Analysis of polymorphic sites in the promoter of the nitric oxide synthase 2 gene in Brazilian patients with leprosy.

abstract：:Sunlight/ultraviolet (UV) irradiation has been recognized as an important risk factor for developing systemic lupus erythematosus (SLE). However, the interpretation of genetic variations involved in UV-light sensitivity is largely unknown. Recent studies indicated that two genetic variations of ERCC2/XPD gene (rs17997...

journal_title：International journal of immunogenetics

authors： Wan L,Lin YJ,Sheu JJ,Huang CM,Tsai Y,Tsai CH,Wong W,Tsai FJ

更新日期：2009-02-01 00:00:00

abstract：:We report here a novel human leukocyte antigen (HLA) allele, DRB1*1449, in the Han-Chinese population. The nature of the new allele was confirmed by the sequencing-based typing (SBT) method. Genomic DNA and six subclones containing DNA fragment of DRB1 exon 2 were sequenced in both forward and reverse directions. The ...

journal_title：International journal of immunogenetics

authors： Miao KR,Xue M,Zhou XY,Xu R,Fei XM,Pan QQ,Zhang JW,Zhao X,Fan S,KuKuruga D,Xu AL,Wang CY

更新日期：2006-02-01 00:00:00

abstract：:Tumour growth in cutaneous malignant melanoma (CMM) is mediated by cell adhesion molecules, including intercellular adhesion molecule-1 (ICAM-1). ICAM-1 expression is associated with increasing Breslow thickness of vertical growth-phase tumours and, in patients with stage 1 disease, may be associated with disease free...

journal_title：International journal of immunogenetics

authors： Howell WM,Rose-Zerilli MJ,Theaker JM,Bateman AC

更新日期：2005-12-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTLs) play an essential role in the control of viral replication during human immunodeficiency virus (HIV) infection. However, the efficacy of the CTL response varies between individuals. We tested the hypothesis that genetic polymorphisms in the lytic effector molecule perforin could influenc...

journal_title：International journal of immunogenetics

authors： McIlroy D,Meyer L,Dudoit Y,Samri A,Delfraissy JF,Autran B,Debré P,Theodorou I

更新日期：2006-04-01 00:00:00

abstract：:FcγRIIB contains a unique immunoreceptor tyrosine-based inhibition motif (ITIM) and functions as a negative feedback regulator of leucocyte activation and antibody production. We have previously reported FcγRIIB-nt645+25A/G gene polymorphism to be associated with prevalence and severity of periodontitis, FcγRIIB expre...

journal_title：International journal of immunogenetics

authors： Wang Y,Sugita N,Kikuchi A,Iwanaga R,Hirano E,Shimada Y,Sasahara J,Tanaka K,Yoshie H

更新日期：2012-12-01 00:00:00

abstract：:It is now over forty years since the first associations between particular HLA antigens and disease susceptibility were described, and the identification of large numbers HLA-associated diseases parallels our increased understanding of the genetic complexity of the HLA system and its extensive polymorphism. However, s...

journal_title：International journal of immunogenetics

authors： Howell WM

更新日期：2014-02-01 00:00:00

abstract：:C-reactive protein (CRP) is an inflammation marker implicated in the pathogenesis of schizophrenia. To investigate association of the CRP rs1417938, rs1800947, rs1205 variants with susceptibility to schizophrenia 208 unrelated Armenians (103 patients and 105 healthy controls) were genotyped. In this pilot study, none ...

journal_title：International journal of immunogenetics

authors： Zakharyan R,Chavushyan A,Khoyetsyan A,Stahelova A,Arakelyan A,Boyajyan A,Mrazek F,Petrek M

更新日期：2010-10-01 00:00:00

abstract：:Routine HLA typing of a renal patient for purposes of registration for transplantation revealed an unusual human leucocyte antigen (HLA)-B and Cw genotype, with three specificities detected. Results were confirmed in a second sample, and in a second laboratory. The possibility of these results reflecting a chimaeric s...

journal_title：International journal of immunogenetics

authors： Poole K,Montague B,Roberts R,Stoves J,Bendukidze N,Clark B

更新日期：2006-08-01 00:00:00

abstract：:Haematopoietic stem cell transplantation (HSCT) remains the only cure for most haematological malignancies, however, the mortality rate remains high. Complications after HSCT include relapse, graft versus host disease (GvHD), graft rejection and infection. Over the last few years several groups, have demonstrated that...

journal_title：International journal of immunogenetics

authors： Norden J,Pearce KF,Irving JAE,Collin MP,Wang XN,Wolff D,Kolb HJ,Socie G,Kuzmina Z,Greinix H,Holler E,Rocha V,Gluckman E,Hromadnikova I,Dickinson AM

更新日期：2018-07-25 00:00:00

abstract：:Leprosy is a chronic infectious disease caused by Mycobacterium leprae, which mainly affects the skin and nervous system. The disease has several clinical forms. This study investigated the MICA and HLA-B genes in 223 samples from leprosy patients and 201 samples from healthy individuals matched for age, gender and et...

journal_title：International journal of immunogenetics

authors： do Sacramento WS,Mazini PS,Franceschi DA,de Melo FC,Braga MA,Sell AM,Tsuneto LT,Visentainer JE

更新日期：2012-06-01 00:00:00

abstract：:Natural killer (NK) cells have killer cell immunoglobulin-like receptors (KIR) that recognize and interact with HLA class I antigen. The KIRs are a multigene family and its members are often highly polymorphic. Evidence is emerging from disease-association studies that KIR receptors can play beneficial roles in viral ...

journal_title：International journal of immunogenetics

authors： Gardiner CM

更新日期：2008-02-01 00:00:00

abstract：:Single nucleotide polymorphisms (SNPs) in immune-related genes have been shown to play a role in driving the development of the severe phenotypes of dengue virus (DENV) infection. We assessed the association between IFNL3 gene SNP (rs12979860) and dengue clinical outcomes in children. Patients with dengue-related symp...

journal_title：International journal of immunogenetics

authors： da Silva Cezar RD,da Silva Castanha PM,Matos Freire N,Mola C,Feliciano do Carmo R,Tenório Cordeiro M,Baptista P,Silva Vasconcelos LR,Moura P,da Silva Teixeira VG

更新日期：2020-08-01 00:00:00

abstract：:Currently, there is a lack of information on polymorphism of human leucocyte antigen-F (HLA-F) gene in ethnically diverse human populations. In this study, HLA-F allelic typing was performed for 690 individuals representing two southern Chinese Han populations (Hunan Han and Guangdong Han) and two northern Chinese pop...

journal_title：International journal of immunogenetics

authors： Pan FH,Liu XX,Tian W

更新日期：2013-10-01 00:00:00

abstract：:Human papillomavirus (HPV) infection can lead to the development of productive epithelial lesions and cervical cancer. Most cervical HPV infections are solved by cell-mediated immunity within 1-2 years, and it is known that chronic inflammation predisposes to lesions progression and tumour development. In this context...

journal_title：International journal of immunogenetics

authors： Mangieri LFL,Sena MM,Cezar-Dos-Santos F,Trugilo KP,Okuyama NCM,Pereira ÉR,Maria GCQ,Watanabe MAE,de Oliveira KB

更新日期：2019-10-01 00:00:00

abstract：:Pemphigus foliaceus (PF) is an autoimmune bullous epidermal disease, characterized by autoantibodies specific to the desmosomal protein desmoglein 1 (dsg1) and by acantholysis, the rupture of the cellular junctions among keratinocytes. Known also as fogo selvagem (wild fire) in Brazil, the disease has distinct epidemi...

journal_title：International journal of immunogenetics

authors： Köhler KF,Petzl-Erler ML

更新日期：2006-04-01 00:00:00

abstract：:Genome-wide association studies identified many loci associated with the two forms of inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative colitis (UC). Components of the interleukin-23 signalling pathway, such as IL23R, JAK2 and STAT3, have been implicated in both diseases. In addition, emerging evid...

journal_title：International journal of immunogenetics

authors： Polgar N,Csongei V,Szabo M,Zambo V,Melegh BI,Sumegi K,Nagy G,Tulassay Z,Melegh B

更新日期：2012-06-01 00:00:00

abstract：:Mannose-binding lectin (MBL) is a protein able to bind to carbohydrate patterns on pathogen membranes; upon MBL binding, its' associated serine protease MBL-associated serine protease type 2 (MASP2) is autoactivated, promoting the activation of complement via the lectin pathway. For both MBL2 and MASP2 genes, the freq...

journal_title：International journal of immunogenetics

authors： Ferraroni NR,Segat L,Guimarães RL,Brandão LA,Crovella S,Constantino-Silva RN,Loja C,da Silva Duarte AJ,Grumach AS

更新日期：2012-02-01 00:00:00

abstract：:The aim of this study was to evaluate the frequency of TNFa-e microsatellites and the promoter region (TNF-308 and TNF-238) in HIV/AIDS-infected patients presenting or not lipodystrophy syndrome (LS). The design is the genetic case-control association study. Microsatellite and the TNF promoter region polymorphisms wer...

journal_title：International journal of immunogenetics

authors： Silva MM,Simões RT,Castelli EC,Mendes-Junior CT,Deghaide NH,Tsuda LC,Machado AA,Donadi EA,Fernandes AP

更新日期：2010-10-01 00:00:00

abstract：:Earlier studies suggested that a variable number tandem repeat (VNTR) polymorphism in intron 2 of the interleukin-1 receptor antagonist (IL-1RA) gene might be associated with some chronic inflammatory diseases, autoimmune diseases and solid tumours. To study the distribution of this polymorphism in China, 1352 samples...

journal_title：International journal of immunogenetics

authors： Jiang J,Zhang X,Sun D,Jin Y,Bai J,Chen F,Fu S

更新日期：2010-04-01 00:00:00

abstract：:In this study, we aimed to find new genes associated with rheumatoid arthritis (RA) so that more comprehensive genes would be used for monitoring and/or diagnosing patients. Illumina digital gene expression profiling was applied in two sample types - peripheral blood mononuclear cells (PBMCs) and synovial cells to com...

journal_title：International journal of immunogenetics

authors： Wang H,Guo J,Jiang J,Wu W,Chang X,Zhou H,Li Z,Zhao J

更新日期：2017-06-01 00:00:00

abstract：:Induced heteroduplex genotyping (IHG) is one of many methods that can be used to determine single nucleotide polymorphisms (SNPs). It is relatively new in comparison to other polymerase chain reaction (PCR)-based techniques. The aim of this study was to compare the results of genotyping using IHG with the results of g...

journal_title：International journal of immunogenetics

authors： Bown MJ,Weston S,Horsburgh T,Nicholson ML,Bell PR,Sayers RD

更新日期：2005-04-01 00:00:00

abstract：:Knowledge on blood group phenotypes is of key importance in clinical practice. It used in blood transfusion practice to determine the direction of recruitment of voluntary donors as required for each population within a country, and for disease association and population genetics studies. This study aimed at reporting...

journal_title：International journal of immunogenetics

authors： Doku GN,Agbozo WK,Annor RA,Kisseh GD,Owusu MA

更新日期：2019-04-01 00:00:00

abstract：:Programmed death ligand-1 (PD-L1) plays an important role in the attenuation of adaptive immune responses in higher vertebrates. Here, we describe the identification of the Pekin duck PD-L1 orthologue (duPD-L1) and its gene structure. The duPD-L1 cDNA encodes a 311-amino acid protein that has an amino acid identity of...

journal_title：International journal of immunogenetics

authors： Yao Q,Fischer KP,Tyrrell DL,Gutfreund KS

更新日期：2015-04-01 00:00:00

abstract：:Mannose binding lectin (MBL) is an important innate immune system pattern recognition molecule. The MBL gene polymorphisms are reported to play a crucial role in outcome of hepatitis B virus (HBV) infection. In this study, we ascertained the association of MBL genotypes with HBV outcome in a South Indian population. T...

journal_title：International journal of immunogenetics

authors： Fletcher GJ,Gnanamony M,Samuel P,Ismail AM,Kannangai R,Daniel D,Eapen CE,Abraham P

更新日期：2010-06-01 00:00:00

abstract：:Pemphigus foliaceus (PF) is an autoimmune skin disease characterized by autoantibodies directed mainly against desmoglein-1. The purpose of this study was to determine whether differential susceptibility to endemic PF in Brazil (fogo selvagem) is associated with polymorphisms at the cytogenetic location 1p13.2. Four s...

journal_title：International journal of immunogenetics

authors： Lobo-Alves SC,de Oliveira LA,Petzl-Erler ML

更新日期：2019-06-01 00:00:00

abstract：:The FCGR locus is characterized by high polymorphism and sequence homology. In particular, the Ile232Thr polymorphism in the FCGR2B gene results in inaccurate genotyping in most published papers. The purpose of the study was to develop an accurate genotyping assay able to discriminate this polymorphism. ...

journal_title：International journal of immunogenetics

authors： Bonatti F,Adorni A,Percesepe A,Martorana D

更新日期：2018-02-01 00:00:00

abstract：:Perforin is one of the key effector molecules of cytotoxic T cells and natural killer cells. The influence of HLA-DRB1 alleles on peripheral blood perforin-positive CD4, CD8, CD16 and CD 56 cells was studied by flow cytometry. HLA-DRB1 typing was done in normal healthy subjects (NHS: n = 156) and patients with pulmona...

journal_title：International journal of immunogenetics

authors： Rajeswari DN,Selvaraj P,Raghavan S,Jawahar MS,Narayanan PR

更新日期：2007-10-01 00:00:00

abstract：:The Luminex xMAP system has become an important tool for HLA antibody screening and identification in sera of transplant patients. Recently, the Luminex single antigen bead assay was shown to be prone to an artefact, the so called prozone phenomenon: Sera with high titer HLA antibodies gave negative results when teste...

journal_title：International journal of immunogenetics

authors： Weinstock C,Schnaidt M

更新日期：2013-06-01 00:00:00

abstract：:Hashimoto's thyroiditis (HT) is the most prevalent autoimmune thyroid disorder caused by an interaction between genes and environmental triggers. Intrathyroid lymphocytic infiltration may lead to progressive destruction of thyroid tissue and consequently to hypothyroidism. Many studies in different populations have sh...

journal_title：International journal of immunogenetics

authors： Djurovic J,Stojkovic O,Ozdemir O,Silan F,Akurut C,Todorovic J,Savic K,Stamenkovic G

更新日期：2015-06-01 00:00:00

abstract：:Matrix metalloproteinase 9 plays an important role in the development of bronchial asthma. We were interested in whether the polymorphisms -T1702A, -C1562T, R279Q and +C6T within the matrix metalloproteinase 9 (MMP-9) gene were associated with asthma in a population of 231 asthmatic children. However, we found no asso...

journal_title：International journal of immunogenetics

authors： Ganter K,Deichmann KA,Heinzmann A

更新日期：2005-08-01 00:00:00