Abstract:
:Routine HLA typing of a renal patient for purposes of registration for transplantation revealed an unusual human leucocyte antigen (HLA)-B and Cw genotype, with three specificities detected. Results were confirmed in a second sample, and in a second laboratory. The possibility of these results reflecting a chimaeric state was rejected following short tandem repeat (STR) analysis. Although cytogenetic analysis has failed to detect a chromosomal abnormality, these findings support the view that the aberrant expression of HLA in this patient resulted from an unequal crossover event, occurring during meiosis in a previous generation.
journal_name
Int J Immunogenetjournal_title
International journal of immunogeneticsauthors
Poole K,Montague B,Roberts R,Stoves J,Bendukidze N,Clark Bdoi
10.1111/j.1744-313X.2006.00610.xsubject
Has Abstractpub_date
2006-08-01 00:00:00pages
269-70issue
4eissn
1744-3121issn
1744-313Xpii
EJI610journal_volume
33pub_type
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