reaction and hybridization with sequence-specific oligonucleotide probes as there is no comprehensive report showing molecu...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2007.00677.x

    authors： Rani R,Marcos C,Lazaro AM,Zhang Y,Stastny P

    更新日期：2007-06-01 00:00:00